TPA induction of Epstein-Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors.


:We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selective enzymatic inhibitors [1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine] (H-7) and Staurosporine. We show that these inhibitors can abrogate the inductive effect of TPA or the combination of TPA plus n-butyrate. The inhibitors have no effect on induction by calcium ionophores or by viral superinfection. In this context the effect of verapamil (a specific calcium channel blocker) and of several calmodulin antagonists was investigated. No inhibitory effect of these agents could be demonstrated on any of the induction systems examined. These observations strengthen the idea that in some instances cellular PKC plays a role in the expression of viral antigens; however, alternative regulatory mechanisms cannot be excluded.


Int J Cancer


Lazdins J,Zompetta C,Grimaldi S,Barile G,Venanzoni M,Frati L,Faggioni A




Has Abstract


1987-12-15 00:00:00












  • Determinants of cervical cancer rates in developing countries.

    abstract::Although cervical cancer (CC) is a leading cause of cancer-related deaths in developing countries, incidence rates vary considerably, ranging from 3 to 61 per 10(5) females. Identifying determinants of high vs. low rates may suggest population-level prevention strategies. CC rates for 175 countries were obtained from ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Drain PK,Holmes KK,Hughes JP,Koutsky LA

    更新日期:2002-07-10 00:00:00

  • Milk drinking, other beverage habits, and lung cancer risk.

    abstract::The reported beverage habits of 569 lung cancer patients and 569 control patients admitted to Roswell Park Memorial Institute (RPMI) were studied, 355 male cases and 214 female cases being matched to controls within strata of age and residence. Smoking history and an index of vitamin A from vegetables had significant,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mettlin C

    更新日期:1989-04-15 00:00:00

  • Expression of SV40 T antigen during the cell cycle of sv40-transformed cells.

    abstract::The expression of the nuclear SV40-induced T antigen was measured by microfluorimetry on individual, asynchronously growing SV40-transformed cells which had been stained with hamster T-antiserum by the indirect immunofluorescence method. The same individual cells were first measured for T antigen and then for DNA by F...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stenman S,Zeuthen J,Ringertz NR

    更新日期:1975-04-15 00:00:00

  • Anti-metastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells.

    abstract::IL-2 gene was introduced through retroviral vectors into the highly malignant and poorly immunogenic 3LL-D122 clone. Both high and low D122-IL-2 secretors showed elimination of tumorigenicity in syngeneic immune-competent mice; however, in nude mice only the high IL-2 secretor showed reduced tumorigenicity as compared...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Porgador A,Gansbacher B,Bannerji R,Tzehoval E,Gilboa E,Feldman M,Eisenbach L

    更新日期:1993-02-01 00:00:00

  • Concordant hypermethylation of intergenic microRNA genes in human hepatocellular carcinoma as new diagnostic and prognostic marker.

    abstract::Epigenetic inactivation by aberrant DNA methylation has been reported for many microRNA genes in various human malignancies. However, relatively little is known about microRNA gene methylation in hepatocellular carcinoma (HCC). Therefore, a systematic screen for identification of aberrantly hypermethylated microRNA ge...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Anwar SL,Albat C,Krech T,Hasemeier B,Schipper E,Schweitzer N,Vogel A,Kreipe H,Lehmann U

    更新日期:2013-08-01 00:00:00

  • Host STAT2/type I interferon axis controls tumor growth.

    abstract::The role of STAT2 in mediating the antigrowth effects of type I interferon (IFN) is well-documented in vitro. Yet evidence of IFN-activated STAT2 as having tumor suppressor function in vivo and participation in antitumor immunity is lacking. Here we show in a syngeneic tumor transplantation model that STAT2 reduces tu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yue C,Xu J,Tan Estioko MD,Kotredes KP,Lopez-Otalora Y,Hilliard BA,Baker DP,Gallucci S,Gamero AM

    更新日期:2015-01-01 00:00:00

  • The urokinase inhibitor p-aminobenzamidine inhibits growth of a human prostate tumor in SCID mice.

    abstract::Malignant cells possess a high degree of proteolytic activity in which the plasminogen activator system plays an important role. An increased expression of urokinase type plasminogen activator (uPA) is of significance for degradation of the extracellular tumor matrix, facilitating invasiveness and growth. Inhibition o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Billström A,Hartley-Asp B,Lecander I,Batra S,Astedt B

    更新日期:1995-05-16 00:00:00

  • Characterization of a lung-cancer-associated auto-antigen.

    abstract::An antigen, protein X (Px), was purified from immune complexes isolated from malignant pleural effusions from patients with adenocarcinoma of the lung by EDTA treatment, PEG 8000 precipitation, protein A affinity chromatography, and Sephadex G-200 separation in the presence of 3 M NaCl. The purified antigen had a M(r)...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zeng CQ,Alpert LC,Alpert E

    更新日期:1992-10-21 00:00:00

  • Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.

    abstract::Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence i...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Tsilidis KK,Allen NE,Key TJ,Sanjoaquin MA,Bakken K,Berrino F,Fournier A,Lund E,Overvad K,Olsen A,Tjønneland A,Byrnes G,Chajes V,Rinaldi S,Boutron-Ruault MC,Clavel-Chapelon F,Chang-Claude J,Kaaks R,Bergmann M,Boeing

    更新日期:2011-04-15 00:00:00

  • Cross-signaling among phosphinositide-3 kinase, mitogen-activated protein kinase and sonic hedgehog pathways exists in esophageal cancer.

    abstract::The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wei L,Xu Z

    更新日期:2011-07-15 00:00:00

  • Selective inhibition of PED protein expression sensitizes B-cell chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis.

    abstract::B-cell chronic lymphocytic leukaemia (B-CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus represents an attractive tool for...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Garofalo M,Romano G,Quintavalle C,Romano MF,Chiurazzi F,Zanca C,Condorelli G

    更新日期:2007-03-15 00:00:00

  • Cancer incidence in Ho Chi Minh City, Viet Nam, 1995-1996.

    abstract::The results from the population-based cancer registry for the city of Ho Chi Minh in 1995-1996 represent the first information on the incidence of cancer in southern Viet Nam. A total of 4,080 cancer cases in males and 4,338 in females were registered, corresponding to age-standardized incidence rates (ASRs) of 130.9 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nguyen QM,Nguyen HC,Parkin DM

    更新日期:1998-05-18 00:00:00

  • All 4 di-leucine motifs in the first hydrophobic domain of the E5 oncoprotein of human papillomavirus type 16 are essential for surface MHC class I downregulation activity and E5 endomembrane localization.

    abstract::The E5 oncoprotein of human papillomavirus type 16 downregulates surface MHC Class I and interacts with the heavy chain of the MHC complex via the first hydrophobic domain, believed to form the first helical transmembrane region (TM1) of E5. TM1 contains 4 equally spaced di-leucine (LL1-LL4) motifs. Di-leucine motifs ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cortese MS,Ashrafi GH,Campo MS

    更新日期:2010-04-01 00:00:00

  • Marker profile of mesothelial cells versus ovarian carcinoma cells.

    abstract::We investigated the marker profile of human ascitic and cultured mesothelial cells, and compared it to that of ovarian carcinoma cells which are related in terms of their histogenesis, unrelated colon carcinomas being used as reference. Mesothelial and ovarian carcinoma cells could not be distinguished by (intermediat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van Niekerk CC,Jap PH,Thomas CM,Smeets DF,Ramaekers FC,Poels LG

    更新日期:1989-06-15 00:00:00

  • Adherence to the mediterranean diet and lymphoma risk in the european prospective investigation into cancer and nutrition.

    abstract::There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Solans M,Benavente Y,Saez M,Agudo A,Naudin S,Hosnijeh FS,Noh H,Freisling H,Ferrari P,Besson C,Mahamat-Saleh Y,Boutron-Ruault MC,Kühn T,Kaaks R,Boeing H,Lasheras C,Rodríguez-Barranco M,Amiano P,Huerta JM,Barricarte A

    更新日期:2019-07-01 00:00:00

  • Ca2+ and calmodulin are involved in the processes conferring stability to DNA in proliferating neoplastic cells.

    abstract::We have examined, in proliferating neoplastic cells, the effect on DNA of EGTA (a chelator of Ca2+) and W7 (an inhibitor of calmodulin). The treatment results in release of single-stranded DNA fragments (2-10 kb) from pre-labelled HMW DNA. When DNA from synchronized neoplastic cells in S phase is examined, almost all ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lönn U,Lönn S

    更新日期:1986-06-15 00:00:00

  • Sequential examination of lymphocyte proliferative capacity in patients with malignant melanoma receiving BCG immunotherapy.

    abstract::A series of 42 patients with malignant melanoma treated with BCG adjuvant immunotherapy were studied for sequential changes in cellular immune reactivity to non-specific mitogens. Lymphocyte preparations were made monthly and stored in a viable condition in liquid nitrogen. After 6 months of treatment, all lymphocyte ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Golub SH,Forsythe AB,Morton DL

    更新日期:1977-01-01 00:00:00

  • Pregnancy outcomes in childhood cancer survivors: probable effects of abdominal irradiation.

    abstract::A postal survey addressed to 2,083 general practitioners of childhood cancer survivors of reproductive age has revealed that females having undergone direct abdominal irradiation (exposed), particularly for Wilms' tumour, have an increased risk of several adverse pregnancy outcomes as compared with female survivors of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hawkins MM,Smith RA

    更新日期:1989-03-15 00:00:00

  • Stable quantitative differences of antigen expression in human melanoma cells isolated by flow cytometric cell sorting.

    abstract::The stability of expression of a membrane antigen on human FME melanoma cells was investigated by means of flow cytometric cell sorting and analysis. The melanoma-associated 250 kd antigen was strongly expressed on all cells, as recognized by binding of the monoclonal antibody 9.2.27. By flow cytometric cell sorting, ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lindmo T,Davies C,Fodstad O,Morgan AC

    更新日期:1984-10-15 00:00:00

  • HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer.

    abstract::Epigenetic alterations play a major role in cancer. Recently we reported that stem cell Polycomb group targets (PcGTs) are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than nontargets. To identify potential, prognostic DNA methylation markers in ovarian cancer we analyzed the DNA met...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fiegl H,Windbichler G,Mueller-Holzner E,Goebel G,Lechner M,Jacobs IJ,Widschwendter M

    更新日期:2008-08-01 00:00:00

  • Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation.

    abstract::Withaferin A (WFA) is purified from the plant Withania somnifera and inhibits the vimentin cytoskeleton. Vimentin overexpression in cancer correlates with metastatic disease, induction of epithelial to mesenchymal transition and reduced patient survival. As vimentin functions in cell motility, we wanted to test the hy...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thaiparambil JT,Bender L,Ganesh T,Kline E,Patel P,Liu Y,Tighiouart M,Vertino PM,Harvey RD,Garcia A,Marcus AI

    更新日期:2011-12-01 00:00:00

  • Epstein-Barr herpesvirus infection: inhibition by immunologically induced mediators with interferon-like properties.

    abstract::When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lai PK,Alpers MP,MacKay-Scollay EM

    更新日期:1977-07-15 00:00:00

  • Evidence of enhancement of the ras oncogene protein product (p21) in a spectrum of human tumors.

    abstract::Using a direct binding liquid competition radioimmunoassay, the amount of the ras oncogene protein product, p21, was quantitated in a variety of human tumors and adjacent apparently normal tissues. In 48 of 50 matched tumor and normal tissue biopsy specimens from 50 patients, more ras p21 was detected in the tumor tha...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: De Biasi F,Del Sal G,Hand PH

    更新日期:1989-03-15 00:00:00

  • Protein content and functional characteristics of serum-purified exosomes from patients with colorectal cancer revealed by quantitative proteomics.

    abstract::Tumor cells of colorectal cancer (CRC) release exosomes into the circulation. These exosomes can mediate communication between cells and affect various tumor-related processes in their target cells. We present a quantitative proteomics analysis of the exosomes purified from serum of patients with CRC and normal volunt...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen Y,Xie Y,Xu L,Zhan S,Xiao Y,Gao Y,Wu B,Ge W

    更新日期:2017-02-15 00:00:00

  • TP53 mutation and survival in aggressive B cell lymphoma.

    abstract::TP53 is mutated in 20-25% of aggressive B-cell lymphoma (B-NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current risk models in aggressive B-NHL, we investigated TP53 gene mutations within the RICOVER-60 trial. Of...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zenz T,Kreuz M,Fuge M,Klapper W,Horn H,Staiger AM,Winter D,Helfrich H,Huellein J,Hansmann ML,Stein H,Feller A,Möller P,Schmitz N,Trümper L,Loeffler M,Siebert R,Rosenwald A,Ott G,Pfreundschuh M,Stilgenbauer S,Ger

    更新日期:2017-10-01 00:00:00

  • A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers.

    abstract::Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are well-characterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup is also a feature of non-MSI canc...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Silver A,Sengupta N,Propper D,Wilson P,Hagemann T,Patel A,Parker A,Ghosh A,Feakins R,Dorudi S,Suraweera N

    更新日期:2012-03-01 00:00:00

  • Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

    abstract::In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Cou

    更新日期:2019-11-15 00:00:00

  • Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells.

    abstract::Studies were performed to characterize the effector cells responsible for natural cytotoxicity of mouse lymphoid cells against a variety of syngeneic and allogeneic tumor lines. Since spleen cells from normal nude mice were found to be highly cytotoxic, they were used for most of these experiments. Only a small propor...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Herberman RB,Nunn ME,Holden HT,Lavrin DH

    更新日期:1975-08-15 00:00:00

  • Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients.

    abstract::There is a well-established link between inflammation and cancer of various organs, but little data are available on inflammation-associated markers of diagnostic and prognostic clinical utility in pulmonary malignancy. Blood samples were prospectively collected from 75 resectable lung cancer patients before surgery a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Infante M,Allavena P,Garlanda C,Nebuloni M,Morenghi E,Rahal D,Roncalli M,Cavuto S,Pesce S,Monari M,Valaperta S,Montanelli A,Solomon D,Bottoni E,Errico V,Voulaz E,Bossi M,Chiesa G,Passera E,Mantovani A,Alloisio M

    更新日期:2016-02-15 00:00:00

  • Heterogeneity of HLA and EBER expression in Epstein-Barr virus-associated nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is an aggressive tumour of multifactorial aetiology that, although rare in most parts of the world, poses a significant mortality problem in its high incidence area of Southern China. Improved therapies are an urgent requirement and, towards this end, immunotherapeutic methods are being ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yao Y,Minter HA,Chen X,Reynolds GM,Bromley M,Arrand JR

    更新日期:2000-12-15 00:00:00