Novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy.

abstract：:Macrophages were isolated from 22 human ascitic ovarian epithelial tumors and their growth-inhibitory capacity was tested using as targets the following in vitro tumor cell lines: murine TLX9 lymphoma and FS6 sarcoma; human myeloid K562 leukemia and human E cell line derived from an ovarian carcinoma. Macrophage prepa...

journal_title：International journal of cancer

authors： Mantovani A,Peri G,Polentarutti N,Bolis G,Mangioni C,Spreafico F

更新日期：1979-02-01 00:00:00

abstract：:Progression from an androgen-dependent to an androgen-independent state often occurs in patients with prostate cancer (PCa) who undergo hormonal therapy. We have investigated whether inhibition of the epidermal growth factor receptor (EGFR) signaling pathway affects the antitumor effect of a nonsteroidal antiandrogen....

journal_title：International journal of cancer

authors： Festuccia C,Gravina GL,Angelucci A,Millimaggi D,Muzi P,Vicentini C,Bologna M

更新日期：2005-07-01 00:00:00

abstract：:A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occurring HPV infectio...

journal_title：International journal of cancer

authors： Giannoudis A,Graham DA,Southern SA,Herrington CS

更新日期：1999-09-24 00:00:00

abstract：:Epstein-Barr virus (EBV) can be detected in Hodgkin and Reed-Sternberg (HRS) cells in about one-half of cases of Hodgkin's disease (HD) in Western countries. To determine whether EBV is also associated with HD in a developing country such as China, we studied paraffin sections from 28 Chinese cases of HD for expressio...

journal_title：International journal of cancer

authors： Zhou XG,Hamilton-Dutoit SJ,Yan QH,Pallesen G

更新日期：1993-09-30 00:00:00

abstract：:The object of our multicenter retrospective study was to compare the new histologic World Health Organization (WHO) classification and the classical histologic Bernatz classification in terms of interobserver agreement and prognostic importance. The influence of coexisting diseases was also analyzed using the Charlson...

journal_title：International journal of cancer

authors： Rieker RJ,Hoegel J,Morresi-Hauf A,Hofmann WJ,Blaeker H,Penzel R,Otto HF

更新日期：2002-04-20 00:00:00

abstract：:We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after w...

journal_title：International journal of cancer

authors： Dorhout B,Te Velde RJ,Ferwerda H,Kingma AW,De Hoog E,Muskiet FA

更新日期：1995-04-10 00:00:00

abstract：:Cytogenetic analysis of short-term cultures from 26 primary bronchial large cell carcinomas and 1 metastasis from a primary large cell carcinoma revealed clonal chromosome abnormalities in 20 tumors and a normal karyotype in 6. No outgrowth was obtained in 1 case. Simple aberrations were present in 3 tumors; in 1, the...

journal_title：International journal of cancer

authors： Johansson M,Dietrich C,Mandahl N,Hambraeus G,Johansson L,Clausen PP,Mitelman F,Heim S

更新日期：1994-05-15 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) have been suggested, on the basis of animal-model studies, to be related not only to cancer development but also to chemotherapeutic effects. Controversy persists, however, as to which types of PUFAs are beneficial in terms of chemosensitivity. In this study, we used the NIH3T3 cell...

journal_title：International journal of cancer

authors： Tsai WS,Nagawa H,Muto T

更新日期：1997-01-27 00:00:00

abstract：:Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase of the cell cycle and trigger apoptosis. To investigate apoptosis induced by paclitaxel in nasopharyngeal carcinoma (NPC), and its possible molecular mechanism of action, the human NPC cell lines HNE-1 (bea...

journal_title：International journal of cancer

authors： Tan G,Heqing L,Jiangbo C,Ming J,Yanhong M,Xianghe L,Hong S,Li G

更新日期：2002-01-10 00:00:00

abstract：:Lymphoma EL-4 of B6 origin was inoculated into lethally-irradiated syngeneic B6 or resistant BD2F1 hybrid recipients. Marked impairment of lymphoma cell proliferation (i.e. hybrid resistance, HR) occurred in the spleen but not in the liver or lung of BD2F1 hosts. Treatment with DTIC at the optimal dose of 80 mg/kg i.p...

journal_title：International journal of cancer

authors： Iorio AM,Neri M,Enrico P,Goldin A,Bonmassar E

更新日期：1981-10-15 00:00:00

abstract：:Increasing evidence indicates the importance of the tumor microenvironment, in particular cancer-associated fibroblasts, in cancer development and progression. In our study, we developed a novel, visually based method to identify new immunohistochemical signatures of these fibroblasts. The method employed a protein li...

journal_title：International journal of cancer

authors： Bozóky B,Savchenko A,Csermely P,Korcsmáros T,Dúl Z,Pontén F,Székely L,Klein G

更新日期：2013-07-15 00:00:00

abstract：:We studied dietary risk factors for lung cancer among never-smokers in a population-based case-control study in Stockholm, 1989-1995. Study subjects were older than 30 years of age and had never smoked regularly. A total of 124 cases (35 men, 89 women) and 235 controls (72 men, 163 women) participated. Exposure inform...

journal_title：International journal of cancer

authors： Nyberg F,Agrenius V,Svartengren K,Svensson C,Pershagen G

更新日期：1998-11-09 00:00:00

abstract：:Matrix metalloproteinases, and notably the gelatinases MMP-2 and MMP-9, have important roles in tumour invasion, metastasis and angiogenesis. Our study investigates the distribution of MMP-2 and MMP-9 in colorectal cancer, the correlation with plasma levels, changes following surgical resection and whether plasma leve...

journal_title：International journal of cancer

authors： Tutton MG,George ML,Eccles SA,Burton S,Swift RI,Abulafi AM

更新日期：2003-11-20 00:00:00

abstract：:Hycanthone was administered to Schistosoma mansoni-infected and non-infected Syrian golden hamsters and Swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose. No tumors attributable to treatment were observed in hamsters. In infected mice, the overall incidence of hepato...

journal_title：International journal of cancer

authors： Bulay O,Urman H,Patil K,Clayson DB,Shubik P

更新日期：1979-01-15 00:00:00

abstract：:We have employed the DNA-mediated gene transfer method to introduce the allogenic major-histocompatibility-complex(MHC)-class-I gene H-2Kb into the K36.16 tumor cells, H-2k, in order to generate tumor-specific immunity. The acquisition of immunogenicity by the H-2Kb-transformed clones following gene transfer is associ...

journal_title：International journal of cancer

authors： Chia KY,Lim SP,Oei AA,Sabapathy TK,Hui KM

更新日期：1994-04-15 00:00:00

abstract：:Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mice, which had not received any ...

journal_title：International journal of cancer

authors： Oesch F,Bentley P,Glatt HR

更新日期：1976-10-15 00:00:00

abstract：:Using data from a large health plan, we performed a cohort study of thyroid cancer among 204,964 persons (aged 10--89 at baseline in 1964--1973, 54% female) followed for a median of 20 years. There were 196 incident thyroid cancers (73 in men, 123 in women). Risk was independently and positively related to female gend...

journal_title：International journal of cancer

authors： Iribarren C,Haselkorn T,Tekawa IS,Friedman GD

更新日期：2001-09-01 00:00:00

abstract：:The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cells is defective in a function essential to the replication of the viral genome. The integrated SV40 sequences were molecularly cloned in a bacteriophage, and a subclone (plasmid pSVHBI) contain...

journal_title：International journal of cancer

authors： Saint-Ruf C,Nardeux P,Cebrian J,Lacasa M,Lavialle C,Cassingena R

更新日期：1989-08-15 00:00:00

abstract：:The role of the mismatch repair (MMR) system in correcting base-base mismatches is well established; its involvement in the response to DNA double strand breaks, however, is less clear. We investigated the influence of the essential component of MMR, the hMLH1 protein, on the cellular response to DNA-double strand bre...

journal_title：International journal of cancer

authors： Bhonde MR,Hanski ML,Stehr J,Jebautzke B,Peiró-Jordán R,Fechner H,Yokoyama KK,Lin WC,Zeitz M,Hanski C

更新日期：2010-06-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) inhibits epithelial cell proliferation. Inactivation of the TGF-beta signaling pathway is thought to play a role in tumorigenesis. Our purpose was to clarify the correlation between TGF-beta receptors or TGF-beta 1 expression and the clinicopathologic characteristics of patie...

journal_title：International journal of cancer

authors： Fukai Y,Fukuchi M,Masuda N,Osawa H,Kato H,Nakajima T,Kuwano H

更新日期：2003-03-20 00:00:00

abstract：:gamma-L-glutaminyl-4-hydroxy-3-iodobenzene (I-GHB), a novel iodinated analog of gamma-L-glutaminyl-4-hydroxybenzene (GHB), demonstrates greater anti-tumor activity in human and in murine melanoma cell lines. These phenolic amides are substrates for gamma-glutamyltranspeptidase (GGTP; E.C. 2.3.2.2), a cell-membrane-ass...

journal_title：International journal of cancer

authors： Prezioso JA,Hughey RP,Wang N,Damodaran KM,Bloomer WD

更新日期：1994-03-15 00:00:00

abstract：:Antibodies directed against idiotypic determinants of the cell-surface IgM of a B lymphoma, 38c, were effective in delaying development of the tumor and in some instances in preventing its growth. The efficacity of the anti-idiotype antibodies was markedly increased when they were injected in combination with anti-neo...

journal_title：International journal of cancer

authors： Hurwitz E,Burowski D,Kashi R,Hollander N,Haimovich J

更新日期：1986-05-15 00:00:00

abstract：:Expression of intermediate filaments (IFs) has been suggested to be a reliable marker for differentiating epithelial and non-epithelial tumors. Moreover, the c-erbB-2 and p53 genes are considered to be involved relatively early in the process of human carcinogenesis. In order to elucidate the origin of uterine carcino...

journal_title：International journal of cancer

authors： Gorai I,Yanagibashi T,Taki A,Udagawa K,Miyagi E,Nakazawa T,Hirahara F,Nagashima Y,Minaguchi H

更新日期：1997-09-04 00:00:00

abstract：:Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...

journal_title：International journal of cancer

authors： Thomson DM

更新日期：1975-06-15 00:00:00

abstract：:Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...

journal_title：International journal of cancer

authors： Marinaccio A,Binazzi A,Marzio DD,Scarselli A,Verardo M,Mirabelli D,Gennaro V,Mensi C,Riboldi L,Merler E,Zotti RD,Romanelli A,Chellini E,Silvestri S,Pascucci C,Romeo E,Menegozzo S,Musti M,Cavone D,Cauzillo G,Tumino

更新日期：2012-05-01 00:00:00

abstract：:Irinotecan-based chemotherapy with bevacizumab is one of the first-line standard therapies for metastatic colorectal cancer (mCRC). TEGAFIRI (UFT/LV + irinotecan) is an irinotecan-based chemotherapy regimen. Currently, few clinical data regarding TEGAFIRI are available. This study evaluated the efficacy and safety of ...

journal_title：International journal of cancer

authors： Shigeta K,Hasegawa H,Okabayashi K,Tsuruta M,Ishii Y,Endo T,Ochiai H,Kondo T,Kitagawa Y

更新日期：2016-08-15 00:00:00

abstract：:Two factors potentially determining the consistent overexpression of sialyl-Le(x) antigen in colon carcinoma and metastases were investigated: (i) the expression of the mucins MUC1 and MUC2, known to carry sialyl-Le(x), by Northern blotting; (ii) the extent of sialic acid O-acetylation, by Western blotting and HPLC. R...

journal_title：International journal of cancer

authors： Mann B,Klussmann E,Vandamme-Feldhaus V,Iwersen M,Hanski ML,Riecken EO,Buhr HJ,Schauer R,Kim YS,Hanski C

更新日期：1997-07-17 00:00:00

abstract：:Endostatin, the proteolytic fragment of collagen XVIII, is an inhibitor of angiogenesis and tumor growth. Interestingly, elevated circulating endostatin levels have been found to correlate with poor patients' prognosis in several cancers. The aim of this study was to assess the prognostic value of endostatin in bladde...

journal_title：International journal of cancer

authors： Szarvas T,László V,Vom Dorp F,Reis H,Szendröi A,Romics I,Tilki D,Rübben H,Ergün S

更新日期：2012-06-15 00:00:00

abstract：:The surface and intracellular expression of mdrI-P-glycoprotein in parental drug-sensitive human breast cancer cells (MCF-7) and their multidrug-resistant (MDR) variants has been studied by using the monoclonal antibodies (MAbs) MM4.17 and MRK-16, which recognize 2 different epitopes of the drug efflux pump molecule. ...

journal_title：International journal of cancer

authors： Molinari A,Cianfriglia M,Meschini S,Calcabrini A,Arancia G

更新日期：1994-12-15 00:00:00

abstract：:Idiotypic protein (Id) produced by myeloma cells is clone-specific and may be a suitable tumor-specific antigen for immune targeting. Advances in dendritic cell (DC) technology suggest the opportunity for using this potent antigen presentation system to deliver myeloma Id to the autologous host to elicit anti-tumor im...

journal_title：International journal of cancer

authors： Lim SH,Bailey-Wood R

更新日期：1999-10-08 00:00:00