Abstract:
:Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing NPC susceptibility remain unknown. Here, 8 polymorphic microsatellite markers distributed over a 1 megabase region surrounding the HLA-A locus were subjected to genetic analysis for the NPC-susceptibility locus. Statistical studies of associated alleles detected on each microsatellite locus showed that the NPC- susceptibility genes are most likely located between the D6S510 and D6S211 markers within a 132 kb segment containing the HLA-A locus. These results undoubtedly would facilitate the further positional cloning of the NPC-susceptibility locus, which has been elusive for the past 30 years.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lu CC,Chen JC,Tsai ST,Jin YT,Tsai JC,Chan SH,Su IJdoi
10.1002/ijc.20946keywords:
subject
Has Abstractpub_date
2005-07-10 00:00:00pages
742-6issue
5eissn
0020-7136issn
1097-0215journal_volume
115pub_type
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