Stimulatory effects of CpG oligodeoxynucleotide on dendritic cell-based immunotherapy of colon cancer in CEA/HLA-A2 transgenic mice.

abstract：:Fibrin deposition in the microenvironment of tumor cells may be critical to tumor growth and metastasis formation. Procoagulant activities of tumor cells themselves, or of infiltrating macrophages, activated by the host's immune system to the tumor, may both contribute to coagulopathies associated with metastases. Lym...

journal_title：International journal of cancer

authors： Geczy CL,Ryan J,Walsh J,Goldstein D

更新日期：1986-05-15 00:00:00

abstract：:Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. Lymph nodes (n = 780) from 36 CRC patients who had developed disease re...

journal_title：International journal of cancer

authors： Doekhie FS,Mesker WE,Kuppen PJ,van Leeuwen GA,Morreau H,de Bock GH,Putter H,Tanke HJ,van de Velde CJ,Tollenaar RA

更新日期：2010-06-01 00:00:00

abstract：:We studied dietary risk factors for lung cancer among never-smokers in a population-based case-control study in Stockholm, 1989-1995. Study subjects were older than 30 years of age and had never smoked regularly. A total of 124 cases (35 men, 89 women) and 235 controls (72 men, 163 women) participated. Exposure inform...

journal_title：International journal of cancer

authors： Nyberg F,Agrenius V,Svartengren K,Svensson C,Pershagen G

更新日期：1998-11-09 00:00:00

abstract：:Abnormal cell adhesion is an important contributing factor in invasion and metastasis. Here, we show that morphologically 'normal' cell-cell and cell-substratum adhesion can be restored to a poorly differentiated carcinoma cell line by activation of protein kinase C (PKC). This cell line, VACO 10MS, grows as multicell...

journal_title：International journal of cancer

authors： Cowell HE,Garrod DR

更新日期：1999-01-29 00:00:00

abstract：:Normal human fibroblasts obtained from a whole embryo were malignantly transformed with only 60Co gamma rays, but after extensive passage. The fibroblasts were exposed intermittently to 60Co gamma rays, 13 times, 2,800 rads in total, from the primary culture to the 40th passage level. At the 50th passage level the cel...

journal_title：International journal of cancer

authors： Mihara K,Bai L,Kano Y,Miyazaki M,Namba M

更新日期：1992-02-20 00:00:00

abstract：:Three lymphoblastoid cell lines were established from splenic lymphocytes of a lymphomatous baboon (Papio hamadryas) by co-cultivation of the lymphocytes with X-irradiated cells of marmoset or baboon lymphoblastoid cell cultures; the baboon splenic lymphocytes failed to grow when cultured alone. A herpesvirus, associa...

journal_title：International journal of cancer

authors： Falk L,Deinhardt F,Nonoyama M,Wolfe LG,Bergholz C

更新日期：1976-12-15 00:00:00

abstract：:Embryonal tumors such as Wilms' tumor (WT), embryonal rhabdomyosarcoma (eRMS) and hepatoblastoma have been thought to have a common pathogenetic mechanism. H19 was found to be inactivated in WT and eRMS either by loss of heterozygosity or by hypermethylation of the maternal allele. We show here that the expression of ...

journal_title：International journal of cancer

authors： Fukuzawa R,Umezawa A,Ochi K,Urano F,Ikeda H,Hata J

更新日期：1999-08-12 00:00:00

abstract：:MAGE genes are frequently expressed in several types of human malignancy and code for antigens recognized by cytotoxic T lymphocytes. We have previously described a monoclonal antibody (MAb), named 6C1, that recognizes the MAGE-1 protein and cross-reacts with a 72-kDa protein present in lysates of melanoma cells such ...

journal_title：International journal of cancer

authors： Rimoldi D,Salvi S,Reed D,Coulie P,Jongeneel VC,De Plaen E,Brasseur F,Rodriguez AM,Boon T,Cerottini JC

更新日期：1999-09-09 00:00:00

abstract：:Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems are, however, controversial concerning a relation between HPV and chromosome instability development. Here we studied this association in 77 primary TSCC with k...

journal_title：International journal of cancer

authors： Mooren JJ,Kremer B,Claessen SM,Voogd AC,Bot FJ,Peter Klussmann J,Huebbers CU,Hopman AH,Ramaekers FC,Speel EJ

更新日期：2013-04-15 00:00:00

abstract：:Idiotypic protein (Id) produced by myeloma cells is clone-specific and may be a suitable tumor-specific antigen for immune targeting. Advances in dendritic cell (DC) technology suggest the opportunity for using this potent antigen presentation system to deliver myeloma Id to the autologous host to elicit anti-tumor im...

journal_title：International journal of cancer

authors： Lim SH,Bailey-Wood R

更新日期：1999-10-08 00:00:00

abstract：:Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. Although previously tobacco-derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex-specificity as a new and additional fac...

journal_title：International journal of cancer

authors： Stapelfeld C,Dammann C,Maser E

更新日期：2020-05-01 00:00:00

abstract：:Tissue recombinants (TRs) composed of mouse urogenital mesenchyme (mUGM) plus an immortalized nontumorigenic human prostatic epithelial cell line (BPH-1) were grown under the kidney capsule of male athymic nude mice under different hormonal conditions. The objectives were to determine temporal plasma concentrations of...

journal_title：International journal of cancer

authors： Ricke WA,Ishii K,Ricke EA,Simko J,Wang Y,Hayward SW,Cunha GR

更新日期：2006-05-01 00:00:00

abstract：:This study was aimed at comparing screen-detected and symptomatic breast carcinomas with regard to the prevalence of positive immunostaining for c-erb-B-2 oncoprotein. Paraffin sections of 81 breast carcinomas detected through the National Screening Programme were examined for the over-expression of c-erbB-2 oncoprote...

journal_title：International journal of cancer

authors： Soomro S,Taylor P,Shepard HM,Feldmann M,Sinnett HD,Shousha S

更新日期：1993-08-19 00:00:00

abstract：:Patients with head-and-neck cancer commonly have immune defects. It was reported that these patients have raised serum IgA levels. We investigated whether IgA-anti-Fab autoantibodies, which occur in association with immune dysfunction, are present in patients with head-and-neck cancer. Sera of 101 patients with squamo...

journal_title：International journal of cancer

authors： Süsal C,Maier H,Lorenz K,Opelz G

更新日期：1994-04-01 00:00:00

abstract：:There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...

journal_title：International journal of cancer

authors： Damber L,Grönberg H,Damber JE

更新日期：1998-10-29 00:00:00

abstract：:Kaposi's sarcoma (KS) is a frequent complication of the acquired immunodeficiency syndrome (AIDS) in homosexual men. Risk factors for developing this malignancy are uncertain, other than immunosuppression and coinfection with human herpesvirus 8 (HHV-8). We therefore examined factors associated with KS in a cross-sect...

journal_title：International journal of cancer

authors： Nawar E,Mbulaiteye SM,Gallant JE,Wohl DA,Ardini M,Hendershot T,Goedert JJ,Rabkin CS,AIDS Cancer Cohort (ACC) Study Collaborators.

更新日期：2005-06-10 00:00:00

abstract：:p27Kip1, one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been reported to be associated ...

journal_title：International journal of cancer

authors： Anayama T,Furihata M,Ishikawa T,Ohtsuki Y,Ogoshi S

更新日期：1998-08-21 00:00:00

abstract：:We treated 72 patients with metastatic renal-cell cancer according to 2 protocols consisting of two 5-week induction cycles of continuous i.v. high-dose interleukin-2 (IL-2), i.m. interferon-alpha (IFN alpha) and ex vivo IL-2-activated lymphocytes, followed for patients with stable disease (SD), partial response (PR) ...

journal_title：International journal of cancer

authors： Gratama JW,Schmitz PI,Goey SH,Lamers CH,Stoter G,Bolhuis RL

更新日期：1996-01-17 00:00:00

abstract：:Epigenetic alterations play an important role in carcinogenesis. Recent studies suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Our study was performed to evaluate histone H3 lysine 4 mono-methyl (H3K4me1), -di-methyl (H3K4me2) and -trimethyl (H3K4me3) pattern...

journal_title：International journal of cancer

authors： Ellinger J,Kahl P,Mertens C,Rogenhofer S,Hauser S,Hartmann W,Bastian PJ,Büttner R,Müller SC,von Ruecker A

更新日期：2010-11-15 00:00:00

abstract：:It is well known that tumors arising from tissues such as kidney, pancreas, liver and stomach are particularly refractory to treatment. Searching for new anticancer drugs using cells in culture has yielded some effective therapies, but these refractory tumors remain intractable. Studies that compare cells grown in sus...

journal_title：International journal of cancer

authors： Stein WD,Litman T,Fojo T,Bates SE

更新日期：2005-03-01 00:00:00

abstract：:A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...

journal_title：International journal of cancer

authors： Goldenberg DM,Pavia RA

更新日期：1975-02-15 00:00:00

abstract：:The distribution of aminoterminal propeptides of type-III procollagen (indicating the presence of type-III pN-collagen, i.e., type-III collagen molecule with a non-cleaved aminoterminal propeptide), laminin and type-IV collagen was studied by immunohistochemical methods. The results were compared with the distribution...

journal_title：International journal of cancer

authors： Karttunen T,Alavaikko M,Apaja-Sarkkinen M,Autio-Harmainen H

更新日期：1988-01-15 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChR) are expressed on bronchial epithelial and non-small cell lung cancer cells and are involved in cell growth regulation. Nicotine (classical nAChR agonist) induced cell proliferation, whereas nAChR antagonists, d- tubocurarine or alpha-cobratoxin (alpha-CbT), induced cell death....

journal_title：International journal of cancer

authors： Paleari L,Sessa F,Catassi A,Servent D,Mourier G,Doria-Miglietta G,Ognio E,Cilli M,Dominioni L,Paolucci M,Calcaterra A,Cesario A,Margaritora S,Granone P,Russo P

更新日期：2009-07-01 00:00:00

abstract：:Inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), is known to play an important role in the development of sporadic clear cell renal cell carcinomas (ccRCCs). Even if available targeted therapies for metastatic RCCs (mRCCs) have helped to improve progression-free survival rates, they have no durable ...

journal_title：International journal of cancer

authors： Bouhamdani N,Joy A,Barnett D,Cormier K,Léger D,Chute IC,Lamarre S,Ouellette R,Turcotte S

更新日期：2017-08-15 00:00:00

abstract：:Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...

journal_title：International journal of cancer

authors： Busson P,Zhang Q,Guillon JM,Gregory CD,Young LS,Clausse B,Lipinski M,Rickinson AB,Tursz T

更新日期：1992-04-01 00:00:00

abstract：:In a series of 87 primary breast tumors, somatostatin receptor (SSR) expression was detected by in vitro autoradiography in 58 tumors. In 41 tumors the SSR expression was homogeneous and in 17 it was heterogeneous. Although the tumors were not selected by the investigators upon entry in the study, examination of the t...

journal_title：International journal of cancer

authors： Bootsma AH,van Eijck C,Schouten KK,Reubi JC,Waser B,Foekens JA,van Pel R,Zwarthoff EC,Lamberts SW,de Klein A

更新日期：1993-05-28 00:00:00

abstract：:Azacytidine and decitabine are approved for treatment of acute myeloid leukemias and myelodysplastic syndromes. While clinical responses are attributed to epigenetic effects and induction of apoptosis in malignant cells, these azanucleosides also affect antitumor immune responses. NK cells as components of innate immu...

journal_title：International journal of cancer

authors： Schmiedel BJ,Arélin V,Gruenebach F,Krusch M,Schmidt SM,Salih HR

更新日期：2011-06-15 00:00:00

abstract：:We studied plasmin receptors on 3 MCF-7 sublines: MCF7, MCF7R which was derived by transfection with v-Ha-ras oncogene, and MCF7MF which has been studied for the secretion of procathepsin D in the presence of estrogen. All 3 sublines bound plasmin (Pli) with a much higher affinity than plasminogen (Pg). The number of ...

journal_title：International journal of cancer

authors： Correc P,Fondanèche MC,Bracke M,Burtin P

更新日期：1990-10-15 00:00:00

abstract：:The steady-state mRNA level of nucleophosmin/B23 in HeLa cells increased after UV irradiation. Nucleophosmin/B23 antisense transfection potentiated ultraviolet (UV)-induced cell killing. A block in G(2)/M phase, larger peak of apoptotic cells and higher caspase-3 in vitro activity were noted in nucleophosmin/B23 antis...

journal_title：International journal of cancer

authors： Wu MH,Chang JH,Chou CC,Yung BY

更新日期：2002-01-20 00:00:00

abstract：:In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-09-24 00:00:00