Equivalent chemotherapy efficacy against leukemia in mice treated with topical vasoconstrictors to prevent cancer therapy side effects.


:Topically applied vasoconstrictor is a new strategy to prevent oral mucositis and alopecia, two complications of chemotherapy and stem-cell transplant. We sought to determine whether mice treated with topical vasoconstrictor minutes before chemotherapy to suppress L1210 leukemia would develop a vasoconstrictor-induced L1210 cell sanctuary, and with it, significantly worse survival outcomes. B6D2F1 mice received 10(4) mouse L1210 leukemia cells via retro-orbital intravenous injection and were then divided into treatment groups, which included: (i) no further treatment, (ii) a single, sub-curative, intraperitoneal dose of cyclophosphamide (90 µg/gm bw) 24 hr after L1210 cell inoculation, (iii) topical epinephrine (25-400 mM) to clipped dorsal backs 20 min before cyclophosphamide or (iv) orotopical phenylephrine (16-130 mM), epinephrine (10 mM) or norepinephrine (25 mM) 20 min before cyclophosphamide. All mice were then followed until day of death. Differences in median survival time and percent survival between mice receiving cyclophosphamide alone and mice treated with either orotopical phenylephrine, epinephrine or norepinephrine; or topical epinephrine before cyclophosphamide were not significantly different. A discernible leukemia sanctuary was not created by topical vasoconstrictor treatment prior to chemotherapy; there was no significant difference in leukemia progression between untreated mice and those treated with either orotopical or topical vasoconstrictor before chemotherapy. We have opened a Phase I/IIa dose escalation trial to evaluate the safety and efficacy of orotopical phenylephrine in preventing oral mucositis in subjects undergoing hematopoietic stem cell transplant conditioning with cyclophosphamide plus total body irradiation. This could provide a cost-effective and convenient method to prevent oral mucositis.


Int J Cancer


Graul-Conroy A,Hicks EJ,Fahl WE




Has Abstract


2016-06-15 00:00:00












  • Cancer-associated mis-sense and deletion mutations impair p16INK4 CDK inhibitory activity.

    abstract::The p16INK4 gene is a candidate tumour-suppressor gene which maps to the genomic locus 9p21, and mutations of this gene are associated with melanoma and other cancers. Biochemical studies suggest that p16INK4 mediates its effects by specifically inhibiting the G1 cyclin-dependent kinases CDK4 and CDK6, thereby regulat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lilischkis R,Sarcevic B,Kennedy C,Warlters A,Sutherland RL

    更新日期:1996-04-10 00:00:00

  • A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis.

    abstract::A-kinase anchoring protein 3 (AKAP3) is a sperm protein and its expression appears to be restricted to the testis in normal adult tissues. We investigated AKAP3 mRNA expression in 20 normal ovaries and 54 ovarian cancers of different histological types, grades and stages by reverse transcription-polymerase chain react...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hasegawa K,Ono T,Matsushita H,Shimono M,Noguchi Y,Mizutani Y,Kodama J,Kudo T,Nakayama E

    更新日期:2004-01-01 00:00:00

  • Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.

    abstract::Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the treatment of metastatic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shanmugam MK,Manu KA,Ong TH,Ramachandran L,Surana R,Bist P,Lim LH,Kumar AP,Hui KM,Sethi G

    更新日期:2011-10-01 00:00:00

  • Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study.

    abstract::Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estroge...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Grioni S,Agnoli C,Krogh V,Pala V,Rinaldi S,Vinceti M,Contiero P,Vescovi L,Malavolti M,Sieri S

    更新日期:2019-05-01 00:00:00

  • Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses.

    abstract::Adenoviral oncolysis is a promising new modality for treatment of cancer based on selective viral replication in tumor cells. However, tumor cell killing by adenoviral oncolysis needs to be improved to achieve therapeutic benefit in the clinic. Towards this end, the activation of anti-tumor immunity by adenoviral onco...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schierer S,Hesse A,Müller I,Kämpgen E,Curiel DT,Schuler G,Steinkasserer A,Nettelbeck DM

    更新日期:2008-01-01 00:00:00

  • Membrane association and shedding of the GPI-anchored Ca-MOv18 antigen in human ovary carcinoma cells.

    abstract::The antigen recognized by the MOv18 MAb (Ca-MOv18) was recently shown to be a glycosylphosphatidylinositol (GPI)-linked protein. In this report we show that GPI-anchorage is not limited to IGROVI cells nor to other ovary carcinoma cell lines, but Ca-MOv18 was also found to be sensitive to phosphatidylinositol-specific...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Miotti S,Alberti S,Facheris P,Mantovani L,Fornaro M,Stella M,Ménard S,Canevari S,Colnaghi MI

    更新日期:1992-05-28 00:00:00

  • Authentication of M14 melanoma cell line proves misidentification of MDA-MB-435 breast cancer cell line.

    abstract::A variety of analytical approaches have indicated that melanoma cell line UCLA-SO-M14 (M14) and breast carcinoma cell line MDA-MB-435 originate from a common donor. This indicates that at some point in the past, one of these cell lines became misidentified, meaning that it ceased to correspond to the reported donor an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Korch C,Hall EM,Dirks WG,Ewing M,Faries M,Varella-Garcia M,Robinson S,Storts D,Turner JA,Wang Y,Burnett EC,Healy L,Kniss D,Neve RM,Nims RW,Reid YA,Robinson WA,Capes-Davis A

    更新日期:2018-02-01 00:00:00

  • Clinicopathologic significance of urokinase receptor- and MMP-9-positive stromal cells in human colorectal cancer: functional multiplicity of matrix degradation on hematogenous metastasis.

    abstract::Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saito K,Takeha S,Shiba K,Matsuno S,Sorsa T,Nagura H,Ohtani H

    更新日期:2000-04-01 00:00:00

  • Interaction of host and viral risk factors for development of cervical carcinoma in situ.

    abstract::Infection by oncogenic human papillomavirus (HPV) is a necessary but not sufficient cause of cervical carcinoma. Several host genetic and viral factors have been reported to increase the risk of carcinoma development given an HPV infection. In our study, we have analysed the contribution of HPV 16 E6 sequence subtype ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Beskow AH,Engelmark MT,Magnusson JJ,Gyllensten UB

    更新日期:2005-11-20 00:00:00

  • Characteristics of membrane and cytosol forms of the mammary tumor glycoprotein molecule MTGP in human breast carcinoma cell cultures and tumors.

    abstract::The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set MTGP, a trace and apparently tumor-specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leung JP,Nelson-Rees WA,Moore GE,Cailleau R,Edgington TS

    更新日期:1981-07-15 00:00:00

  • Expression of the cyclin-dependent kinase inhibitors p16INK4, p15INK4B and p21WAF1/CIP1 in human breast cancer.

    abstract::Aberrant cyclin expression has been implicated in oncogenesis in a number of human cancers. Since altered function of regulators of cyclin-dependent kinase (CDK) activity other than cyclins, in particular CDK inhibitors, might play a similar role in oncogenesis, we examined the expression and regulation of the CDK inh...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Musgrove EA,Lilischkis R,Cornish AL,Lee CS,Setlur V,Seshadri R,Sutherland RL

    更新日期:1995-11-15 00:00:00

  • Evaluation of the hybrid capture 2 assay for detecting anal high-grade dysplasia.

    abstract::Hybrid Capture 2 (HC2) Human Papillomavirus (HPV) DNA Test® is FDA approved and is a proven aid in detecting HPV infections of the cervix and as an aid in diagnosing, with cytology, cervical disease. A prospective feasibility study was conducted to determine if HC2 testing has utility when screening for high-grade ana...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Goldstone SE,Lowe B,Rothmann T,Nazarenko I

    更新日期:2012-10-01 00:00:00

  • Evaluation of synergism by a novel three-dimensional model for the combined action of cisplatin and etoposide on the growth of a human small-cell lung-cancer cell line, SBC-3.

    abstract::Although the combination of cisplatin and etoposide has been used as standard therapy for small-cell lung cancer, it is difficult to demonstrate combination effects between cisplatin and etoposide in vitro. We therefore adopted a 3-dimensional (3-D) model to analyze the combination effects of anticancer drugs, and com...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kanzawa F,Nishio K,Fukuoka K,Fukuda M,Kunimoto T,Saijo N

    更新日期:1997-05-02 00:00:00

  • Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer.

    abstract::There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hong AM,Dobbins TA,Lee CS,Jones D,Fei J,Clark JR,Armstrong BK,Harnett GB,Milross CG,Tran N,Peculis LD,Ng C,Milne AG,Loo C,Hughes LJ,Forstner DF,O'Brien CJ,Rose BR

    更新日期:2011-04-01 00:00:00

  • In vitro and in vivo antitumor activity of liposomal Fenretinide targeted to human neuroblastoma.

    abstract::Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In advanced disease stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic retinoid Fenretinide (HPR) induces apoptosis in NB and melanoma cell lines. We reported an in vitro potenti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Raffaghello L,Pagnan G,Pastorino F,Cosimo E,Brignole C,Marimpietri D,Montaldo PG,Gambini C,Allen TM,Bogenmann E,Ponzoni M

    更新日期:2003-05-01 00:00:00

  • Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function.

    abstract::Resistance to cisplatin-based chemotherapy is a major cause of treatment failure in human ovarian cancer. Wild-type TP53 status is often, but not always, associated with cisplatin sensitivity, suggesting that additional factors may be involved. Overexpression/activation of the phosphatidylinositol-3-kinase/Akt pathway...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fraser M,Bai T,Tsang BK

    更新日期:2008-02-01 00:00:00

  • Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.

    abstract::A cyclin-dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Shima K,Nosho K,Baba Y,Cantor M,Meyerhardt JA,Giovannucci EL,Fuchs CS,Ogino S

    更新日期:2011-03-01 00:00:00

  • Lifestyle factors, autoimmune disease and family history in prognosis of non-hodgkin lymphoma overall and subtypes.

    abstract::Lifestyle factors and medical history are known to influence risk of non-Hodgkin lymphoma (NHL). Whether these factors affect the prognosis of NHL, especially its subtypes, is unclear. To investigate this, the association between these factors and all-cause and lymphoma-related mortality was assessed in a population-b...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Simard JF,Baecklund F,Chang ET,Baecklund E,Hjalgrim H,-Olov Adami H,Glimelius B,Smedby KE

    更新日期:2013-06-01 00:00:00

  • Analysis of human meningiomas for aberrations of the MADH2, MADH4, APM-1 and DCC tumor suppressor genes on the long arm of chromosome 18.

    abstract::We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and anaplastic meningiomas but rare in benign meningiomas. In the present study, we have investigated a series of 37 meningiomas for mutation and expression of 4 tumor suppressor genes (MADH2, MADH4,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Büschges R,Boström J,Wolter M,Blaschke B,Weber RG,Lichter P,Collins VP,Reifenberger G

    更新日期:2001-05-15 00:00:00

  • The relationship between blood IL-12p40 level and melanoma progression.

    abstract::Cytokines such as Interleukin (IL)-12p70 ("IL-12") and IL-23 can influence tumor progression. We tested the hypothesis that blood levels of IL-12p40, the common subunit of both cytokines, are associated with melanoma progression. Blood from 2,048 white melanoma patients were collected at a single institution between M...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fang S,Wang Y,Chun YS,Liu H,Ross MI,Gershenwald JE,Cormier JN,Royal RE,Lucci A,Schacherer CW,Reveille JD,Sui D,Bassett RL Jr,Wang LE,Wei Q,Amos CI,Lee JE

    更新日期:2015-04-15 00:00:00

  • Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study.

    abstract::Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential effects of vitamin D on premenopaus...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Abbas S,Chang-Claude J,Linseisen J

    更新日期:2009-01-01 00:00:00

  • Genetic variation of XPA gene and risk of cancer: a systematic review and pooled analysis.

    abstract::XPA, a zinc-finger DNA-binding protein, play an important role in both global genome and transcription-coupled repair pathways. XPA -4G>A polymorphism was identified in the 5' noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Ding D,Zhang Y,Yu H,Guo Y,Jiang L,He X,Ma W,Zheng W

    更新日期:2012-07-15 00:00:00

  • IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas.

    abstract::The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a protein that plays a critical role in tumor suppression, in part by modulating bioavailability of a potent mitogen, insulin-like growth factor-2 (IGF2). We tested the hypothesis that the common nonsynonymous genetic variants in M6P/IGF...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Hoyo C,Schildkraut JM,Murphy SK,Chow WH,Vaughan TL,Risch H,Marks JR,Jirtle RL,Calingaert B,Mayne S,Fraumeni J Jr,Gammon MD

    更新日期:2009-12-01 00:00:00

  • Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.

    abstract::A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into drug by human beta-glucuronidase (GUS) released from tumor cells in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Houba PH,Boven E,van der Meulen-Muileman IH,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

    更新日期:2001-02-15 00:00:00

  • Loss of expression of the tumour suppressor gene AIMP3 predicts survival following radiotherapy in muscle-invasive bladder cancer.

    abstract::The aim of this study was to test the utility of AIMP3, an upstream regulator of DNA damage response following genotoxic stress, as a clinical biomarker in muscle-invasive bladder cancer (MIBC). AIMP3 was identified from a meta-analysis of a global gene-expression dataset. AIMP3 protein expression was determined by im...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Gurung PM,Veerakumarasivam A,Williamson M,Counsell N,Douglas J,Tan WS,Feber A,Crabb SJ,Short SC,Freeman A,Powles T,Hoskin PJ,West CM,Kelly JD

    更新日期:2015-02-01 00:00:00

  • Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase.

    abstract::Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ellies LG,Fishman M,Hardison J,Kleeman J,Maglione JE,Manner CK,Cardiff RD,MacLeod CL

    更新日期:2003-08-10 00:00:00

  • Cervical nitric oxide release and persistence of high-risk human papillomavirus in women.

    abstract::Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rahkola P,Väisänen-Tommiska M,Tuomikoski P,Ylikorkala O,Mikkola TS

    更新日期:2011-06-15 00:00:00

  • Molecular characteristics and physical state of human papillomavirus DNA change with progressing malignancy: studies in a patient with epidermodysplasia verruciformis.

    abstract::In order to establish the role of human papillomavirus (HPV) in carcinogenesis of epidermodysplasia verruciformis (EV), the presence, the molecular characteristics and the physical state of HPV DNA in a benign lesion, a primary carcinoma and a metastatic carcinoma developing in the same EV patient were studied and com...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yabe Y,Tanimura Y,Sakai A,Hitsumoto T,Nohara N

    更新日期:1989-06-15 00:00:00

  • In vitro sensitivity of human melanoma xenografts to cytotoxic drugs. Correlation with in vivo chemosensitivity.

    abstract::Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin. The in vitro chemosensitivity of the cells...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tveit KM,Fodstad O,Olsnes S,Pihl A

    更新日期:1980-12-15 00:00:00

  • OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer.

    abstract::OCT-4 (also known as POU5F1) is a key regulator of self-renewal in embryonic stem cells. Regarding the new cancer stem cell concept, the expression of such genes is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior, such as tumor recurrence or resistance to therapies. Although OCT...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Atlasi Y,Mowla SJ,Ziaee SA,Bahrami AR

    更新日期:2007-04-01 00:00:00