Abstract:
:Infection by oncogenic human papillomavirus (HPV) is a necessary but not sufficient cause of cervical carcinoma. Several host genetic and viral factors have been reported to increase the risk of carcinoma development given an HPV infection. In our study, we have analysed the contribution of HPV 16 E6 sequence subtype and allelic variation at human leukocyte antigen (HLA) class II loci to the risk of developing cervical carcinoma in situ. Non-European-like HPV 16 E6 sequence subtypes were not found to be associated with an increased risk of cervical carcinoma, as compared to European-like variants. However, an association was found between the HPV 16 E6 L83V variant and the DR*04-DQ*03 haplotype. This association has been observed in several independent studies and shows that both the host HLA class II genotype and viral subtype will affect the risk of an infection progressing into cervical carcinoma.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Beskow AH,Engelmark MT,Magnusson JJ,Gyllensten UBdoi
10.1002/ijc.21212keywords:
subject
Has Abstractpub_date
2005-11-20 00:00:00pages
690-2issue
4eissn
0020-7136issn
1097-0215journal_volume
117pub_type
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2002-07-01 00:00:00
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journal_title:International journal of cancer
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更新日期:2007-11-01 00:00:00
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更新日期:1998-03-02 00:00:00
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更新日期:1999-03-15 00:00:00
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