Tumor-promoting activity of 2,4-dinitrofluorobenzene.

abstract：:We have used differential-display PCR (DD-PCR) to compare renal-cell carcinoma (RCC) and normal kidney gene expression with the aim of identifying genes specifically associated with RCC. Using a modified DD-PCR approach, which was non-radioactive, quicker and simpler than the conventional method, 24 cDNA samples were ...

journal_title：International journal of cancer

authors： Rae FK,Stephenson SA,Nicol DL,Clements JA

更新日期：2000-12-01 00:00:00

abstract：:The object of our multicenter retrospective study was to compare the new histologic World Health Organization (WHO) classification and the classical histologic Bernatz classification in terms of interobserver agreement and prognostic importance. The influence of coexisting diseases was also analyzed using the Charlson...

journal_title：International journal of cancer

authors： Rieker RJ,Hoegel J,Morresi-Hauf A,Hofmann WJ,Blaeker H,Penzel R,Otto HF

更新日期：2002-04-20 00:00:00

abstract：:Oncogene-transformed fibroblasts which expressed IL-1, spontaneously or after activation with conditioned medium (CM) and lipopolysaccharide (LPS), regressed in the syngeneic host. Since regression was significantly influenced by the immune competence of the host (see companion report), we speculated that regression w...

journal_title：International journal of cancer

authors： Zöller M,Douvdevani A,Segal S,Apte RN

更新日期：1992-02-01 00:00:00

abstract：:MET is a master gene controlling a genetic program driving proliferation, apoptosis protection and invasion. The ROR1 pseudokinase acts as a MET substrate. However, its contribution to MET signaling and MET-dependent biological outcomes remains to be elucidated. By structure-function analysis of ROR1 mutants, we show ...

journal_title：International journal of cancer

authors： Gentile A,Lazzari L,Benvenuti S,Trusolino L,Comoglio PM

更新日期：2014-11-15 00:00:00

abstract：:This study evaluates the association of antibodies against HPV-16-derived peptides with cervical cancer and estimates the sensitivity and specificity of the serological assays in relation to HPV DNA detection in cervical cells by PCR. Study subjects were derived from 4 case-control studies carried out in Spain and Col...

journal_title：International journal of cancer

authors： De Sanjosé S,Hamsíková E,Muñoz N,Bosch FX,Hofmannová V,Gili M,Izarzugaza I,Viladiu P,Tormo MJ,Moreo P,Muñoz MT,Ascunce N,Tafur L,Shah KV,Vonka V

更新日期：1996-03-28 00:00:00

abstract：:There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternati...

journal_title：International journal of cancer

authors： Luu HN,Neelakantan N,Geng TT,Wang R,Goh GB,Clemente JC,Jin A,van Dam RM,Jia W,Behari J,Koh WP,Yuan JM

更新日期：2020-10-31 00:00:00

abstract：:Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos...

journal_title：International journal of cancer

authors： Ishikawa K,Fukasawa M,Tsujimoto H,Else JG,Isahakia M,Ubhi NK,Ishida T,Takenaka O,Kawamoto Y,Shotake T

更新日期：1987-08-15 00:00:00

abstract：:A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence was carried out by SSCP and PTT. We identified 5 frameshift mutations: 185delAG (2 times), 189insTGTC, 1241delAC, and 5537delA and 3 missense mutations in BRCA1: 330A > G, 1240C > T, and 5263G > A. ...

journal_title：International journal of cancer

authors： Díez O,Cortés J,Domènech M,Brunet J,Del Río E,Pericay C,Sanz J,Alonso C,Baiget M

更新日期：1999-11-12 00:00:00

abstract：:Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. Under various assumptions and using past data on CIN grade 3 (CIN3) registrations in England and Scotland, we estimate what...

journal_title：International journal of cancer

authors： Sasieni P,Castanon A,Parkin DM

更新日期：2009-01-15 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases. PCNA-positive expression was detected in <25% of tumour cells in 172 (59%) cases and in > 25% in 121 (41%) cases. ...

journal_title：International journal of cancer

authors： Sun XF,Carstensen JM,Stål O,Zhang H,Nordenskjöld B

更新日期：1996-02-20 00:00:00

abstract：:Germline CDKN2A mutations are found in 5-20% of melanoma families. Numerous studies have shown that carriers of CDKN2A mutations have increased risks of non-melanoma cancers, but so far there have been no studies investigating cancer risks in CDKN2A wild type (wt) melanoma families. In this prospective cohort study, i...

journal_title：International journal of cancer

authors： Helgadottir H,Höiom V,Tuominen R,Jönsson G,Månsson-Brahme E,Olsson H,Hansson J

更新日期：2015-11-01 00:00:00

abstract：:Chemotherapy-induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict an individual patient's risk of CIGT. It is believed the gut microbiome...

journal_title：International journal of cancer

authors： Secombe KR,Coller JK,Gibson RJ,Wardill HR,Bowen JM

更新日期：2019-05-15 00:00:00

abstract：:Pancreatic tumors overexpress FGF-2 and t-PA, but the implication of the growth factor in t-PA synthesis and t-PA-dependent tumor invasion remains unknown. FGF-2 is present in different isoforms: The 18 kDa FGF-2 is secreted, while the 22.5 kDa one is nuclearized and exerts intracrine regulations bypassing cell-surfac...

journal_title：International journal of cancer

authors： Escaffit F,Estival A,Bertrand C,Vaysse N,Hollande E,Clemente F

更新日期：2000-02-15 00:00:00

abstract：:A panel of human breast cancer specimens was examined for single base change mutations by DNA sequencing and for larger deletions using a PCR-based assay. In the cancer specimens examined, no sequencing variants were detected other than a previously characterized polymorphism. Although most of the specimens contained ...

journal_title：International journal of cancer

authors： Anandappa SY,Sibson R,Platt-Higgins A,Winstanley JH,Rudland PS,Barraclough R

更新日期：2000-10-15 00:00:00

abstract：:Meningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population-based case-control consortium study of meningioma in five geographic areas. We also studied serum levels of a marker of atopic allergy (IgE) in a subset of study partici...

journal_title：International journal of cancer

authors： Wiemels JL,Wrensch M,Sison JD,Zhou M,Bondy M,Calvocoressi L,Black PM,Yu H,Schildkraut JM,Claus EB

更新日期：2011-10-15 00:00:00

abstract：:Family history of urogenital cancers has been associated with an increased risk of cancer at the same sites. To evaluate the risks of bladder, prostate and renal cell neoplasms for family history of urogenital cancers in first-degree relatives, we analysed data from a case-control study conducted in northern Italy bet...

journal_title：International journal of cancer

authors： Randi G,Pelucchi C,Negri E,Talamini R,Galeone C,Franceschi S,La Vecchia C

更新日期：2007-12-15 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC). Current efforts to eradicate CRC predominantly focused on targeting the proliferation of rapidly growing cancer epithelial cells. This is largely ineffective with resistance arising in most tumors after exposure to chemotherapy. De...

journal_title：International journal of cancer

authors： Deng X,Ruan H,Zhang X,Xu X,Zhu Y,Peng H,Zhang X,Kong F,Guan M

更新日期：2020-03-15 00:00:00

abstract：:We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...

journal_title：International journal of cancer

authors： Pathak DR,Speizer FE,Willett WC,Rosner B,Lipnick RJ

更新日期：1986-01-15 00:00:00

abstract：:Metastasis of colorectal cancer (CRC) is the leading cause of CRC-associated mortality. Angiogenin (ANG), a member of the ribonuclease A superfamily, not only activates endothelial cells to induce tumor angiogenesis, but also targets tumor cells to promote cell survival, proliferation and/or migration. However, its cl...

journal_title：International journal of cancer

authors： Li S,Shi X,Chen M,Xu N,Sun D,Bai R,Chen H,Ding K,Sheng J,Xu Z

更新日期：2019-09-01 00:00:00

abstract：:Initial studies have investigated the association between inflammation and colorectal cancer (CRC) using C-reactive protein (CRP) as a proinflammatory biomarker and have noted inconsistent results among women. We here report the findings from a large prospective study with repeat measurements of CRP, as well as serum ...

journal_title：International journal of cancer

authors： Toriola AT,Cheng TY,Neuhouser ML,Wener MH,Zheng Y,Brown E,Miller JW,Song X,Beresford SA,Gunter MJ,Caudill MA,Ulrich CM

更新日期：2013-06-01 00:00:00

abstract：:People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer dia...

journal_title：International journal of cancer

authors： Trickey A,May MT,Gill MJ,Grabar S,Vehreschild J,Wit FWNM,Bonnet F,Cavassini M,Abgrall S,Berenguer J,Wyen C,Reiss P,Grabmeier-Pfistershammer K,Guest JL,Shepherd L,Teira R,d'Arminio Monforte A,Del Amo J,Justice A,Cost

更新日期：2020-06-01 00:00:00

abstract：:Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperatio...

journal_title：International journal of cancer

authors： Bertino P,Marconi A,Palumbo L,Bruni BM,Barbone D,Germano S,Dogan AU,Tassi GF,Porta C,Mutti L,Gaudino G

更新日期：2007-07-01 00:00:00

abstract：:Evidence indicates that acquired resistance of cancers to chemotherapeutic agents can occur via epigenetic mechanisms. Down-regulation of expression of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in the biosynthesis of arginine, has been associated with the development of platinum resistance in ovari...

journal_title：International journal of cancer

authors： Nicholson LJ,Smith PR,Hiller L,Szlosarek PW,Kimberley C,Sehouli J,Koensgen D,Mustea A,Schmid P,Crook T

更新日期：2009-09-15 00:00:00

abstract：:In a prospective study with a median follow-up of 13 months on a series of 71 breast cancer patients, 9 developed haematogenous metastases. The neu protein was found on the cell membranes in 27 of the 71 carcinomas (38%) by an immunohistochemical technique using a monoclonal antibody (MAb). Eight of the 9 patients wit...

journal_title：International journal of cancer

authors： De Potter CR,Beghin C,Makar AP,Vandekerckhove D,Roels HJ

更新日期：1990-01-15 00:00:00

abstract：:The epidemiologic association between physical activity and breast cancer has been corroborated in many studies. Some inconsistencies remain, possibly due to variation in life periods for exposure assessment, confounding and undetected effect modification. In our cohort study, we address some of these questions by tak...

journal_title：International journal of cancer

authors： Moradi T,Adami HO,Ekbom A,Wedrén S,Terry P,Floderus B,Lichtenstein P

更新日期：2002-07-01 00:00:00

abstract：:Data on human T-cell lymphotropic-virus-type-I (HTLV-I) status and hematology from 528 individuals were analyzed for associations with low reactivity to the purified protein derivative (PPD) of Mycobacterium tuberculosis recall antigen. Subjects were classified as HTLV-I carriers with abnormal lymphocytes (Ably), carr...

journal_title：International journal of cancer

authors： Welles SL,Tachibana N,Okayama A,Shioiri S,Ishihara S,Murai K,Mueller NE

更新日期：1994-02-01 00:00:00

abstract：:Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...

journal_title：International journal of cancer

authors： Bagheri-Yarmand R,Mazumdar A,Sahin AA,Kumar R

更新日期：2006-06-01 00:00:00

abstract：:It has been suggested that smoking is associated with estrogen-negative breast cancer but not with estrogen-positive breast cancer. A population-based case-control study was conducted in Geneva, Switzerland, to determine the relation of passive and active smoking to breast cancer when the referent unexposed category c...

journal_title：International journal of cancer

authors： Morabia A,Bernstein M,Ruiz J,Héritier S,Diebold Berger S,Borisch B

更新日期：1998-01-30 00:00:00

abstract：:Insulin-like growth factor-binding protein 7 (IGFBP7) functions in several cellular processes including proliferation, senescence and apoptosis. This study analyzed IGFBP7 function in hepatocellular carcinoma (HCC) cells by gene manipulation and investigated the prognostic significance of IGFBP7 expression in clinical...

journal_title：International journal of cancer

authors： Tomimaru Y,Eguchi H,Wada H,Kobayashi S,Marubashi S,Tanemura M,Umeshita K,Kim T,Wakasa K,Doki Y,Mori M,Nagano H

更新日期：2012-01-15 00:00:00

abstract：:Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM leve...

journal_title：International journal of cancer

authors： Gào X,Wilsgaard T,Jansen EH,Holleczek B,Zhang Y,Xuan Y,Anusruti A,Brenner H,Schöttker B

更新日期：2019-07-01 00:00:00