Abstract：
:The hedgehog (Hh) signaling pathway is essential for the development of tissues and organs. Hyperactive Hh signaling has been implicated in many gastric cancers, including esophageal cancer. However, the interaction between the Hh pathway and other potential signaling pathways in primary esophageal tumorigenesis has not been well investigated. In our study, we found that esophageal cancer cells expressed Hh signaling molecules and that the hyperexpression of Hh target genes was related to protein kinase B (AKT) activation but not extracellular signal-regulated kinase activation. We analyzed the relationship between Gli1 or p-AKT expression and clinicopathological features in esophageal carcinoma samples and found that Gli1 expression was associated with lymph vessel invasion (p = 0.016), blood vessel invasion (p = 0.006) and a poor prognosis (p = 0.003), and p-AKT expression was associated with blood vessel invasion (p = 0.031) and a poor prognosis (p = 0.031). We also studied the relationship between Hh and phosphinositide-3 kinase (PI3K)/AKT or mitogen-activated protein kinase (MAPK) signaling pathways in both TE-1 and TE-10 cell lines. We found that the PI3K/AKT pathway played a critical role in Hh signaling after stimulation with epidermal growth factor, Gβγ and N-Shh. Conversely, PI3K/AKT and MAPK signaling cooperated with the Shh pathway to promote esophageal cancer cell survival and proliferation. The results from esophageal cancer cells shed light on the significance of Hh signaling in esophageal tumor formation and the crosstalk of the Hh pathway with other basic signaling pathways, which is consistent with that observed in human tumor samples.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Wei L,Xu Zdoi
10.1002/ijc.25673subject
Has Abstractpub_date
2011-07-15 00:00:00pages
275-84issue
2eissn
0020-7136issn
1097-0215journal_volume
129pub_type
杂志文章abstract：:Epidermodysplasia verruciformis (EV) is considered as a model of genetic cancer due to unusual susceptibility to EV-specific human papillomaviruses (HPVs). We established an in vivo experimental system for long-term propagation of EV tissue which should facilitate the study of tumor progression in EV. Skin fragments f...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910560519
更新日期：1994-03-01 00:00:00
abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC. However, the contribution of TERT promoter mutation ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31225
更新日期：2018-05-15 00:00:00
abstract：:661 bp coding for the carboxyl end of the large sub-unit of EBV ribonucleotide reductase was cloned into the pMal plasmid vector. Purified recombinant protein was tested in IgG and IgA ELISAs. For the IgG assay, 81 out of 100 NPC patients tested positive, whereas for the IgA assay, 60 tested positive. Among 100 normal...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910590604
更新日期：1994-12-15 00:00:00
abstract：:We undertook a study to determine the role and regulation of expression of urokinase-type plasminogen activator in squamous-cell carcinoma of the oral cavity. The contribution of urokinase to the invasive process was clearly demonstrated in experiments in which in vitro invasion by a cultured squamous-cell carcinoma c...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910540113
更新日期：1993-04-22 00:00:00
abstract：:Invasion of malignant cells requires altered cellular interaction with extracellular matrix. Integrin-type cell adhesion receptors play an important role in this process. Integrin-related cell biological phenomena explain cancer cell migration, and recent developments in the field have made it possible to propose that...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/(SICI)1097-0215(19960315)65:6<717::AID-IJC
更新日期：1996-03-15 00:00:00
abstract：:Inactivation of the tumor-suppressor gene p16 (MTS1/ CDKN2/INK4a) has been described in various human malignancies. Although p16 deletion has been found in various ovarian tumor cell lines, p16 inactivation by homozygous deletion or mutation has been reported only sporadically in primary ovarian carcinomas. In a compr...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980220)79:1<61::aid-ijc1
更新日期：1998-02-20 00:00:00
abstract：:In mice as well as humans, cytotoxic T lymphocytes (CTL) specific for wild-type-sequence (wt) p53 peptides have been shown to react against a wide range of tumors, but not normal cells. As such, they are attractive candidates for developing broadly applicable cancer vaccines. Of particular interest is the potential of...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20686
更新日期：2005-03-01 00:00:00
abstract：:To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24392
更新日期：2009-08-01 00:00:00
abstract：:We investigated the ability of endogenous and recombinant interleukin-2 (IL-2)-stimulated NK cells from normal donors and ovarian cancer patients to mediate lysis of ovarian tumors, and found that peripheral blood (PB) mononuclear cells of normal donors or cancer patients did not display tumoricidal activity against o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910420214
更新日期：1988-08-15 00:00:00
abstract：:The mounting of a specific immune response against the human papillomavirus type 16 E7 protein (HPV16 E7) is important for eradication of HPV16 E7-expressing cancer cells from the cervical mucosa. To induce a mucosal immune response by oral delivery of the E7 antigen, we expressed the HPV16 E7 antigen on the surface o...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22035
更新日期：2006-10-01 00:00:00
abstract：:The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(20010520)95:3<168::aid-ijc1029>3
更新日期：2001-05-20 00:00:00
abstract：:Hormone refractory prostate cancer poses a huge problem and standard of care chemotherapy has not been very successful. We used a novel strategy to combine properties of 2 well-studied class of compounds (selenium and COX-2 inhibitor) and examined the resulting effectiveness against prostate cancer. Bearing in mind th...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25033
更新日期：2010-07-01 00:00:00
abstract：:Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (E...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(20000415)86:2<229::aid-ijc
更新日期：2000-04-15 00:00:00
abstract：:Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22292
更新日期：2007-02-01 00:00:00
abstract：:ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.27415
更新日期：2012-10-01 00:00:00
abstract：:Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Pr...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24393
更新日期：2009-07-15 00:00:00
abstract：:In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and com...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20614
更新日期：2005-02-20 00:00:00
abstract：:In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32014
更新日期：2019-05-01 00:00:00
abstract：:Although aneuploidy is commonly observed in human cancers, the molecular mechanism underlying aneuploidization remains unclear. We used multiploid cancer model that had diploid and aneuploid cancer cells within the same cancerous tissue and attempted to detect specific epigenetic alterations associated with tumor cell...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22847
更新日期：2007-10-01 00:00:00
abstract：:Membrane-type metalloproteinase-1 (MT1-MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro-MMP-2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP-2 activation that yields to the mature form is less understoo...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10134
更新日期：2002-03-01 00:00:00
abstract：:The metastatic spread of tumor cells is the most lethal aspect of cancer and can occur via various routes, including the lymphatic vasculature. Studies of tumor models in animals and clinicopathological data have indicated that growth of lymphatic vessels (lymphangiogenesis) in the vicinity of solid tumors may contrib...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.21899
更新日期：2006-10-15 00:00:00
abstract：:The incidence of testicular cancer was examined in the Nordic and Baltic countries, Poland and Germany by collaboration among 10 cancer registries. Population-based registers were used to analyze a total of 34,309 cases, diagnosed from the start of registration (varying from 1943 in Denmark to 1980 in Latvia and Lithu...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910590108
更新日期：1994-10-01 00:00:00
abstract：:MM is a B-cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, presence of paraprotein in serum and occurrence of osteolytic bone lesions. MMPs are a family of proteolytic enzymes that can contribute to cancer growth, invasion, angiogenesis, bone degradation and other processes impor...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10642
更新日期：2002-10-20 00:00:00
abstract：:Co-injection of fibroblasts with human epithelial breast-tumor MCF7 cells in the presence of Matrigel enhances tumor growth in nude mice. While most of the matrix metalloproteinases (MMPs) have been shown to be produced by stromal cells, tumor cells such as MCF7 cells are unable to produce MMPs. We therefore, hypothes...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980413)76:2<267::aid-ijc
更新日期：1998-04-13 00:00:00
abstract：:Telomerase, the enzyme responsible for maintenance of the telomeres, is absent from the vast majority of somatic cells but is present in most tumours. Little is known about how telomerase is activated in cancer, although it is thought vital for immortalisation to occur. The aim of our study was to identify genetic cha...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19991022)84:5<516::aid-ijc
更新日期：1999-10-22 00:00:00
abstract：:Cytogenetic deletions of the short arm of chromosome 9, 9p, have been detected in cell lines of malignant mesothelioma as well as in tumor material. Many tumor types carry deletions of chromosome 9 or more specifically of 9p21. The tumor-suppressor genes, CDKN2A and CDKN2B, each of which encodes a structurally and fun...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980209)75:4<649::aid-ijc
更新日期：1998-02-09 00:00:00
abstract：:The insulin like growth factor (IGF) signaling pathway has been shown to contribute to melanoma progression, but little is known about the role of the IGF binding protein 3 (IGFBP-3) in melanoma biology. The aim of the present study was to characterize expression, function and regulation of IGFBP-3 in malignant melano...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24727
更新日期：2010-01-15 00:00:00
abstract：:Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32908
更新日期：2020-09-01 00:00:00
abstract：:The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited high antitumor activity against human colorectal cancer xenografts. This study was conducted to investigate the advantages of NK012 over irinotecan hydrochloride (CPT-11) administered in comb...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23381
更新日期：2008-05-01 00:00:00
abstract：:This article describes the characteristics of 3 dominant features of breast cancer epidemiology. These characteristics include the association of disease risk with childbearing, its relationship to ovarian activity and its international variation (particularly as the latter differs in the years before and after menopa...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.21404
更新日期：2006-05-15 00:00:00
