Abstract:
:The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as the WHO Blue Books. The first volume to be produced is on the classification of Digestive System tumours, replacing the successful 2010 version. It has been rewritten and updated accordingly. This article summarises the major diagnostic innovations that have occurred over the last decade and that have now been incorporated in the classification. As an example, it incorporates the recently proposed classification of neuroendocrine tumours, based on the recognition that neuroendocrine tumours and carcinomas differ substantially in the genetic abnormalities that drive their growth, findings relevant to treatment selection and outcome prediction. Several themes have emerged during the production process. One is the importance of the progression from hyperplasia to dysplasia to carcinoma in the evolution of the malignant process. Advances in imaging techniques and endoscopy have resulted in enhanced access to precancerous lesions in the gastrointestinal and biliary tract, necessitating both changes in classification schema and clinical practice. Diagnosis of tumours is no longer the sole purview of pathologists, and some patients now receive treatment before tissue is obtained, based on clinical, radiological and liquid biopsy results. This makes the classification relevant to many disciplines involved in the care of patients with tumours of the digestive system.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Washington MK,Goldberg RM,Chang GJ,Limburg P,Lam AK,Salto-Tellez M,Arends MJ,Nagtegaal ID,Klimstra DS,Rugge M,Schirmacher P,Lazar AJ,Odze RD,Carneiro F,Fukayama M,Cree IA,WHO Classification of Tumours Editorial Board.doi
10.1002/ijc.33210subject
Has Abstractpub_date
2021-03-01 00:00:00pages
1040-1050issue
5eissn
0020-7136issn
1097-0215journal_volume
148pub_type
杂志文章abstract::We, and others, have recently shown that recombinant feline leukaemia viruses (FeLV) containing the myc gene (FeLV-myc) occur in up to 30% of naturally occurring cases of T-cell lymphosarcoma. Investigation of the disease spectrum of two FeLV-myc isolates showed that they induced clonal or oligoclonal T-cell tumours a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400108
更新日期:1987-07-15 00:00:00
abstract::Malignant glioma is one of the most aggressive cancers. For the development of effective therapeutic strategies against such malignant diseases, elucidation of molecular targets is necessary. We found that inactivated Sendai virus particle (HVJ-E) induced extensive cell death in the human glioblastoma cell line U251MG...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24965
更新日期:2010-04-15 00:00:00
abstract::The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23360
更新日期:2008-05-01 00:00:00
abstract::Nickel-2,3,7,8,12,13,17,18-octaacetic acid-5,10,15,20-tetra-[3-carboranyl-methoxyphenyl]-porphyrin octamethylester (NiTCP) was given in a Cremophor EL, a polyethoxylated castor oil, and propylene glycol emulsion to BALB/c mice bearing transplanted s.c. KHJJ mammary carcinomas. A total dose of 244 microg NiTCP/gram bod...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960927)68:1<114::AID-IJC
更新日期:1996-09-27 00:00:00
abstract::Histologic characteristics of bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan, were evaluated. In each of these areas broadly-based series of cases were assembled during a collaborative case-control study. The present analysis was based on 589 cases in Boston, 484 cases in Manchester, and 241 cases in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300605
更新日期:1982-12-15 00:00:00
abstract::The expression of the Wilms tumor suppressor gene WT1 is largely restricted to elements of the developing urogenital system. In the fetal kidney, WT1 transcripts are present at low levels in the condensing mesenchyme and at much higher levels in differentiating glomerular epithelium and are not detected in other mesen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981005)78:2<182::aid-ijc
更新日期:1998-10-05 00:00:00
abstract::Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33230
更新日期:2021-02-01 00:00:00
abstract::The purpose of this study was to induce in postnatal life the selective growth of altered hepatocytic populations which had been induced in utero by various chemicals. Pregnant rats of a Wistar strain were given a single dose of various chemical carcinogens on the 18th gestational day. From two months postpartum, both...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290317
更新日期:1982-03-15 00:00:00
abstract::Thermal injury resulting from drinking very hot beverages has been incriminated as a risk factor for oesophageal cancer, although no information is available on the lesions caused by this injury in human or experimental animals. The drinking of hot maté tea is very common in areas of moderately high incidence of oesop...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390609
更新日期:1987-06-15 00:00:00
abstract::miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and prog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25452
更新日期:2011-03-15 00:00:00
abstract::Use of dietary supplements is rising in countries where colorectal cancer is prevalent. We conducted a systematic literature review and meta-analyses of prospective cohort studies on dietary supplement use and colorectal cancer risk. We identified relevant studies in Medline, Embase and Cochrane up to January 2013. Or...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/ijc.29277
更新日期:2015-05-15 00:00:00
abstract::With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarco...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990209)80:4<581::aid-ijc
更新日期:1999-02-09 00:00:00
abstract::In a formal prospective-retrospective analysis of the phase III SBG0102 clinical trial randomizing metastatic breast cancer patients to gemcitabine-docetaxel or to single agent docetaxel, patients with basal-like tumors by PAM50 gene expression had significantly better overall survival in the gemcitabine arm. By immun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31969
更新日期:2019-05-15 00:00:00
abstract::Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11732
更新日期:2004-04-10 00:00:00
abstract::We reported that tumor endothelial cells (TECs) differ from normal endothelial cells (NECs) in many aspects, such as gene expression profiles. Although CXCR7 is reportedly highly expressed in blood vessels of several tumors, its function in TECs is still unknown. To investigate this role, we isolated TECs from mouse t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29655
更新日期:2015-12-15 00:00:00
abstract::To develop a prognostic biomarker for esophageal squamous cell carcinoma (ESCC), we examined the proteomic profile of ESCC using two-dimensional difference gel electrophoresis (2D-DIGE), and identified proteins associated with prognosis by mass spectrometry. The prognostic performance of the identified proteins was ex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24194
更新日期:2009-05-01 00:00:00
abstract::Although adult obesity is known to increase endometrial cancer risk, evidence for childhood obesity is limited. We prospectively examined the association between body fatness throughout life and endometrial cancer risk. 47,289 participants in the Nurses' Health Study (NHS) and 105,386 of the Nurses' Health Study II (N...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29427
更新日期:2015-08-01 00:00:00
abstract::Mouse and human lymphoid cells were cultivated in the presence of T-cell growth factor (TCGF) and evaluated for their in vivo anti-tumor effect in mice. Cultured spleen cells of normal BALB/c mice or of mice bearing the M109 tumor had a high level of cytotoxic activity in vitro against a variety of tumor target cells ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280208
更新日期:1981-08-15 00:00:00
abstract::By using a functional complementation approach, suppression of tumorigenicity was observed after transfer of intact or truncated copies of chromosome 3 into a nasopharyngeal carcinoma (NPC) HONE1 cell line. The extra exogenous chromosome 3 in the microcell hybrids (MCHs) significantly extended the lag period of tumor ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23528
更新日期:2008-07-15 00:00:00
abstract::The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28987
更新日期:2015-01-15 00:00:00
abstract::The occurrence of metastasis severely affects prognosis and survival of breast cancer patients. In order to metastasize, breast cancer cells need to cross the basement membrane (BM) tissue boundaries. Matrix metalloproteases (MMPs) are enzymes with proteolytic activity towards extracellular matrix components (ECM) of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20009
更新日期:2004-05-01 00:00:00
abstract::To investigate whether human melanoma cells intrinsically resistant to autologous LAKs do exist, and whether a relationship between the level of lysis of LAKs and spontaneous drug resistance can be identified at the clonal level, we studied 44 clones obtained from a metastatic melanoma lesion. The antigenic phenotype ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420412
更新日期:1988-10-15 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the 5-year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the p...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.33352
更新日期:2020-10-22 00:00:00
abstract::Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep-CAM) by monoclonal antibody CO17-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients. In pre-clinical...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::A panel of eight conditionally immortal lines derived by infection of human breast epithelial cells with an amphotropic retrovirus transducing a ts mutant of SV40 large T-antigen was analyzed with respect to individual retroviral integration patterns. Each line contained multiple integration sites which were clonal an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570616
更新日期:1994-06-15 00:00:00
abstract::The sensitivity of human tissues and tumors to infection with type C adenoviruses correlates with the expression of the human coxsackie B- and adenovirus receptor, hCAR. HCAR is heterogeneously expressed in various tissues and types of human cancer cells, which has implications for the use of adenoviruses as vectors i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10891
更新日期:2003-03-01 00:00:00
abstract::Progress in the systemic control of osteosarcoma has been limited over the past decades thus indicating the urgent clinical need for the development of novel treatment strategies. Therefore, we have recently developed new preclinical models to study promising novel agents for the treatment of pediatric osteosarcoma. T...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32814
更新日期:2020-08-15 00:00:00
abstract::Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990301)80:5<764::aid-ijc
更新日期:1999-03-01 00:00:00
abstract::We examined the geospatial dimension of delays to diagnosis of breast cancer in a prospective study of 1541 women newly diagnosed in the African Breast Cancer - Disparities in Outcomes (ABC-DO) Study. Women were recruited at cancer treatment facilities in Namibia, Nigeria, Uganda, and Zambia. The baseline interview in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33400
更新日期:2020-11-16 00:00:00
abstract::Our aim was to compare the occurrence and prognostic significance over 14-20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains positively 56% of th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-20 00:00:00