Differential effects of polyunsaturated fatty acids on chemosensitivity of NIH3T3 cells and its transformants.

abstract：:Previously, the induction of pancreatic carcinogenesis in the rat using azaserine has involved a multiple-dose treatment protocol. The objective of the present study was to determine the effect of multiple azaserine treatments on pancreatic DNA synthesis and to develop a protocol for a single-dose initiation of pancre...

journal_title：International journal of cancer

authors： Yager JD Jr,Roebuck BD,Zurlo J,Longnecker DS,Weselcouch EO,Wilpone SA

更新日期：1981-11-15 00:00:00

abstract：:The monoclonal antibody trastuzumab has brought survival benefit to patients with advanced gastric cancer (AGC) that have human epidermal growth factor receptor 2 (HER2) over expression or amplification. This study was designed to compare the clinical outcomes of HER2-negative and HER2-positive AGC patients with or wi...

journal_title：International journal of cancer

authors： Qiu MZ,Li Q,Wang ZQ,Liu TS,Liu Q,Wei XL,Jin Y,Wang DS,Ren C,Bai L,Zhang DS,Wang FH,Li YH,Xu RH

更新日期：2014-05-15 00:00:00

abstract：:In a novel attempt to understand the variations in DNA sequences underlying HLA class I alleles associated with HPV16-related CaCx, we determined the alleles by reconstructing SNP-based haplotypes from resequencing of the most polymorphic exons 2 and 3 of HLA-A, HLA-B and HLA-C. We also determined the impact of SNPs a...

journal_title：International journal of cancer

authors： Das Ghosh D,Mukhopadhyay I,Bhattacharya A,Roy Chowdhury R,Mandal NR,Roy S,Sengupta S

更新日期：2017-06-01 00:00:00

abstract：:Angiogenesis and inflammation are the 2 major stroma reactions in colorectal carcinoma (CRC). Guanylate binding protein-1 (GBP-1) is a key mediator of angiostatic effects of inflammation. Therefore, we hypothesized that GBP-1 may be a biomarker of intrinsic angiostasis associated with an improved outcome in CRC patien...

journal_title：International journal of cancer

authors： Naschberger E,Croner RS,Merkel S,Dimmler A,Tripal P,Amann KU,Kremmer E,Brueckl WM,Papadopoulos T,Hohenadl C,Hohenberger W,Stürzl M

更新日期：2008-11-01 00:00:00

abstract：:A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of...

journal_title：International journal of cancer

authors： Ghadirian P,Stein GF,Gorodetzky C,Roberfroid MB,Mahon GA,Bartsch H,Day NE

更新日期：1985-05-15 00:00:00

abstract：:HPP1 is a recently discovered gene that is epigenetically silenced in a number of tumor types, suggesting a potential role as a tumor suppressor. However, whether HPP1 has tumor suppressor activity is not clearly known. We have sought to investigate the effects of HPP1 on tumor growth and survival and to identify sign...

journal_title：International journal of cancer

authors： Elahi A,Zhang L,Yeatman TJ,Gery S,Sebti S,Shibata D

更新日期：2008-04-01 00:00:00

abstract：:Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human ...

journal_title：International journal of cancer

authors： Vajdic CM,van Leeuwen MT,Turner JJ,McDonald AM,Webster AC,McDonald SP,Chapman JR,Kaldor JM,Grulich AE

更新日期：2010-12-01 00:00:00

abstract：:The presented results show the effect of targeting of collagen receptor, alpha1beta1 integrin expressed on the endothelial cells on the development of experimental melanoma and pathological angiogenesis. Obtustatin, a snake venom KTS-disintegrin, was applied as a specific inhibitor of this integrin. This low molecular...

journal_title：International journal of cancer

authors： Brown MC,Staniszewska I,Del Valle L,Tuszynski GP,Marcinkiewicz C

更新日期：2008-11-01 00:00:00

abstract：:The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specific luminometric immunoa...

journal_title：International journal of cancer

authors： Norberg T,Lennerstrand J,Inganäs M,Bergh J

更新日期：1998-08-21 00:00:00

abstract：:We present a pilot study that aims to examine the possibility to easily and noninvasively detect and discriminate females with ovarian cancer (OC) from females that have no tumor(s) and from females that have benign genital tract neoplasia, using exhaled breath samples. The study is based on clinical samples and data ...

journal_title：International journal of cancer

authors： Amal H,Shi DY,Ionescu R,Zhang W,Hua QL,Pan YY,Tao L,Liu H,Haick H

更新日期：2015-03-15 00:00:00

abstract：:To further examine the association between oral hygiene and esophageal squamous cell carcinoma (ESCC) risk and the effect modification of other exposures, we conducted a population-based case-control study between 2010 and 2012 in Taixing, China, a high-risk area for ESCC. Cases were primarily recruited from endoscopy...

journal_title：International journal of cancer

authors： Chen X,Yuan Z,Lu M,Zhang Y,Jin L,Ye W

更新日期：2017-02-01 00:00:00

abstract：:Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publicatio...

journal_title：International journal of cancer

authors： Kim HB,Myung SK,Park YC,Park B

更新日期：2017-02-01 00:00:00

abstract：:The major goal in cancer immunotherapy is the induction of tumor-specific T lymphocytes capable of killing tumor cells. As both dendritic cells (DCs) and interleukin-12 (IL-12) can play immunostimulatory roles in vivo, the use of a combination of these has become a promising approach. In the present study, we used a m...

journal_title：International journal of cancer

authors： Furumoto K,Arii S,Yamasaki S,Mizumoto M,Mori A,Inoue N,Isobe N,Imamura M

更新日期：2000-09-01 00:00:00

abstract：:These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...

journal_title：International journal of cancer

authors： Tanaka E,Sendo F

更新日期：1993-04-22 00:00:00

abstract：:Although thyroid cancer is suspected to have a nutritional etiology, prospective studies examining the relationship between diet and thyroid cancer are lacking. During 1996-1997, NIH-AARP Diet and Health Study participants, ages 51-72 years, completed a 37-item food frequency questionnaire about diet at ages 12-13 yea...

journal_title：International journal of cancer

authors： Braganza MZ,Potischman N,Park Y,Thompson FE,Hollenbeck AR,Kitahara CM

更新日期：2015-11-15 00:00:00

abstract：:Representational difference analysis was used to identify genes that are expressed in a human melanoma cell line and not in normal skin. A cDNA clone that appeared to be specific for tumors was obtained and the corresponding gene was sequenced. This new gene was named LAGE-I. Using a LAGE-I probe to screen a cDNA libr...

journal_title：International journal of cancer

authors： Lethé B,Lucas S,Michaux L,De Smet C,Godelaine D,Serrano A,De Plaen E,Boon T

更新日期：1998-06-10 00:00:00

abstract：:Using high-throughput analyses and the TRANSFAC database, we characterized TF signatures of head and neck squamous cell carcinoma (HNSCC) subgroups by inferential analysis of target gene expression, correcting for the effects of DNA methylation and copy number. Using this discovery pipeline, we determined that human p...

journal_title：International journal of cancer

authors： Gaykalova DA,Manola JB,Ozawa H,Zizkova V,Morton K,Bishop JA,Sharma R,Zhang C,Michailidi C,Considine M,Tan M,Fertig EJ,Hennessey PT,Ahn J,Koch WM,Westra WH,Khan Z,Chung CH,Ochs MF,Califano JA

更新日期：2015-10-15 00:00:00

abstract：:It was suggested that the brain microenvironment plays a role in glioma progression. Here we investigate the mechanism by which astrocytes which are abundant in glioma tumors, promote cancer cell invasion. In this study, we evaluated the effects of astrocytes on glioma biology both in vitro and in vivo and determined ...

journal_title：International journal of cancer

authors： Shabtay-Orbach A,Amit M,Binenbaum Y,Na'ara S,Gil Z

更新日期：2015-09-01 00:00:00

abstract：:Effects of therapeutic and supratherapeutic concentrations of bosutinib, a dual Src/Abl tyrosine kinase inhibitor, on the corrected QT interval (QTc) in 60 healthy adults were assessed, according to ICH-E14 guidelines, in this 2-part, randomized, single-dose, double-blind, crossover, placebo- and open-label moxifloxac...

journal_title：International journal of cancer

authors： Abbas R,Hug BA,Leister C,Sonnichsen D

更新日期：2012-08-01 00:00:00

abstract：:The expression of a gastrointestinal carcinoma-associated antigen (GICA), a monosialoganglioside, was investigated in tissues from human fetuses of various gestational ages (10-40 weeks). Mouse monoclonal antibody NS-19-9, generated in mice immunized with SW1116 human colon carcinoma cells, was used along with a secon...

journal_title：International journal of cancer

authors： Olding LB,Thurin J,Svalander C,Koprowski H

更新日期：1984-08-15 00:00:00

abstract：:The results of a survey of a population with a high incidence of oral and oesophageal cancer are presented. The population under study appears to have several epidemiologic characteristics, some of which may be associated with a high incidence of oral and oesophageal cancer. A remarkably high proportion (41%) of the m...

journal_title：International journal of cancer

authors： Zaridze DG,Blettner M,Trapeznikov NN,Kuvshinov JP,Matiakin EG,Poljakov BP,Poddubni BK,Parshikova SM,Rottenberg VI,Chamrakulov FS

更新日期：1985-08-15 00:00:00

abstract：:Tumorigenic clonal lines derived from soft agar colonies induced by DMBA-transformed feline embryo cells were isolated and characterized. The morphologically altered clonal cells formed large aggregates, growing in this aggregate form when suspended in liquid growth medium above an agar base and forming colonies in so...

journal_title：International journal of cancer

authors： Rhim JS,Koh KS,Chen A,Essex M

更新日期：1981-07-15 00:00:00

abstract：:General cell-mediated immune (CMI) functions in NPC patients were investigated by the in vivo Mantoux and in vitro lymphocyte response to PHA assays. Thirty-eight (50%) of 76 untreated NPC patients were hyporesponsive in the Mantoux assay compared to 27 (25%) of 110 control patients. Forty-three (65.2%) of 66 untreate...

journal_title：International journal of cancer

authors： Chan SH,Chew TS,Goh EH,Simons MJ,Shanmugaratnam K

更新日期：1976-08-15 00:00:00

abstract：:The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cas...

journal_title：International journal of cancer

authors： Olsen AO,Gjøen K,Sauer T,Orstavik I,Naess O,Kierulf K,Sponland G,Magnus P

更新日期：1995-05-04 00:00:00

abstract：:The causative role of human papillomaviruses (HPV) and HPV16 variants has been extensively studied in uterine cervix dysplastic lesions and invasive carcinoma; few such studies, however, have been performed in penile tumors. We have investigated HPV genotype and HPV16 variant distribution on 41 penile cancer biopsies ...

journal_title：International journal of cancer

authors： Tornesello ML,Duraturo ML,Losito S,Botti G,Pilotti S,Stefanon B,De Palo G,Gallo A,Buonaguro L,Buonaguro FM

更新日期：2008-01-01 00:00:00

abstract：:Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA de novo synthesis and the salvage pathway in cancer cells, respectively. Intratumoral TS and DPD gene expressions were evaluated to determine the correlation between the expression of the 2 genes in both normal stromal tis...

journal_title：International journal of cancer

authors： Ichikawa W,Takahashi T,Suto K,Nihei Z,Shirota Y,Shimizu M,Sasaki Y,Hirayama R

更新日期：2004-12-20 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. In vitro proliferation assays demonstrated that belinostat potently inhibited the growth of prostate canc...

journal_title：International journal of cancer

authors： Qian X,Ara G,Mills E,LaRochelle WJ,Lichenstein HS,Jeffers M

更新日期：2008-03-15 00:00:00

abstract：:The association between subtypes of hepatitis C virus (HCV) and risk of hepatocellular carcinoma (HCC) remained inconclusive and evaluated in both case-control and cohort studies. In the case-control study, 397 HCC cases from medical centers were compared with 410 community-based non-HCC controls. All of them were ant...

journal_title：International journal of cancer

authors： Lee MH,Yang HI,Lu SN,Jen CL,You SL,Wang LY,L'Italien G,Chen CJ,Yuan Y,REVEAL-HCV Study Group.

更新日期：2014-09-01 00:00:00

abstract：:Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...

journal_title：International journal of cancer

authors： Marinaccio A,Binazzi A,Marzio DD,Scarselli A,Verardo M,Mirabelli D,Gennaro V,Mensi C,Riboldi L,Merler E,Zotti RD,Romanelli A,Chellini E,Silvestri S,Pascucci C,Romeo E,Menegozzo S,Musti M,Cavone D,Cauzillo G,Tumino

更新日期：2012-05-01 00:00:00

abstract：:DNA copy number alterations (CNAs) are frequent in cancer, and recently developed CNA signatures revealed their value in molecular tumor stratification for patient prognosis and platinum resistance prediction in ovarian cancer. Head and neck squamous cell carcinoma (HNSCC) is also characterized by high CNAs. In this s...

journal_title：International journal of cancer

authors： Essers PBM,van der Heijden M,Vossen D,de Roest RH,Leemans CR,Brakenhoff RH,van den Brekel MWM,Bartelink H,Verheij M,Vens C

更新日期：2020-09-15 00:00:00