Expression of Burkitt lymphoma-associated antigen (defined by the monoclonal antibody 38.13) on both normal and malignant germinal-centre B cells.

Abstract:

:Monoclonal antibody 38.13 was raised against the Burkitt lymphoma cell line Daudi and has been previously shown to recognize a globotriaosylceramide (Pk) determinant expressed selectively on Burkitt and a few other B-cell lymphomas. We report here that 38.13 binds to a subset of normal B lymphocytes in germinal centres of secondary lymphoid follicles as well as to blood vessels. In malignant populations equivalent to various developmental compartments of the B-cell lineage, only those with a follicular phenotype express the Pk determinant at detectable levels. The expression of this tumour-associated antigen, in common with many others, is therefore regulated in concert with cell lineage and maturation status.

journal_name

Int J Cancer

authors

Murray LJ,Habeshaw JA,Wiels J,Greaves MF

doi

10.1002/ijc.2910360508

subject

Has Abstract

pub_date

1985-11-15 00:00:00

pages

561-5

issue

5

eissn

0020-7136

issn

1097-0215

journal_volume

36

pub_type

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