Parity and hepatocellular carcinoma. A population-based study in Sweden.


:The association between parity and hepatocellular carcinoma (HCC) was studied using a data-base generated by linking 2 Swedish nation-wide registries; the Cancer Registry and the Fertility Registry. Among women born between 1925 and 1960, 133 patients with HCC recorded in the Cancer Registry between 1958 and 1984 were compared with 665 age-matched controls. In this nested case-control study there was no positive association between parity, age at first birth or frequency of twinning on the one hand, and risk of HCC on the other. It appears that the positive association between parity and HCC previously reported is limited to cases of HCC caused by chronic infection with hepatitis B virus; these cases represent only a small fraction of HCC cases in Sweden.


Int J Cancer


Lambe M,Trichopoulos D,Hsieh CC,Ekbom A,Pavia M




Has Abstract


1993-11-11 00:00:00












  • Association of menstrual and reproductive factors with breast cancer risk: results from the Shanghai Breast Cancer Study.

    abstract::The incidence of breast cancer among women in Shanghai, a traditionally low-risk population, has increased substantially over the past 20 years. To evaluate the association of menstrual and reproductive factors with breast cancer risk and the influence of these factors on the temporal trend of breast cancer incidence,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gao YT,Shu XO,Dai Q,Potter JD,Brinton LA,Wen W,Sellers TA,Kushi LH,Ruan Z,Bostick RM,Jin F,Zheng W

    更新日期:2000-07-15 00:00:00

  • Diacylglycerols and the protein kinase inhibitor H-7 suppress cell polarity and locomotion of Walker 256 carcinosarcoma cells.

    abstract::We show that diacylglycerols, like phorbol myristate acetate (PMA), suppress cell polarity and locomotor activity of Walker carcinosarcoma cells in a dose-dependent fashion in vitro. OAG and diC8 show significant activity at concentrations above 3 x 10(-5) M. The inhibitory effect on locomotion is due to a reduction i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Keller HU,Zimmermann A,Niggli V

    更新日期:1989-11-15 00:00:00

  • SULT1A1 polymorphism and esophageal cancer in males.

    abstract::Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G-->A transition at codon 213, carries a significantly higher risk for women to ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Wu MT,Wang YT,Ho CK,Wu DC,Lee YC,Hsu HK,Kao EL,Lee JM

    更新日期:2003-01-01 00:00:00

  • Deficiency of natural killer cell activity in patients with chronic lymphocytic leukemia.

    abstract::Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ziegler HW,Kay NE,Zarling JM

    更新日期:1981-03-15 00:00:00

  • Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma.

    abstract::The genetic events underlying the development of prostate cancer are poorly defined. c-Myc is often activated in tumors that have progressed to metastatic status, so events that promote this process may be important. Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ge K,Minhas F,Duhadaway J,Mao NC,Wilson D,Buccafusca R,Sakamuro D,Nelson P,Malkowicz SB,Tomaszewski J,Prendergast GC

    更新日期:2000-04-15 00:00:00

  • Matched-pair analysis comparing the outcomes of primary breast and nodal diffuse large B-cell lymphoma in patients treated with rituximab plus chemotherapy.

    abstract::Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's lymphoma that has been associated with poorer clinical outcomes compared with nodal DLBCL in the pre-rituximab era. The aim of this study was to investigate the impact of rituximab on clinical outcomes in patients w...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Yhim HY,Kim JS,Kang HJ,Kim SJ,Kim WS,Choi CW,Eom HS,Kim JA,Lee JH,Won JH,Shim H,Huh J,Lee DH,Suh C,Kwak JY

    更新日期:2012-07-01 00:00:00

  • Function but not phenotype of melanoma peptide-specific CD8(+) T cells correlate with survival in a multiepitope peptide vaccine trial (ECOG 1696).

    abstract::ECOG 1696 was a Phase II multi-center trial testing vaccination with melanoma peptides, gp100, MART-1 and tyrosinase delivered alone, with GM-CSF, IFN-α2b or both cytokines to HLA-A2(+) patients with metastatic melanoma. Here, the frequency of circulating CD8(+) tetramer(+) (tet(+) ) T cells and maturation stages of...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Schaefer C,Butterfield LH,Lee S,Kim GG,Visus C,Albers A,Kirkwood JM,Whiteside TL

    更新日期:2012-08-15 00:00:00

  • Cloning and characterization of putative genes that specify sensitivity to neoplastic transformation by tumor promoters.

    abstract::Two putative genes (termed pro 1 and pro 2) specifying sensitivity to induction of neoplastic transformation by TPA in mouse epidermal JB6 cells were cloned by sib selection from a size-selected genomic library of clonal cells sensitive to promotion of transformation. By restriction analysis, heteroduplex analysis, di...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lerman MI,Hegamyer GA,Colburn NH

    更新日期:1986-02-15 00:00:00

  • MAGE-1 and MAGE-3 or -6 expression in neuroblastoma-related pediatric solid tumors.

    abstract::MAGE-1 and MAGE-3 or -6 are genes encoding melanoma-rejection antigens recognized by cytotoxic T lymphocytes in an HLA-A1 restriction manner. MAGE-1 and MAGE-3 or -6 were expressed in 5/14 (36%) and 6/14 (43%) neuroblastoma (NB) cell lines, and in 20/41 (49%) and 24/41 (59%) clinical NB-related tumors, respectively. A...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ishida H,Matsumura T,Salgaller ML,Ohmizono Y,Kadono Y,Sawada T

    更新日期:1996-10-21 00:00:00

  • The association of hormonal contraceptive use and HPV prevalence.

    abstract::Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the associa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Marks M,Gravitt PE,Gupta SB,Liaw KL,Kim E,Tadesse A,Phongnarisorn C,Wootipoom V,Yuenyao P,Vipupinyo C,Rugpao S,Sriplienchan S,Celentano DD

    更新日期:2011-06-15 00:00:00

  • Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology.

    abstract::HnRNP G is a member of heterogeneous nuclear ribonucleoprotein (hnRNP) family with potent tumor suppressive activities. Human transformer-2-beta1 (hTra2-beta1) belongs to the arginine-serine rich like proteins and is found over-expressed in various human cancers. It was recently shown that hnRNP G and hTra2-beta1 exer...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ouyang YQ,zur Hausen A,Orlowska-Volk M,Jäger M,Bettendorf H,Hirschfeld M,Tong XW,Stickeler E

    更新日期:2011-05-01 00:00:00

  • Gastrointestinal stromal tumors: from a surgical to a molecular approach.

    abstract::Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. These tumors span a wide clinical spectrum from benign to malignant and have long been recognized for their nearly absolute resistance to chemotherapy and radiation treatment. We reviewed the worldwide experience on ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Rossi CR,Mocellin S,Mencarelli R,Foletto M,Pilati P,Nitti D,Lise M

    更新日期:2003-11-01 00:00:00

  • Second primary tumors in patients with hereditary retinoblastoma: a register-based follow-up study, 1945-1994.

    abstract::The aim of this register-based follow-up study was to evaluate the long-term cumulative incidence of second primary tumors (SPT) among survivors of hereditary retinoblastoma, with special interest for the incidence of pineoblastoma in retinoblastoma patients born after 1970. The Dutch Retinoblastoma Register was compl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Moll AC,Imhof SM,Bouter LM,Kuik DJ,Den Otter W,Bezemer PD,Koten JW,Tan KE

    更新日期:1996-08-07 00:00:00

  • Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate.

    abstract::Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Karlsson M,Jensen PR,in 't Zandt R,Gisselsson A,Hansson G,Duus JØ,Meier S,Lerche MH

    更新日期:2010-08-01 00:00:00

  • Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers.

    abstract::Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Piipari R,Savela K,Nurminen T,Hukkanen J,Raunio H,Hakkola J,Mäntylä T,Beaune P,Edwards RJ,Boobis AR,Anttila S

    更新日期:2000-06-01 00:00:00

  • HER2 amplification in recurrent breast cancer following breast-conserving therapy correlates with distant metastasis and poor survival.

    abstract::The authors analyzed the HER2 status in early-stage nonrecurrent and recurrent breast cancer groups following breast-conserving treatment. Retrospective analyses of a group of 36 invasive early breast cancer (IBC) patients who developed a local recurrence as a first event and of a random control group of 69 IBC patien...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: López-Guerrero JA,Llombart-Cussac A,Noguera R,Navarro S,Pellin A,Almenar S,Vazquez-Alvadalejo C,Llombart-Bosch A

    更新日期:2006-04-01 00:00:00

  • Human papillomavirus-related anogenital premalignancies and cancer in renal transplant recipients: A Danish nationwide, registry-based cohort study.

    abstract::In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Reinholdt K,Thomsen LT,Dehlendorff C,Larsen HK,Sørensen SS,Haedersdal M,Kjaer SK

    更新日期:2020-05-01 00:00:00

  • Body size in early life and risk of lymphoid malignancies and histological subtypes in adulthood.

    abstract::Risk of adult lymphoid malignancy is associated with recent adiposity. Some have reported apparent associations with adiposity in childhood or early adulthood, but whether these associations are independent of recent adiposity is unknown. Birth weight, body size at age 10 years, clothes size at age 20 years, and recen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yang TO,Cairns BJ,Kroll ME,Reeves GK,Green J,Beral V,Million Women Study Collaborators.

    更新日期:2016-07-01 00:00:00

  • Novel metastasis model of human lung cancer in SCID mice depleted of NK cells.

    abstract::Metastasis is a critical problem in the treatment of human lung cancer. Thus, a suitable animal model of metastasis of human lung cancer is required for in vivo biological and preclinical studies. In this study, we tried to establish a suitable model for this, using SCID mice. Neither human SCLC H69/VP cells (5 x 10(6...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yano S,Nishioka Y,Izumi K,Tsuruo T,Tanaka T,Miyasaka M,Sone S

    更新日期:1996-07-17 00:00:00

  • Dysregulated expression of transforming growth factor beta and its type-I and type-II receptors in basal-cell carcinoma.

    abstract::In mammals, transforming growth factor-beta (TGF-beta) is found in 3 highly homologous isoforms that exert their effects via heteromeric complexes of type-I and type-II receptors (TbetaR-I and TbetaR-II). TGF-beta regulates the growth and metabolism of various cell types, including keratinocytes. We have investigated ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Furue M,Kato M,Nakamura K,Nashiro K,Kikuchi K,Okochi H,Miyazono K,Tamaki K

    更新日期:1997-05-16 00:00:00

  • Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer.

    abstract::The mismatch repair (MMR) genes are involved in the maintenance of genomic integrity. Recently, we showed that common variants in these genes are unlikely to contribute significantly to colorectal cancer risk. The aim of this study was to investigate the role of common variants in the mismatch repair pathway as progno...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Koessler T,Azzato EM,Perkins B,Macinnis RJ,Greenberg D,Easton DF,Pharoah PD

    更新日期:2009-04-15 00:00:00

  • Circadian nutritional behaviours and cancer risk: New insights from the NutriNet-santé prospective cohort study: Disclaimers.

    abstract::Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

    更新日期:2018-11-15 00:00:00

  • Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma.

    abstract::The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We examined whether MM...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cheung WY,Zhai R,Bradbury P,Hopkins J,Kulke MH,Heist RS,Asomaning K,Ma C,Xu W,Wang Z,Hooshmand S,Su L,Christiani DC,Liu G

    更新日期:2012-12-01 00:00:00

  • Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites.

    abstract::Within the Netherlands Cohort Study on diet and cancer, we investigated associations between total alcohol consumption, specific alcoholic beverage consumption and risk of colorectal cancer (CRC) according to anatomical subsite. Hazard Ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bongaerts BW,van den Brandt PA,Goldbohm RA,de Goeij AF,Weijenberg MP

    更新日期:2008-11-15 00:00:00

  • Oncogenesis by interspecific interaction of malignant murine and non-malignant hamster cells in vitro.

    abstract::A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Goldenberg DM,Pavia RA

    更新日期:1975-02-15 00:00:00

  • Site distribution of different types of skin cancer: new aetiological clues.

    abstract::Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Franceschi S,Levi F,Randimbison L,La Vecchia C

    更新日期:1996-07-03 00:00:00

  • Non-MHC-restricted target-cell lysis by a CD4-CD8- TCR alpha beta T-cell line, as well as by TCR gamma delta T-cell lines, results from lymphokine-activated killing.

    abstract::A long-term CD4-CD8- TCR alpha beta human T-cell line, as well as similar CD4-CD8- TCR gamma delta T-cell lines for comparison, were generated from various tissues by negative selection using anti-CD4 and anti-CD8 monoclonal antibodies (MAbs) followed by positive selection with specific anti-TCR MAb and then repeated ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Maziarz RT,Groh V,Prendergast M,Fabbi M,Strominger JL,Burakoff SJ

    更新日期:1991-04-22 00:00:00

  • Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies.

    abstract::Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM leve...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Gào X,Wilsgaard T,Jansen EH,Holleczek B,Zhang Y,Xuan Y,Anusruti A,Brenner H,Schöttker B

    更新日期:2019-07-01 00:00:00

  • Benefits of catch-up in vaccination against human papillomavirus in medium- and low-income countries.

    abstract::Human papillomavirus (HPV) vaccination of a birth cohort of girls in the 9-13 age range is recommended as a priority, but decreases in HPV vaccine cost may make catch-up of a few additional cohorts more attractive not only in high-income countries. We assessed the reduction in HPV16 and 18 infections that could be ach...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Baussano I,Lazzarato F,Ronco G,Dillner J,Franceschi S

    更新日期:2013-10-15 00:00:00

  • TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor.

    abstract::Maspin is a Class II tumor suppressor protein and plays a role in tumor growth by inhibiting cellular invasion and motility. It is a member of the serpin family of protease inhibitors and has been shown to reduce angiogenesis. Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-relat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Spiesbach K,Tannapfel A,Mössner J,Engeland K

    更新日期:2005-04-20 00:00:00