Abstract:
:The Hong Kong Chinese population has an unusually high incidence of colorectal cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 years old) Chinese colorectal cancer patients referred to the Hong Kong Hereditary Gastrointestinal Cancer Registry from 1995 to 1998. By medical record review and personal interview, we searched for distinct clinical features associated with the manifestation of MSI in this group of patients. For patients with MSI tumours, blood was taken for detection of germline mutation in 2 mismatch repair (MMR) genes. MSI was present in 33 tumours from 23 males and 10 females (26.6%). Ongoing mutation analysis has so far identified MMR gene mutations in 8 patients with MSI tumours. The incidence of MSI increased significantly with decreasing age at cancer diagnosis. For patients aged 30 to 49, MSI tumours were located mainly at the proximal colon. However, for exceptionally young patients (<30 years), MSI tumours tended to be at the distal large bowel. This observation suggested a differential activity of the MMR pathway in colorectal carcinogenesis in different age groups. On multivariate analysis, young age at cancer diagnosis, proximal tumour location, a strong family history of colorectal cancer, and a personal history of metachronous cancer were independent predictors for MSI status. This knowledge may have an impact on the management of young colorectal cancer patients and their families.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ho JW,Yuen ST,Chung LP,Kwan KY,Chan TL,Leung SY,Chan AS,Tse Cw,Lam PW,Luk ISdoi
10.1002/1097-0215(20000720)89:4<356::aid-ijc7>3.0.keywords:
subject
Has Abstractpub_date
2000-07-20 00:00:00pages
356-60issue
4eissn
0020-7136issn
1097-0215pii
10.1002/1097-0215(20000720)89:4<356::AID-IJC7>3.0.journal_volume
89pub_type
杂志文章abstract::Paclitaxel has antiangiogenic properties, but the mechanisms for the enhanced sensitivity of endothelial cells (ECs) to this drug are not established. The aims of our study were to compare the distribution of paclitaxel into ECs with other cell types, to assess the effects of low doses of paclitaxel on Cox-2 expressio...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.20595
更新日期:2005-01-20 00:00:00
abstract::The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA transfection in a NIH/...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470112
更新日期:1991-01-02 00:00:00
abstract::HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathoge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10240
更新日期:2002-04-10 00:00:00
abstract::The European Study Group for Pancreatic Cancer (ESPAC-1) study is the largest study of adjuvant treatment for pancreatic ductal adenocarcinoma to date and confirmed a survival advantage for adjuvant chemotherapy but not for chemoradiation. The importance of parallel evaluation of survival and quality of life (QoL) has...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.24270
更新日期:2009-06-15 00:00:00
abstract::Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastri...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27390
更新日期:2012-09-15 00:00:00
abstract::The steady-state level of nucleophosmin/B23 mRNA decreased during berberine-induced (25 microg/ml, 24 to 96 hr) apoptosis of human leukemia HL-60 cells. A decline in telomerase activity was also observed in HL-60 cells treated with berberine. A stable clone of nucleophosmin/B23 overexpressed in HL-60 cells was selecte...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990611)81:6<923::aid-ijc
更新日期:1999-06-11 00:00:00
abstract::In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermenta...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.29012
更新日期:2015-10-01 00:00:00
abstract::A cDNA library specific for mRNA over-expressed in prostate cancer was generated by subtractive hybridization of transcripts originating from prostatic hyperplasia and cancer tissues. cDNA encoding ribosomal proteins L4, L5, L7a, L23a, L30, L37, S14 and S18 was found to be present among 100 analyzed clones. Levels of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980925)78:1<27::aid-ijc6
更新日期:1998-09-25 00:00:00
abstract::The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26490
更新日期:2012-09-01 00:00:00
abstract::The impact of screening by visual inspection with acetic acid (VIA), cytology or HPV testing on cervical cancer incidence and mortality is investigated in a cluster randomized controlled trial in India. We report findings after the screening phase, when 52 clusters, with a total of 142,701 women aged 30-59 years in Os...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.21050
更新日期:2005-09-10 00:00:00
abstract::Human blood monocytes are very potent to take up antigens. Like macrophages in tissue, they efficiently degrade exogenous protein and are less efficient than dendritic cells (DCs) at cross-presenting antigens to CD8+ T cells. Although it is generally accepted that DCs take up tissue antigens and then migrate to lymph ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31037
更新日期:2018-01-01 00:00:00
abstract::Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12ql3-15, and atypical lipomatous tumors (ALT) by supernumerary ring chromosomes or giant markers known to contain amplified 12q sequences. In a series of 228 cytogenetically analyzed and histopathol...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960904)67:5<632::AID-IJC
更新日期:1996-09-04 00:00:00
abstract::Although the combination of cisplatin and etoposide has been used as standard therapy for small-cell lung cancer, it is difficult to demonstrate combination effects between cisplatin and etoposide in vitro. We therefore adopted a 3-dimensional (3-D) model to analyze the combination effects of anticancer drugs, and com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970502)71:3<311::aid-ijc
更新日期:1997-05-02 00:00:00
abstract::Human leukocyte antigen (HLA)-G acts as negative regulator of the immune responses and its expression in tumor cells may enable them to escape immunosurveillance. The purpose of this study was to investigate the influence of HLA-G polymorphism on risk of high-grade cervical intraepithelial neoplasia (HG-CIN) and cervi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27356
更新日期:2012-08-01 00:00:00
abstract::Nuclear factor-κB (NF-κB) is constitutively activated in many cancers, including oral squamous cell carcinoma (OSCC), and is involved in the invasive characteristics of OSCC, such as growth, antiapoptotic activity and protease production. However, the cellular mechanism underlying NF-κB's promotion of bone invasion by...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27435
更新日期:2012-09-01 00:00:00
abstract::Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of mesothelioma, ovarian cancer and other malignant tumors. The interaction between mesothelin and CA125 (also called MUC16) may facilitate the implantation and metastasis of tumors in the peritoneal cavity....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25557
更新日期:2011-05-01 00:00:00
abstract::Although reproductive factors have been shown to be related to the composition of bile and functioning of the biliary system, their relationship with biliary tract cancer has not been studied in detail. Between 1984 and 1987 we conducted a case-control study of 75 women with cancer of the biliary tract and 252 control...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570203
更新日期:1994-04-15 00:00:00
abstract::The effects on breast cancer mortality seen after 16 years of biennial screening of younger women are assessed in this prospective cohort study. Since 1975 some 13,500 women, aged 35-49 in 1975, were invited to participate in the Nijmegen screening programme comprising a mammographic examination every 2 years. By the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600614
更新日期:1995-03-16 00:00:00
abstract::To identify CTL-directed antigens in gastrointestinal cancer, we have investigated antigens recognized by the HLA-A2-restricted CTL line established from T cells infiltrating into colon cancer and report herein cleavage and polyadenylation specificity factor (CPSF) as a potent antigen holding peptides capable of induc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10377
更新日期:2002-05-20 00:00:00
abstract::A novel intra-operative chemotherapy nude mouse model for human hepatocellular carcinoma (HCC) has been developed. Intra-peritoneal (i.p.) administration of 5-fluorouracil (5-FU) was begun 2 hr before hepatic resection of HCC and then continued post-operatively for 4 consecutive days. This regime, termed intra-hepatec...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1042>3
更新日期:2001-01-15 00:00:00
abstract::It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and wome...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11150
更新日期:2003-07-10 00:00:00
abstract::Oncolytic adenoviruses are being developed as novel anticancer therapeutics and currently undergoing clinical trials. We previously demonstrated that telomerase-specific replication-competent adenovirus (Telomelysin: OBP-301), in which the human telomerase reverse transcriptase (hTERT) promoter regulates viral replica...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21846
更新日期:2006-07-15 00:00:00
abstract::Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270108
更新日期:1981-01-15 00:00:00
abstract::Epigenetic alterations play an important role in carcinogenesis. Recent studies suggested that global histone modifications are predictors of cancer recurrence in various tumor entities. Our study was performed to evaluate histone H3 lysine 4 mono-methyl (H3K4me1), -di-methyl (H3K4me2) and -trimethyl (H3K4me3) pattern...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25250
更新日期:2010-11-15 00:00:00
abstract::Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the 'patient interval'). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with genera...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28763
更新日期:2014-09-01 00:00:00
abstract::The present study was undertaken to determine the role of the metalloproteinase MMP-9 in the invasive phenotype of squamous-cell carcinoma of the oral cavity and the regulation of its expression. Zymographic analysis of conditioned medium from 2 highly invasive squamous-cell-carcinoma cell lines indicated large amount...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550104
更新日期:1993-08-19 00:00:00
abstract::Over 10% of children with Wilms tumor (WT) have an underlying cancer predisposition syndrome (CPS). Cognizant of increasing demand for genetic evaluation and limited resources across health care settings, there is an urgent need to rationalize genetic referrals for this population. The McGill Interactive Pediatric Onc...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.32561
更新日期:2020-02-15 00:00:00
abstract::Daphnane-type diterpene gnidimacrin isolated from the Chinese plant Stellera chamaejasme L. is an antitumor agent that activates protein kinase C (PKC). The mechanism of antitumor action of gnidimacrin and the possible involvement of PKC were examined using sensitive K562 and refractory HLE cells. Gnidimacrin did bind...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980717)77:2<243::aid-ijc
更新日期:1998-07-17 00:00:00
abstract::The LIM 1863 colon carcinoma cell line grows in the form of morphologically and functionally organized organoids. Cells are arranged around a central lumen with a brush border and nuclei are polarized to the periphery. The organoids contain 3 morphological cell types (columnar, goblet and caveolated cells). By agar cl...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500515
更新日期:1992-03-12 00:00:00
abstract::The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570407
更新日期:1994-05-15 00:00:00