Serological response to HPV16 in CIN-III and cervical cancer patients. Case-control studies in Spain and Colombia.


:This study evaluates the association of antibodies against HPV-16-derived peptides with cervical cancer and estimates the sensitivity and specificity of the serological assays in relation to HPV DNA detection in cervical cells by PCR. Study subjects were derived from 4 case-control studies carried out in Spain and Colombia. Sera from 544 cases of CIN III and invasive cancer and of 543 age-matched controls were tested for antibodies to 5 peptides derived from E2, E7 (3 partially overlapping frames of HPV 16 denoted E7/ 1, E7/2, E7/3) and L2 open reading frames of HPV 16. HPV DNA was detected using a L1-PCR based method. Among cancer controls, antibody response to E2 and E7/1, E7/2, E7/3 was higher in Colombia (22.5%,7.2%,11.7%,12.6% respectively) than in Spain (17.1 %, 4.7%, 5.9%, 5.9%). E7 antibodies were related to stage, particularly in CIN III vs. invasive stages and less markedly within invasive stages. Detection of antibodies to the E7/1 was associated to CIN III (OR = 1.8). The risk of invasive cervical cancer was increased among those with antibodies to E2 (OR = 2.2), to E7/1 (OR = 4.2), to E7/2 (OR = 4.3), and to E7/3 (OR = 2.5). Presence of antibodies to all the 3 E7 peptides increased the risk of CIN III (OR = 5.6) and that of invasive cancer (OR = 17.5). High levels of antibodies to E7/1 or E7/2 or E7/3 increased the risk of invasive cervical cancer (OR for high levels of antibodies vs. negatives to E7/1 OR = 22.6; E7/2 OR = 7.5, E7/3 OR = 3.4). In the present analysis, antibodies to L2 were not associated with either CIN III or cervical cancer. Serological markers of HPV 16 detected less than half of the HPV-16-DNA-positive cases. It is concluded that antibodies to E2 and particularly E7 antigens are strongly associated with cervical cancer. Antibodies to E7 seem to be a moderate marker of tumor burden.


Int J Cancer


De Sanjosé S,Hamsíková E,Muñoz N,Bosch FX,Hofmannová V,Gili M,Izarzugaza I,Viladiu P,Tormo MJ,Moreo P,Muñoz MT,Ascunce N,Tafur L,Shah KV,Vonka V




Has Abstract


1996-03-28 00:00:00














  • Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma.

    abstract::The insulin like growth factor (IGF) signaling pathway has been shown to contribute to melanoma progression, but little is known about the role of the IGF binding protein 3 (IGFBP-3) in melanoma biology. The aim of the present study was to characterize expression, function and regulation of IGFBP-3 in malignant melano...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oy GF,Slipicevic A,Davidson B,Solberg Faye R,Maelandsmo GM,Flørenes VA

    更新日期:2010-01-15 00:00:00

  • Castration induces autoantibody and T cell responses that correlate with inferior outcomes in an androgen-dependent murine tumor model.

    abstract::We recently reported that hormone therapy induces antigen-specific autoantibody responses in prostate cancer patients. However, the contribution of autoantibody responses to clinical outcomes is unknown. We used an animal model to test the hypothesis that hormone therapy-induced immune responses may be associated with...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hahn S,Nesslinger NJ,Drapala RJ,Bowden M,Rennie PS,Pai HH,Ludgate C,Nelson BH

    更新日期:2009-12-15 00:00:00

  • Geographic variation of gallbladder cancer mortality and risk factors in Chile: a population-based ecologic study.

    abstract::Chile's gallbladder cancer rates are among the highest in the world, being the leading cause of cancer deaths among Chilean women. To provide insights into the etiology of gallbladder cancer, we conducted an ecologic study examining the geographical variation of gallbladder cancer and several putative risk factors. Th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Andia ME,Hsing AW,Andreotti G,Ferreccio C

    更新日期:2008-09-15 00:00:00

  • Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer.

    abstract::There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hong AM,Dobbins TA,Lee CS,Jones D,Fei J,Clark JR,Armstrong BK,Harnett GB,Milross CG,Tran N,Peculis LD,Ng C,Milne AG,Loo C,Hughes LJ,Forstner DF,O'Brien CJ,Rose BR

    更新日期:2011-04-01 00:00:00

  • Expression of Burkitt lymphoma-associated antigen (defined by the monoclonal antibody 38.13) on both normal and malignant germinal-centre B cells.

    abstract::Monoclonal antibody 38.13 was raised against the Burkitt lymphoma cell line Daudi and has been previously shown to recognize a globotriaosylceramide (Pk) determinant expressed selectively on Burkitt and a few other B-cell lymphomas. We report here that 38.13 binds to a subset of normal B lymphocytes in germinal centre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Murray LJ,Habeshaw JA,Wiels J,Greaves MF

    更新日期:1985-11-15 00:00:00

  • Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3.

    abstract::Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by which the STAT3 is activated in cancer cells is poorly understood. We observed that human ovarian xenograft tumors (A2780) in mice were severely hypoxic (pO(2) app...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Selvendiran K,Bratasz A,Kuppusamy ML,Tazi MF,Rivera BK,Kuppusamy P

    更新日期:2009-11-01 00:00:00

  • c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line.

    abstract::Transcription factor c-Jun serves for cellular proliferation, survival, differentiation and transformation and is recognized as an important factor in cancer development, including hepatocellular carcinoma (HCC). The purpose of present study is to determine the involvement of c-Jun in matrix metalloproteinase-1 (MMP-1...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sugioka Y,Watanabe T,Inagaki Y,Kushida M,Niioka M,Endo H,Higashiyama R,Okazaki I

    更新日期:2004-05-10 00:00:00

  • Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis.

    abstract::Suppression of apoptosis may favor the onset and progression of cancer. Survivin is an inhibitor of apoptosis that has been suggested as a novel diagnostic/prognostic marker of bladder cancer. In this study, survivin mRNA expression was measured by a sensitive real-time PCR assay in tumor tissue and urine from bladder...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weikert S,Christoph F,Schrader M,Krause H,Miller K,Müller M

    更新日期:2005-08-10 00:00:00

  • Quantitative determination of water-soluble scavengers in neoplastic and non-neoplastic human breast tissue.

    abstract::The water-soluble scavengers ascorbic acid (Asc), cysteine (Cys), glutathione (GSH) and uric acid (UA) as well as DNA content were determined in 40 breast tissue samples (neoplastic and non-neoplastic tissues from 20 patients). To allow proper homogenization to take place, a fixed number of sections was cut from a tis...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Honegger CG,Torhorst J,Langemann H,Kabiersch A,Krenger W

    更新日期:1988-05-15 00:00:00

  • Genetic features of multicentric/multifocal intramucosal gastric carcinoma.

    abstract::Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mizuguchi A,Takai A,Shimizu T,Matsumoto T,Kumagai K,Miyamoto S,Seno H,Marusawa H

    更新日期:2018-10-15 00:00:00

  • Effect of retinoids on the proliferation, morphology and expression of glial fibrillary acidic protein of an anaplastic astrocytoma cell line.

    abstract::We studied the effect of retinoids on the growth and differentiation of a cell line (U 343 MG-A) derived from a human malignant astrocytoma. Cultures treated with all-trans or 13-cis retinoic acid showed a dose-dependent inhibition of proliferation and a marked reduction in the mean cell number at the plateau phase of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rutka JT,De Armond SJ,Giblin J,McCulloch JR,Wilson CB,Rosenblum ML

    更新日期:1988-09-15 00:00:00

  • Second primary cancers after anogenital, skin, oral, esophageal and rectal cancers: etiological links?

    abstract::The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hemminki K,Jiang Y,Dong C

    更新日期:2001-07-15 00:00:00

  • Regulation of urokinase-type plasminogen activator expression in squamous-cell carcinoma of the oral cavity.

    abstract::We undertook a study to determine the role and regulation of expression of urokinase-type plasminogen activator in squamous-cell carcinoma of the oral cavity. The contribution of urokinase to the invasive process was clearly demonstrated in experiments in which in vitro invasion by a cultured squamous-cell carcinoma c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Clayman G,Wang SW,Nicolson GL,el-Naggar A,Mazar A,Henkin J,Blasi F,Goepfert H,Boyd DD

    更新日期:1993-04-22 00:00:00

  • Functional role of sialyl Lewis X and fibronectin-derived RGDS peptide analogue on tumor-cell arrest in lungs followed by extravasation.

    abstract::Our study demonstrates that synthetic sialyl Lewis X (SLex) as a ligand for selectins and fibronectin-derived RGDS peptide analogue [Ar(DRGDS)3] inhibits lung metastases produced by i.v. co-injection of B16-BL6 melanoma cells. To investigate the inhibitory mechanisms in a living animal, we performed positron-emission ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saiki I,Koike C,Obata A,Fujii H,Murata J,Kiso M,Hasegawa A,Komazawa H,Tsukada H,Azuma I,Okada S,Oku N

    更新日期:1996-03-15 00:00:00

  • Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes.

    abstract::Oncogenes of the myc family c-raf-1 and K-ras have been reported to modulate radiosensitivity. We examined the possible relationship between in vivo radiosensitivity to single-dose irradiation with 3-10 Gy, and activity of these proto-oncogenes in 2 sets of small-cell lung cancer (SCLC) xenografts, the CPH and the GLC...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rygaard K,Slebos RJ,Spang-Thomsen M

    更新日期:1991-09-09 00:00:00

  • Microsatellite instability in synchronous gastric carcinomas.

    abstract::Synchronous gastric carcinomas are found in 4% to 10% of all gastric carcinomas, and the tumor multiplicity is believed to be related to genetic predisposition. To investigate the role of mismatch repair error in synchronous gastric carcinomas, we analyzed the microsatellite instability (MSI) status of 101 cancers fro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee HS,Lee BL,Kim SH,Woo DK,Kim HS,Kim WH

    更新日期:2001-03-01 00:00:00

  • Enhancement by TPA of phenotypes associated with transformation in carcinogen-treated human cells: evidence for a selective mechanism.

    abstract::The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) was found to increase the incidence of phenotypic alterations induced by the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in human endometrial stromal cells. Following carcinogen treatment, changes in saturation density, gamma-glutam...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Siegfried JM,Kaufman DG

    更新日期:1983-10-15 00:00:00

  • Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-90.

    abstract::China was one of the countries with the highest esophagus cancer risk in the world during the 1970s. This report provides data on time trends of esophagus cancer incidence and mortality during the 1970s-90s in selected geographic areas of China. Information on newly diagnosed cancer cases and cancer deaths is based on...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ke L

    更新日期:2002-11-20 00:00:00

  • A randomized, placebo-controlled, phase 1/2 study of tivantinib (ARQ 197) in combination with irinotecan and cetuximab in patients with metastatic colorectal cancer with wild-type KRAS who have received first-line systemic therapy.

    abstract::Cetuximab in combination with an irinotecan-containing regimen is a standard treatment in patients with KRAS wild-type (KRAS WT), metastatic colorectal cancer (mCRC). We investigated the addition of the oral MET inhibitor tivantinib to cetuximab + irinotecan (CETIRI) based on preclinical evidence that activation of th...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Eng C,Bessudo A,Hart LL,Severtsev A,Gladkov O,Müller L,Kopp MV,Vladimirov V,Langdon R,Kotiv B,Barni S,Hsu C,Bolotin E,von Roemeling R,Schwartz B,Bendell JC

    更新日期:2016-07-01 00:00:00

  • Antibody responses to Herpesvirus papio antigens in baboons with lymphoma.

    abstract::An Epstein-Barr virus-related herpesvirus, termed Herpesvirus papio (HVP), was isolated from baboons (Papio hamadryas) at the Institute of Experimental Pathology and Therapy, Sukhumi, USSR, where there is a continuing outbreak of lymphoma. In the present study sera from diseased baboons and from age- and sex-matched c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Neubauer RH,Rabin H,Strnad BC,Lapin BA,Yakovleva LA,Indzie E

    更新日期:1979-02-01 00:00:00

  • Increased levels of 5-fluorouracil-induced DNA lesions in Bloom's syndrome.

    abstract::In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lönn U,Lönn S,Nylen U,Winblad G

    更新日期:1990-03-15 00:00:00

  • Chronic inflammation and risk of colorectal and other obesity-related cancers: The health, aging and body composition study.

    abstract::Evidence of the association between chronic inflammation and the risk of colorectal cancer (CRC) and other obesity-related cancers (OBRC) remains inconsistent, possibly due to a paucity of studies examining repeated measures of inflammation. In the Health ABC prospective study of 2,490 adults aged 70-79 years at basel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Izano M,Wei EK,Tai C,Swede H,Gregorich S,Harris TB,Klepin H,Satterfield S,Murphy R,Newman AB,Rubin SM,Braithwaite D,Health ABC study.

    更新日期:2016-03-01 00:00:00

  • Nanoparticle-based photothermal and photodynamic immunotherapy for tumor treatment.

    abstract::Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Hou X,Tao Y,Pang Y,Li X,Jiang G,Liu Y

    更新日期:2018-12-15 00:00:00

  • Elevated cerebrospinal fluid fibronectin concentration at diagnosis indicates poor prognosis in children with acute lymphoblastic leukemia.

    abstract::We investigated whether the concentration of fibronectin (FN) in the cerebrospinal fluid (CSF) could be used for identifying patients with subclinical blast-cell infiltration in the central nervous system (CNS) and an increased risk of CNS relapse later in the course of their leukemia. Our series comprised 36 children...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rautonen J,Koskiniemi M,Siimes MA,Salonen EM,Vaheri A

    更新日期:1989-01-15 00:00:00

  • 7-Deoxynarciclasine shows promising antitumor efficacy by targeting Akt against hepatocellular carcinoma.

    abstract::Akt is a promising therapeutic target for cancer treatment. In our study, we have identified that 7-deoxynarciclasine (7-DONCS) is a potential inhibitor of Akt, which results in the repression of multiple oncogenic processes in hepatocellular carcinoma (HCC). We have found that 7-DONCS suppresses the growth of HCC by ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yin S,Qiu Y,Jin C,Wang R,Wu S,Liu H,Koo S,Han L,Zhang Y,Gao X,Pang X,Wang T,Yu H

    更新日期:2019-12-15 00:00:00

  • Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function.

    abstract::Resistance to cisplatin-based chemotherapy is a major cause of treatment failure in human ovarian cancer. Wild-type TP53 status is often, but not always, associated with cisplatin sensitivity, suggesting that additional factors may be involved. Overexpression/activation of the phosphatidylinositol-3-kinase/Akt pathway...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fraser M,Bai T,Tsang BK

    更新日期:2008-02-01 00:00:00

  • Characterization of a human papillomavirus from epidermodysplasia verruciformis lesions of a patient from Upper-volta.

    abstract::A case of epidermodysplasia verruciformis in a patient from Upper-Volta is described. Slightly elevated, flat warts were observed on hands, feet, arms and legs, and pityriasis versicolor-like lesions were found mainly on the trunk. The patient showed no malignant tumors. Histological examination revealed hyperkeratosi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pfister H,Nürnberger F,Gissmann L,zur Hausen H

    更新日期:1981-05-15 00:00:00

  • Activation of ras oncogenes and expression of tumor-specific transplantation antigens in methylcholanthrene-induced murine fibrosarcomas.

    abstract::The DNA of 22 fibrosarcomas, newly induced in BALB/c mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonucleotide hybridizati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Carbone G,Borrello MG,Molla A,Rizzetti MG,Pierotti MA,Della Porta G,Parmiani G

    更新日期:1991-02-20 00:00:00

  • Randomized trial on the effect of radiotherapy in addition to 6 cycles CMF in node-positive breast-cancer patients. The German Breast-Cancer Study Group.

    abstract::In 1984 the GBSG started a multicenter randomized trial to compare the effectiveness of 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) with or without radiotherapy (RT) as adjuvant treatment in node-positive breast-cancer patients treated by mastectomy. During 5 years, 199 patients were randomized. ...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Schmoor C,Bastert G,Dunst J,Bojar H,Christmann D,Unbehaun V,Tümmers G,Bauer W,Sauerbrei W,Schumacher M

    更新日期:2000-05-01 00:00:00

  • Mitotic activity, apoptosis and TRPM-2 mRNA expression in DMBA-induced rat mammary carcinoma treated with anti-estrogen toremifene.

    abstract::Anti-estrogen toremifene inhibits growth of the 7,12-dimethylbenz(a)anthracene(DMBA)-induced rat mammary carcinoma. The changes in proliferation and cell death were studied in detail. Proliferation was measured by counting mitotic figures in histologic sections, expressed by volume-corrected mitotic index (M/V INDEX)....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huovinen R,Wärri A,Collan Y

    更新日期:1993-10-21 00:00:00