Abstract:
:The site-specific relationship between melanoma and sun exposure was investigated in the high-risk region of New Zealand. Age and latitude of residence were used as biological and geographical proxy measures of exposure for the 16,117 newly incident cases and 3,150 death records reported between 1968 and 1993. Age-standardized rates were the highest for the trunk in males and for the lower limbs in females, but once body surface area was accounted for, highest rates were found on fully exposed sites, particularly the ears in men. Melanomas occurred at a substantially younger age on intermittently exposed sites than chronically exposed ones (difference of about 13 and 27 years for men and women, respectively, between the trunk and the face). Age and latitude were found to influence melanoma rates in a sex- and site-specific fashion. For heavily exposed body areas, incidence rates increased more modestly with age before age 50 than after. In contrast, sharp increases in risk occurred from early age for episodically exposed sites with a reversal of trend observed among the elderly. For males, the magnitude of the latitude gradient was about 65% (incidence) and 50% (mortality) greater for body areas most intermittently exposed compared with those with a least intermittent pattern of exposure. The latitude gradient was steeper for males than females and for incidence than mortality, regardless of the pattern of site exposure. Sex- and age-specific differences in risk were largely explained by the varying patterns of exposure. These results confirm that intermittent exposure is probably more effective than continuous exposure in producing an early onset of melanoma. Reducing the episodes of acute exposure remains a paramount aspect to melanoma prevention strategies.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Bulliard JLdoi
10.1002/(sici)1097-0215(20000301)85:5<627::aid-ijckeywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
627-32issue
5eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(20000301)85:5<627::AID-IJCjournal_volume
85pub_type
杂志文章abstract::A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550227
更新日期:1993-09-09 00:00:00
abstract::HPP1 is a recently discovered gene that is epigenetically silenced in a number of tumor types, suggesting a potential role as a tumor suppressor. However, whether HPP1 has tumor suppressor activity is not clearly known. We have sought to investigate the effects of HPP1 on tumor growth and survival and to identify sign...
journal_title:International journal of cancer
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journal_title:International journal of cancer
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abstract::Experimental and epidemiological evidence supports a role for sex steroid hormones in the pathogenesis of ovarian cancer. We investigated the association between ovarian cancer risk and pre-diagnostic blood concentrations of testosterone, androstenedione, DHEAS, estrone and SHBG. A case-control study nested within 3 c...
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abstract::Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. In vitro proliferation assays demonstrated that belinostat potently inhibited the growth of prostate canc...
journal_title:International journal of cancer
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更新日期:1997-06-11 00:00:00
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journal_title:International journal of cancer
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更新日期:2007-03-01 00:00:00
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journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2002-01-10 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1992-02-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1994-10-15 00:00:00
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journal_title:International journal of cancer
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pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of cancer
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更新日期:2006-09-15 00:00:00
abstract::Benzene is considered a carcinogen, mostly based on evidence of causality for myeloid leukemia from high levels of exposure in occupational studies. We used United States Environmental Protection Agency National Ambient Toxics Assessment (NATA) estimates of low-level ambient benzene to examine potential associations f...
journal_title:International journal of cancer
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更新日期:2019-11-15 00:00:00