Expression of MaTu-MN protein in human tumor cultures and in clinical specimens.


:MaTu is a novel agent which may be of relevance in human oncogenesis, and has 2 components. One of them, the exogenous MX (coding for protein p58X), is transmissible to human fibroblasts, to HeLa and to HeLa x fibroblast (H/F) hybrids. The other component, MN, is a cellular gene. Its product, the protein p54/58N, is inducible by infecting HeLa cells with MX or by growing them in dense cultures. This p54/58N appears to be a tumor-associated antigen: it is expressed in HeLa and in tumorigenic cells (H/F-T), but not in fibroblasts or in nontumorigenic hybrid cells (H/F-N). Proteins related to p54/58N were also found on immunoblots prepared from human carcinomas of ovary, endometrium and uterine cervix, but not from normal tissues from corresponding organs or from placenta. Using genetically engineered MN protein, we developed a radioimmunoassay for MN-specific antibodies, and for quantitative determination of MN proteins in cell extracts. In HeLa cells infected with MX we observed conspicuous ultrastructural alterations: formation of abundant filaments on the cell surface and amplification of mitochondria. Using immunogold-staining, we visualized the p54/58N on the surface microvilli and in the nucleus, particularly in nucleoli.


Int J Cancer


Závada J,Závadová Z,Pastoreková S,Ciampor F,Pastorek J,Zelník V




Has Abstract


1993-05-08 00:00:00












  • 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer.

    abstract::The major obstacle for the treatment of gastric cancer is recurrence and metastasis; yet, its molecular mechanism is largely unknown. 2-methoxyestradiol (2-ME), a metabolite of the estradiol-17beta, has recently been demonstrated to have multifactorial effects against tumor proliferation and angiogenesis; how these ef...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lin HL,Yang MH,Wu CW,Chen PM,Yang YP,Chu YR,Kao CL,Ku HH,Lo JF,Liou JP,Chi CW,Chiou SH

    更新日期:2007-12-01 00:00:00

  • Vitamin D binding protein and risk of renal cell carcinoma in the prostate, lung, colorectal and ovarian cancer screening trial.

    abstract::Our group has conducted two previous studies on the association between vitamin D binding protein (DBP) and renal cell carcinoma (RCC), the most common form of kidney cancer, finding strong inverse associations. We undertook the current analysis to replicate our findings in a different study population that included w...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kratzer TB,Weinstein SJ,Albanes D,Mondul AM

    更新日期:2020-08-01 00:00:00

  • Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors.

    abstract::Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomerase-associated protein (TPI) and human telomerase catalytic subunit (hTERT), have been identified. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kyo S,Kanaya T,Takakura M,Tanaka M,Yamashita A,Inoue H,Inoue M

    更新日期:1999-03-15 00:00:00

  • Difference in mesothelin-binding ability of serum CA125 between patients with endometriosis and epithelial ovarian cancer.

    abstract::The epithelial ovarian carcinoma (EOC) is an aggressive malignant tumor, and is currently the leading cause of gynecologic cancer death. CA125 is the most commonly used serum marker for EOC, but shows a high-false-positive rate for several benign diseases such as endometriosis. The purpose of our study is therefore to...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sasaki A,Akita K,Ito F,Mori T,Kitawaki J,Nakada H

    更新日期:2015-04-15 00:00:00

  • Human papillomavirus-related anogenital premalignancies and cancer in renal transplant recipients: A Danish nationwide, registry-based cohort study.

    abstract::In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Reinholdt K,Thomsen LT,Dehlendorff C,Larsen HK,Sørensen SS,Haedersdal M,Kjaer SK

    更新日期:2020-05-01 00:00:00

  • Dietary catechins and epithelial cancer incidence: the Zutphen elderly study.

    abstract::The flavonoids, a group of more than 4,000 polyphenolic antioxidants, are potential cancer preventive components of fruits and vegetables. Catechins, one of the 6 major groups of flavonoids, are present in high concentrations in tea as well. Our objective was to evaluate the association between intake of catechins and...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Arts IC,Hollman PC,Bueno De Mesquita HB,Feskens EJ,Kromhout D

    更新日期:2001-04-15 00:00:00

  • Liver endothelial cells participate in T-cell-dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo.

    abstract::Tumor growth and metastasis of lacZ-transduced murine lymphoma ESbL cells inoculated into syngeneic DBA/2 mice are characterized by a transient plateau phase with a constant tumor diameter and low metastatic load, indicating a host response against the tumor. Here we show that endothelial cells participate in a T-cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rocha M,Krüger A,Van Rooijen N,Schirrmacher V,Umansky V

    更新日期:1995-11-03 00:00:00

  • Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

    abstract::The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weedon SJ,Green NK,McNeish IA,Gilligan MG,Mautner V,Wrighton CJ,Mountain A,Young LS,Kerr DJ,Searle PF

    更新日期:2000-06-15 00:00:00

  • Health impact of delayed implementation of cervical cancer screening programs in India: A modeling analysis.

    abstract::India has the highest burden of cervical cancer in the world. To estimate the consequences of delaying implementation of organized cervical cancer screening, we projected the avertable burden of disease under different implementation scenarios of a screening program. We used an individual-based microsimulation model o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Campos NG,Tsu V,Jeronimo J,Regan C,Resch S,Clark A,Sy S,Kim JJ

    更新日期:2019-02-15 00:00:00

  • A CD16/CD30 bispecific monoclonal antibody induces lysis of Hodgkin's cells by unstimulated natural killer cells in vitro and in vivo.

    abstract::In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell line HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternberg cell-associated CD...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hombach A,Jung W,Pohl C,Renner C,Sahin U,Schmits R,Wolf J,Kapp U,Diehl V,Pfreundschuh M

    更新日期:1993-11-11 00:00:00

  • Fried potatoes and human cancer.

    abstract::A considerable public concern about cancer risk from acrylamide-rich foods followed the announcement that high concentrations of acrylamide are found in fried potatoes and potato chips and, more generally, in starch-containing foods cooked at high temperatures. From a series of hospital-based case-control studies cond...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pelucchi C,Franceschi S,Levi F,Trichopoulos D,Bosetti C,Negri E,La Vecchia C

    更新日期:2003-07-01 00:00:00

  • RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.

    abstract::Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guo D,Lui GYL,Lai SL,Wilmott JS,Tikoo S,Jackett LA,Quek C,Brown DL,Sharp DM,Kwan RYQ,Chacon D,Wong JH,Beck D,van Geldermalsen M,Holst J,Thompson JF,Mann GJ,Scolyer RA,Stow JL,Weninger W,Haass NK,Beaumont KA

    更新日期:2019-06-15 00:00:00

  • A functional and quantitative mutational analysis of p53 mutations in yeast indicates strand biases and different roles of mutations in DMBA- and BBN-induced tumors in rats.

    abstract::In order to analyze the mutational events and to understand the biological significance of the p53 gene in chemical carcinogenesis, we applied a new yeast-based p53 functional assay to ovarian tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA), as well as to transitional cell carcinomas of the urinary bladder in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamamoto K,Nakata D,Tada M,Tonoki H,Nishida T,Hirai A,Ba Y,Aoyama T,Hamada J,Furuuchi K,Harada H,Hirai K,Shibahara N,Katsuoka Y,Moriuchi T

    更新日期:1999-11-26 00:00:00

  • HER2 amplification in recurrent breast cancer following breast-conserving therapy correlates with distant metastasis and poor survival.

    abstract::The authors analyzed the HER2 status in early-stage nonrecurrent and recurrent breast cancer groups following breast-conserving treatment. Retrospective analyses of a group of 36 invasive early breast cancer (IBC) patients who developed a local recurrence as a first event and of a random control group of 69 IBC patien...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: López-Guerrero JA,Llombart-Cussac A,Noguera R,Navarro S,Pellin A,Almenar S,Vazquez-Alvadalejo C,Llombart-Bosch A

    更新日期:2006-04-01 00:00:00

  • Patterns of growth and differentiation in the colon carcinoma cell line LIM 1863.

    abstract::The LIM 1863 colon carcinoma cell line grows in the form of morphologically and functionally organized organoids. Cells are arranged around a central lumen with a brush border and nuclei are polarized to the periphery. The organoids contain 3 morphological cell types (columnar, goblet and caveolated cells). By agar cl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hayward IP,Whitehead RH

    更新日期:1992-03-12 00:00:00

  • Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast cancer.

    abstract::Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Raguz S,Randle RA,Sharpe ER,Foekens JA,Sieuwerts AM,Meijer-van Gelder ME,Melo JV,Higgins CF,Yagüe E

    更新日期:2008-03-01 00:00:00

  • Prognosis and chemosensitivity of deficient MMR phenotype in patients with metastatic colorectal cancer: An AGEO retrospective multicenter study.

    abstract::Mismatch repair-deficient (dMMR) and/or microsatellite instability-high (MSI) colorectal cancers (CRC) represent about 5% of metastatic CRC (mCRC). Prognosis and chemosensitivity of dMMR/MSI mCRC remain unclear. This multicenter study included consecutive patients with dMMR/MSI mCRC from 2007 to 2017. The primary endp...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tougeron D,Sueur B,Zaanan A,de la Fouchardiére C,Sefrioui D,Lecomte T,Aparicio T,Des Guetz G,Artru P,Hautefeuille V,Coriat R,Moulin V,Locher C,Touchefeu Y,Lecaille C,Goujon G,Ferru A,Evrard C,Chautard R,Gentilhomme

    更新日期:2020-07-01 00:00:00

  • The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities.

    abstract::With an increasing cancer rate worldwide, there is an urgent quest for the improvement of anticancer drugs. One of the main problems of present chemotherapy in treatment of tumor patients is the toxicity of drugs. Most of the existent anticancer drugs, unfortunately, attack also proliferating normal cells. In recent y...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhu JY,Lavrik IN,Mahlknecht U,Giaisi M,Proksch P,Krammer PH,Li-Weber M

    更新日期:2007-10-15 00:00:00

  • In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

    abstract::We present an investigation of tumor pH regulation, designed to support a new anticancer therapy concept that we had previously proposed. Our study uses a tumor model of ras-transformed hamster fibroblasts, CCL39, xenografted in the thighs of nude mice. We demonstrate, for the first time, that genetic modifications of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chiche J,Le Fur Y,Vilmen C,Frassineti F,Daniel L,Halestrap AP,Cozzone PJ,Pouysségur J,Lutz NW

    更新日期:2012-04-01 00:00:00

  • Two distinct regions of deletion on chromosome 13q in primary nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tsang YS,Lo KW,Leung SF,Choi PH,Fong Y,Lee JC,Huang DP

    更新日期:1999-10-29 00:00:00

  • The value of the 1981 WHO histological classification in inter-observer reproducibility and changing pattern of lung cancer.

    abstract::A series of 722 lung carcinomas, surgically resected and typed some years ago according to the 1967 WHO classification, was independently reviewed by 2 observers in order to test the reproducibility of histopathological typing when using the criteria of the 1981 WHO classification. Typing was fully agreed upon in 87% ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Campobasso O,Andrion A,Ribotta M,Ronco G

    更新日期:1993-01-21 00:00:00

  • Resistance to verapamil sensitization of multidrug-resistant cells grown as multicellular spheroids.

    abstract::The ability of verapamil to overcome resistance to adriamycin in a multidrug-resistant derivative of the V79 cell line (LZ), grown as multicellular spheroids or as monolayers, was examined. Verapamil was much less effective in overcoming resistance to adriamycin in spheroids than in monolayers. Verapamil increased the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sakata K,Kwok TT,Gordon GR,Waleh NS,Sutherland RM

    更新日期:1994-10-15 00:00:00

  • The ROR1 pseudokinase diversifies signaling outputs in MET-addicted cancer cells.

    abstract::MET is a master gene controlling a genetic program driving proliferation, apoptosis protection and invasion. The ROR1 pseudokinase acts as a MET substrate. However, its contribution to MET signaling and MET-dependent biological outcomes remains to be elucidated. By structure-function analysis of ROR1 mutants, we show ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gentile A,Lazzari L,Benvenuti S,Trusolino L,Comoglio PM

    更新日期:2014-11-15 00:00:00

  • Characterization of a lung-cancer-associated auto-antigen.

    abstract::An antigen, protein X (Px), was purified from immune complexes isolated from malignant pleural effusions from patients with adenocarcinoma of the lung by EDTA treatment, PEG 8000 precipitation, protein A affinity chromatography, and Sephadex G-200 separation in the presence of 3 M NaCl. The purified antigen had a M(r)...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zeng CQ,Alpert LC,Alpert E

    更新日期:1992-10-21 00:00:00

  • Tumor infiltrating lymphocytes in seminoma lesions comprise clonally expanded cytotoxic T cells.

    abstract::Seminoma lesions are characterized by a brisk inflammatory infiltrate containing both CD4 and CD8 T cells, which is of prognostic significance. However, whether seminoma cells express the HLA molecules required for classical T-cell recognition remains controversial. In the present study, we conducted a molecular, phen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hadrup SR,Braendstrup O,Jacobsen GK,Mortensen S,Pedersen LØ,Seremet T,Andersen MH,Becker JC,Straten PT

    更新日期:2006-08-15 00:00:00

  • Presentation of native TROP-2 tumor antigens to human cytotoxic T lymphocytes by engineered antigen-presenting cells.

    abstract::Professional antigen-presenting cells (APC), e.g. dendritic cells, express immuno-proteasome components and process proteins for MHC presentation differently from non-immune cells. Thus, they induce reactivities against sets of peptides that do not overlap with those generated by non-professional APC, i.e., tumor cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mangino G,Grazia Capri M,Barnaba V,Alberti S

    更新日期:2002-10-01 00:00:00

  • Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic MAb MK2-23. Immunohistochemical analysis of the reactivity of anti-anti-idiotypic MAb with surgically removed melanoma lesions.

    abstract::The mouse anti-id MAb MK2-23 bears the internal image of the antigenic determinant defined by anti-HMW-MAA MAb 763.74. Active specific immunotherapy with anti-id MAb MK2-23 is associated with a statistically significant prolongation of survival in patients with malignant melanoma. Characterization of the immune respon...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kageshita T,Hirai S,Ono T,Ferrone S

    更新日期:1995-01-27 00:00:00

  • Evaluation of circulating EBV microRNA BART2-5p in facilitating early detection and screening of nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma is an Epstein-Barr Virus (EBV) associated malignancy which is highly prevalent in Southeast Asia. EBV-related antibodies have been widely used as screening markers for early nasopharyngeal carcinoma (NPC) detection. However, due to its low positive predictive rate, it is essential to develop n...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jiang C,Chen J,Xie S,Zhang L,Xiang Y,Lung M,Kam NW,Kwong DL,Cao S,Guan XY

    更新日期:2018-12-15 00:00:00

  • Hormone replacement therapy and oral contraceptives and risk of oesophageal adenocarcinoma: a systematic review and meta-analysis.

    abstract::There is an unexplained strong male predominance in the aetiology of oesophageal adenocarcinoma (OAC). The hypothesis that oestrogens are protective, deserves attention. A potential protective influence of exogenous oestrogen exposure, that is, hormone replacement therapy (HRT) and oral contraceptives (OC) has been ad...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Lagergren K,Lagergren J,Brusselaers N

    更新日期:2014-11-01 00:00:00

  • Identification of microRNAs specifically expressed in hepatitis C virus-associated hepatocellular carcinoma.

    abstract::Although several studies have investigated the association of miRNAs with hepatocellular carcinoma (HCC), the data published so far are not concordant. A reason for these discrepancies may be the fact that most studies used the nontumorous tissue surrounding the HCC lesion as a control, which is almost invariably affe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Diaz G,Melis M,Tice A,Kleiner DE,Mishra L,Zamboni F,Farci P

    更新日期:2013-08-15 00:00:00