Ovarian cancer-derived copy number alterations signatures are prognostic in chemoradiotherapy-treated head and neck squamous cell carcinoma.

abstract：:Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms lead...

journal_title：International journal of cancer

authors： Li S,Dai W,Mo W,Li J,Feng J,Wu L,Liu T,Yu Q,Xu S,Wang W,Lu X,Zhang Q,Chen K,Xia Y,Lu J,Zhou Y,Fan X,Xu L,Guo C

更新日期：2017-12-15 00:00:00

abstract：:The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...

journal_title：International journal of cancer

authors： Weedon SJ,Green NK,McNeish IA,Gilligan MG,Mautner V,Wrighton CJ,Mountain A,Young LS,Kerr DJ,Searle PF

更新日期：2000-06-15 00:00:00

abstract：:Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to ...

journal_title：International journal of cancer

authors： Trichopoulos D,Day NE,Kaklamani E,Tzonou A,Muñoz N,Zavitsanos X,Koumantaki Y,Trichopoulou A

更新日期：1987-01-15 00:00:00

abstract：:Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from mortalin inhibition by the SHetA2 drug combined with reactivation of mutant p53 with the PRIMA...

journal_title：International journal of cancer

authors： Ramraj SK,Elayapillai SP,Pelikan RC,Zhao YD,Isingizwe ZR,Kennedy AL,Lightfoot SA,Benbrook DM

更新日期：2020-08-15 00:00:00

abstract：:Infection with human papillomavirus-16 (HPV-16) is the cause of most anogenital carcinomas. This virus is also detected in about 20% of all head and neck squamous cell carcinomas. While there is strong evidence for a causal etiological role in the case of tonsillar carcinomas, causal association with malignant lesions...

journal_title：International journal of cancer

authors： Balderas-Loaeza A,Anaya-Saavedra G,Ramirez-Amador VA,Guido-Jimenez MC,Kalantari M,Calleja-Macias IE,Bernard HU,Garcia-Carranca A

更新日期：2007-05-15 00:00:00

abstract：:The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Yano H,Iseki K,Uehara H,Nakaizumi A

更新日期：1998-01-30 00:00:00

abstract：:Gene expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT) have been shown to be associated with response to 5-fluorouracil-based therapies. Analyzing these gene expression levels in liver metastases is importan...

journal_title：International journal of cancer

authors： Kuramochi H,Hayashi K,Uchida K,Miyakura S,Shimizu D,Vallbohmer D,Park S,Danenberg KD,Takasaki K,Danenberg PV

更新日期：2006-08-01 00:00:00

abstract：:A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occurring HPV infectio...

journal_title：International journal of cancer

authors： Giannoudis A,Graham DA,Southern SA,Herrington CS

更新日期：1999-09-24 00:00:00

abstract：:Sprague-Dawley rats were given combinations of aminopyrine or oxytetracycline and sodium nitrite in drinking water. Of 30 animals receiving 0.1% (1,000 ppm) of aminopyrine and sodium nitrite for 30 weeks, 29 died with hemangioendothelial sarcomas of the liver. The same tumor caused death in 26 of 30 animals that recei...

journal_title：International journal of cancer

authors： Taylor HW,Lijinsky W

更新日期：1975-08-15 00:00:00

abstract：:Complement-dependent cytotoxicity against melanoma cells was demonstrated with a microassay in sera from melanoma patients. The response was tumor-specific and histologic type-specific since 16 out of 52 (30%) melanoma patient sera taken before surgery reacted against melanoma cells, whereas 3 out of 43 (7%) control s...

journal_title：International journal of cancer

authors： Canevari S,Fossati G,Della Porta G,Balzarini GP

更新日期：1975-11-15 00:00:00

abstract：:After a steady increase between the 1950s and the 1970s, laryngeal cancer mortality has been levelling off since the early 1980s in men from most western and southern European countries and since the early 1990s in central and eastern Europe. To update trends in laryngeal cancer mortality, we analyzed data provided by...

journal_title：International journal of cancer

authors： Chatenoud L,Garavello W,Pagan E,Bertuccio P,Gallus S,La Vecchia C,Negri E,Bosetti C

更新日期：2016-02-15 00:00:00

abstract：:The secretion of antibody by hybridoma cells allows the growth of individual cells to be measured by a hemolytic plaque assay. Similarly, plaque reduction assays were sensitive indicators of tumor immunity. A series of strains of hybridoma have been isolated from an original isolate which is sensitive to cytotoxic T c...

journal_title：International journal of cancer

authors： Ezaki T,Marbrook J

更新日期：1985-01-15 00:00:00

abstract：:Allogeneic mixed leukocytes reaction has been reported to activate vast numbers of T lymphocytes and produce large amounts of type 1 cytokines that are linked to an initiation of antitumor immunity. Using poor immunogeneic B16-F10 and Lewis lung carcinoma (LLC) tumor model, we evaluated the effects of inactivated allo...

journal_title：International journal of cancer

authors： Su X,Guo S,Zhou C,Wang D,Ma W,Zhang S

更新日期：2009-03-01 00:00:00

abstract：:We have shown in the preceding paper that AKR mice are highly resistant to M-MSV tumor development, and that resistance is transmitted as a dominant character. In the present studies the tumor-response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c and B10BR) following injection w...

journal_title：International journal of cancer

authors： Colombatti A,Collavo D,Biasi G,Chieco-Bianchi L

更新日期：1975-09-15 00:00:00

abstract：:Histologic characteristics of bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan, were evaluated. In each of these areas broadly-based series of cases were assembled during a collaborative case-control study. The present analysis was based on 589 cases in Boston, 484 cases in Manchester, and 241 cases in...

journal_title：International journal of cancer

authors： Morrison AS,Proppe KH,Verhoek WG,Aoki K,Leck I,Ohno Y,Obata K

更新日期：1982-12-15 00:00:00

abstract：:We have separated subpopulations of macrophages from an immunogenic fibrosarcoma by the technique of unit gravity velocity sedimentation. The activation state of these subpopulations was determined by measurement of the Fc receptor avidity of adherent cells, and by their 5' nucleotidase and acid phosphatase activity. ...

journal_title：International journal of cancer

authors： Moore K,McBride WH

更新日期：1980-11-15 00:00:00

abstract：:Adenoviral oncolysis is a promising new modality for treatment of cancer based on selective viral replication in tumor cells. However, tumor cell killing by adenoviral oncolysis needs to be improved to achieve therapeutic benefit in the clinic. Towards this end, the activation of anti-tumor immunity by adenoviral onco...

journal_title：International journal of cancer

authors： Schierer S,Hesse A,Müller I,Kämpgen E,Curiel DT,Schuler G,Steinkasserer A,Nettelbeck DM

更新日期：2008-01-01 00:00:00

abstract：:Human papillomavirus-induced cervical carcinomas often show impaired expression of MHC class I molecules resulting in the inability of tumor cells to directly present viral peptides to cytotoxic T lymphocytes. Loss of MHC class I expression combined with the expression of activating NK cell receptor ligands renders tu...

journal_title：International journal of cancer

authors： Textor S,Dürst M,Jansen L,Accardi R,Tommasino M,Trunk MJ,Porgador A,Watzl C,Gissmann L,Cerwenka A

更新日期：2008-11-15 00:00:00

abstract：:For many years, clinicians and scientists attempt to develop methods to stimulate the immune system to target malignant cells. Recent data suggest that effective cancer vaccination requires combination immunotherapies to overcome tumor immune evasion. Through presentation of both MHC-I and II molecules, DCs-based vacc...

journal_title：International journal of cancer

authors： Sharbi-Yunger A,Grees M,Cafri G,Bassan D,Eichmüller SB,Tzehoval E,Utikal J,Umansky V,Eisenbach L

更新日期：2019-02-15 00:00:00

abstract：:The murine B16 melanoma (H-2b) was transfected with a retroviral vector containing the mouse IFN-alpha 1 gene. IFN-alpha 1-transfected cells produced IFN-alpha in vitro and exhibited an altered phenotype characterized by a decreased rate of multiplication, enhanced expression of H-2 antigens, an antiviral state to VSV...

journal_title：International journal of cancer

authors： Kaido T,Bandu MT,Maury C,Ferrantini M,Belardelli F,Gresser I

更新日期：1995-01-17 00:00:00

abstract：:The purpose was to evaluate alternative cytological screening methods in population-based screening for cervical cancer up to cancer incidence and mortality outcome. Automation-assisted screening was compared to conventional cytological screening in a randomized design. The study was based on follow-up of 503,391 wome...

journal_title：International journal of cancer

authors： Anttila A,Pokhrel A,Kotaniemi-Talonen L,Hakama M,Malila N,Nieminen P

更新日期：2011-03-01 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a causative factor of humoral hypercalcemia in malignancy. However, it is difficult to explain the mechanism of anorexia/cachexia with PTHrP secretion in detail. Previously, we demonstrated that the expressions of orexigenic peptides increased and anorexigenic peptides de...

journal_title：International journal of cancer

authors： Suzuki H,Hashimoto H,Kawasaki M,Watanabe M,Otsubo H,Ishikura T,Fujihara H,Ohnishi H,Onuma E,Yamada-Okabe H,Takuwa Y,Ogata E,Nakamura T,Ueta Y

更新日期：2011-05-01 00:00:00

abstract：:MicroRNAs (mirs) are small noncoding RNA molecules (~22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we screened for altered microRNA ex...

journal_title：International journal of cancer

authors： Chang SS,Jiang WW,Smith I,Poeta LM,Begum S,Glazer C,Shan S,Westra W,Sidransky D,Califano JA

更新日期：2008-12-15 00:00:00

abstract：:Risk factors for prostate cancer could differ for various sub-groups, such as for "aggressive" and "non-aggressive" cancers or by grade or stage. Determinants of mortality could differ from those for incidence. Using data from the Health Professionals Follow-Up Study, we re-examined 10 factors (cigarette smoking histo...

journal_title：International journal of cancer

authors： Giovannucci E,Liu Y,Platz EA,Stampfer MJ,Willett WC

更新日期：2007-10-01 00:00:00

abstract：:Analysis of the length of circulating DNA in plasma has been reported as a marker for solid tumor detection. We assessed the sensitivity and specificity of increased plasma DNA length to identify patients with head and neck squamous cell carcinoma (HNSCC) and monitor posttreatment disease status. Fifty-eight HNSCC pat...

journal_title：International journal of cancer

authors： Jiang WW,Zahurak M,Goldenberg D,Milman Y,Park HL,Westra WH,Koch W,Sidransky D,Califano J

更新日期：2006-12-01 00:00:00

abstract：:A panel of 7 mouse monoclonal antibodies and the lectin from Ulex europeus, detecting blood-group-related antigens of the ABH and Lewis systems, have been used to define the distribution of these antigenic structures within the human gastrointestinal tract, and to characterize their expression and modulation in colore...

journal_title：International journal of cancer

authors： Cordon-Cardo C,Lloyd KO,Sakamoto J,McGroarty ME,Old LJ,Melamed MR

更新日期：1986-05-15 00:00:00

abstract：:The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited high antitumor activity against human colorectal cancer xenografts. This study was conducted to investigate the advantages of NK012 over irinotecan hydrochloride (CPT-11) administered in comb...

journal_title：International journal of cancer

authors： Nakajima TE,Yasunaga M,Kano Y,Koizumi F,Kato K,Hamaguchi T,Yamada Y,Shirao K,Shimada Y,Matsumura Y

更新日期：2008-05-01 00:00:00

abstract：:Human 8-oxoguanine DNA glycosylase 1 (hOGG1) plays a major role in the repair of 8-hydroxyguanine, one of the major forms of DNA damage generated by reactive oxygen species in tobacco smoke. If left unrepaired by hOGG1, 8-hydroxyguanine can produce G:C-to-T:A transversions. Recent studies have suggested that the hOGG1...

journal_title：International journal of cancer

authors： Hu YC,Ahrendt SA

更新日期：2005-04-10 00:00:00

abstract：:To compare the presentation and prognosis of non-Hodgkin lymphoma (NHL) in people with AIDS (PWA) and in the general Italian population, a record linkage study was carried out. The fraction of NHLs attributable to HIV/AIDS was also estimated. Information from the National AIDS Registry (RAIDS) was linked with records ...

journal_title：International journal of cancer

authors： Dal Maso L,Rezza G,Zambon P,Tagliabue G,Crocetti E,Vercelli M,Zanetti R,Falcini F,Tonini G,Mangone L,De Lisi V,Ferretti S,Tumino R,Stanta G,Vitarelli S,Serraino D,Franceschi S,Cancer and AIDS Registry Linkage Study.

更新日期：2001-08-01 00:00:00

abstract：:Inhibitors of matrix metalloproteinases (MMPs) were developed as anticancer agents based on the observation that MMPs facilitate local tumor spread and metastasis by promoting matrix degradation and cell migration. Unfortunately, these inhibitors were unsuccessful in the clinical treatment of several cancers, includin...

journal_title：International journal of cancer

authors： Chen X,Su Y,Fingleton B,Acuff H,Matrisian LM,Zent R,Pozzi A

更新日期：2005-08-10 00:00:00