Abstract:
:Serum and tumor tissue from breast cancer patients were evaluated for the presence of alpha subunit of hCG, by means of the specific radioimmunoassay. Elevated serum levels occurred in 0/50 (0%) of normal female controls, 1/17 (6%) of patients with benign breast disease, 3/53 (6%) of patients with primary breast cancer, and 12/84 (14%) of patients with metastatic breast cancer. Cytosols from 10/56 (18%) primary tumors and 10/37 (28%) metastatic tumors were found to contain the alpha subunit. Comparison of serum and tumor cytosol levels in nine patients with metastatic disease showed a correspondence between elevated cytosol levels and elevated serum levels. No similar correspondence in 25 patients with primary disease was observed. Alpha subunit was isolated from one tumor cytosol and was characterized with respect to its immunochemical cross-reactivity and molecular weight as compared with native alpha subunit from hCG. For both parameters, the native and ectopic alpha subunit were found to be identical.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Shindelman JE,Ortmeyer AE,Wada HG,Stockdale F,Sussman HHdoi
10.1002/ijc.2910250508subject
Has Abstractpub_date
1980-05-15 00:00:00pages
599-604issue
5eissn
0020-7136issn
1097-0215journal_volume
25pub_type
杂志文章abstract::IgG binding to purified mouse mammary tumor virus (MuMTV) was quantitated by an enzyme-linked immunoassay (ELISA) using sera from patients with breast cancer or benign breast disease, or from healthy age-matched controls. Significantly greater binding (p<0.01) was found in breast-cancer-derived sera than in the other ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250606
更新日期:1980-06-15 00:00:00
abstract::T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusion (DLI) due to graft-versus-leukemia effect. For better characterization of the T cell responses, we assessed frequency ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31753
更新日期:2019-03-01 00:00:00
abstract::A comparative case-referent study was conducted using data from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), with the aim of clarifying whether histologic subtypes of gastric cancer exhibit different risk-factor patterns of habitual smoking. Our study comprised 995 histologically...
journal_title:International journal of cancer
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更新日期:1999-03-31 00:00:00
abstract::It has been established that the Hedgehog (Hh) and epithelial-mesenchymal transition (EMT) signals act on morphogenesis of embryonic and adult tissues. Recently, both signals have been involved in tumor malignancy. However, little is known as to whether Hh and EMT signals act on normal and malignant epithelial cells i...
journal_title:International journal of cancer
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更新日期:2009-09-01 00:00:00
abstract::Vaccination strategies based on repeated injections of NY-ESO-1 protein formulated in ISCOMATRIX particles (NY-ESO-1 ISCOMATRIX) have shown to elicit combined NY-ESO-1 specific antibody and T cell responses. However, it remains unclear whether heterologous prime-boost strategies based on the combination with NY-ESO-1 ...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
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更新日期:2015-03-15 00:00:00
abstract::Frequently, the number of circulating tumor cells (CTC) isolated in 7.5 mL of blood is too small to reliably determine tumor heterogeneity and to be representative as a "liquid biopsy". In the EU FP7 program CTCTrap, we aimed to validate and optimize the recently introduced Diagnostic LeukApheresis (DLA) to screen lit...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
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更新日期:2018-11-15 00:00:00
abstract::Use of dietary supplements is rising in countries where colorectal cancer is prevalent. We conducted a systematic literature review and meta-analyses of prospective cohort studies on dietary supplement use and colorectal cancer risk. We identified relevant studies in Medline, Embase and Cochrane up to January 2013. Or...
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pub_type: 杂志文章,meta分析,评审
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abstract::Vaccination against oncogenic human papillomavirus (HPV) types is one key intervention for cervical cancer prevention. This follow-up study assessed the persistence of the systemic and mucosal immune responses together with the safety profile of the HPV-16/18 AS04-adjuvanted vaccine administered to young women aged 10...
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-11-01 00:00:00
abstract::Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...
journal_title:International journal of cancer
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更新日期:2003-09-01 00:00:00
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更新日期:1985-11-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910180304
更新日期:1976-09-15 00:00:00
abstract::The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330210
更新日期:1984-02-15 00:00:00
abstract::Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30911
更新日期:2017-11-15 00:00:00
abstract::Immunostimulatory DNA containing unmethylated cytosine-guanine (CpG) motifs have been successfully used as adjuvants to enhance the immunity of vaccines designed to trigger antitumor T-cell responses. We examined the effect of a CpG oligodeoxynucleotide (CpG ODN) for its ability to potentiate the activity of tumor ant...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24009
更新日期:2009-02-15 00:00:00
abstract::The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the "molecular switch" model, postulates that CIN3 can evolve directly from ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31549
更新日期:2018-10-01 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30517
更新日期:2017-04-01 00:00:00
abstract::Although new treatments have been widely studied to improve the survival of patients with metastatic breast cancer (BC), prognosis continues to be poor with an average survival time no longer than 3 years. We carried on a population-based study with the purpose of evaluating the outcome of metastatic breast cancer in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29503
更新日期:2015-09-15 00:00:00
abstract::In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell line HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternberg cell-associated CD...
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doi:10.1002/ijc.2910630215
更新日期:1995-10-09 00:00:00
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doi:10.1002/(sici)1097-0215(20000501)86:3<408::aid-ijc
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doi:10.1002/ijc.2910300111
更新日期:1982-07-15 00:00:00
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journal_title:International journal of cancer
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abstract::A clonal cell line, 1-1ras1000, transformed by the activated c-Ha-ras oncogene, does not form metastases after i.v. injection into mice (experimental metastasis assay). Here, we show that this cell line is useful as a recipient to detect metastasis-inducing genes, using a transfection assay. Cells (1-1ras1000) were su...
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doi:10.1002/(sici)1097-0215(19970328)71:1<88::aid-ijc1
更新日期:1997-03-28 00:00:00
abstract::Inbred rats were treated with extranuclear tumour membrane fractions or 3 M KCl-solubilized extracts of two antigenically distinct 3-methylcholanthrene-induced sarcomas, Mc7 and Mc57. The rats developed tumour-specific humoral antibody responses, but were not immune to tumour challenge. Moreover, they were unresponsiv...
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更新日期:1976-11-15 00:00:00
abstract::A population-based case-control study was conducted to evaluate risk of developing multiple myeloma (MM) associated with personal history of autoimmune diseases and occurrence of autoimmune and selected hematologic disorders in first-degree relatives. Data were obtained for all (n = 8,406) MM cases diagnosed in Sweden...
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abstract::The application of glucocorticoids (GC3) in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.R1-R5, isolated from the GC-sensitive human acute-T-cell-leukemic line, CCRF-CEM-C7, by se...
journal_title:International journal of cancer
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更新日期:1996-11-27 00:00:00
abstract::The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...
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