Abstract:
:The stroma of ductal infiltrating carcinoma of the human breast shows characteristic and localized areas of collagen rarefaction and fragmentation. This finding has been correlated with a peculiar type of fibrillar damage, observed in a small percentage of collagen fibrils isolated in the native state from the tumour stroma. The same pattern of lesion has been reproduced in vitro by human collagenase digestion on reconstituted fibrils. No effect has been detected by other nonspecific proteases in the same system.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Pucci-Minafra I,Luparello C,Schillaci R,Sciarrino Sdoi
10.1002/ijc.2910390510subject
Has Abstractpub_date
1987-05-15 00:00:00pages
599-603issue
5eissn
0020-7136issn
1097-0215journal_volume
39pub_type
杂志文章abstract::Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated in nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with renal tumorigenesis. In this study...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29522
更新日期:2015-10-01 00:00:00
abstract::To investigate the relationship between p16 methylation and Helicobacter pylori infection in precancerous gastric lesions, a population-based study was conducted in Linqu County, a high-risk area of gastric cancer in China. Methylation status of p16 was evaluated by methylation-specific polymerase chain reaction in 92...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23891
更新日期:2009-01-15 00:00:00
abstract::Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25637
更新日期:2011-06-15 00:00:00
abstract::Breast cancer is heterogeneous in clinical behavior by subtypes; however, it is unclear how this heterogeneity is related to epidemiological factors. To evaluate the differences in epidemiological factors by breast tumor subtypes, we investigated the associations of epidemiological factors between tumor subtypes in Ko...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.28685
更新日期:2014-08-01 00:00:00
abstract::miRNAs have emerged as post-transcriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Cdc42, one of the best characterized members of the Rho GTPase family, is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and prog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25452
更新日期:2011-03-15 00:00:00
abstract::Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980911)77:6<833::aid-ijc
更新日期:1998-09-11 00:00:00
abstract::Management of oral leukoplakia-a potentially malignant disorder-is currently not evidence-based. Of the few randomized trials that have been reported, most have negative data. Therefore, a multi-centre, randomized, double-blind controlled trial (RCT) was undertaken to evaluate the use of low-dose beta-carotene combine...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ijc.29156
更新日期:2015-04-01 00:00:00
abstract::We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selective enzymatic inhibi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400624
更新日期:1987-12-15 00:00:00
abstract::Clinical case reports have suggested that specific bacterial infections are associated with certain non-Hodgkin lymphoma (NHL) subtypes. Epidemiological case-control studies have been conducted using antibiotics as a proxy for bacterial infections, but with inconclusive results. The aim of this study was, in a cohort ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27626
更新日期:2012-10-01 00:00:00
abstract::Effects of pretreatment with BCG, strain Japan, on tumor growth were studied using a transplatable methylcholanthrene (MCA)-induced fibrosarcoma in C3H/He mice. Injection of BCG7 weeks before tumor inoculation at a site distant from the tumor caused a slight inhibition of tumor growth. A low dose of tumor cells did no...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210112
更新日期:1978-01-15 00:00:00
abstract::Streptovaricins (Sv), ansa macrolide antibiotics, inhibited Rauscher leukemia virus (RLV) splenomegaly by 25-50%. All streptovaricins tested were effective when administered orally either by diet ad lib or by intubation from infection to time of killing. When delivered by intubation, Sv was measurable in plasma for up...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910140616
更新日期:1974-12-15 00:00:00
abstract::Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210216
更新日期:1978-02-15 00:00:00
abstract::Cancer cells have the capacity to lyse erythrocytes by a cell-contact-requiring phenomenon. Subcellular fractionation procedures have revealed that the hemolytic principle resides in the cancer cell plasma membrane. In this study we report the detergent extraction of a potent hemolytic factor from the plasma membranes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470217
更新日期:1991-01-21 00:00:00
abstract::Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastri...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27390
更新日期:2012-09-15 00:00:00
abstract::Colibactin-producing E. coli (CoPEC) are frequently detected in colorectal cancer (CRC) and exhibit procarcinogenic properties. Because increasing evidence show the role of immune environment and especially of antitumor T-cells in CRC development, we investigated the impact of CoPEC on these cells in human CRC and in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32920
更新日期:2020-06-01 00:00:00
abstract::In order to gain new insights into the risk factors influencing human-T-cell-leukemia/lymphoma-virus-type-I (HTLV-I) mother-to-child transmission, a retrospective study of HTLV-I infection among children born to HTLV-I-seropositive women was carried out in a highly HTLV-I-endemic population of African origin living in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990909)82:6<832::aid-ijc
更新日期:1999-09-09 00:00:00
abstract::Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32505
更新日期:2020-02-15 00:00:00
abstract::Neuroendocrine gastrointestinal tumors take up, decarboxylate and store large amounts of monoamines. Radioactive-labeled monoamines like the norepinephrine analogue meta-iodobenzylguanidine (MIBG) have been used for the imaging of neuroendocrine tumors for many years. MIBG is selectively taken up via norepinephrine tr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10553
更新日期:2002-09-20 00:00:00
abstract::Imatinib mesylate has become an effective agent for the treatment of chronic myeloid leukemia (CML). However, the development of drug resistance has led to examination of combination therapies. In this study, we investigated the effects of combining imatinib with immunotherapy against a murine bcr-abl(+) leukemia, 12B...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20115
更新日期:2004-06-10 00:00:00
abstract::The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27461
更新日期:2012-10-15 00:00:00
abstract::We evaluated cell survival, DNA double strand breaks (dsbs), and DNA synthesis following camptothecin (CPT) alone or concurrent CPT and X-radiation treatments in exponential-phase cultures of a radioresistant human melanoma cell line. Cell survival was measured by a clonogenic assay. DNA dsbs were measured by pulsed-f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1031
更新日期:2001-10-20 00:00:00
abstract::The genetic events underlying the development of prostate cancer are poorly defined. c-Myc is often activated in tumors that have progressed to metastatic status, so events that promote this process may be important. Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000415)86:2<155::aid-ijc
更新日期:2000-04-15 00:00:00
abstract::Data from a hospital-based matched case-control study with 531 male pairs were analyzed for risks of cancer of the lower urinary tract associated with previous employment and particular occupational exposures. Statistically significant odds ratios were obtained for ever-employment as mining workers (2.0), turners (2.3...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410309
更新日期:1988-03-15 00:00:00
abstract::The predictive effect of circulating tumor DNA (ctDNA) in colorectal cancer (CRC) treatment is still highly discussed. The primary objective of our study was to investigate a possible prognostic/predictive value of ctDNA under regorafenib treatment. This prospective multicenter translational biomarker phase II pilot s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33303
更新日期:2021-03-15 00:00:00
abstract::Dichlorodiphenyltrichloroethane (p,p'-DDT), an organochlorine pesticide known to have deleterious health effects in humans, has been linked to hepatocellular carcinoma (HCC) in rodents. A recent study has reported that p,p'-DDT and its most persistent metabolite, dichlorodiphenyldichloroethylene (p,p'-DDE), may also b...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27459
更新日期:2012-11-01 00:00:00
abstract::The presence of androgen receptor variant 7 (AR-V7) variants becomes a significant hallmark of castration-resistant prostate cancer (CRPC) relapsed from hormonal therapy and is associated with poor survival of CRPC patients because of lacking a ligand-binding domain. Currently, it still lacks an effective agent to tar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30893
更新日期:2017-11-15 00:00:00
abstract::A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27479
更新日期:2012-11-01 00:00:00
abstract::The flavonoids, a group of more than 4,000 polyphenolic antioxidants, are potential cancer preventive components of fruits and vegetables. Catechins, one of the 6 major groups of flavonoids, are present in high concentrations in tea as well. Our objective was to evaluate the association between intake of catechins and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(200102)9999:9999<::aid-ijc1187>3
更新日期:2001-04-15 00:00:00
abstract::Mouse-transformed keratinocytes cultured in the presence of transforming growth factor beta1 (TGF-beta1) acquire an array of morphologic and functional properties that give rise to a migratory phenotype that expresses mesenchymal molecular markers. This cellular conversion involves activation of the Ras-ERK pathway, e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11457
更新日期:2003-12-10 00:00:00
abstract::The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22807
更新日期:2007-09-01 00:00:00