Abstract:
:General cell-mediated immune (CMI) functions in NPC patients were investigated by the in vivo Mantoux and in vitro lymphocyte response to PHA assays. Thirty-eight (50%) of 76 untreated NPC patients were hyporesponsive in the Mantoux assay compared to 27 (25%) of 110 control patients. Forty-three (65.2%) of 66 untreated NPC patients also showed lymphocyte hyporesponsiveness to PHA compared to 15 (15.5%) of 97 control patients. Combined deficiencies were observed in 35 (42.2%) of 83 NPC patients compared to only 2 (3.3%) of 61 control patients. No difference in the frequency of immunodeficiency was observed between "early" and "late" disease patients. CMI functions of treated "remission" NPC patients were found to be impaired to the same extent as those of untreated NPC patients.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Chan SH,Chew TS,Goh EH,Simons MJ,Shanmugaratnam Kdoi
10.1002/ijc.2910180202subject
Has Abstractpub_date
1976-08-15 00:00:00pages
139-44issue
2eissn
0020-7136issn
1097-0215journal_volume
18pub_type
杂志文章abstract::A panel of 24 healthy seropositive donors have been followed prospectively over a period of 15 months and monitored (1) for the level of EB virus shedding in the throat by means of a sensitive cord-blood transformation assay; (2) for the level of virus-infected B cells in the blood via a new in vitro protocol where "s...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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