Abstract:
:Ovarian cancer is one of the most common gynecological malignancies. The tumor microenvironment plays an important role in regulating the progression of ovarian cancer. Macrophages, which are important immune cells in the tumor microenvironment, participate in the regulation of various biological behaviors and influence the prognosis of ovarian cancer. A large number of studies have targeted macrophages for the treatment of ovarian cancer. In addition, macrophages also play a regulatory role by interacting with other immune cells, including T cells and mesothelial cells, in the ovarian cancer microenvironment. In this review, we discuss the progress made in macrophage-targeted therapy for ovarian cancer. Although there are still several challenges in using this treatment, targeted macrophage therapy is still a promising treatment for ovarian cancer.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
An Y,Yang Qdoi
10.1002/ijc.33408subject
Has Abstractpub_date
2020-11-24 00:00:00eissn
0020-7136issn
1097-0215pub_type
杂志文章,评审abstract::TDE2, a gene with sequence similarity to the mouse testicular tumor-differentially-expressed (Tde1/MUSTETU) gene, was identified by serial analysis of gene expression (SAGE) in nonsmall cell lung cancers (NSCLC). Here we characterized the TDE2 gene and determined its transcript levels in a panel of lung tumors, adjace...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11391
更新日期:2003-11-01 00:00:00
abstract::Biliary glycoprotein I (BGP I) is a member of carcinoembryonic antigen (CEA) gene family consisting of at least 11 related genes. The transcription of BGP I gene was analysed in malignant and non-malignant human liver tissues with a 396-bp 3'-untranslated region probe from a cDNA clone 4-13 which was newly isolated fr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450516
更新日期:1990-05-15 00:00:00
abstract::The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25673
更新日期:2011-07-15 00:00:00
abstract::Three monoclonal antibodies (MAbs) against p53 protein (PAb 24o, DO-I and PAb1801) were used to define the immunophenotype of 13 melanoma cell lines. Immunoreactions could be detected in 12 out of 13 cell lines by using the indirect immunofluorescence technique. In 7 of these the majority of cells displayed cytoplasmi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540427
更新日期:1993-06-19 00:00:00
abstract::Carcinoma of the breast is a leading hormone-dependent malignancy, resulting in a high rate of morbidity and mortality. During the complex multi-step process of tumor promotion, this common cancer is initiated as hormone-responsive (HR), non-metastatic cancer, followed by a gradual transition into a highly metastatic ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990505)81:3<443::aid-ijc
更新日期:1999-05-05 00:00:00
abstract::The present experiments were performed to investigate the possibility of inhibiting tumor growth in vivo with syngeneic lymphocytes sensitized in vitro on monolayers of the tumor under test, and to study the effect of a thymic humoral factor (THF) in this sensitization process. Monolayers of fibrosarcoma cells were us...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150612
更新日期:1975-06-15 00:00:00
abstract::The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980130)75:3<396::aid-ijc
更新日期:1998-01-30 00:00:00
abstract::Although thyroid cancer is suspected to have a nutritional etiology, prospective studies examining the relationship between diet and thyroid cancer are lacking. During 1996-1997, NIH-AARP Diet and Health Study participants, ages 51-72 years, completed a 37-item food frequency questionnaire about diet at ages 12-13 yea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29600
更新日期:2015-11-15 00:00:00
abstract::Several changes in smoking patterns over the past decades in Spain can be expected to result in a shift in lung-cancer mortality rates. We examined time trends in lung-cancer mortality from 1973-1997 using a log-linear Poisson age-period-cohort model. The standardized lung-cancer mortality rate for men almost doubled,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1575
更新日期:2002-01-01 00:00:00
abstract::Spleen cells from mice infected with Friend leukemia virus (FLV) inoculated by the intravenous route give rise to macroscopically visible colonies in the spleens of normal F1 histocompatible hybrid hosts. A study of H-2 antigens as generic markers for identification of strains of origin of cells constituting the splee...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220418
更新日期:1978-10-15 00:00:00
abstract::Aberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer. We used CpG microarray and differential methylation hybridization strategies to identify potential tumor suppressor genes and recovered glutamate receptor, ionotropic, kainate 2 (GRIK2) as a novel epigeneti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24958
更新日期:2010-06-01 00:00:00
abstract::Adhesion molecules involved in attachment between human pancreatic carcinoma and activated endothelial cells in vitro were investigated. Basal adhesion occurred between 6 pancreatic carcinoma cell lines and unstimulated human umbilical vein endothelial cells (HUVEC), and augmented basal adhesion to activated HUVEC was...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540618
更新日期:1993-07-30 00:00:00
abstract::Fibroblast-like cells (F-cells) and epithelial-like (E-cells) derived from cultures of rabbit VX-2 carcinoma released collagenase in both active and latent forms in serum-free medium at a level higher than that of normal rabbit fibroblast cultures. The enhanced capacity of the F-cells to release the enzyme, however, c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310317
更新日期:1983-03-15 00:00:00
abstract::A multi-national, hospital-based, case-control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral c...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1989-02-15 00:00:00
abstract::A wide variety of primary and metastatic human neoplasms express somatostatin receptors (SS-Rs). We evaluated the SS-R status of malignant lymphomas that had been surgically removed from 31 patients by use of in vitro SS-R autoradiography with the SS analog 125I-[Tyr3]-octreotide as radioligand. Of 11 low-grade-malign...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500613
更新日期:1992-04-01 00:00:00
abstract::Human papillomavirus (HPV)-associated penile lesions in men may increase the risk of HPV transmission to their female partners. Risk factor data on HPV-associated penile lesions are needed from regions with a high burden of cervical cancer. Visual inspection of the penis was conducted using a colposcope at the 24-mont...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26196
更新日期:2012-04-15 00:00:00
abstract::FTY720, a derivative of fungus, has demonstrated dramatic anticancer effect in several malignancies recently. Our study evaluates the therapeutic potential of FTY720 in the treatment of androgen-independent prostate cancer using a human prostate cancer xenograft in nude mice. CWR22R, an androgen-independent human pros...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21243
更新日期:2005-12-20 00:00:00
abstract::A goal of oncology is to predict chemosensitivity of tumors. This approach assumes that in a patient all tumor deposits are homogeneous. We have tested the heterogeneity between several samples of the same liver metastasis (LM; intrametastatic heterogeneity) or between multiple LM (intermetastatic heterogeneity) from ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25114
更新日期:2010-09-01 00:00:00
abstract::We describe 2-step and 3-step strategies for intraperitoneal tumor radio-localization by means of monoclonal antibodies (MAbs). Nude mice bearing intraperitoneal human colon carcinoma tumors were injected i.p. with biotinylated MAb AUAI, followed 24 hr later by radioiodinated streptavidin (2-step). The uptake of radio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450632
更新日期:1990-06-15 00:00:00
abstract::Tumorigenic clonal lines derived from soft agar colonies induced by DMBA-transformed feline embryo cells were isolated and characterized. The morphologically altered clonal cells formed large aggregates, growing in this aggregate form when suspended in liquid growth medium above an agar base and forming colonies in so...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280110
更新日期:1981-07-15 00:00:00
abstract::Cervical cancer and many other anogenital and oropharyngeal carcinomas are strongly associated with high-risk human papillomavirus (HPV) persistent infections. HPV E7 oncoprotein is the major viral transforming factor, emerging as a natural candidate for immunotherapy, since it is constitutively expressed in HPV-induc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26294
更新日期:2012-04-15 00:00:00
abstract::We analyzed the role of reproductive factors on the risk of endometrial cancer using data from a case-control study conducted in Italy. Cases were 752 women with histologically confirmed endometrial cancer < 75 years of age. Controls were 2,606 patients < 75 years of age admitted for acute, non-gynecological non-hormo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980610)76:6<784::aid-ijc
更新日期:1998-06-10 00:00:00
abstract::Both the tumour growth and progression and the systemic inflammatory response have the potential to increase oxidative stress. We therefore examined the relationship between lipid-soluble antioxidant vitamins, lipid peroxidation, the systemic inflammatory response and survival in patients with primary operable (n = 53...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23811
更新日期:2008-11-15 00:00:00
abstract::In experimental tumor immunotherapy, incomplete Freund's adjuvant (IFA) has been considered as the "gold standard" for T-cell vaccination in mice and humans in spite of its considerable adverse effects. Recently, we succeeded in eliciting strong CTL responses in mice after vaccination with biodegradable poly(D,L-lacti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25914
更新日期:2011-07-15 00:00:00
abstract::The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1639
更新日期:2002-02-01 00:00:00
abstract::It has been established that disturbances in intracellular signaling pathways play a considerable part in the oncologic process. Phosphatidylinositol-3-kinase (PI3K) has become of key interest in cancer therapy because of its high mutation frequency and/or gain in function of its catalytic subunits in cancer cells. We...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29040
更新日期:2015-02-15 00:00:00
abstract::Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40,000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox reg...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26408
更新日期:2012-08-01 00:00:00
abstract::p16(INK4a), a cell cycle regulation protein, accumulates in abnormal epithelial cells infected with high-risk human papilloma virus (HPV). In immunostaining studies, p16(INK4a) has shown potential as a marker of high grade cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. To evaluate its potential...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22612
更新日期:2007-06-01 00:00:00
abstract::Female residents of six counties in Washington and Utah in whom a diagnosis of ovarian cancer was made during 1975-79 were interviewed concerning prior use of oral contraceptives. Interviews with a random sample of women drawn from these same counties were obtained for comparison. A smaller proportion of women with ep...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280602
更新日期:1981-12-01 00:00:00
abstract::Metastasis-associated protein MTA1 and histone deacetylase form a protein complex with histone deacetylase activity that plays an important role in histone deacetylation, alteration of chromatin structure and transcriptional control. The precise role of the MTA1 protein in the malignant progression of human cancers re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20154
更新日期:2004-06-20 00:00:00