Abstract:
:Monoclonal antibody 38.13 was raised against the Burkitt lymphoma cell line Daudi and has been previously shown to recognize a globotriaosylceramide (Pk) determinant expressed selectively on Burkitt and a few other B-cell lymphomas. We report here that 38.13 binds to a subset of normal B lymphocytes in germinal centres of secondary lymphoid follicles as well as to blood vessels. In malignant populations equivalent to various developmental compartments of the B-cell lineage, only those with a follicular phenotype express the Pk determinant at detectable levels. The expression of this tumour-associated antigen, in common with many others, is therefore regulated in concert with cell lineage and maturation status.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Murray LJ,Habeshaw JA,Wiels J,Greaves MFdoi
10.1002/ijc.2910360508subject
Has Abstractpub_date
1985-11-15 00:00:00pages
561-5issue
5eissn
0020-7136issn
1097-0215journal_volume
36pub_type
杂志文章abstract::Under the aegis of EUROCARE, a European Union project to assemble survival data from population-based cancer registries and analyze them according to standardized procedures, we have investigated and compared colon-cancer survival in 10 European countries. We analyzed 68,283 colon-cancer cases diagnosed between 1978 a...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910630109
更新日期:1995-09-27 00:00:00
abstract::Previous studies have been inconsistent with respect to the reported associations between phospho-Akt (p-Akt) overexpression and lung cancer prognosis. In this study, we conducted a systematic review and meta-analysis to assess the prognostic value of p-Akt in patients with non-small cell lung carcinoma (NSCLC). Relev...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/ijc.28788
更新日期:2014-09-15 00:00:00
abstract::We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.22281
更新日期:2007-03-01 00:00:00
abstract::Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11049
更新日期:2003-06-10 00:00:00
abstract::Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560608
更新日期:1994-03-15 00:00:00
abstract::In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32565
更新日期:2020-05-01 00:00:00
abstract::Non-neoplastic mesenchymal cells, along with 33 benign and 87 malignant soft-tissue tumors (STT) were examined for expression of HLA-A,B,C, beta 2-microglobulin (beta 2m), HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). Serial frozen sections were immunostained using monoclonal antibodies...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460512
更新日期:1990-11-15 00:00:00
abstract::The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1319
更新日期:2001-07-15 00:00:00
abstract::We have obtained a novel multidrug resistant cell line, derived from HT29 G(+) human colon carcinoma cells, by selection with gradually increasing concentrations of the anti-mitotic, microtubule-disrupting agent colchicine. This HT29(col) cell line displayed a 25-fold increase in colchicine resistance and exhibited cr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000715)87:2<172::aid-ijc3>3.0.
更新日期:2000-07-15 00:00:00
abstract::Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently avai...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28048
更新日期:2013-08-01 00:00:00
abstract::We sought to analyze utilization and survival outcomes of cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (RCC) before and after introduction of targeted therapy. We identified patients with metastatic RCC between 1993 and 2010 in the SEER registry and examined temporal trends in utiliz...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28553
更新日期:2014-05-01 00:00:00
abstract::BPV-1 induces focus formation in murine C127 cells and fibropapillomas in bovine fetal skin xenografts. In this study, we compared the specificity of neutralization of BPV-1 in both assay systems, using sera and monoclonal antibodies (MAbs) selected to define neutralizing epitopes. Sera from rabbits and cattle, inocul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490224
更新日期:1991-09-09 00:00:00
abstract::Although a screening program for gastric cancer, using barium X-ray examination, has been carried out widely in Japan for the past 3 decades, there is insufficient evidence to confirm its effectiveness in terms of reducing mortality. To evaluate the effectiveness of the screening, a population-based case-control study...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600106
更新日期:1995-01-03 00:00:00
abstract::Using radioiodinated Staphylococcus aureus protein A [125I]SPA to measure syngeneic, allogeneic and heterogeneic IgG bound to murine tumor cells, we performed a serological analysis of surface antigens of 8 solid tumors and 2 leukemias of BALB/c mice (3 chemically-induced colon carcinomas, 3 chemically-induced sarcoma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230317
更新日期:1979-03-15 00:00:00
abstract::Epstein-Barr virus (EBV) is present in Reed-Sternberg (RS) cells of a substantial proportion of Hodgkin's lymphoma cases. Most EBV-positive cases are also MHC class I-positive, whereas the majority of EBV-negative cases lack detectable levels of MHC class I expression. Application of the SAGE technique has led to the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000515)86:4<548::aid-ijc
更新日期:2000-05-15 00:00:00
abstract::The role of plasma oxidant-antioxidant status in survival after breast cancer surgery was investigated in a cohort of patients (n = 363) hospitalized in Southern France between 1989 and 1992. The median follow-up was 8 years after surgery for histologically confirmed breast cancer. Plasma analyses were performed after...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10099
更新日期:2002-02-10 00:00:00
abstract::Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32908
更新日期:2020-09-01 00:00:00
abstract::The 26S proteasome, consisting of the 20S core and 19S regulatory complexes, regulates intracellular protein concentration through proteolytic degradation of targeted substrates. Composition of the 19S regulatory complex as well as posttranslational modifications of the 19S subunits can effectively regulate the activi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20261
更新日期:2004-09-01 00:00:00
abstract::The role of gastrin in the control of growth of renal G401 cells isolated from a human nephroblastoma (Wilms' tumour) was investigated. G401 cell growth was enhanced in the presence of exogenous gastrin. Addition of anti-gastrin antibodies to serum-free medium significantly inhibited the growth of G401 cells. G401 cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570316
更新日期:1994-05-01 00:00:00
abstract::Insulin-like growth factor-binding protein 7 (IGFBP7) functions in several cellular processes including proliferation, senescence and apoptosis. This study analyzed IGFBP7 function in hepatocellular carcinoma (HCC) cells by gene manipulation and investigated the prognostic significance of IGFBP7 expression in clinical...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25994
更新日期:2012-01-15 00:00:00
abstract::Previous studies indicate that the triterpene glycoside actein from the herb black cohosh inhibits growth of human breast cancer cells. This study seeks to identify genes altered in human breast cancer cells by treatment with actein, using gene expression analysis. We treated MDA-MB-453 human breast cancer cells with ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22897
更新日期:2007-11-01 00:00:00
abstract::As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910570602
更新日期:1994-06-15 00:00:00
abstract::Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins, many of which play critical roles in tumor cell growth and survival. The ansamycin-based Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in Phase III clinical tes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24815
更新日期:2010-03-01 00:00:00
abstract::Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001001)88:1<58::aid-ijc9>3.0.c
更新日期:2000-10-01 00:00:00
abstract::Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall surv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31195
更新日期:2018-04-15 00:00:00
abstract::An experiment in which rats were injected intrapleurally with asbestos, the injection taking place at an age of either 2 or 10 months, is reported. In the former group 19 out of 48 rats developed a mesothelioma compared with 17 out of 90 in the latter group. However, by considering the two groups at equal times after ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170410
更新日期:1976-04-15 00:00:00
abstract::Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal uroth...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990219)84:1<39::aid-ijc8
更新日期:1999-02-19 00:00:00
abstract::Cloned lines from 4 different families of B-16 melanoma cells were heated repeatedly in tissue culture at 45 degrees C with step-up time intervals. These lines included the partially heat-resistant lines previously selected at 43 degrees C(HR 43 degrees) from wheat-germ-agglutinin-resistant mutant (WGAR, HR43 degrees)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:1985-09-15 00:00:00
abstract::Production of interleukin-6 (IL-6) by human pancreatic carcinoma cells inversely correlates with potentials for blood-borne metastasis to the liver in nude mice. IL-6 cDNA was transfected to PCI-43, one of our cultured pancreatic carcinoma cell lines that does not produce IL-6 and generates numerous metastases to the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980119)75:2<284::aid-ijc
更新日期:1998-01-19 00:00:00
abstract::Our study investigated the association of breast cancer risk as assessed by mammographic density with insulin-like growth factor I (IGF-I) and one of its binding proteins (IGFBP-3) in healthy premenopausal women with different ethnic backgrounds. In a cross-sectional design, we analyzed the baseline mammograms and fas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11505
更新日期:2003-12-20 00:00:00