Abstract：
:Studies in Shanghai and in north-east China indicate that cigarette smoking is a major contributor to the high rates of lung cancer in those areas, but doubts persist regarding the influence of cigarette use on lung cancer rates in other areas of China. In addition, the risk of lung cancer associated with other methods of tobacco consumption--in particular, the use of bamboo water-pipes and long-stem pipes--is uncertain. A population-based case-control study of 427 male lung cancer patients residing in a mining area of Southern China and 1,011 controls was carried out to address this and other issues. Of these patients, 63% smoked cigarettes and (water and long-stem) pipes; 17% and 14% smoked only cigarettes or pipes, respectively; and 6% did not smoke. Compared to non-smokers, smokers of cigarettes only, smokers of pipes only and mixed smokers were at increased risk; OR = 2.6 (95% CI 1.1-6.2), 1.8 (95% CI 0.8-4.2) and 4.1 (95% CI 2.3-9.2), respectively. Risk increased with duration of tobacco use; however, the rate of increase with years of cigarette use was significantly greater than for years of pipe use (p = 0.03). In addition, risks increased 8-fold in the highest quartile of number of cigarettes per day compared to non-cigarette smokers vs. 2.3-fold for the highest quartile of number of liang (50 g) smoked per month compared to non-pipe-smokers; the trends in the ORs differed significantly (p less than 0.001). Results suggest that, in this area of China, tobacco use is an important cause of lung cancer, and that smoking cigarettes may be more deleterious than smoking pipes (primarily water pipes).
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Lubin JH,Li JY,Xuan XZ,Cai SK,Luo QS,Yang LF,Wang JZ,Yang L,Blot WJdoi
10.1002/ijc.2910510310keywords:
subject
Has Abstractpub_date
1992-05-28 00:00:00pages
390-5issue
3eissn
0020-7136issn
1097-0215journal_volume
51pub_type
杂志文章abstract：:Polyamines are essential for cell growth and differentiation. Their specific uptake contributes to the regulation of intracellular polyamine levels. In this study, we describe the modulation of this transport mechanism in a rat tumoral pancreatic acinar cell line (AR4-2J) and analyze the transport system characteristi...
journal_title：International journal of cancer
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abstract：:An automated fluorometric microculture cytotoxicity assay (FMCA) based on the measurement of fluorescence generated from cellular hydrolysis of fluorescein diacetate (FDA) to fluorescein was employed for chemotherapeutic-drug-sensitivity testing of tumor-cell suspensions from patients with leukemia. Fluorescence was l...
journal_title：International journal of cancer
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journal_title：International journal of cancer
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更新日期：1998-07-03 00:00:00
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更新日期：2006-07-01 00:00:00
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journal_title：International journal of cancer
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更新日期：1995-09-04 00:00:00
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journal_title：International journal of cancer
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doi：10.1002/ijc.2910490111
更新日期：1991-08-19 00:00:00
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journal_title：International journal of cancer
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更新日期：2003-11-20 00:00:00
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更新日期：1980-06-15 00:00:00
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journal_title：International journal of cancer
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更新日期：2000-02-15 00:00:00
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journal_title：International journal of cancer
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更新日期：1986-01-15 00:00:00
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journal_title：International journal of cancer
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更新日期：1999-03-15 00:00:00
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更新日期：2006-04-15 00:00:00
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journal_title：International journal of cancer
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更新日期：1993-08-19 00:00:00
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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doi：10.1002/ijc.2910490223
更新日期：1991-09-09 00:00:00
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