Burden of disease from breast cancer attributable to smoking and second-hand smoke exposure in Europe.

abstract：:The variable domain of functional heavy chain antibodies (VHH) devoid of light chains, found in camels, constitute the smallest intact antigen-binding domain fragment. Two camel single-domain fragments, cAb-Lys2 and cAb-Lys3, recognizing an overlapping epitope of lysozyme with a dissociation constant of 2 nM and 65 nM...

journal_title：International journal of cancer

authors： Cortez-Retamozo V,Lauwereys M,Hassanzadeh Gh G,Gobert M,Conrath K,Muyldermans S,De Baetselier P,Revets H

更新日期：2002-03-20 00:00:00

abstract：:Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in e...

journal_title：International journal of cancer

authors： Weiss JM,Huang WY,Rinaldi S,Fears TR,Chatterjee N,Hsing AW,Crawford ED,Andriole GL,Kaaks R,Hayes RB

更新日期：2008-05-15 00:00:00

abstract：:Several tumour-derived factors have recently been identified which induce tissue factor (TF) expression in endothelial cells in vitro. However, there is only limited evidence that endothelial cells lining tumour blood vessels express elevated procoagulant activity (PCA) in vivo. We have investigated the effects of hum...

journal_title：International journal of cancer

authors： Hewett PW,Murray C

更新日期：1996-06-11 00:00:00

abstract：:Tumor-induced immunosuppression remains a major challenge for immunotherapy of cancer patients. To further elucidate why an allogeneic gene-modified [interleukin-7 (IL-7)/CD80-cotransfected] renal cell cancer (RCC) vaccine failed to induce clinically relevant TH-1-polarized immune responses, peripheral blood mononucle...

journal_title：International journal of cancer

authors： Flörcken A,Grau M,Wolf A,Weilemann A,Kopp J,Dörken B,Blankenstein T,Pezzutto A,Lenz P,Lenz G,Westermann J

更新日期：2015-04-15 00:00:00

abstract：:Risk of adult lymphoid malignancy is associated with recent adiposity. Some have reported apparent associations with adiposity in childhood or early adulthood, but whether these associations are independent of recent adiposity is unknown. Birth weight, body size at age 10 years, clothes size at age 20 years, and recen...

journal_title：International journal of cancer

authors： Yang TO,Cairns BJ,Kroll ME,Reeves GK,Green J,Beral V,Million Women Study Collaborators.

更新日期：2016-07-01 00:00:00

abstract：:Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we tested the hypothesis that a C to T variant (Thr241Met) of DNA...

journal_title：International journal of cancer

authors： Shen H,Sturgis EM,Dahlstrom KR,Zheng Y,Spitz MR,Wei Q

更新日期：2002-06-20 00:00:00

abstract：:Hormonal therapies targeting androgen receptor (AR) are effective in prostate cancer (PCa), but often the cancers progress to fatal castrate-resistant disease. Improved understanding of the cellular events during androgen deprivation would help to identify survival and stress pathways whose inhibition could synergize ...

journal_title：International journal of cancer

authors： Saeed K,Östling P,Björkman M,Mirtti T,Alanen K,Vesterinen T,Sankila A,Lundin J,Lundin M,Rannikko A,Nordling S,Mpindi JP,Kohonen P,Iljin K,Kallioniemi O,Rantala JK

更新日期：2015-06-01 00:00:00

abstract：:We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors). In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 87...

journal_title：International journal of cancer

authors： Minafra S,Giambelluca C,Andriolo M,Pucci-Minafra I

更新日期：1995-09-15 00:00:00

abstract：:Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance ...

journal_title：International journal of cancer

authors： Campa D,Butterbach K,Slager SL,Skibola CF,de Sanjosé S,Benavente Y,Becker N,Foretova L,Maynadie M,Cocco P,Staines A,Kaaks R,Boffetta P,Brennan P,Conde L,Bracci PM,Caporaso NE,Strom SS,Camp NJ,Cerhan JR,GEC Consort

更新日期：2012-08-15 00:00:00

abstract：:We have quantified the expression of all 4 isoforms of vascular endothelial growth factor (VEGF) mRNA in non-small-cell lung cancer (NSCLC) using a new kinetic quantitative PCR method, real-time quantitative (RTQ) RT-PCR, and investigated the association between VEGF expression at the mRNA and protein levels and the c...

journal_title：International journal of cancer

authors： Yuan A,Yu CJ,Chen WJ,Lin FY,Kuo SH,Luh KT,Yang PC

更新日期：2000-11-20 00:00:00

abstract：:Breast cancer (BC) is the leading cause of cancer in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported in Uganda and Zimbabwe. However, the magnitude of these rising trends in premenopausal and postmenopausal women is unknown in most African countries. We used data from the African Cancer Regis...

journal_title：International journal of cancer

authors： Joko-Fru WY,Jedy-Agba E,Korir A,Ogunbiyi O,Dzamalala CP,Chokunonga E,Wabinga H,Manraj S,Finesse A,Somdyala N,Liu B,McGale P,Jemal A,Bray F,Parkin DM

更新日期：2020-10-15 00:00:00

abstract：:Multiple myeloma (MM) is a B lymphocyte malignancy that remains incurable despite extensive research efforts. This is due, in part, to frequent disease recurrences associated with the persistence of myeloma cancer stem cells (mCSCs). Bone marrow mesenchymal stromal cells (BMSCs) play critical roles in supporting mCSCs...

journal_title：International journal of cancer

authors： Choi DS,Stark DJ,Raphael RM,Wen J,Su J,Zhou X,Chang CC,Zu Y

更新日期：2015-03-01 00:00:00

abstract：:To assess whether there has been a change in histological features and prognostic factors of primary cutaneous malignant melanoma (CMM) in young individuals in Sweden, an unselected, population-based study was undertaken; 177 cases of primary CMM in persons below 20 years of age were reported to the Swedish National C...

journal_title：International journal of cancer

authors： Sander B,Karlsson P,Rosdahl I,Westermark P,Boeryd B

更新日期：1999-03-01 00:00:00

abstract：:Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...

journal_title：International journal of cancer

authors： Narayan A,Ji W,Zhang XY,Marrogi A,Graff JR,Baylin SB,Ehrlich M

更新日期：1998-09-11 00:00:00

abstract：:Malignant gliomas recur even after extensive surgery and chemo-radiotherapy. Although a relatively novel chemotherapeutic agent, temozolomide (TMZ), has demonstrated promising activity against gliomas, the effects last only a few months and drug resistance develops thereafter in many cases. It has been acknowledged th...

journal_title：International journal of cancer

authors： Zhuang D,Liu Y,Mao Y,Gao L,Zhang H,Luan S,Huang F,Li Q

更新日期：2012-01-15 00:00:00

abstract：:Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation...

journal_title：International journal of cancer

authors： Cuschieri K,Ronco G,Lorincz A,Smith L,Ogilvie G,Mirabello L,Carozzi F,Cubie H,Wentzensen N,Snijders P,Arbyn M,Monsonego J,Franceschi S

更新日期：2018-08-15 00:00:00

abstract：:Resistance to cisplatin is a major obstacle to successful treatment of head and neck squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this resistance, we compared the gene expression profiles between the cisplatin-sensitive SCC cell lines (Sa-3, H-1 and KB) and the cisplatin-resistant cell li...

journal_title：International journal of cancer

authors： Yamano Y,Uzawa K,Saito K,Nakashima D,Kasamatsu A,Koike H,Kouzu Y,Shinozuka K,Nakatani K,Negoro K,Fujita S,Tanzawa H

更新日期：2010-01-15 00:00:00

abstract：:Stage 4 neuroblastoma (NB) is a devastating childhood cancer whose poor outcome has remained essentially unchanged in the last 20 years. Receptor tyrosine kinases have important roles in the control of proliferation, differentiation and apoptosis of NB cells. Thus, we tested the activity of second-generation tyrosine ...

journal_title：International journal of cancer

authors： Vitali R,Mancini C,Cesi V,Tanno B,Piscitelli M,Mancuso M,Sesti F,Pasquali E,Calabretta B,Dominici C,Raschellà G

更新日期：2009-12-01 00:00:00

abstract：:The Cancer Incidence in Five Continents (CI5) series comprises nine volumes that bring together peer-reviewed results from population-based cancer registries worldwide. The aim of each is to make available comparable data on cancer incidence from as wide a range of geographical locations as possible. In addition, the ...

journal_title：International journal of cancer

authors： Parkin DM,Ferlay J,Curado MP,Bray F,Edwards B,Shin HR,Forman D

更新日期：2010-12-15 00:00:00

abstract：:A family history of stomach cancer in first-degree relatives increases the risk of stomach cancer, but uncertainties remain as concerns the variation of the risk according to age, sex and type of relative, as well as on the role of family history of other cancers. We investigated the issue using data from a multicentr...

journal_title：International journal of cancer

authors： Foschi R,Lucenteforte E,Bosetti C,Bertuccio P,Tavani A,La Vecchia C,Negri E

更新日期：2008-09-15 00:00:00

abstract：:Human lung tumors express different types of growth-factor receptors and corresponding ligands that might modulate several biological functions such as proliferation, differentiation, adhesion, and chemotaxis. In the present study, we have investigated the expression of different growth-factor receptors and their liga...

journal_title：International journal of cancer

authors： Bredin CG,Liu Z,Hauzenberger D,Klominek J

更新日期：1999-07-30 00:00:00

abstract：:Because of the absence of data on smoking history for patients in cancer registries, large population-based studies have been unable to directly assess the role of smoking in the risk of multiple primary cancers. In a random sample of 618 adults diagnosed with invasive cancer in 2002 and reported to the population-bas...

journal_title：International journal of cancer

authors： Polednak AP

更新日期：2006-07-01 00:00:00

abstract：:LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...

journal_title：International journal of cancer

authors： To MD,Faseruk SA,Gokgoz N,Pinnaduwage D,Done SJ,Andrulis IL

更新日期：2005-07-01 00:00:00

abstract：:A multi-national, hospital-based, case-control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral c...

journal_title：International journal of cancer

authors：

更新日期：1989-02-15 00:00:00

abstract：:A case-control study involving interviews with 1,244 patients (758 males and 486 females) with cancer of the esophagus or gastric cardia and 1,314 population-based controls (789 males, 525 females) was carried out in Linxian, a rural county in North Central China with one of the world's highest mortality rates for the...

journal_title：International journal of cancer

authors： Li JY,Ershow AG,Chen ZJ,Wacholder S,Li GY,Guo W,Li B,Blot WJ

更新日期：1989-05-15 00:00:00

abstract：:Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...

journal_title：International journal of cancer

authors： Busson P,Zhang Q,Guillon JM,Gregory CD,Young LS,Clausse B,Lipinski M,Rickinson AB,Tursz T

更新日期：1992-04-01 00:00:00

abstract：:A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast-cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER+ tumors is analyzed. ER,...

journal_title：International journal of cancer

authors： Levin E,Actis AM,Caruso S,Gass H,Romero R,Qualeta N,Levin RW

更新日期：1997-11-14 00:00:00

abstract：:Wilms tumor is the most frequent renal neoplasm in children, but our understanding of its genetic basis is still limited. We performed cDNA microarray experiments using 63 primary Wilms tumors with the aim of detecting new candidate genes associated with malignancy grade and tumor progression. All tumors had received ...

journal_title：International journal of cancer

authors： Zirn B,Hartmann O,Samans B,Krause M,Wittmann S,Mertens F,Graf N,Eilers M,Gessler M

更新日期：2006-04-15 00:00:00

abstract：:Factors related to energy metabolism and the metabolic syndrome, such as higher body mass index (BMI), blood glucose, or blood lipids, and blood pressure, are associated with an increased risk of colorectal cancer (CRC). However, CRC is a heterogeneous disease, developing through distinct pathways with differences in ...

journal_title：International journal of cancer

authors： Myte R,Gylling B,Häggström J,Häggström C,Zingmark C,Löfgren Burström A,Palmqvist R,Van Guelpen B

更新日期：2019-07-15 00:00:00

abstract：:Expression of the MDR1 (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR1 mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDR1-expressing normal colonic cells. In 4 colon c...

journal_title：International journal of cancer

authors： Frommel TO,Coon JS,Tsuruo T,Roninson IB

更新日期：1993-09-09 00:00:00