Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC).


:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food frequency questionnaire data. Between 1992 and 2000, detailed information on diet and life-style of 478,590 individuals participating in EPIC was collected. During a median follow-up of 6.4 years, 1,126 lung cancer cases were observed. Multivariate Cox proportional hazard models were applied for statistical evaluation. In the whole study population, fruit consumption was significantly inversely associated with lung cancer risk while no association was found for vegetable consumption. In current smokers, however, lung cancer risk significantly decreased with higher vegetable consumption; this association became more pronounced after calibration, the hazard ratio (HR) being 0.78 (95% CI 0.62-0.98) per 100 g increase in daily vegetable consumption. In comparison, the HR per 100 g fruit was 0.92 (0.85-0.99) in the entire cohort and 0.90 (0.81-0.99) in smokers. Exclusion of cases diagnosed during the first 2 years of follow-up strengthened these associations, the HR being 0.71 (0.55-0.94) for vegetables (smokers) and 0.86 (0.78-0.95) for fruit (entire cohort). Cancer incidence decreased with higher consumption of apples and pears (entire cohort) as well as root vegetables (smokers). In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers.


Int J Cancer


Linseisen J,Rohrmann S,Miller AB,Bueno-de-Mesquita HB,Büchner FL,Vineis P,Agudo A,Gram IT,Janson L,Krogh V,Overvad K,Rasmuson T,Schulz M,Pischon T,Kaaks R,Nieters A,Allen NE,Key TJ,Bingham S,Khaw KT,Amiano P,Bar




Has Abstract


2007-09-01 00:00:00












  • The decline in the incidence of stomach cancer in Sweden 1960-1984: a birth cohort phenomenon.

    abstract::Trends in the incidence of stomach cancer among 52,604 patients notified to the National Swedish Cancer Registry in 1960 through 1984 were analysed. Age-standardized incidence rates declined throughout the period, from 47.1 to 24.6 per 10(5) in males and from 23.8 to 12.7 per 10(5) in females. Among males the decline ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hansson LE,Bergström R,Sparén P,Adami HO

    更新日期:1991-02-20 00:00:00

  • Analysis of the NF2 tumor-suppressor gene and of chromosome 22 deletions in gliomas.

    abstract::Recurrent deletions of chromosome fragments observed in neoplasms are thought to participate in tumor development through the inactivation of tumor-suppressor genes. In gliomas, the most frequent deletions involve chromosome arms 9p, 10q, 17p, 19q and 22q. We have analysed deletions of chromosome 22 in gliomas by stud...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hoang-Xuan K,Merel P,Vega F,Hugot JP,Cornu P,Delattre JY,Poisson M,Thomas G,Delattre O

    更新日期:1995-02-08 00:00:00

  • Arsenic trioxide sensitizes CD95/Fas-induced apoptosis through ROS-mediated upregulation of CD95/Fas by NF-kappaB activation.

    abstract::CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for. In the present study, we show that sublethal doses of ar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woo SH,Park IC,Park MJ,An S,Lee HC,Jin HO,Park SA,Cho H,Lee SJ,Gwak HS,Hong YJ,Hong SI,Rhee CH

    更新日期:2004-11-20 00:00:00

  • Socioeconomic inequality and short-term outcome in Hodgkin's lymphoma.

    abstract::Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

    更新日期:2007-02-15 00:00:00

  • Enhancement of thermal killing by polyamines. I. Survival of Chinese hamster cells.

    abstract::Exposure of Chinese hamster cells to polyamines at an elevated temperature (42 degrees C) results in synergistic cell killing. The effectiveness of polyamines in potentiating thermal killing decreases in the following order: spermine greater than spermidine greater than cadaverine greater than putrescine. The magnitud...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ben-Hur E,Prager A,Riklis E

    更新日期:1978-11-15 00:00:00

  • SOCS3 as a tumor suppressor in breast cancer cells, and its regulation by PRL.

    abstract::Suppressor of cytokine signaling 3 (SOCS3), as a key regulator of cytokine signaling, has the potential to modulate numerous cellular processes. Its involvement in inflammatory disease is well established, and there is increasing evidence for a role in breast cancer as a regulator of signal transducers and activators ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Barclay JL,Anderson ST,Waters MJ,Curlewis JD

    更新日期:2009-04-15 00:00:00

  • Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology.

    abstract::HnRNP G is a member of heterogeneous nuclear ribonucleoprotein (hnRNP) family with potent tumor suppressive activities. Human transformer-2-beta1 (hTra2-beta1) belongs to the arginine-serine rich like proteins and is found over-expressed in various human cancers. It was recently shown that hnRNP G and hTra2-beta1 exer...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ouyang YQ,zur Hausen A,Orlowska-Volk M,Jäger M,Bettendorf H,Hirschfeld M,Tong XW,Stickeler E

    更新日期:2011-05-01 00:00:00

  • Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping.

    abstract::Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lu CC,Chen JC,Tsai ST,Jin YT,Tsai JC,Chan SH,Su IJ

    更新日期:2005-07-10 00:00:00

  • Is growth inhibition and induction of apoptosis in lung cancer cell lines by fenretinide [N-(4-hydroxyphenyl)retinamide] sufficient for cancer therapy?

    abstract::The synthetic retinoid fenretinide [N-(4-hydroxyphenyl)retinamide, 4-HPR] has demonstrated growth inhibition and induction of apoptosis of various malignant cells, including lung cancer cell lines. 4-HPR is now being investigated in several clinical trials. In our study, we show that 4-HPR inhibits growth on a broad p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ohlmann CH,Jung C,Jaques G

    更新日期:2002-08-10 00:00:00

  • Cotargeting BET proteins overcomes resistance arising from PI3K/mTOR blockade-induced protumorigenic senescence in colorectal cancer.

    abstract::Therapeutics targeting the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee HS,Lee S,Cho KH

    更新日期:2020-11-15 00:00:00

  • Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis.

    abstract::The mechanism of tumor cell killing by OXI4503 was investigated by studying vascular functional and morphological changes post drug administration. SCID mice bearing MHEC5-T hemangioendothelioma were given a single dose of OXI4503 at 100 mg/kg. Tumor blood flow, measured by microsphere fluorescence, was reduced by 50%...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sheng Y,Hua J,Pinney KG,Garner CM,Kane RR,Prezioso JA,Chaplin DJ,Edvardsen K

    更新日期:2004-09-10 00:00:00

  • Endometriosis as a prognostic factor for cancer survival.

    abstract::Studies have shown an increased risk of malignancies in women with endometriosis. Little is known about the impact of endometriosis on cancer survival. We investigated whether the survival after a diagnosis of a malignancy differs in women with a previously diagnosed endometriosis compared to other women. Women with a...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Melin A,Lundholm C,Malki N,Swahn ML,Sparen P,Bergqvist A

    更新日期:2011-08-15 00:00:00

  • Thymidylate synthase and dihydropyrimidine dehydrogenase gene expression in relation to differentiation of gastric cancer.

    abstract::Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA de novo synthesis and the salvage pathway in cancer cells, respectively. Intratumoral TS and DPD gene expressions were evaluated to determine the correlation between the expression of the 2 genes in both normal stromal tis...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ichikawa W,Takahashi T,Suto K,Nihei Z,Shirota Y,Shimizu M,Sasaki Y,Hirayama R

    更新日期:2004-12-20 00:00:00

  • Geographic variation of gallbladder cancer mortality and risk factors in Chile: a population-based ecologic study.

    abstract::Chile's gallbladder cancer rates are among the highest in the world, being the leading cause of cancer deaths among Chilean women. To provide insights into the etiology of gallbladder cancer, we conducted an ecologic study examining the geographical variation of gallbladder cancer and several putative risk factors. Th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Andia ME,Hsing AW,Andreotti G,Ferreccio C

    更新日期:2008-09-15 00:00:00

  • Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer.

    abstract::Paraffin sections (n = 168, 27 benign, 16 low malignant potential [LMP] and 125 malignant tumours) from epithelial ovarian tumours were evaluated immunohistochemically for expression of retinoblastoma gene product (pRB) and p53 protein, and the relationship among pRB, p53 and cyclin-dependent kinase inhibitor 2 (CDKN2...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dong Y,Walsh MD,McGuckin MA,Cummings MC,Gabrielli BG,Wright GR,Hurst T,Khoo SK,Parsons PG

    更新日期:1997-08-22 00:00:00

  • Parental smoking and risk of childhood brain tumors.

    abstract::Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. Tobacco smoke contains 61 known carcinogens and increases the risk of several adult cancers. This study investigated associations between parental smoking and risk of CBT in a population-based ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Milne E,Greenop KR,Scott RJ,Ashton LJ,Cohn RJ,de Klerk NH,Armstrong BK

    更新日期:2013-07-01 00:00:00

  • A yeast two-hybrid system using Sp17 identified Ropporin as a novel cancer-testis antigen in hematologic malignancies.

    abstract::Since most intracellular proteins are expressed with their ligands, ligands of cancer-testis (CT) antigens may also be CT in their distribution. Applying Sperm protein 17 (Sp17) as the bait in a yeast 2-hybrid system of a testicular cDNA library, 17 interacting clones were isolated and all encoded Ropporin, a spermato...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Li Z,Li W,Meklat F,Wang Z,Zhang J,Zhang Y,Lim SH

    更新日期:2007-10-01 00:00:00

  • Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas.

    abstract::The karyotypes of cells from 10 Burkitt lymphoma (BL) biopsies, eight cell lines established from BL and nine cell lines from non-BL sources were studied by chromosome banding techniques. With the exception of the BL-derived cell lines BJAB, GC-BJAB, Maku and U-8691 all biopsies and lines of Burkitt origin contained a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zech L,Haglund U,Nilsson K,Klein G

    更新日期:1976-01-15 00:00:00

  • Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice.

    abstract::The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Haranaka K,Satomi N,Sakurai A

    更新日期:1984-08-15 00:00:00

  • Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines.

    abstract::Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli (APC), has a major role in colorectal cancer (CRC). Most components have not been assessed for mutation in sporadic CRC. We have analyzed AXIN2, CK1alpha, DKK1, GSK-3beta, SOX17, LRP6 and PPP2R1B, beta-catenin and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Suraweera N,Robinson J,Volikos E,Guenther T,Talbot I,Tomlinson I,Silver A

    更新日期:2006-10-15 00:00:00

  • Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies.

    abstract::Double-label immunofluorescence was used to monitor basement-membrane composition and integrity in 22 human colon polyps, 36 adenocarcinomas and 2 metastases. Cryostat sections were stained with polyclonal anti-laminin anti-serum combined with monoclonal antibodies (MAbs) to all major basement-membrane components (lam...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ljubimov AV,Bartek J,Couchman JR,Kapuller LL,Veselov VV,Kovarik J,Perevoshchikov AG,Krutovskikh VA

    更新日期:1992-02-20 00:00:00

  • Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB.

    abstract::Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis. Although there is evidence that inhibiting integrins might enhance the efficiency of radiotherapy, little is known about the exact mechanisms involved in the integrin-dependent modulation of tumor radiosensitivity. The purpose o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Monferran S,Skuli N,Delmas C,Favre G,Bonnet J,Cohen-Jonathan-Moyal E,Toulas C

    更新日期:2008-07-15 00:00:00

  • c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line.

    abstract::Transcription factor c-Jun serves for cellular proliferation, survival, differentiation and transformation and is recognized as an important factor in cancer development, including hepatocellular carcinoma (HCC). The purpose of present study is to determine the involvement of c-Jun in matrix metalloproteinase-1 (MMP-1...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sugioka Y,Watanabe T,Inagaki Y,Kushida M,Niioka M,Endo H,Higashiyama R,Okazaki I

    更新日期:2004-05-10 00:00:00

  • Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo.

    abstract::Hyaluronan (HA) has been shown to play crucial roles in the tumorigenicity of malignant tumors. Previous studies demonstrated that inhibition of HA suppressed the tumorigenicity of various malignant tumors including breast cancer. 4-methylumbelliferone (MU) has been reported to inhibit HA synthesis in several cell typ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Urakawa H,Nishida Y,Wasa J,Arai E,Zhuo L,Kimata K,Kozawa E,Futamura N,Ishiguro N

    更新日期:2012-01-15 00:00:00

  • Characterization of humoral immune responses against p16, p53, HPV16 E6 and HPV16 E7 in patients with HPV-associated cancers.

    abstract::The cellular tumor suppressor p16 is strongly overexpressed in cervical cancers and precancers. We have previously demonstrated that infiltrating T lymphocytes reactive against p16 can be found in cervical cancer patients. Here, we analyzed whether p16 induces humoral immune responses. Sera of patients with cervical c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Reuschenbach M,Waterboer T,Wallin KL,Einenkel J,Dillner J,Hamsikova E,Eschenbach D,Zimmer H,Heilig B,Kopitz J,Pawlita M,Doeberitz Mv,Wentzensen N

    更新日期:2008-12-01 00:00:00

  • Impact of an HPV6/11/16/18 L1 virus-like particle vaccine on progression to cervical intraepithelial neoplasia in seropositive women with HPV16/18 infection.

    abstract::The impact of a human papillomavirus (HPV) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (CIN2-3/AIS) in women with ongoing HPV16 or 18 infections prevaccination is reported. Seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 random...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Haupt RM,Wheeler CM,Brown DR,Garland SM,Ferris DG,Paavonen JA,Lehtinen MO,Steben M,Joura EA,Giacoletti KE,Radley DR,James MK,Saah AJ,Sings HL,FUTURE I and II Investigators.

    更新日期:2011-12-01 00:00:00

  • The macrophage electrophoretic mobility test: Results on carcinoma of the colon and rectum.

    abstract::The macrophage electrophoretic mobility (MEM) test was performed on guinea-pig macrophages treated with the interaction products of encephalitogenic protein and peripheral lymphocytes from 44 patients with colorectal cancer and 33 "healthy" controls. In 54/60 tests involving patients, statistically significant reducti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Glaves D,Harlos JP,Weiss L

    更新日期:1977-04-15 00:00:00

  • Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype.

    abstract::Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chatterjee M,van Golen KL

    更新日期:2011-07-01 00:00:00

  • The international classification of childhood cancer.

    abstract::The International Classification of Childhood Cancer (ICCC) updates the widely used Birch and Marsden classification scheme. ICCC is based on the second edition of the International Classification of Diseases for Oncology (ICD-O-2). The purpose of the new classification is to accommodate important changes in recogniti...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Kramárová E,Stiller CA

    更新日期:1996-12-11 00:00:00

  • Regional variations in cancer survival: Impact of tumour stage, socioeconomic status, comorbidity and type of treatment in Norway.

    abstract::Cancer survival varies by place of residence, but it remains uncertain whether this reflects differences in tumour, patient and treatment characteristics (including tumour stage, indicators of socioeconomic status (SES), comorbidity and information on received surgery and radiotherapy) or possibly regional differences...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Skyrud KD,Bray F,Eriksen MT,Nilssen Y,Møller B

    更新日期:2016-05-01 00:00:00