Abstract:
:Two HLA-A2 restricted epitopes have recently been identified from the broadly expressed tumor antigen survivin, and several vaccination trials in cancer patients based on these survivin-derived peptides have been initiated. Consequently, there is a crucial need for the identification of survivin epitopes restricted to other HLA-molecules in order to extend the proportion of patients that can enter these ongoing clinical trials. In the present study, we characterized 2 survivin-derived epitopes, which are restricted to HLA-B35. Specific T-cell reactivity against these survivin-derived epitopes was found in the peripheral blood from patients with different B-cell malignancies and melanoma. Substitution of the C-terminal anchor residue of the survivin-derived peptides improved the recognition by tumor-infiltrating lymphocytes from melanoma patients. Furthermore, we demonstrated spontaneous cytotoxic T-cell responses to survivin in a primary melanoma lesion. The characterization of these epitopes allows more patients can be included in the ongoing peptide-based survivin vaccination trials against cancer.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Reker S,Becker JC,Svane IM,Ralfkiaer E,Straten PT,Andersen MHdoi
10.1002/ijc.11634keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
937-41issue
6eissn
0020-7136issn
1097-0215journal_volume
108pub_type
杂志文章abstract::In previous studies, the antigen CSH-275 (RTNKEASIC) was found expressed in tissue specimens from colorectal cancer but not in normal colonic mucosa. It was also naturally expressed in the DHD-K12 experimental colorectal cancer in BDIX rats. In this study, we describe the effect of vaccination with the synthetic nonap...
journal_title:International journal of cancer
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更新日期:2004-05-20 00:00:00
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journal_title:International journal of cancer
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更新日期:2003-09-10 00:00:00
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journal_title:International journal of cancer
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abstract::We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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abstract::Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms lead...
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journal_title:International journal of cancer
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更新日期:2014-05-01 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910200505
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更新日期:2004-11-10 00:00:00
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更新日期:2006-06-15 00:00:00
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journal_title:International journal of cancer
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