Abstract:
:Human lung tumors express different types of growth-factor receptors and corresponding ligands that might modulate several biological functions such as proliferation, differentiation, adhesion, and chemotaxis. In the present study, we have investigated the expression of different growth-factor receptors and their ligands in 5 established human lung-cancer cell lines. Using RT-PCR, we found that IGF-II/mannose-6-phosphate (M6P), c-met, EGF and c-kit receptors are expressed in 5/5 human lung-cancer cell lines. In order to investigate the biological function of these receptors, we performed Boyden-chamber assays using various growth factors as chemo-attractants. Human non-small-cell-lung-cancer cells (non-SCLC) migrated to recombinant human (rh)IGF I and IGF II at concentrations ranging from 1 to 1000 ng/ml, to HGF at 10 to 100 ng/ml, to EGF at 1 to 100 ng/ml and SCF at 1 to 50 ng/ml. In addition, we performed Boyden-chamber assays using U-1810-, U-1752- and Wart-derived serum-free conditioned medium as chemo-attractants. Serum-free conditioned medium stimulated migration of producer cells in a dose-dependent manner. The autocrine motility stimulating effect of U-1810-derived serum-free conditioned medium could be inhibited by 50% in the presence of neutralizing ahIGF-II antibodies in the assay, suggesting a possible autocrine motility loop in vitro.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Bredin CG,Liu Z,Hauzenberger D,Klominek Jdoi
10.1002/(sici)1097-0215(19990730)82:3<338::aid-ijckeywords:
subject
Has Abstractpub_date
1999-07-30 00:00:00pages
338-45issue
3eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19990730)82:3<338::AID-IJCjournal_volume
82pub_type
杂志文章abstract::Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23774
更新日期:2008-11-15 00:00:00
abstract::The androgen receptor (AR) gene is a transcription factor responsible for mediating the physiological effects of androgens. Evidence suggests that androgens and the androgen receptor are involved in uterine cell proliferation. A polymorphic CAG repeat in exon 1 of the AR gene encodes a polyglutamine tract that is inve...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21436
更新日期:2006-03-01 00:00:00
abstract::Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22414
更新日期:2007-03-01 00:00:00
abstract::Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33230
更新日期:2021-02-01 00:00:00
abstract::Dietary patterns reflect combinations of dietary exposures, and here we examine these in relation to prostate cancer risk. In a case-control study, 80 incident primary prostate cancer cases and 334 urology clinic controls were enrolled from 1997 through 1999 in Kingston, Ontario, Canada. Food-frequency questionnaires ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21112
更新日期:2005-09-10 00:00:00
abstract::Extranodal, nasal NK/T-cell lymphomas are regularly Epstein-Barr virus (EBV)-positive, with a type II latency pattern, expressing thus EBNA-1 and LMP1. The contribution of EBV to the tumor development is not known. Similarly to normal natural killer (NK) cells, cell lines derived from malignancies with a NK phenotype ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22139
更新日期:2006-12-15 00:00:00
abstract::Inhibitors of matrix metalloproteinases (MMPs) were developed as anticancer agents based on the observation that MMPs facilitate local tumor spread and metastasis by promoting matrix degradation and cell migration. Unfortunately, these inhibitors were unsuccessful in the clinical treatment of several cancers, includin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20997
更新日期:2005-08-10 00:00:00
abstract::Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11049
更新日期:2003-06-10 00:00:00
abstract::The role of retinoic acid receptor (RAR) expression in sensitivity to N-(4-hydroxyphenyl)retinamide (4HPR or fenretinide) as well as on the tumorigenicity of human ovarian carcinoma cells was examined. Two human ovarian cancer cell lines, A2780 and IGROV-1, with a 10-fold difference in sensitivity to 4HPR were chosen ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990531)81:5<829::aid-ijc
更新日期:1999-05-31 00:00:00
abstract::Experimental studies have suggested that the biosynthesis of arachidonic acid-derived eicosanoids such as prostaglandin E2 via the cyclo-oxygenase pathway may play a significant role in supporting cell proliferation in human prostate cancer cell lines. However, the aetiological significance of this for clinical prosta...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980812)77:4<511::aid-ijc
更新日期:1998-08-12 00:00:00
abstract::T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580311
更新日期:1994-08-01 00:00:00
abstract::Although treatment of Hodgkin's lymphoma (HL) with a multi-drug approach has been very successful, its toxicity becomes evident after several years as secondary malignancies and cardiovascular disease. Therefore, the current goal in HL treatment is to find new therapies that specifically target the deregulated signali...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23477
更新日期:2008-07-01 00:00:00
abstract::The protein C4.4A, a structural homologue of the urokinase-type plasminogen activator receptor, is a potential new biomarker in non-small cell lung cancer, with high levels of expression recently shown to correlate to poor survival of adenocarcinoma patients. In this study, C4.4A immunoreactivity in precursor lesions ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26305
更新日期:2012-06-01 00:00:00
abstract::Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000601)86:5<741::aid-ijc
更新日期:2000-06-01 00:00:00
abstract::The mounting of a specific immune response against the human papillomavirus type 16 E7 protein (HPV16 E7) is important for eradication of HPV16 E7-expressing cancer cells from the cervical mucosa. To induce a mucosal immune response by oral delivery of the E7 antigen, we expressed the HPV16 E7 antigen on the surface o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22035
更新日期:2006-10-01 00:00:00
abstract::The incidence of adult T-cell leukemia/lymphoma (ATL) and its impact on that of total non-Hodgkin lymphoma (NHL) were evaluated in Nagasaki, an area in southwestern Japan where human T-cell lymphotropic virus type I (HTLV-I) is endemic. The first study area comprised 4 towns located on the K Islands, which had a popul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000201)85:3<319::aid-ijc
更新日期:2000-02-01 00:00:00
abstract::Risk factors for prostate cancer could differ for various sub-groups, such as for "aggressive" and "non-aggressive" cancers or by grade or stage. Determinants of mortality could differ from those for incidence. Using data from the Health Professionals Follow-Up Study, we re-examined 10 factors (cigarette smoking histo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22788
更新日期:2007-10-01 00:00:00
abstract::Moderate to high-dose radiotherapy is known to increase the risk of breast cancer. Uncertainties remain about the effects of low-dose chest X-rays, particularly in individuals at increased genetic risk. We analyzed case-control data from the Breast Cancer Family Registry. Self-reported data on therapeutic and diagnost...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22668
更新日期:2007-07-15 00:00:00
abstract::Galunisertib (LY2157299), a promising small-molecule inhibitor of the transforming growth factor-beta (TGF-β) receptor, is currently in mono- and combination therapy trials for various cancers including glioblastoma, hepatocellular carcinoma and breast cancer. Using genetically modified mouse models, we investigated t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32568
更新日期:2020-03-15 00:00:00
abstract::High-risk Human papilloma virus (HPV) types are the causative agents of cervical cancer and several other anogenital malignancies. The viral proteins expressed in the (pre)malignant cells are considered ideal targets for immunological intervention. Many approaches have been evaluated for this purpose, mostly aiming at...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30679
更新日期:2017-07-15 00:00:00
abstract::CD4(+) Th cells that are restricted by MHC class II molecules play an important role in the induction of antitumor immune responses. We have established a stable CD4(+) Th cell clone (Th35-1A) from the PBMCs of a patient with primary cutaneous melanoma. The Th cell clone is noncytolytic and proliferates specifically i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10964
更新日期:2003-04-10 00:00:00
abstract::A panel of 7 diagnostic cytopathologists, i.e., physicians trained to diagnose the malignant potential of human cells in Papanicolaou-stained smears, was asked to evaluate two sets of microscope slides of stained coverslip preparations of 28 cell culture lines, 15 of which were neoplastic. Slide Set I consisted of 13 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380310
更新日期:1986-09-15 00:00:00
abstract::Retinoids play essential roles in the regulation of cell differentiation and in the proliferation of various epithelial tissues, and atRA is one such active metabolite of retinoids. However, despite the known functions of atRA, its clinical applications are limited due to the induced metabolism by the specific cytochr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11354
更新日期:2003-10-20 00:00:00
abstract::The association between parity and hepatocellular carcinoma (HCC) was studied using a data-base generated by linking 2 Swedish nation-wide registries; the Cancer Registry and the Fertility Registry. Among women born between 1925 and 1960, 133 patients with HCC recorded in the Cancer Registry between 1958 and 1984 were...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550508
更新日期:1993-11-11 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is a major inducer of angiogenesis in tumors. Basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) have both been shown to interact with VEGF. The involvement of VEGF, bFGF, and EGF in melanoma angiogenesis was investigated here. Four human melanoma cell lin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980610)76:6<836::aid-ijc
更新日期:1998-06-10 00:00:00
abstract::Human mammary tumours which are histologically well differentiated are more likely to synthesize receptors for estrogen (ER) and progesterone (PR) and to respond to systemic endocrine therapy. The aim of this study was to explore the relationship between differentiation, receptors and endocrine responsiveness in more ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420203
更新日期:1988-08-15 00:00:00
abstract::The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low-dose computed tomography (LDCT) for lung cancer (LC) screening through age 80. However, the risk of overdiagnosis among older populations is a concern. Using four comparative models from the C...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30602
更新日期:2017-06-01 00:00:00
abstract::The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing NPC. We previously demonstrated that unaffected individuals from high-risk families had elevated anti-EBV antibody levels compar...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.21396
更新日期:2006-02-01 00:00:00
abstract::The effects on cell survival in tissue culture of Adriamycin, of various Adriamycin derivatives and of the parent compound, daunomycin, have been studied. Adriamycin and three of its C-14 derivatives show similar toxicities towards cells chronically exposed in culture. Acute (30 min) exposures are significantly less t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190209
更新日期:1977-02-15 00:00:00
abstract::Trends in the incidence of stomach cancer among 52,604 patients notified to the National Swedish Cancer Registry in 1960 through 1984 were analysed. Age-standardized incidence rates declined throughout the period, from 47.1 to 24.6 per 10(5) in males and from 23.8 to 12.7 per 10(5) in females. Among males the decline ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470405
更新日期:1991-02-20 00:00:00