Characteristics of membrane and cytosol forms of the mammary tumor glycoprotein molecule MTGP in human breast carcinoma cell cultures and tumors.

abstract：:Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...

journal_title：International journal of cancer

authors： Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ

更新日期：2018-04-01 00:00:00

abstract：:The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of ...

journal_title：International journal of cancer

authors： Kang S,Kim JW,Kang GH,Lee S,Park NH,Song YS,Park SY,Kang SB,Lee HP

更新日期：2006-05-01 00:00:00

abstract：:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...

journal_title：International journal of cancer

authors： Linseisen J,Rohrmann S,Miller AB,Bueno-de-Mesquita HB,Büchner FL,Vineis P,Agudo A,Gram IT,Janson L,Krogh V,Overvad K,Rasmuson T,Schulz M,Pischon T,Kaaks R,Nieters A,Allen NE,Key TJ,Bingham S,Khaw KT,Amiano P,Bar

更新日期：2007-09-01 00:00:00

abstract：:The antigen K-1-2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K-1-2 occurs in melanoma cell line SK-Mel 25, but not in cell line A-375. A-375 has a higher...

journal_title：International journal of cancer

authors： Suter L,Brüggen J,Bröcker EB,Sorg C

更新日期：1985-06-15 00:00:00

abstract：:Cytotoxic antibodies against glioblastoma-associated antigen(s) have been sought for in glioma patient sera. Complement-dependent cytotoxicity (CDC) I and antibody-dependent cell-mediated cytotoxicity (ADCC) assays were used to test sera from 80 patients using 51 Cr labelled target cells derived from eight different g...

journal_title：International journal of cancer

authors： Martin-Achard A,Diserens AC,de Tribolet N,Carrel S

更新日期：1980-02-15 00:00:00

abstract：:UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time was considered to be only a toxic waste product of hemoglobin degradation, but recent findings have...

journal_title：International journal of cancer

authors： Lacko M,Roelofs HM,Te Morsche RH,Voogd AC,Ophuis MB,Peters WH,Manni JJ

更新日期：2010-12-15 00:00:00

abstract：:We use the population-based Family-Cancer Database from Sweden to study familial breast cancer. The size of the population and the nation-wide registration of cancer offer unique possibilities for epidemiological studies of familial cancer, including complete and unbiased identification of cases in the probands and in...

journal_title：International journal of cancer

authors： Hemminki K,Vaittinen P

更新日期：1998-07-29 00:00:00

abstract：:Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those fro...

journal_title：International journal of cancer

authors： Gillespie GY,Jensen FC,Russell SW

更新日期：1978-02-15 00:00:00

abstract：:Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...

journal_title：International journal of cancer

authors： Fleuren ED,O'Toole S,Millar EK,McNeil C,Lopez-Knowles E,Boulghourjian A,Croucher DR,Schramek D,Brummer T,Penninger JM,Sutherland RL,Daly RJ

更新日期：2010-09-01 00:00:00

abstract：:ET-743, an experimental antitumor drug with promising activity in sarcoma, breast and ovarian carcinoma, is currently under phase 2 clinical evaluation. It is hepatotoxic in animals and patients. We tested the hypothesis that indole-3-carbinol (I3C), the hydrolysis product of glucosinolates occurring in cruciferous ve...

journal_title：International journal of cancer

authors： Donald S,Verschoyle RD,Greaves P,Colombo T,Zucchetti M,Falcioni C,Zaffaroni M,D'Incalci M,Manson MM,Jimeno J,Steward WP,Gescher AJ

更新日期：2004-10-10 00:00:00

abstract：:MAGE-1 and MAGE-3 or -6 are genes encoding melanoma-rejection antigens recognized by cytotoxic T lymphocytes in an HLA-A1 restriction manner. MAGE-1 and MAGE-3 or -6 were expressed in 5/14 (36%) and 6/14 (43%) neuroblastoma (NB) cell lines, and in 20/41 (49%) and 24/41 (59%) clinical NB-related tumors, respectively. A...

journal_title：International journal of cancer

authors： Ishida H,Matsumura T,Salgaller ML,Ohmizono Y,Kadono Y,Sawada T

更新日期：1996-10-21 00:00:00

abstract：:Folate is required for biological methylation and nucleotide synthesis, aberrations of which are thought to be the mechanisms that enhance colorectal carcinogenesis produced by folate inadequacy. These functions of folate also depend on the availability of other B-vitamins that participate in "one-carbon metabolism," ...

journal_title：International journal of cancer

authors： Liu Z,Choi SW,Crott JW,Smith DE,Mason JB

更新日期：2008-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Little is known about its molecular pathogenesis and the relevance of DNA methylation for disease initiation and progression. Nevertheless, promoter methylation of some genes has been implicated as potential marker for HCC. Thirty-four HCC, 34...

journal_title：International journal of cancer

authors： Harder J,Opitz OG,Brabender J,Olschewski M,Blum HE,Nomoto S,Usadel H

更新日期：2008-06-15 00:00:00

abstract：:Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway whose epigenetic downregulation have been shown to be involved in hepatocarcinogenesis. However, dysregulation of SFRPs induced by hepatitis B virus (HBV) X protein (HBx) has never been studied in HBV-related hepatocellular carcino...

journal_title：International journal of cancer

authors： Xie Q,Chen L,Shan X,Shan X,Tang J,Zhou F,Chen Q,Quan H,Nie D,Zhang W,Huang AL,Tang N

更新日期：2014-08-01 00:00:00

abstract：:Eight squirrel monkeys (Saimiri sciureus) challenged with EBV or EBV-transformed SLCL were naturally or experimentally infected with Plasmodium knowlesi or Pl. brasilianum. Most of the animals had been splenectomized and unilaterally nephrectomized. Three of these monkeys received one dose of 6 to 12 X 10(8) autologou...

journal_title：International journal of cancer

authors： Leibold W,Huldt G,Flanagan TD,Andersson M,Dalens M,Wright DH,Voller A,Klein G

更新日期：1976-04-15 00:00:00

abstract：:A family history of stomach cancer in first-degree relatives increases the risk of stomach cancer, but uncertainties remain as concerns the variation of the risk according to age, sex and type of relative, as well as on the role of family history of other cancers. We investigated the issue using data from a multicentr...

journal_title：International journal of cancer

authors： Foschi R,Lucenteforte E,Bosetti C,Bertuccio P,Tavani A,La Vecchia C,Negri E

更新日期：2008-09-15 00:00:00

abstract：:Diet is the primary source of cadmium-a proven Group 1 human carcinogen-for non-smokers. Observational studies investigating the effect of cadmium from food sources on breast cancer risk have produced inconsistent results. We examined the association between dietary cadmium and risk of breast cancer defined by estroge...

journal_title：International journal of cancer

authors： Grioni S,Agnoli C,Krogh V,Pala V,Rinaldi S,Vinceti M,Contiero P,Vescovi L,Malavolti M,Sieri S

更新日期：2019-05-01 00:00:00

abstract：:alpha beta+ TCR T cells recognize peptide fragments displayed by MHC-class I or -class II molecules. Recently, additional mechanisms of antigen recognition by T cells have been identified, including CD1-mediated presentation of nonpeptide antigens. Only a limited number of CD1 antigens is retained in the mouse, i.e., ...

journal_title：International journal of cancer

authors： Fiedler T,Walter W,Reichert TE,Maeurer MJ

更新日期：2002-03-20 00:00:00

abstract：:People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer dia...

journal_title：International journal of cancer

authors： Trickey A,May MT,Gill MJ,Grabar S,Vehreschild J,Wit FWNM,Bonnet F,Cavassini M,Abgrall S,Berenguer J,Wyen C,Reiss P,Grabmeier-Pfistershammer K,Guest JL,Shepherd L,Teira R,d'Arminio Monforte A,Del Amo J,Justice A,Cost

更新日期：2020-06-01 00:00:00

abstract：:Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families...

journal_title：International journal of cancer

authors： Hartley AL,Birch JM,Blair V,Kelsey AM,Morris Jones PH

更新日期：1994-03-01 00:00:00

abstract：:Mouse IFN gamma preparations purified 30-fold were found to have direct cytolytic activity against a number of tumor and normal cells. Cell killing was determined using a sensitive, rapid and accurate assay which employed very low numbers of cells and very small quantities of interferon. The cytolytic activity of IFN ...

journal_title：International journal of cancer

authors： Tyring S,Klimpel GR,Fleischmann WR Jr,Baron S

更新日期：1982-07-15 00:00:00

abstract：:A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or dimethyl sulfoxide (c...

journal_title：International journal of cancer

authors： Cho HY,Arnstein P,Rhim JS

更新日期：1978-01-15 00:00:00

abstract：:In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants repor...

journal_title：International journal of cancer

authors： Sutcliffe S,Giovannucci E,Leitzmann MF,Rimm EB,Stampfer MJ,Willett WC,Platz EA

更新日期：2007-04-01 00:00:00

abstract：:Tamoxifen is an important selective estrogen receptor (ER) modulator for treatment of steroid hormone positive breast cancer. In addition to the beneficial effect, tamoxifen is one risk factor for endometrial carcinoma (EnCa) development. We hypothesized that, (1) dysregulation of gene expression and protein phosphory...

journal_title：International journal of cancer

authors： Strissel PL,Ellmann S,Loprich E,Thiel F,Fasching PA,Stiegler E,Hartmann A,Beckmann MW,Strick R

更新日期：2008-12-15 00:00:00

abstract：:We used oligonucleotide microarrays to investigate gene expression changes associated with multi-step human papillomavirus type 16 (HPV16)-mediated carcinogenesis in vitro. Gene expression profiles in 4 early passage HPV16-immortalized human keratinocyte (HKc) lines derived from different donors were compared with the...

journal_title：International journal of cancer

authors： Wan F,Miao X,Quraishi I,Kennedy V,Creek KE,Pirisi L

更新日期：2008-07-01 00:00:00

abstract：:A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...

journal_title：International journal of cancer

authors： Sun X,Nair J,Linseisen J,Owen RW,Bartsch H

更新日期：2012-11-01 00:00:00

abstract：:Macrophages were isolated from 22 human ascitic ovarian epithelial tumors and their growth-inhibitory capacity was tested using as targets the following in vitro tumor cell lines: murine TLX9 lymphoma and FS6 sarcoma; human myeloid K562 leukemia and human E cell line derived from an ovarian carcinoma. Macrophage prepa...

journal_title：International journal of cancer

authors： Mantovani A,Peri G,Polentarutti N,Bolis G,Mangioni C,Spreafico F

更新日期：1979-02-01 00:00:00

abstract：:Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU homeobox genes in human breast cancer cell lines and human breast ti...

journal_title：International journal of cancer

authors： Jin T,Branch DR,Zhang X,Qi S,Youngson B,Goss PE

更新日期：1999-03-31 00:00:00

abstract：:Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...

journal_title：International journal of cancer

authors： Cornall AM,Roberts JM,Garland SM,Hillman RJ,Grulich AE,Tabrizi SN

更新日期：2013-11-01 00:00:00

abstract：:The human MUC1 gene expresses at least 2 type 1 membrane proteins: MUC1/REP, a polymorphic high m.w. MUC1 glycoprotein often highly expressed in breast cancer tissues and containing a variable number of tandem 20 amino acid repeat units, and the MUC1/Y protein, which lacks this repeat array and, therefore, is not poly...

journal_title：International journal of cancer

authors： Baruch A,Hartmann M,Zrihan-Licht S,Greenstein S,Burstein M,Keydar I,Weiss M,Smorodinsky N,Wreschner DH

更新日期：1997-05-29 00:00:00