Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide.

abstract：:Flavone acetic acid (FAA) is a potentially useful anti-tumour agent which has been reported to induce changes in tumour vasculature, in particular loss of bloodflow. This led us to examine whether endothelium could be a cellular target of FAA action, with resultant modulation of cell-surface coagulant properties leadi...

journal_title：International journal of cancer

authors： Murray JC,Clauss M,Denekamp J,Stern D

更新日期：1991-09-09 00:00:00

abstract：:Retinoids play essential roles in the regulation of cell differentiation and in the proliferation of various epithelial tissues, and atRA is one such active metabolite of retinoids. However, despite the known functions of atRA, its clinical applications are limited due to the induced metabolism by the specific cytochr...

journal_title：International journal of cancer

authors： Choi Y,Kim SY,Kim SH,Yang J,Park K,Byun Y

更新日期：2003-10-20 00:00:00

abstract：:T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...

journal_title：International journal of cancer

authors： Kudoh S,Stanley J,Edinger MG,Tubbs RR,Klein E,Bukowski RM,Finke JH

更新日期：1994-08-01 00:00:00

abstract：:Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal uroth...

journal_title：International journal of cancer

authors： Cindolo L,Benvenuto G,Salvatore P,Pero R,Salvatore G,Mirone V,Prezioso D,Altieri V,Bruni CB,Chiariotti L

更新日期：1999-02-19 00:00:00

abstract：:Recent reports suggest that autoantibodies directed to aberrantly glycosylated mucins, in particular MUC1 and MUC4, are found in patients with colorectal cancer. There is, however, limited information on the autoantibody levels before clinical diagnosis, and their utility in cancer screening in the general population....

journal_title：International journal of cancer

authors： Pedersen JW,Gentry-Maharaj A,Nøstdal A,Fourkala EO,Dawnay A,Burnell M,Zaikin A,Burchell J,Papadimitriou JT,Clausen H,Jacobs I,Menon U,Wandall HH

更新日期：2014-05-01 00:00:00

abstract：:A "divergent pathway" model for the development of cutaneous melanoma has been proposed. The model hypothesizes that melanomas occurring in people with a low tendency to develop nevi will, on average, arise more commonly on habitually sun-exposed body sites such as the head and neck. In contrast, people with an inhere...

journal_title：International journal of cancer

authors： Olsen CM,Zens MS,Stukel TA,Sacerdote C,Chang YM,Armstrong BK,Bataille V,Berwick M,Elwood JM,Holly EA,Kirkpatrick C,Mack T,Bishop JN,Østerlind A,Swerdlow AJ,Zanetti R,Green AC,Karagas MR,Whiteman DC

更新日期：2009-02-15 00:00:00

abstract：:Bladder cancer-associated protein (BLCAP) is a highly conserved protein among species, and it is considered a novel candidate tumor suppressor gene originally identified from human bladder carcinoma. However, little is known about the regulation or the function of this protein. Here, we show that the human BLCAP trans...

journal_title：International journal of cancer

authors： Galeano F,Leroy A,Rossetti C,Gromova I,Gautier P,Keegan LP,Massimi L,Di Rocco C,O'Connell MA,Gallo A

更新日期：2010-07-01 00:00:00

abstract：:We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...

journal_title：International journal of cancer

authors： Pathak DR,Speizer FE,Willett WC,Rosner B,Lipnick RJ

更新日期：1986-01-15 00:00:00

abstract：:Endometrial carcinoma (EC) is traditionally characterized as endometrioid and nonendometrioid based on histopathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between Mar...

journal_title：International journal of cancer

authors： Jones NL,Xiu J,Chatterjee-Paer S,Buckley de Meritens A,Burke WM,Tergas AI,Wright JD,Hou JY

更新日期：2017-03-15 00:00:00

abstract：:The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour ...

journal_title：International journal of cancer

authors： Pucci-Minafra I,Luparello C,Schillaci R,Sciarrino S

更新日期：1987-05-15 00:00:00

abstract：:Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...

journal_title：International journal of cancer

authors： Tian X,Ge D,Zhang F,Zhang B,Bai W,Xu X,Li Z,Cao Y,Li P,Zou K,Zou L

更新日期：2021-02-15 00:00:00

abstract：:Loss of heterozygosity (LOH) is an important event of tumorigenesis. In gastric cancer, we found a novel region of LOH in chromosome 9q having about 800 kb deletions at 9q31.1. The microsatellite marker D9S938 in that region exhibiting the highest LOH frequency, 56.5%. In addition, the LOH at 9q31.1 did not show any r...

journal_title：International journal of cancer

authors： Kakinuma N,Kohu K,Sato M,Yamada T,Nakajima M,Akiyama T,Ohwada S,Shibanaka Y

更新日期：2004-03-01 00:00:00

abstract：:The mechanism of chemotherapy resistance in breast cancer is unresolved. MDR1/P-glycoprotein (P-Gp) over-expression confers multidrug resistance in vitro and might play a role in clinical breast cancer. Studies using clinical samples have yielded conflicting results. MDR1/P-Gp mRNA expression was determined relative t...

journal_title：International journal of cancer

authors： Faneyte IF,Kristel PM,van de Vijver MJ

更新日期：2001-07-01 00:00:00

abstract：:Irinotecan-based chemotherapy with bevacizumab is one of the first-line standard therapies for metastatic colorectal cancer (mCRC). TEGAFIRI (UFT/LV + irinotecan) is an irinotecan-based chemotherapy regimen. Currently, few clinical data regarding TEGAFIRI are available. This study evaluated the efficacy and safety of ...

journal_title：International journal of cancer

authors： Shigeta K,Hasegawa H,Okabayashi K,Tsuruta M,Ishii Y,Endo T,Ochiai H,Kondo T,Kitagawa Y

更新日期：2016-08-15 00:00:00

abstract：:Human colon cancer cells produce and secrete a variety of polypeptide growth factors. The functional role of these growth factors, however, is poorly understood. Though the secretion of epidermal growth factor (EGF)-like activity and EGF-related molecules by human colon cancer cells in culture has been reported, it is...

journal_title：International journal of cancer

authors： Huang S,Trujillo JM,Chakrabarty S

更新日期：1992-12-02 00:00:00

abstract：:More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

journal_title：International journal of cancer

authors： Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

更新日期：2021-01-01 00:00:00

abstract：:We transduced a human gastric carcinoma cell line, HR, with the interleukin 2 (IL-2) gene. Stable HR transfectants secreted nanogram quantities of biologically active IL-2 and had significantly increased expression of IL-2 mRNA relative to that in parental cells. Expression of intracellular IL-2 protein was not quanti...

journal_title：International journal of cancer

authors： Nagashima S,Kashii Y,Reichert TE,Suminami Y,Suzuki T,Whiteside TL

更新日期：1997-07-03 00:00:00

abstract：:In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the occurrence of breast cancer. However, the underlying mechanism is not known. Combining a case-control study with a large cohort of women from Southern China with breast cancer and functional analyses with trans-mitochondrial techno...

journal_title：International journal of cancer

authors： Ma L,Fu Q,Xu B,Zhou H,Gao J,Shao X,Xiong J,Gu Q,Wen S,Li F,Shen L,Chen G,Fang H,Lyu J

更新日期：2018-05-01 00:00:00

abstract：:Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...

journal_title：International journal of cancer

authors： Horiuchi A,Hayashi T,Kikuchi N,Hayashi A,Fuseya C,Shiozawa T,Konishi I

更新日期：2012-10-15 00:00:00

abstract：:As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the combined effects of COX-1 and COX-2 selective inhibitors on spontaneous p...

journal_title：International journal of cancer

authors： Kitamura T,Itoh M,Noda T,Matsuura M,Wakabayashi K

更新日期：2004-04-20 00:00:00

abstract：:G-banding analyses of 14 independently derived B-cell lymphomas showed the frequent occurrence of chromosome 15 trisomy. It was present in seven of nine spontaneous B-cell lymphomas, but in company with other trisomies, monosomies and marker chromosomes. In five carcinogen-induced primary B-cell leukemias, trisomy 15 ...

journal_title：International journal of cancer

authors： Wiener F,Babonits M,Spira J,Bregula U,Klein G,Merwin RM,Asofsky R,Lynes M,Haughton G

更新日期：1981-01-15 00:00:00

abstract：:The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set MTGP, a trace and apparently tumor-specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both c...

journal_title：International journal of cancer

authors： Leung JP,Nelson-Rees WA,Moore GE,Cailleau R,Edgington TS

更新日期：1981-07-15 00:00:00

abstract：:Cultured murine hepatic tumor (HT) cells respond to the polar solvent dimethylsulfoxide (DMSO) with specific alterations in morphology, proliferative kinetics, and biochemical properties. These include entrance into a quiescent "Qi" substate (characterized by accumulation of cells in G1 phase and lowered cellular RNA ...

journal_title：International journal of cancer

authors： Ryan MP,Higgins PJ

更新日期：1988-08-15 00:00:00

abstract：:We examined the expression of tumor-suppressor protein p53 in a variety of laryngeal carcinomas from 43 patients (25 primary, 13 metastatic and 5 recurrent cases), 13 normal laryngeal tissues and 7 benign laryngeal nodule biopsy specimens, using the polyclonal antibody CM-1. Previously we have reported a high incidenc...

journal_title：International journal of cancer

authors： Anwar K,Nakakuki K,Imai H,Naiki H,Inuzuka M

更新日期：1993-04-01 00:00:00

abstract：:Six permanent human tumor cell lines (OV-MZ-1 to 6) were established from 6 patients with serous adenocarcinomas of the ovary. These cell lines were derived from both solid tumors and ascites, from pre-treated and untreated patients, and are available over a range of in vitro passage numbers. The tumor cells grow as m...

journal_title：International journal of cancer

authors： Möbus V,Gerharz CD,Press U,Moll R,Beck T,Mellin W,Pollow K,Knapstein PG,Kreienberg R

更新日期：1992-08-19 00:00:00

abstract：:The object of our multicenter retrospective study was to compare the new histologic World Health Organization (WHO) classification and the classical histologic Bernatz classification in terms of interobserver agreement and prognostic importance. The influence of coexisting diseases was also analyzed using the Charlson...

journal_title：International journal of cancer

authors： Rieker RJ,Hoegel J,Morresi-Hauf A,Hofmann WJ,Blaeker H,Penzel R,Otto HF

更新日期：2002-04-20 00:00:00

abstract：:Long-term survival rates for advanced ovarian cancer patients have not changed appreciably over the past four decades; therefore, development of new, effective treatment modalities remains a high priority. Tumor Treating Fields (TTFields), a clinically active anticancer modality utilize low-intensity, intermediate fre...

journal_title：International journal of cancer

authors： Voloshin T,Munster M,Blatt R,Shteingauz A,Roberts PC,Schmelz EM,Giladi M,Schneiderman RS,Zeevi E,Porat Y,Bomzon Z,Urman N,Itzhaki A,Cahal S,Kirson ED,Weinberg U,Palti Y

更新日期：2016-12-15 00:00:00

abstract：:We have found previously that the retinoblastoma (Rb) suppressor associated protein 46 (RbAp46) is a gene upregulated by the Wilms' tumor suppressor, WT1, and functions as a potent growth inhibitor. To investigate the effect of RbAp46 overexpression on early development of breast cancer, we established stable cell lin...

journal_title：International journal of cancer

authors： Li GC,Guan LS,Wang ZY

更新日期：2003-07-20 00:00:00

abstract：:Elevated plasma lipoprotein(a) has been associated with an increased risk of cardiovascular disease. We report a significant elevation of total plasma apolipoprotein(a) levels in cancer patients compared with hospitalized control patients and normal healthy blood donors. Of the cancer patients studied, 48% had levels ...

journal_title：International journal of cancer

authors： Wright LC,Sullivan DR,Muller M,Dyne M,Tattersall MH,Mountford CE

更新日期：1989-02-15 00:00:00

abstract：:Oral leukoplakia is a heterogeneous lesion with risk of cancer development; there are no biomarkers to predict its potential of malignant transformation. Tissue proteomic analysis of oral leukoplakia using iTRAQ labeling liquid chromatography-mass spectrometry showed overexpression of heterogeneous ribonucleoprotein K...

journal_title：International journal of cancer

authors： Matta A,Tripathi SC,DeSouza LV,Grigull J,Kaur J,Chauhan SS,Srivastava A,Thakar A,Shukla NK,Duggal R,DattaGupta S,Ralhan R,Michael Siu KW

更新日期：2009-09-15 00:00:00