Targeting multidrug resistant tumor cells with a recombinant single-chain FV fragment directed to P-glycoprotein.

abstract：:The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane d...

journal_title：International journal of cancer

authors： Huang X,Gao P,Sun J,Chen X,Song Y,Zhao J,Xu H,Wang Z

更新日期：2015-01-01 00:00:00

abstract：:The second most common target of prostate-cancer metastasis is bone, and the phenomenon of skeletal metastasis represents the incurable stage of disease. Histologically, skeletal metastasis from prostate cancer is distinctive due to its osteoblastic nature. The osteoblastic bone metastasis shows extensive new bone for...

journal_title：International journal of cancer

authors： Thomas R,True LD,Lange PH,Vessella RL

更新日期：2001-07-01 00:00:00

abstract：:The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...

journal_title：International journal of cancer

authors： Hemminki K,Jiang Y,Dong C

更新日期：2001-07-15 00:00:00

abstract：:To assess long-term trends in the prevalence of oncogenic human papillomavirus (HPV) infection, we performed a cross-sectional serosurvey of the seroprevalence of the major oncogenic HPV type, HPV16, among 3,512 pregnant women undergoing population-based serological screening at the first trimester of pregnancy in the...

journal_title：International journal of cancer

authors： af Geijersstam V,Wang Z,Lewensohn-Fuchs I,Eklund C,Schiller JT,Forsgren M,Dillner J

更新日期：1998-05-04 00:00:00

abstract：:The association between Lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n = 13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. These patients were linked with sub...

journal_title：International journal of cancer

authors： Halonen P,Jakobsson M,Heikinheimo O,Riska A,Gissler M,Pukkala E

更新日期：2018-01-01 00:00:00

abstract：:Evidence from randomized controlled trials suggests that calcium may protect against recurrence of colorectal adenomas, which could lead to the subsequent prevention of cancer. Yet the trials used only a large single dose and were of small sizes, and thus, knowledge of the dose-response relationship and influence on h...

journal_title：International journal of cancer

authors： Keum N,Lee DH,Greenwood DC,Zhang X,Giovannucci EL

更新日期：2015-04-01 00:00:00

abstract：:Squamous cell carcinoma of the conjunctiva (SCCC) has been associated with HIV infection in equatorial Africa, but the evidence for association with HIV in developed countries, where SCCC is rarer, is controversial. We investigated the risk for SCCC and other eye cancers in the updated U.S. HIV/AIDS Cancer Match Regis...

journal_title：International journal of cancer

authors： Guech-Ongey M,Engels EA,Goedert JJ,Biggar RJ,Mbulaiteye SM

更新日期：2008-06-01 00:00:00

abstract：:Indoor air pollution (IAP) caused by cooking has been associated with lung cancer risk in retrospective case-control studies in developing and rural countries. We report the association of cooking conditions, fuel use, oil use, and risk of lung cancer in a developed urban population in a prospective cohort of women in...

journal_title：International journal of cancer

authors： Kim C,Gao YT,Xiang YB,Barone-Adesi F,Zhang Y,Hosgood HD,Ma S,Shu XO,Ji BT,Chow WH,Seow WJ,Bassig B,Cai Q,Zheng W,Rothman N,Lan Q

更新日期：2015-02-01 00:00:00

abstract：:It is well known that tumors arising from tissues such as kidney, pancreas, liver and stomach are particularly refractory to treatment. Searching for new anticancer drugs using cells in culture has yielded some effective therapies, but these refractory tumors remain intractable. Studies that compare cells grown in sus...

journal_title：International journal of cancer

authors： Stein WD,Litman T,Fojo T,Bates SE

更新日期：2005-03-01 00:00:00

abstract：:Fecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all FOBT-positive persons have screen-detected adenomas. Despite removal of these, patients with large/multiple adenomas have increased risk of later developing new advanced adenomas and CRC....

journal_title：International journal of cancer

authors： Bjerrum A,Lindebjerg J,Andersen O,Fischer A,Lynge E

更新日期：2020-08-15 00:00:00

abstract：:We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selective enzymatic inhibi...

journal_title：International journal of cancer

authors： Lazdins J,Zompetta C,Grimaldi S,Barile G,Venanzoni M,Frati L,Faggioni A

更新日期：1987-12-15 00:00:00

abstract：:Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been observed in several types of human cancer including lung cancer and breast cancer. In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor locus 3p21.3. The CpG ...

journal_title：International journal of cancer

authors： Yoon JH,Dammann R,Pfeifer GP

更新日期：2001-10-15 00:00:00

abstract：:Cancer vaccines directed against tumor associate antigen (TAA) have produced encouraging results in preclinical models but not in cancer patients. A major limitation of this strategy is the relative degree of tolerance to these antigens and the low and heterogeneous tumor cell expression of TAA and major histocompatib...

journal_title：International journal of cancer

authors： Correale P,Aquino A,Giuliani A,Pellegrini M,Micheli L,Cusi MG,Nencini C,Petrioli R,Prete SP,De Vecchis L,Turriziani M,Giorgi G,Bonmassar E,Francini G

更新日期：2003-04-20 00:00:00

abstract：:There is a well-established link between inflammation and cancer of various organs, but little data are available on inflammation-associated markers of diagnostic and prognostic clinical utility in pulmonary malignancy. Blood samples were prospectively collected from 75 resectable lung cancer patients before surgery a...

journal_title：International journal of cancer

authors： Infante M,Allavena P,Garlanda C,Nebuloni M,Morenghi E,Rahal D,Roncalli M,Cavuto S,Pesce S,Monari M,Valaperta S,Montanelli A,Solomon D,Bottoni E,Errico V,Voulaz E,Bossi M,Chiesa G,Passera E,Mantovani A,Alloisio M

更新日期：2016-02-15 00:00:00

abstract：:Six permanent human tumor cell lines (OV-MZ-1 to 6) were established from 6 patients with serous adenocarcinomas of the ovary. These cell lines were derived from both solid tumors and ascites, from pre-treated and untreated patients, and are available over a range of in vitro passage numbers. The tumor cells grow as m...

journal_title：International journal of cancer

authors： Möbus V,Gerharz CD,Press U,Moll R,Beck T,Mellin W,Pollow K,Knapstein PG,Kreienberg R

更新日期：1992-08-19 00:00:00

abstract：:Murine monoclonal antibody HRS-4 (Ab1), which defines the cell-bound and soluble CD30 antigen associated with Hodgkin's lymphoma, was used to generate monoclonal anti-idiotypic antibodies (Ab2) in syngeneic BALB/c mice. Murine monoclonal Ab2 14G9 and Ab2 9G10 directed against HRS-4 were shown to be anti-idiotypic Ab2 ...

journal_title：International journal of cancer

authors： Pohl C,Renner C,Schwonzen M,Sieber M,Lorenz P,Pfreundschuh M,Diehl V

更新日期：1992-04-01 00:00:00

abstract：:The MYH gene has recently been shown to be associated with a recessive form of colorectal adenomatous polyposis. Two common mutations in the MYH gene have been identified that lend themselves to rapid screening. We have examined a series of 302 individuals comprising 120 control subjects, 120 patients diagnosed with a...

journal_title：International journal of cancer

authors： Kairupan CF,Meldrum CJ,Crooks R,Milward EA,Spigelman AD,Burgess B,Groombridge C,Kirk J,Tucker K,Ward R,Williams R,Scott RJ

更新日期：2005-08-10 00:00:00

abstract：:Our study demonstrates that synthetic sialyl Lewis X (SLex) as a ligand for selectins and fibronectin-derived RGDS peptide analogue [Ar(DRGDS)3] inhibits lung metastases produced by i.v. co-injection of B16-BL6 melanoma cells. To investigate the inhibitory mechanisms in a living animal, we performed positron-emission ...

journal_title：International journal of cancer

authors： Saiki I,Koike C,Obata A,Fujii H,Murata J,Kiso M,Hasegawa A,Komazawa H,Tsukada H,Azuma I,Okada S,Oku N

更新日期：1996-03-15 00:00:00

abstract：:Pediatric high-grade gliomas (HGGs) are highly malignant tumors that remain incurable and relatively understudied. The crucial role of noncoding RNAs (ncRNAs) has been reported in various cancers. However, the study on miRNAs in pediatric HGGs is scant and there is no report till date on the status of other small ncRN...

journal_title：International journal of cancer

authors： Jha P,Agrawal R,Pathak P,Kumar A,Purkait S,Mallik S,Suri V,Chand Sharma M,Gupta D,Suri A,Sharma BS,Julka PK,Kulshreshtha R,Sarkar C

更新日期：2015-11-15 00:00:00

abstract：:Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowe...

journal_title：International journal of cancer

authors： Tavani A,Pelucchi C,Parpinel M,Negri E,Franceschi S,Levi F,La Vecchia C

更新日期：2003-05-20 00:00:00

abstract：:In the Japanese atomic bomb survivors, risk of lung cancer has been shown to increase with greater acute exposure to ionizing radiation. Although similar findings have been observed in populations exposed to low-dose, protracted radiation, such studies lack information on cigarette smoking history, a potential confoun...

journal_title：International journal of cancer

authors： Velazquez-Kronen R,Gilbert ES,Linet MS,Moysich KB,Freudenheim JL,Wactawski-Wende J,Simon SL,Cahoon EK,Alexander BH,Doody MM,Kitahara CM

更新日期：2020-12-01 00:00:00

abstract：:It has been proposed that the timing of breast-cancer surgery in relation to menstrual phase has a prognostic impact on outcome. We carefully evaluated a combined 2-center series of 385 pre-menopausal women operated on for stage-I and stage-II breast cancer with a median follow-up of 5 years for a possible impact on o...

journal_title：International journal of cancer

authors： Gnant MF,Seifert M,Jakesz R,Adler A,Mittlboeck M,Sevelda P

更新日期：1992-11-11 00:00:00

abstract：:Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antiobiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics, tumor selectivit...

journal_title：International journal of cancer

authors： Zou Y,Ling YH,Reddy S,Priebe W,Perez-Soler R

更新日期：1995-05-29 00:00:00

abstract：:The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of pri-miR-34b/c (423 bp from the transcription start site), located...

journal_title：International journal of cancer

authors： Xu Y,Liu L,Liu J,Zhang Y,Zhu J,Chen J,Liu S,Liu Z,Shi H,Shen H,Hu Z

更新日期：2011-01-15 00:00:00

abstract：:In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are li...

journal_title：International journal of cancer

authors： Reduzzi C,Vismara M,Silvestri M,Celio L,Niger M,Peverelli G,De Braud F,Daidone MG,Cappelletti V

更新日期：2020-06-15 00:00:00

abstract：:Both retinoids and anti-estrogens inhibit breast cancer cell proliferation with accumulation of cells in the G1 phase of the cell cycle, but the effect of retinoids is delayed compared to that of anti-estrogens. To determine whether this temporal difference is due to a simple delay in the action of retinoids on a comm...

journal_title：International journal of cancer

authors： Wilcken NR,Musgrove EA,Sutherland RL

更新日期：1997-01-27 00:00:00

abstract：:Imbalance in the Kb and Db region encoded molecules is observed in Lewis lung carcinoma clones. The uncloned metastatic population and the D122 high-metastatic clone show no expression of H-2Kb products, while the nonmetastatic A9 clone expresses Kb products. Twenty-nine new subclones of 3LL and A9 were analyzed for D...

journal_title：International journal of cancer

authors： Eisenbach L,Segal S,Feldman M

更新日期：1983-07-15 00:00:00

abstract：:Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates. The reasons for the discrepancies have been debated in the literature, with the focus on whether the observed increases are...

journal_title：International journal of cancer

authors： Milne E,Laurvick CL,de Klerk N,Robertson L,Thompson JR,Bower C

更新日期：2008-03-01 00:00:00

abstract：:The identification of specific tumor mRNA markers by reverse transcription-polymerase chain reaction might be a valuable diagnostic adjunct for the detection of breast cancer metastases in axillary sentinel lymph nodes (SLNs). In this study we have compared the diagnostic accuracy of an extensive histopathologic exami...

journal_title：International journal of cancer

authors： Manzotti M,Dell'Orto P,Maisonneuve P,Zurrida S,Mazzarol G,Viale G

更新日期：2001-09-20 00:00:00

abstract：:Experimental studies have consistently shown a protective effect of nonsteroidal antiinflammatory drugs (NSAIDs) against nonmelanoma skin cancers (NMSC). However, little human epidemiological research has been done in this regard. We used data from the Skin Cancer Chemoprevention Study to explore the association of NS...

journal_title：International journal of cancer

authors： Grau MV,Baron JA,Langholz B,Karagas M,Greenberg ER,Stukel TA,Mandel JS

更新日期：2006-08-01 00:00:00