Abstract:
:Cultured murine hepatic tumor (HT) cells respond to the polar solvent dimethylsulfoxide (DMSO) with specific alterations in morphology, proliferative kinetics, and biochemical properties. These include entrance into a quiescent "Qi" substate (characterized by accumulation of cells in G1 phase and lowered cellular RNA content), enhanced production of liver-specific proteins, and decreased expression of growth traits characteristic of the transformed phenotype. Entrance of HT cells into Qi was associated with increased monolayer compaction and a shift from an elaborate surface fibronectin (FN) network to a sparse and restricted distribution of FN fibers. This marked decrease in the extent and complexity of the cellular FN network, as a consequence of DMSO exposure, was reflected in a 90% decline in the amount of FN secreted into the culture medium. These data complement previous studies indicating that the accumulation and composition of liver cell matrix substances reflect altered patterns of hepatocyte-specific gene expression. In the HT cell system, DMSO appears to act in a bifunctional manner, increasing the production of certain tissue-specific proteins (e.g., albumin and alpha-fetoprotein) while decreasing the secretion and deposition of other cellular components (FN). DMSO may directly regulate expression of these proteins in HT cells or alter the pattern of cellular response to specific autocrine growth factors.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ryan MP,Higgins PJdoi
10.1002/ijc.2910420222subject
Has Abstractpub_date
1988-08-15 00:00:00pages
273-8issue
2eissn
0020-7136issn
1097-0215journal_volume
42pub_type
杂志文章abstract::In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490406
更新日期:1991-10-21 00:00:00
abstract::The growth of 7/9 Burkitt's lymphoma (BL) cell lines and 5/6 human melanoma cell lines was inhibited by certain human fibroblast-like cell lines, especially human myofibroblast cell lines. In contrast to BL lines, 3/5 lymphoblastoid cell lines were less susceptible and 3/4 human leukaemic lines were resistant. The eff...
journal_title:International journal of cancer
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abstract::To identify prognostic factors in medulloblastoma, a common malignant brain tumor of childhood, expression of the oncogene c-myc was examined at the mRNA level by in situ hybridization. c-myc mRNA expression was observed in 30 of 72 tumors (42%). The c-myc gene copy number was determined by quantitative PCR from genom...
journal_title:International journal of cancer
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doi:
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910310518
更新日期:1983-05-15 00:00:00
abstract::The variants within the human melanocortin 1 receptor (MC1R) gene are associated with an increased risk of different skin cancers. In this study, we genotyped by direct sequencing, 529 cases of basal cell carcinoma of the skin (BCC) and 533 healthy controls for polymorphisms in the entire MC1R gene. In addition to 10 ...
journal_title:International journal of cancer
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更新日期:2008-04-15 00:00:00
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journal_title:International journal of cancer
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更新日期:1987-05-15 00:00:00
abstract::Use of hormone replacement therapy (HRT) has been hypothesized to affect survival of epithelial ovarian cancer (EOC). We studied 5-year survival in patients with invasive EOC and borderline ovarian tumors (BOT) according to HRT use before and after diagnosis in a prospective nation-wide cohort study of 799 women diagn...
journal_title:International journal of cancer
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更新日期:2006-12-15 00:00:00
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420319
更新日期:1988-09-15 00:00:00
abstract::Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...
journal_title:International journal of cancer
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doi:10.1002/ijc.27394
更新日期:2012-10-01 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910260513
更新日期:1980-11-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/(sici)1097-0215(19971219)74:6<625::aid-ijc
更新日期:1997-12-19 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the 5-year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the p...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.33352
更新日期:2020-10-22 00:00:00
abstract::HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathoge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10240
更新日期:2002-04-10 00:00:00
abstract::CD4(+) Th cells that are restricted by MHC class II molecules play an important role in the induction of antitumor immune responses. We have established a stable CD4(+) Th cell clone (Th35-1A) from the PBMCs of a patient with primary cutaneous melanoma. The Th cell clone is noncytolytic and proliferates specifically i...
journal_title:International journal of cancer
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doi:10.1002/ijc.10964
更新日期:2003-04-10 00:00:00
abstract::It has been established that the Hedgehog (Hh) and epithelial-mesenchymal transition (EMT) signals act on morphogenesis of embryonic and adult tissues. Recently, both signals have been involved in tumor malignancy. However, little is known as to whether Hh and EMT signals act on normal and malignant epithelial cells i...
journal_title:International journal of cancer
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doi:10.1002/ijc.24400
更新日期:2009-09-01 00:00:00
abstract::Familial atypical multiple mole melanoma (FAMMM) is an autosomal dominant disease characterized by the familial occurrence of malignant melanoma of the skin and multiple atypical precursor lesions. Germline mutations in the p16 (CDKN2A) gene have been reported in at least a quarter of such families. An association has...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-15 00:00:00
abstract::The high recurrence rate of bladder cancer is probably due to an efficient repopulation of the bladder by residual transformed cells after resection of the tumour. However, the regenerating capacity of the normal urothelial cells is very high. To study the balance between regenerating normal urothelium and out-growth ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600523
更新日期:1995-03-03 00:00:00
abstract::A segment of 712 bases coding for part of the human stearoyl-CoA desaturase gene was made by polymerase chain reaction (PCR) using primers based on published rat cDNA sequences. The human PCR product was confirmed by DNA sequencing. It was next cloned into a vector from which anti-sense, highly radioactive RNA transcr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570310
更新日期:1994-05-01 00:00:00
abstract::Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. Tobacco smoke contains 61 known carcinogens and increases the risk of several adult cancers. This study investigated associations between parental smoking and risk of CBT in a population-based ca...
journal_title:International journal of cancer
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doi:10.1002/ijc.28004
更新日期:2013-07-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:1990-04-15 00:00:00
abstract::Colorectal cancer (CRC) screening rates are currently suboptimal. Blood-based screening could improve rates of earlier detection for CRC and adenomatous colorectal polyps. In this study, we evaluated the feasibility of plasma-based detection of early CRC and adenomatous polyps using array-mediated analysis methylation...
journal_title:International journal of cancer
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更新日期:2012-09-01 00:00:00
abstract::Dietary intake of many fruits and vegetables has been shown to be associated with reduced risk of cancer. We investigated the in vivo efficacy of grape seed extract (GSE, patented as Traconol) against prostate cancer (PCA) and associated molecular events. Athymic nude mice were implanted with hormone-refractory human ...
journal_title:International journal of cancer
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更新日期:2004-02-20 00:00:00
abstract::There are no reliable serologic tumor markers for transitional cell carcinoma (TCC) of the urinary bladder and noninvasive urine investigations are inadequate. We used fluorescent microsatellite analysis (MSA) to detect serum DNA and urine-sediment DNA alterations in patients with bladder cancer and prospectively coll...
journal_title:International journal of cancer
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更新日期:2001-10-01 00:00:00
abstract::We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...
journal_title:International journal of cancer
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更新日期:2007-04-01 00:00:00
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