Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transc

abstract：:The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated association...

journal_title：International journal of cancer

authors： Zhang C,Sturgis EM,Zheng H,Song X,Wei P,Jin L,Chao L,Wei Q,Li G

更新日期：2014-04-15 00:00:00

abstract：:This study was aimed at comparing screen-detected and symptomatic breast carcinomas with regard to the prevalence of positive immunostaining for c-erb-B-2 oncoprotein. Paraffin sections of 81 breast carcinomas detected through the National Screening Programme were examined for the over-expression of c-erbB-2 oncoprote...

journal_title：International journal of cancer

authors： Soomro S,Taylor P,Shepard HM,Feldmann M,Sinnett HD,Shousha S

更新日期：1993-08-19 00:00:00

abstract：:Breast cancer is the cancer diagnosed most frequently in women worldwide. In Europe it is the most common cancer in the female population, with approximately 350,000 new cases diagnosed each year including 130,000 deaths. Incidence rates are increasing in the majority of European countries, whereas a decline in mortal...

journal_title：International journal of cancer

authors： Tyczynski JE,Plesko I,Aareleid T,Primic-Zakelj M,Dalmas M,Kurtinaitis J,Stengrevics A,Parkin DM

更新日期：2004-12-20 00:00:00

abstract：:We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...

journal_title：International journal of cancer

authors： Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH

更新日期：2010-04-01 00:00:00

abstract：:Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid tumors, the pattern of NK-cell subsets and their recognition of mesothelioma cells remain to be explored. We used RNA expression data of MM biopsies derived fro...

journal_title：International journal of cancer

authors： Sottile R,Tannazi M,Johansson MH,Cristiani CM,Calabró L,Ventura V,Cutaia O,Chiarucci C,Covre A,Garofalo C,Pontén V,Tallerico R,Frumento P,Micke P,Maio M,Kärre K,Carbone E

更新日期：2019-10-15 00:00:00

abstract：:In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Frameshift mutations,...

journal_title：International journal of cancer

authors： Salomons GS,Buitenhuis CK,Martínez Muñoz C,Verwijs-Jassen M,Behrendt H,Zsiros J,Smets LA

更新日期：1998-06-19 00:00:00

abstract：:We have induced plasmacytomas (MPC) in BALB/c radiochimeras (RCh) repopulated with syngeneic hemopoietic cells carrying distinctive chromosomal markers. A group of 38 RCh that received 0.5 ml pristane, followed by Abelson virus infection 2-3 weeks later, developed 7 tumors (18.5%) of donor origin after a relatively sh...

journal_title：International journal of cancer

authors： Silva S,Babonits M,Wiener F,Klein G

更新日期：1989-08-15 00:00:00

abstract：:We have employed the DNA-mediated gene transfer method to introduce the allogenic major-histocompatibility-complex(MHC)-class-I gene H-2Kb into the K36.16 tumor cells, H-2k, in order to generate tumor-specific immunity. The acquisition of immunogenicity by the H-2Kb-transformed clones following gene transfer is associ...

journal_title：International journal of cancer

authors： Chia KY,Lim SP,Oei AA,Sabapathy TK,Hui KM

更新日期：1994-04-15 00:00:00

abstract：:The tumor site is a strong clinical factor in head and neck squamous cell carcinoma (HNSCC). To clarify the biologic and clinical role of p53 alterations in HNSCC, we have examined the prevalence and the nature of p53 alterations in a large cohort of tumors from the different sites. For immunohistochemical analysis of...

journal_title：International journal of cancer

authors： Bosch FX,Ritter D,Enders C,Flechtenmacher C,Abel U,Dietz A,Hergenhahn M,Weidauer H

更新日期：2004-09-10 00:00:00

abstract：:Classical midgut carcinoids are rare intestinal neuroendocrine tumors that often present with metastases at diagnosis. In contrast to foregut carcinoids, midgut carcinoids are not related to the multiple endocrine neoplasia type 1 syndrome, and the mechanisms involved in their tumorigenesis are unknown. Eight classica...

journal_title：International journal of cancer

authors： Löllgen RM,Hessman O,Szabo E,Westin G,Akerström G

更新日期：2001-06-15 00:00:00

abstract：:Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. Lymph nodes (n = 780) from 36 CRC patients who had developed disease re...

journal_title：International journal of cancer

authors： Doekhie FS,Mesker WE,Kuppen PJ,van Leeuwen GA,Morreau H,de Bock GH,Putter H,Tanke HJ,van de Velde CJ,Tollenaar RA

更新日期：2010-06-01 00:00:00

abstract：:The correlation between tumorigenicity and cell-surface adhesiveness was investigated in eight mouse fibroblastoid cell lines. Four of the lines (Mc 11-Mc 15) were derived from mouse MC-induced fibrosarcomas, two were derivatives of L cells (A9, A9HT), and two (clone 3 and clone 7 H7F4) were obtained by fusion of A9HT...

journal_title：International journal of cancer

authors： Bubeník J,Perlmann P,Fenyö EM,Jandlová T,Suhajová E,Malkovský M

更新日期：1979-03-15 00:00:00

abstract：:von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor specimens, as determined by immuno-histochemical staining for vWF or other endothelial cell markers, is a negative prognostic factor f...

journal_title：International journal of cancer

authors： Zanetta L,Marcus SG,Vasile J,Dobryansky M,Cohen H,Eng K,Shamamian P,Mignatti P

更新日期：2000-01-15 00:00:00

abstract：:To find out whether manipulation of H-2 expression on metastatic cells could alter their metastatic properties, we immunoselected in vivo H-2 antigen variants from a metastatic clone of the T10 sarcoma [originating in a (C57BL/6J X C3H.eB)FI mouse] and tested their metastatic capacity. The unselected metastatic cells ...

journal_title：International journal of cancer

authors： Katzav S,Segal S,Feldman M

更新日期：1984-03-15 00:00:00

abstract：:Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic in...

journal_title：International journal of cancer

authors： Pagnan G,Montaldo PG,Pastorino F,Raffaghello L,Kirchmeier M,Allen TM,Ponzoni M

更新日期：1999-04-12 00:00:00

abstract：:Epidemiological and animal studies have demonstrated that vitamin A and its natural and synthetic derivatives, retinoids, are effective agents in preventing the development of tobacco-associated cancers. Unfortunately, clinical trials of retinoids on cigarette smokers have shown lack of efficacy in preventing lung can...

journal_title：International journal of cancer

authors： Chen GQ,Lin B,Dawson MI,Zhang XK

更新日期：2002-05-10 00:00:00

abstract：:Previous studies have reported that poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum (Por & Muc) show a low incidence and poor prognosis. However, genetic alterations and tumourigenesis of Por & Muc remain unclear. In our study, we analyzed the genetic and epigenetic alterations of P...

journal_title：International journal of cancer

authors： Kanazawa T,Watanabe T,Kazama S,Tada T,Koketsu S,Nagawa H

更新日期：2002-11-20 00:00:00

abstract：:Deletion of chromosome 5q is common in prostate cancer and is linked to aggressive disease. Most previous studies focused on 5q21 where CHD1 is located, but deletion of mapping studies has identified a second deletion hotspot at 5q13. To clarify the prevalence and clinical relevance of 5q13 deletions and to determine ...

journal_title：International journal of cancer

authors： Möller K,Kluth M,Ahmed M,Burkhardt L,Möller-Koop C,Büscheck F,Weidemann S,Tsourlakis MC,Minner S,Heinzer H,Huland H,Graefen M,Sauter G,Schlomm T,Dum D,Simon R

更新日期：2021-02-01 00:00:00

abstract：:The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR-E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was found between women with breast ...

journal_title：International journal of cancer

authors： Reed MJ,Beranek PA,Cheng RW,Ghilchik MW,James VH

更新日期：1985-04-15 00:00:00

abstract：:The influence of 4 murine monoclonal antibodies (MAbs) directed against surface determinants of a metastasizing rat adenocarcinoma (BSp73ASML) on metastatic spread was evaluated and compared to their in vivo binding as well as to the induction of a humoral anti-MAb response, especially with respect to the development ...

journal_title：International journal of cancer

authors： Reber S,Matzku S,Günthert U,Ponta H,Herrlich P,Zöller M

更新日期：1990-11-15 00:00:00

abstract：:In a series of 87 primary breast tumors, somatostatin receptor (SSR) expression was detected by in vitro autoradiography in 58 tumors. In 41 tumors the SSR expression was homogeneous and in 17 it was heterogeneous. Although the tumors were not selected by the investigators upon entry in the study, examination of the t...

journal_title：International journal of cancer

authors： Bootsma AH,van Eijck C,Schouten KK,Reubi JC,Waser B,Foekens JA,van Pel R,Zwarthoff EC,Lamberts SW,de Klein A

更新日期：1993-05-28 00:00:00

abstract：:The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as ...

journal_title：International journal of cancer

authors： Washington MK,Goldberg RM,Chang GJ,Limburg P,Lam AK,Salto-Tellez M,Arends MJ,Nagtegaal ID,Klimstra DS,Rugge M,Schirmacher P,Lazar AJ,Odze RD,Carneiro F,Fukayama M,Cree IA,WHO Classification of Tumours Editorial Board.

更新日期：2021-03-01 00:00:00

abstract：:The results of a survey of a population with a high incidence of oral and oesophageal cancer are presented. The population under study appears to have several epidemiologic characteristics, some of which may be associated with a high incidence of oral and oesophageal cancer. A remarkably high proportion (41%) of the m...

journal_title：International journal of cancer

authors： Zaridze DG,Blettner M,Trapeznikov NN,Kuvshinov JP,Matiakin EG,Poljakov BP,Poddubni BK,Parshikova SM,Rottenberg VI,Chamrakulov FS

更新日期：1985-08-15 00:00:00

abstract：:A variable fraction of anaplastic large-cell lymphomas (ALCLs) exhibits a t(2;5)(p23;q35) translocation that results in expression of the chimeric hyperphosphorylated protein NPM-ALK (p80). Tumor cells expressing NPM-ALK exhibit markedly enhanced proliferative activity, but comparative cellular kinetic studies on ALK(...

journal_title：International journal of cancer

authors： Leoncini L,Lazzi S,Scano D,Mura A,Onida A,Massarelli G,Tosi P,Barbini P,Cevenini G,Massai MR,Pileri S,Falini B,Giordano A,Kraft R,Laissue JA,Cottier H

更新日期：2000-06-15 00:00:00

abstract：:Histone H3 lysine 9 trimethylation (H3K9me3) is associated with transcriptional repression and regulated by histone lysine methyltransferases such as SUV39H1 and ESET. However, the functional roles of these enzymes in hepatocellular carcinoma (HCC) remain uncertain. In this study, we conducted loss-of-function assays ...

journal_title：International journal of cancer

authors： Chiba T,Saito T,Yuki K,Zen Y,Koide S,Kanogawa N,Motoyama T,Ogasawara S,Suzuki E,Ooka Y,Tawada A,Otsuka M,Miyazaki M,Iwama A,Yokosuka O

更新日期：2015-01-15 00:00:00

abstract：:Endometrial serous adenocarcinoma (ESC) is aggressive and carries a poor prognosis. p53 is frequently mutated in ESC. microRNAs (miRNAs) are a direct p53 target and have been implicated in cancer cell behavior. In this study, we compared miRNA expression levels in ESC with the levels in endometrial endometrioid adenoc...

journal_title：International journal of cancer

authors： Hiroki E,Suzuki F,Akahira J,Nagase S,Ito K,Sugawara J,Miki Y,Suzuki T,Sasano H,Yaegashi N

更新日期：2012-08-15 00:00:00

abstract：:Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR...

journal_title：International journal of cancer

authors： Kabat GC,Kim MY,Stefanick M,Ho GYF,Lane DS,Odegaard AO,Simon MS,Bea JW,Luo J,Wassertheil-Smoller S,Rohan TE

更新日期：2018-08-01 00:00:00

abstract：:Fluoropyrimidines induce cytotoxicity, in part, by inhibiting the proliferation-coordinated enzyme thymidylate synthase (TS), which is essential for DNA synthesis. Tumor TS levels are clinically predictive of post-surgical tumor recurrence and of response to fluoropyrimidine chemotherapy. Fluoropyrimidine drug toxicit...

journal_title：International journal of cancer

authors： Lincoln DW 2nd,Hrushesky WJ,Wood PA

更新日期：2000-11-01 00:00:00

abstract：:Gefitinib has shown meaningful antitumor activity with tolerable toxicity in chemotherapy-refractory NSCLC in previous studies. Moreover, EGFR expression failed to show a correlation with response. In an attempt to identify predictive markers of response, we have investigated the tumoral expression of key signaling mo...

journal_title：International journal of cancer

authors： Han SW,Hwang PG,Chung DH,Kim DW,Im SA,Kim YT,Kim TY,Heo DS,Bang YJ,Kim NK

更新日期：2005-01-01 00:00:00

abstract：:The effects of long-term treatment with mouse interferon on the phenotype of untransformed C3H/10T1/2 cells and cloned derivatives transformed by methylcholanthrene (MCA) and Simian virus 40 (SV40) were investigated. Continuous presence of interferon induced morphologic reversion, with the development of thick, submem...

journal_title：International journal of cancer

authors： Brouty-Boyé D,Wybier-Franqui J,Calvo C,Feunteun J,Gresser I

更新日期：1984-07-15 00:00:00