Abstract:
:Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. Under various assumptions and using past data on CIN grade 3 (CIN3) registrations in England and Scotland, we estimate what cervical cancer rates would have been in the absence of screening. Data on registrations of cervical carcinoma in situ for England and Scotland were used to project the additional numbers of invasive cervical cancers that would have resulted had the carcinoma in situ not been treated. We compare the resulting cervical cancer rates (under different models) with rates recorded in Cancer Incidence in 5 Continents. In order for the projected rates in England and Scotland at ages 20-24 not to be exceptionally high compared to maximum recorded rates for each registry in Cancer Incidence in 5 Continents, the progression rate from CIN3 to invasive cancer in women aged 20-24 should not exceed 1% per year. Similar progression rates were reasonable for women aged 25-29. Under the previously accepted assumption of 4.33% progression per year, cervical cancer rates in women aged 20-29 in both England and Scotland would have been 2-5 times greater than any observed rate (other than one registry, based on just 4 cases). From this analysis, at most 1.5% of women treated (equivalent to 3% of CIN3 registrations) would have had cancer by age 25, whereas it is reasonable to assume that over half of them would have regressed by age 25.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Sasieni P,Castanon A,Parkin DMdoi
10.1002/ijc.23922subject
Has Abstractpub_date
2009-01-15 00:00:00pages
461-4issue
2eissn
0020-7136issn
1097-0215journal_volume
124pub_type
杂志文章abstract::With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33394
更新日期:2020-11-13 00:00:00
abstract::Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy charged particles in space necessitate the study of the basic biological mechanisms associated with exposure to heavy ions. As the most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.26445
更新日期:2012-03-01 00:00:00
abstract::It is unclear which chromosome arms frequently show loss of heterozygosity (LOH) in adenocarcinoma of the uterine cervix. To identify such chromosomal arms, LOH on 52 different chromosome loci was examined using laser capture microdissection and PCR-LOH analysis in 25 common-type adenocarcinomas, comprising 13 cases o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10228
更新日期:2002-04-10 00:00:00
abstract::Oncogenic mutations of the ras gene leading to constitutive activation of downstream effectors have been detected in a large spectrum of human cancers (pancreas, thyroid, colon and NSCLC). Membrane anchorage of Ras required for functional activity in signal transduction is facilitated by post-translational modificatio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19991008)83:2<283::aid-ijc
更新日期:1999-10-08 00:00:00
abstract::The murine B16 melanoma (H-2b) was transfected with a retroviral vector containing the mouse IFN-alpha 1 gene. IFN-alpha 1-transfected cells produced IFN-alpha in vitro and exhibited an altered phenotype characterized by a decreased rate of multiplication, enhanced expression of H-2 antigens, an antiviral state to VSV...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600216
更新日期:1995-01-17 00:00:00
abstract::Studies have shown an increased risk of malignancies in women with endometriosis. Little is known about the impact of endometriosis on cancer survival. We investigated whether the survival after a diagnosis of a malignancy differs in women with a previously diagnosed endometriosis compared to other women. Women with a...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.25718
更新日期:2011-08-15 00:00:00
abstract::Twin studies suggest a familial aggregation of bladder cancer but elements of this increased familial risk of bladder cancer are not well understood. To characterize familial risk of bladder cancer, we examined the relationship between family history of bladder and other types of cancer among first-degree relatives an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33486
更新日期:2021-01-27 00:00:00
abstract::In 1979, a hypothesis-generating, population-based case-control study was undertaken in Montreal, Canada, to explore the association between occupational exposure to 294 substances, 130 occupations and industries, and various cancers. Interviews were carried out with 3, 630 histologically confirmed cancer cases, of wh...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000915)87:6<874::aid-ijc18>3.0
更新日期:2000-09-15 00:00:00
abstract::The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390510
更新日期:1987-05-15 00:00:00
abstract::The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cells is defective in a function essential to the replication of the viral genome. The integrated SV40 sequences were molecularly cloned in a bacteriophage, and a subclone (plasmid pSVHBI) contain...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440230
更新日期:1989-08-15 00:00:00
abstract::The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing NPC. We previously demonstrated that unaffected individuals from high-risk families had elevated anti-EBV antibody levels compar...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.21396
更新日期:2006-02-01 00:00:00
abstract::Alterations in the gene copy numbers of the proto-oncogenes HER2/neu and c-myc in primary human breast cancer investigated in 73 patients. We detected amplification of HER2/neu in 17 patient samples and amplification of c-myc in 11, while amplification of both was seen in 6 samples. There was no correlation of age, ho...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.2910430218
更新日期:1989-02-15 00:00:00
abstract::V-ATPases are proton-translocating enzymes, which are found not only in numerous intracellular organelles but also in the plasma membranes of many eukaryotic cells. Using differential display, we have identified one of the proton pump subunit genes, ATP6C, as a cisplatin-inducible gene. Northern blot analysis demonstr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1418
更新日期:2001-09-01 00:00:00
abstract::GC-binding factor 2 (GCF2), a transcriptional repressor that decreases the activity of several genes is capable of binding directly to the GC-rich sequence of the EGFR promoter and repressing the transcriptional activity of EGFR. In addition to its function as a transcriptional repressor, GCF2 can directly interact wi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25837
更新日期:2011-10-01 00:00:00
abstract::The transcription factor PAX3 is expressed during early embryogenesis and in multiple cancer types, including embryonal rhabdomyosarcoma (ERMS), Ewing sarcoma (ES) and malignant melanoma (MEL), suggesting that it could function as a general tumor associated antigen. Major histocompatibility complex (MHC) peptide bindi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21817
更新日期:2006-07-01 00:00:00
abstract::Epstein-Barr virus genome-positive Burkitt's lymphoma is endemic in Africa and Papua New Guinea and in both countries the tumour is restricted to regions with holoendemic malaria. The present work has compared groups of healthy indigenous individuals living in malarious and non-malarious regions of Papua New Guinea fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310609
更新日期:1983-06-15 00:00:00
abstract::More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33181
更新日期:2021-01-01 00:00:00
abstract::A new cell line from a sporadic Wilms' tumor was established and extensively characterized. In nude mice, the tumor cells rapidly formed tumors which, in histological characteristics and extracellular-matrix (ECM) composition resembled sarcomatoid Wilms' tumor. The tumor cells produced B chains of laminin, but no A ch...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540524
更新日期:1993-07-09 00:00:00
abstract::Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31578
更新日期:2018-10-15 00:00:00
abstract::The purpose of this study is to help clarify the use of prostate size as a selection factor for prostate brachytherapy. From 1997 to 1998, 33 patients with a TRUS-based prostate volume greater than 50 cc were treated at the University of Washington by I-125 (144 Gy) or Pd-103 (115 Gy) implantation for prostatic carcin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-08-20 00:00:00
abstract::Despite the substantial benefit of androgen deprivation therapy (ADT) for metastatic prostate cancer, patients often progress to castration-resistant disease (CRPC) that is more difficult to treat. CRPC is associated with renewed androgen receptor activity in tumor cells and restoration of tumor androgen levels throug...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30450
更新日期:2017-01-15 00:00:00
abstract::An increased risk of prostate cancer associated with a family history of prostate cancer has been documented in multiple published reports. Risk has been shown to vary by degree of relationship and age of onset of disease in the affected relative. Several studies, using various designs, have estimated the relative ris...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11466
更新日期:2003-12-10 00:00:00
abstract::Surveillance guidelines for the management of familial colorectal cancer (FCC), a dominant family history of colorectal cancer in which the polyposis syndromes and Lynch syndrome have been excluded, are not firmly established. The outcome of colonoscopic surveillance is studied using data from six centers. DNA mismatc...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.28397
更新日期:2014-02-15 00:00:00
abstract::The alpha 5 beta 1 integrin (CD49e/CD29), a heterodimeric membrane protein, is the "classical" fibronectin receptor on many cell types. During B-cell ontogeny, expression of the alpha 5-subunit is developmentally regulated. The alpha 5 beta 1 is decisive for migration on fibronectin substrate and very likely cooperate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600623
更新日期:1995-03-16 00:00:00
abstract::Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23149
更新日期:2008-03-01 00:00:00
abstract::Smoking and second-hand smoke (SHS) exposure have been recently linked to a higher risk of breast cancer in women. The aim of this work is to estimate the number of deaths and disability-adjusted life years (DALYs) from breast cancer attributable to these two risk factors in the European Union (EU-28) in 2017. The com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33021
更新日期:2020-11-01 00:00:00
abstract::Claudin7 (cld7) is a cancer-initiating cell (CIC) marker in gastrointestinal tumors, a cld7-knockdown (kd) being accompanied by loss of tumor progression. Tumor exosomes (TEX) restoring CIC activities, we explored the contribution of cld7. This became particularly interesting, as tight junction (TJ)- and glycolipid-en...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32312
更新日期:2019-10-15 00:00:00
abstract::Although the incidence of testis cancer has risen markedly in many Western populations over the past half-century, it is not clear whether rates in other populations also have increased. To clarify this issue, we examined testis cancer incidence rates over the 25-year time period of 1973-1997 for selected populations ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20931
更新日期:2005-07-10 00:00:00
abstract::Two HLA-A2 restricted epitopes have recently been identified from the broadly expressed tumor antigen survivin, and several vaccination trials in cancer patients based on these survivin-derived peptides have been initiated. Consequently, there is a crucial need for the identification of survivin epitopes restricted to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11634
更新日期:2004-03-01 00:00:00
abstract::A series of 111 human bladder tumors were screened using oligonucleotide mutant specific probes, restriction enzyme analysis and single-stranded confirmation polymorphism (SSCP) for the presence of H-ras activation events. Thirty-three tumors were found to harbor H-ras mutations where a glycine to valine (G-->T) chang...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550516
更新日期:1993-11-11 00:00:00