Abstract：
:Our aim was to compare the occurrence and prognostic significance over 14-20 years of immunocytochemically detected S100A4 and other tumour variables in primary tumours from 349 patients with operable breast cancer. For a cut-off of 1% staining of the malignant cells, the antibody to S100A4 stains positively 56% of the carcinomas. There was a significant association of staining for S100A4 with tumours fixed to the chest wall, staining for c-erbB-2, c-erbB-3, pS2, cathepsin D and, inversely, at borderline levels with staining for estrogen receptor. Using Wilcoxon statistics in univariate analyses, staining for S100A4, nodal status, tumour class, histological grade and staining for c-erbB-2, p53 were associated negatively and staining for estrogen receptor, progesterone receptor were associated positively with patient survival times. The survival times of patients with S100A4-negative carcinomas with or without one of the other tumour variables showed no significant differences, whilst those of patients with S100A4-positive carcinomas showed significant differences in a negative or a positive way. Multivariate regression analysis for 137 patients showed that staining for S100A4 is most highly correlated with patient deaths, but involved lymph nodes, fixed tumours, high histological grade and staining for progesterone receptor were also significant independent prognostic variables. Our results suggest that in this set of patients, the tumour variable most tightly correlated with patient death is S100A4.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Platt-Higgins AM,Renshaw CA,West CR,Winstanley JH,De Silva Rudland S,Barraclough R,Rudland PSkeywords:
subject
Has Abstractpub_date
2000-03-20 00:00:00pages
198-208issue
2eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(20000320)89:2<198::AID-IJCjournal_volume
89pub_type
杂志文章abstract：:Cervical cancer is a public health concern as it represents the second cause of cancer death in women worldwide. High-risk human papillomaviruses (HPV) are the etiologic agents, and HPV E6 and/or E7 oncogene-specific therapeutic vaccines are under development to treat HPV-related lesions in women. Whether the use of m...
journal_title：International journal of cancer
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abstract：:Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. Lymph nodes (n = 780) from 36 CRC patients who had developed disease re...
journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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abstract：:The relationship between occupation and exposure to several occupational agents and Hodgkin's disease (HD) was investigated in a case-control study of 152 cases and 613 controls with acute diseases admitted to all hospitals in Pordenone province, north-east Italy. Among cases, there was a significant excess of individ...
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