Intracellular localization of metaiodobenzyl guanidine in human neuroblastoma cells by electron spectroscopic imaging.

abstract：:We compared and contrasted intracranial (i.c.) and subcutaneous (s.c.) heterotransplantation of small-cell carcinoma of the lung (SCCL) into athymic nude mice. Fresh human SCCL tumor specimens, tumor colonies grown in soft agarose and continuous cell lines were used. Tumors induced by the three types of specimens were...

journal_title：International journal of cancer

authors： Gazdar AF,Carney DN,Sims HL,Simmons A

更新日期：1981-12-01 00:00:00

abstract：:The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...

journal_title：International journal of cancer

authors： Bartel F,Meye A,Würl P,Kappler M,Bache M,Lautenschläger C,Grünbaum U,Schmidt H,Taubert H

更新日期：2001-05-20 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC. However, the contribution of TERT promoter mutation ...

journal_title：International journal of cancer

authors： Bu R,Siraj AK,Divya SP,Kong Y,Parvathareddy SK,Al-Rasheed M,Al-Obaisi KAS,Victoria IG,Al-Sobhi SS,Al-Dawish M,Al-Dayel F,Al-Kuraya KS

更新日期：2018-05-15 00:00:00

abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

journal_title：International journal of cancer

authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

更新日期：2007-02-15 00:00:00

abstract：:Dendritic cells (DCs) display an extraordinary capacity to induce T-cell responses providing the opportunity of DC-based cancer vaccination strategies. Additional findings indicate that DCs may also play a crucial role for the activation of natural killer (NK) cells, which are important effectors in innate antitumor i...

journal_title：International journal of cancer

authors： Wehner R,Löbel B,Bornhäuser M,Schäkel K,Cartellieri M,Bachmann M,Rieber EP,Schmitz M

更新日期：2009-01-15 00:00:00

abstract：:Histologic characteristics of bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan, were evaluated. In each of these areas broadly-based series of cases were assembled during a collaborative case-control study. The present analysis was based on 589 cases in Boston, 484 cases in Manchester, and 241 cases in...

journal_title：International journal of cancer

authors： Morrison AS,Proppe KH,Verhoek WG,Aoki K,Leck I,Ohno Y,Obata K

更新日期：1982-12-15 00:00:00

abstract：:A cDNA library specific for mRNA over-expressed in prostate cancer was generated by subtractive hybridization of transcripts originating from prostatic hyperplasia and cancer tissues. cDNA encoding ribosomal proteins L4, L5, L7a, L23a, L30, L37, S14 and S18 was found to be present among 100 analyzed clones. Levels of ...

journal_title：International journal of cancer

authors： Vaarala MH,Porvari KS,Kyllönen AP,Mustonen MV,Lukkarinen O,Vihko PT

更新日期：1998-09-25 00:00:00

abstract：:In order to study the mechanisms responsible for resistance to CDDP, 5 human tumor cell lines were made resistant to CDDP by repeated in vitro exposures. After cloning it was found that the cell lines developed were between 3.3-fold and 17-fold more resistant to CDDP than the parental cell lines at the IC90. These lin...

journal_title：International journal of cancer

authors： Teicher BA,Holden SA,Herman TS,Sotomayor EA,Khandekar V,Rosbe KW,Brann TW,Korbut TT,Frei E 3rd

更新日期：1991-01-21 00:00:00

abstract：:The survival experience of 284 patients with cancer of the cervix uteri registered by the population-based Zimbabwe National Cancer Registry in 1995-1997 is described. The vital status of these subjects was established by linkage with death registration and by retrieval of patient files from medical records department...

journal_title：International journal of cancer

authors： Chokunonga E,Ramanakumar AV,Nyakabau AM,Borok MZ,Chirenje ZM,Sankila R,Parkin DM

更新日期：2004-03-20 00:00:00

abstract：:Synchronous gastric carcinomas are found in 4% to 10% of all gastric carcinomas, and the tumor multiplicity is believed to be related to genetic predisposition. To investigate the role of mismatch repair error in synchronous gastric carcinomas, we analyzed the microsatellite instability (MSI) status of 101 cancers fro...

journal_title：International journal of cancer

authors： Lee HS,Lee BL,Kim SH,Woo DK,Kim HS,Kim WH

更新日期：2001-03-01 00:00:00

abstract：:The mouse anti-id MAb MK2-23 bears the internal image of the antigenic determinant defined by anti-HMW-MAA MAb 763.74. Active specific immunotherapy with anti-id MAb MK2-23 is associated with a statistically significant prolongation of survival in patients with malignant melanoma. Characterization of the immune respon...

journal_title：International journal of cancer

authors： Kageshita T,Hirai S,Ono T,Ferrone S

更新日期：1995-01-27 00:00:00

abstract：:We have previously reported a complete allelotype study of 86 primary breast carcinomas, in which each non-acrocentric chromosome arm was studied with at least one polymorphic DNA-marker for the presence of allelic imbalance (AI, allelic loss or allelic gain) in the tumor. Here we report the statistical analysis of th...

journal_title：International journal of cancer

authors： Cornelisse CJ,Kuipers-Dijkshoorn N,van Vliet M,Hermans J,Devilee P

更新日期：1992-02-20 00:00:00

abstract：:The putative tumor suppressors RASSF1A and BLU are mapped adjacent to one another on chromosome 3p21.3, a region frequently deleted in lung cancer. These genes are often inactivated by promoter hypermethylation, but the association of this inactivation with clinical features of the disease or with carcinogen exposure ...

journal_title：International journal of cancer

authors： Marsit CJ,Kim DH,Liu M,Hinds PW,Wiencke JK,Nelson HH,Kelsey KT

更新日期：2005-03-20 00:00:00

abstract：:The role of gastrin in the control of growth of renal G401 cells isolated from a human nephroblastoma (Wilms' tumour) was investigated. G401 cell growth was enhanced in the presence of exogenous gastrin. Addition of anti-gastrin antibodies to serum-free medium significantly inhibited the growth of G401 cells. G401 cel...

journal_title：International journal of cancer

authors： Blackmore M,Doherty E,Manning JE,Hirst BH

更新日期：1994-05-01 00:00:00

abstract：:Rapid tumor growth and metastasis are 2 major problems associated with treatment of malignant melanoma. Therefore, drugs that can intervene these processes are of clinical importance. Pentoxifylline (PTX), a methyl xanthine derivative, has been shown to inhibit B16F10 melanoma tumor growth and metastasis. We hypothesi...

journal_title：International journal of cancer

authors： Dua P,Ingle A,Gude RP

更新日期：2007-10-01 00:00:00

abstract：:Due to the generally poor prognosis of head and neck squamous cell carcinoma (HNSCC), treatment has been intensified, these last decades, leading to an increase of serious side effects. High-risk human papillomavirus (HR-HPV) infection has been recently etiologically linked to a subset of oropharyngeal squamous cell c...

journal_title：International journal of cancer

authors： Mirghani H,Amen F,Blanchard P,Moreau F,Guigay J,Hartl DM,Lacau St Guily J

更新日期：2015-04-01 00:00:00

abstract：:It has been proposed that the timing of breast-cancer surgery in relation to menstrual phase has a prognostic impact on outcome. We carefully evaluated a combined 2-center series of 385 pre-menopausal women operated on for stage-I and stage-II breast cancer with a median follow-up of 5 years for a possible impact on o...

journal_title：International journal of cancer

authors： Gnant MF,Seifert M,Jakesz R,Adler A,Mittlboeck M,Sevelda P

更新日期：1992-11-11 00:00:00

abstract：:Multiple myeloma (MM) is a B lymphocyte malignancy that remains incurable despite extensive research efforts. This is due, in part, to frequent disease recurrences associated with the persistence of myeloma cancer stem cells (mCSCs). Bone marrow mesenchymal stromal cells (BMSCs) play critical roles in supporting mCSCs...

journal_title：International journal of cancer

authors： Choi DS,Stark DJ,Raphael RM,Wen J,Su J,Zhou X,Chang CC,Zu Y

更新日期：2015-03-01 00:00:00

abstract：:The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of s...

journal_title：International journal of cancer

authors： Mestdagt M,Polette M,Buttice G,Noël A,Ueda A,Foidart JM,Gilles C

更新日期：2006-01-01 00:00:00

abstract：:The growth of a spontaneous adenocarcinoma (ADK-1t) of BALB/c mice (H-2d, MIsb) induces progressive hyporesponsiveness of spleen cells stimulated with PHA or irradiated leukocytes from DBA/2 strain (H-2d, MIsa) in mixed leukocyte culture. This hyporesponsiveness is due to the suppressor activity of macrophage-like cel...

journal_title：International journal of cancer

authors： Forni G,Giovarelli M,Lanfrancone L,Varesio L

更新日期：1982-06-15 00:00:00

abstract：:We characterized 8 human hepatocellular-carcinoma cell lines established from the primary tumors of Korean patients. All lines showed substrate adherence and one line from anaplastic tumor also grew as floating aggregates. Most cultured cells maintained many morphological characteristics of the original tumors from wh...

journal_title：International journal of cancer

authors： Park JG,Lee JH,Kang MS,Park KJ,Jeon YM,Lee HJ,Kwon HS,Park HS,Yeo KS,Lee KU

更新日期：1995-07-28 00:00:00

abstract：:Breast cancer (BC) is the leading cause of cancer in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported in Uganda and Zimbabwe. However, the magnitude of these rising trends in premenopausal and postmenopausal women is unknown in most African countries. We used data from the African Cancer Regis...

journal_title：International journal of cancer

authors： Joko-Fru WY,Jedy-Agba E,Korir A,Ogunbiyi O,Dzamalala CP,Chokunonga E,Wabinga H,Manraj S,Finesse A,Somdyala N,Liu B,McGale P,Jemal A,Bray F,Parkin DM

更新日期：2020-10-15 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are widespread, chemically-stable environmental contaminants; some congeners are commonly found in human adipose tissue and breast milk. We investigated the effects of a single dose of one PCB mixture (Aroclor 1254) on tumors initiated by N-nitrosodimethylamine (NDMA), also a common en...

journal_title：International journal of cancer

authors： Anderson LM,Ward JM,Fox SD,Isaaq HJ,Riggs CW

更新日期：1986-07-15 00:00:00

abstract：:The objectives of this prospective multicentre international cohort study are to describe the characteristics of a cohort of HIV-1 positive women and determine the best management system by comparing cervical pathology according to results of cytology, colposcopy and human papillomavirus (HPV) testing at baseline and ...

journal_title：International journal of cancer

authors： Kitchener H,Nelson L,Adams J,Mesher D,Sasieni P,Cubie H,Moore C,Heard I,Agarossi A,Casolati E,Denny L,Bradbeer C,Lyons F,Beattie G,Niemiec T

更新日期：2007-12-01 00:00:00

abstract：:Dietary factors in the aetiology of stomach cancer were investigated using data from a case-control study conducted in Northern Italy on 206 histologically confirmed carcinomas and 474 control subjects in hospital for acute, non-digestive conditions, unrelated to any of the potential risk factors for gastric cancer. D...

journal_title：International journal of cancer

authors： La Vecchia C,Negri E,Decarli A,D'Avanzo B,Franceschi S

更新日期：1987-10-15 00:00:00

abstract：:We studied dietary risk factors for lung cancer among never-smokers in a population-based case-control study in Stockholm, 1989-1995. Study subjects were older than 30 years of age and had never smoked regularly. A total of 124 cases (35 men, 89 women) and 235 controls (72 men, 163 women) participated. Exposure inform...

journal_title：International journal of cancer

authors： Nyberg F,Agrenius V,Svartengren K,Svensson C,Pershagen G

更新日期：1998-11-09 00:00:00

abstract：:The acyclic nucleoside phosphonate analogue cidofovir is a broad-spectrum anti-DNA virus agent, which also possesses potent inhibitory activity against various tumors associated with papillomaviruses in animal models and patients. Moreover, we recently described the potent inhibition of polyomavirus (PyV)-induced hema...

journal_title：International journal of cancer

authors： Liekens S,Verbeken E,De Clercq E,Neyts J

更新日期：2001-04-15 00:00:00

abstract：:Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2...

journal_title：International journal of cancer

authors： Dong Y,Walsh MD,McGuckin MA,Cummings MC,Gabrielli BG,Wright GR,Hurst T,Khoo SK,Parsons PG

更新日期：1997-08-22 00:00:00

abstract：:The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) was found to increase the incidence of phenotypic alterations induced by the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in human endometrial stromal cells. Following carcinogen treatment, changes in saturation density, gamma-glutam...

journal_title：International journal of cancer

authors： Siegfried JM,Kaufman DG

更新日期：1983-10-15 00:00:00

abstract：:Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C...

journal_title：International journal of cancer

authors： Dowling P,Clarke C,Hennessy K,Torralbo-Lopez B,Ballot J,Crown J,Kiernan I,O'Byrne KJ,Kennedy MJ,Lynch V,Clynes M

更新日期：2012-08-15 00:00:00