Characteristics of membrane and cytosol forms of the mammary tumor glycoprotein molecule MTGP in human breast carcinoma cell cultures and tumors.


:The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set MTGP, a trace and apparently tumor-specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both cytosol and membrane-associated forms of MTGP were analyzed, and each was phenotyped by reference to isoelectric point and buoyant density. All cells or tissues of mammary carcinoma origin contained membrane MTGP, whereas cytosol MTGP was undetectable in cell cultures from half of the mammary carcinomas. Neither membrane nor cytosol MTGP were detectable in cells other than mammary carcinomas. Cytosol MTGP could be assigned to three groups by reference to presence, isoelectric point and buoyant density. Membrane MTGP also exhibited heterogeneity between different tumors and could be assigned to three groups by isoelectric point and buoyant density. Each form of MTGP was homogeneous for a given single tumor or cell culture and retained its phenotypic features with passage and cloning. Four general types of MTGP are proposed, through there may be additional fine heterogeneity that cannot be further resolved at this time. These data provide an initial characterization of the membrane form of MTGP and an integrated characterization that is consistent with the concept that tumor-specific antigens may possess both constant regions by reference to antigens recognized by the antisera and variable structure by reference to physicochemical characteristics.


Int J Cancer


Leung JP,Nelson-Rees WA,Moore GE,Cailleau R,Edgington TS




Has Abstract


1981-07-15 00:00:00












  • Modulation of intra-epithelial expansion of human T24 bladder-carcinoma cells in murine urothelium by growth factors and extracellular-matrix components.

    abstract::The high recurrence rate of bladder cancer is probably due to an efficient repopulation of the bladder by residual transformed cells after resection of the tumour. However, the regenerating capacity of the normal urothelial cells is very high. To study the balance between regenerating normal urothelium and out-growth ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rebel JM,Thijssen CD,Vermey M,Zwarthoff EC,Van der Kwast TH

    更新日期:1995-03-03 00:00:00

  • Novel function of Oncostatin M as a potent tumour-promoting agent in lung.

    abstract::Oncostatin M is a leukocyte product that has been reported to have anti-proliferative effects directly on melanoma and other cancer cell lines in vitro. However, its function(s) in cancers in vivo appears complex and its roles in cancer growth in lungs are unknown. Here, we show that OSM promotes marked growth of tumo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lauber S,Wong S,Cutz JC,Tanaka M,Barra N,Lhoták S,Ashkar A,Richards CD

    更新日期:2015-02-15 00:00:00

  • Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.

    abstract::ARID1A has been identified as a novel tumor suppressor gene in ovarian cancer and subsequently in various other tumor types. ARID1A belongs to the ARID domain containing gene family, which comprises of 15 genes involved, for example, in transcriptional regulation, proliferation and chromatin remodeling. In this study,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cajuso T,Hänninen UA,Kondelin J,Gylfe AE,Tanskanen T,Katainen R,Pitkänen E,Ristolainen H,Kaasinen E,Taipale M,Taipale J,Böhm J,Renkonen-Sinisalo L,Mecklin JP,Järvinen H,Tuupanen S,Kilpivaara O,Vahteristo P

    更新日期:2014-08-01 00:00:00

  • Family history of cancer and stomach cancer risk.

    abstract::A family history of stomach cancer in first-degree relatives increases the risk of stomach cancer, but uncertainties remain as concerns the variation of the risk according to age, sex and type of relative, as well as on the role of family history of other cancers. We investigated the issue using data from a multicentr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Foschi R,Lucenteforte E,Bosetti C,Bertuccio P,Tavani A,La Vecchia C,Negri E

    更新日期:2008-09-15 00:00:00

  • Effect of different platelet agonists on intracellular free Ca++ concentrations in human tumor cells: possible role in tumor growth.

    abstract::Modulation of cytoplasmic Ca++ concentration is a mechanism common to signal transduction pathways regulating many cellular phenomena, including the interactions of tumors with the hemostatic system. We have investigated the pro-aggregating and pro-coagulant activities of human tumor cell lines cultured in vitro and t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saporiti A,Brocchieri A,Porta C,Moroni M,Grignani G

    更新日期:1995-07-28 00:00:00

  • The use of hybridoma cells as a murine model to study tumor immunity.

    abstract::The secretion of antibody by hybridoma cells allows the growth of individual cells to be measured by a hemolytic plaque assay. Similarly, plaque reduction assays were sensitive indicators of tumor immunity. A series of strains of hybridoma have been isolated from an original isolate which is sensitive to cytotoxic T c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ezaki T,Marbrook J

    更新日期:1985-01-15 00:00:00

  • FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.

    abstract::FTY720, a derivative of fungus, has demonstrated dramatic anticancer effect in several malignancies recently. Our study evaluates the therapeutic potential of FTY720 in the treatment of androgen-independent prostate cancer using a human prostate cancer xenograft in nude mice. CWR22R, an androgen-independent human pros...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chua CW,Lee DT,Ling MT,Zhou C,Man K,Ho J,Chan FL,Wang X,Wong YC

    更新日期:2005-12-20 00:00:00

  • Inverse regulation of neuronal cellular adhesion molecule (NCAM) by IFN-gamma in melanoma cell cultures established from CNS lesions.

    abstract::In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

    更新日期:1999-09-24 00:00:00

  • Acceleration of invasive activity via matrix metalloproteinases by transfection of the estrogen receptor-alpha gene in endometrial carcinoma cells.

    abstract::It is well known that the functions of reproductive organs are regulated by sex steroids and their receptors and it is hypothesized that the progression of neoplasms that originate from the reproductive organs is influenced by them. However, the correlation between sex steroids and tumor progression, especially tumor ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mizumoto H,Saito T,Ashihara K,Nishimura M,Tanaka R,Kudo R

    更新日期:2002-08-01 00:00:00

  • Alterations in c-myc expression in relation to maturational status of human colon carcinoma cells.

    abstract::Previous work from this laboratory established a large bank of human colon carcinoma cell lines in culture and classified them with respect to growth regulatory phenotypes based on several biological and biochemical characteristics. In the present report, Northern analysis indicates that addition of the maturational a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mulder KM,Brattain MG

    更新日期:1988-07-15 00:00:00

  • Potentiation of the anti-tumor effect of actinomycin D by tumor necrosis factor alpha in mice: correlation between in vitro and in vivo results.

    abstract::The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lasek W,Giermasz A,Kuc K,Wańkowicz A,Feleszko W,Gołab J,Zagozdzon R,Stokłosa T,Jakóbisiak M

    更新日期:1996-05-03 00:00:00

  • Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer.

    abstract::MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycyti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Watanabe K,Emoto N,Hamano E,Sunohara M,Kawakami M,Kage H,Kitano K,Nakajima J,Goto A,Fukayama M,Nagase T,Yatomi Y,Ohishi N,Takai D

    更新日期:2012-06-01 00:00:00

  • Inhibition of stromal matrix metalloproteases: effects on breast-tumor promotion by fibroblasts.

    abstract::Co-injection of fibroblasts with human epithelial breast-tumor MCF7 cells in the presence of Matrigel enhances tumor growth in nude mice. While most of the matrix metalloproteinases (MMPs) have been shown to be produced by stromal cells, tumor cells such as MCF7 cells are unable to produce MMPs. We therefore, hypothes...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Noël A,Hajitou A,L'Hoir C,Maquoi E,Baramova E,Lewalle JM,Remacle A,Kebers F,Brown P,Calberg-Bacq CM,Foidart JM

    更新日期:1998-04-13 00:00:00

  • Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer.

    abstract::In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Song IS,Ha GH,Kim JM,Jeong SY,Lee HC,Kim YS,Kim YJ,Kwon TK,Kim NS

    更新日期:2011-11-01 00:00:00

  • STLV-I antibodies in feral populations of East African vervet monkeys (Cercopithecus aethiops).

    abstract::Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, from 114 monkeys in central Ethiopia in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dracopoli NC,Turner TR,Else JG,Jolly CJ,Anthony R,Gallo RC,Saxinger WC

    更新日期:1986-10-15 00:00:00

  • The molecular rationale of Src inhibition in colorectal carcinomas.

    abstract::Src has been one of the most studied proto-oncogenes. The cellular Src (c-Src) holds a critical role in several human malignancies and has emerged as a key factor that promotes tumor progression during the multistep process of colorectal cancer (CRC) pathogenesis. The robust activation of Src in CRC of aggressive phen...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Gargalionis AN,Karamouzis MV,Papavassiliou AG

    更新日期:2014-05-01 00:00:00

  • Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis.

    abstract::To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Can...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saberi Hosnijeh F,Casabonne D,Nieters A,Solans M,Naudin S,Ferrari P,Mckay JD,Benavente Y,Weiderpass E,Freisling H,Severi G,Boutron Ruault MC,Besson C,Agnoli C,Masala G,Sacerdote C,Tumino R,Huerta JM,Amiano P,Rodrigu

    更新日期:2020-10-31 00:00:00

  • Dynamic analysis of circulating tumor DNA to predict prognosis and monitor therapeutic response in metastatic relapsed cervical cancer.

    abstract::Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tian X,Ge D,Zhang F,Zhang B,Bai W,Xu X,Li Z,Cao Y,Li P,Zou K,Zou L

    更新日期:2021-02-15 00:00:00

  • Morphological and microbiological signs of endogenous C-virus in human oocytes.

    abstract::Human oocytes in different stages of maturation were obtained by follicular aspiration from women given Clomovid and Gonadex. Particles similar to type-C virus were observed in three out of 16 oocytes. The particles were irregularly distributed along the oocyte membrane. They were seen both in a state of budding and l...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Larsson E,Nilsson BO,Sundström P,Widéhn S

    更新日期:1981-11-15 00:00:00

  • Tumor progression in human malignant melanoma is associated with changes in alpha 6/beta 1 laminin receptor.

    abstract::Cells of the melanocytic lineage have been shown to be capable of producing laminin and to lose this property during transformation. In the present study, we have evaluated immunohistochemically whether these changes are paralleled by an altered expression of the alpha 6/beta 1 laminin receptor. Results of this analys...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Natali PG,Nicotra MR,Cavaliere R,Giannarelli D,Bigotti A

    更新日期:1991-09-09 00:00:00

  • Non-Hodgkin's lymphoma and farming: an expanded case-control study.

    abstract::A previously published case-control study of agricultural risk factors involved male cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases (ICD). This study has been expanded with the inclusion of cases registered under ICD code 200, and additional controls. The expa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pearce NE,Sheppard RA,Smith AH,Teague CA

    更新日期:1987-02-15 00:00:00

  • Postmenopausal hormone replacement therapy and colorectal cancer risk by molecular subtypes and pathways.

    abstract::Postmenopausal hormone replacement therapy (HRT) was found to be associated with lower risk of colorectal cancer (CRC). However, little is known regarding associations with molecular subtypes of CRC. The current study includes female participants of a large German population-based case-control study (922 CRC cases and...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Amitay EL,Carr PR,Jansen L,Alwers E,Roth W,Herpel E,Kloor M,Bläker H,Chang-Claude J,Brenner H,Hoffmeister M

    更新日期:2020-08-15 00:00:00

  • PITX2: a promising predictive biomarker of patients' prognosis and chemoradioresistance in esophageal squamous cell carcinoma.

    abstract::The paired-like homeodomain transcription factor 2 (PITX2), a downstream effector of wnt/β-catenin signaling, is well known to play critical role during normal embryonic development. However, the possible involvement of PITX2 in human tumorigenesis remains unclear. In this study, we extend its function in human esopha...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhang JX,Tong ZT,Yang L,Wang F,Chai HP,Zhang F,Xie MR,Zhang AL,Wu LM,Hong H,Yin L,Wang H,Wang HY,Zhao Y

    更新日期:2013-06-01 00:00:00

  • Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma.

    abstract::Stem cell-like cells have recently been identified in melanoma cell lines, but their relevance for melanoma pathogenesis is controversial. To characterize the stem cell signature of melanoma, expression of stem cell markers BMI-1 and nestin was studied in 64 cutaneous melanomas, 165 melanoma metastases as well as 53 m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mihic-Probst D,Kuster A,Kilgus S,Bode-Lesniewska B,Ingold-Heppner B,Leung C,Storz M,Seifert B,Marino S,Schraml P,Dummer R,Moch H

    更新日期:2007-10-15 00:00:00

  • Presentation of native TROP-2 tumor antigens to human cytotoxic T lymphocytes by engineered antigen-presenting cells.

    abstract::Professional antigen-presenting cells (APC), e.g. dendritic cells, express immuno-proteasome components and process proteins for MHC presentation differently from non-immune cells. Thus, they induce reactivities against sets of peptides that do not overlap with those generated by non-professional APC, i.e., tumor cell...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mangino G,Grazia Capri M,Barnaba V,Alberti S

    更新日期:2002-10-01 00:00:00

  • p16/MTS1 inactivation in ovarian carcinomas: high frequency of reduced protein expression associated with hyper-methylation or mutation in endometrioid and mucinous tumors.

    abstract::Inactivation of the tumor-suppressor gene p16 (MTS1/ CDKN2/INK4a) has been described in various human malignancies. Although p16 deletion has been found in various ovarian tumor cell lines, p16 inactivation by homozygous deletion or mutation has been reported only sporadically in primary ovarian carcinomas. In a compr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Milde-Langosch K,Ocon E,Becker G,Löning T

    更新日期:1998-02-20 00:00:00

  • Adiponectin blocks multiple signaling cascades associated with leptin-induced cell proliferation in Apc Min/+ colon epithelial cells.

    abstract::We previously demonstrated that leptin, an adipose-derived hormone, induces cell proliferation in a model of preneoplastic (IMCE (Apc(Min/+)), but not normal (YAMC (Apc(+/+)), colon epithelial cells by inducing autocrine IL-6 production and trans-IL-6 signaling. Low serum adiponectin is associated with colon, prostate...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fenton JI,Birmingham JM,Hursting SD,Hord NG

    更新日期:2008-06-01 00:00:00

  • The risk of brain tumours in hereditary non-polyposis colorectal cancer (HNPCC).

    abstract::Hereditary non-polyposis colorectal cancer (HNPCC) is known to be associated with several extracolonic cancers, e.g., cancers of the endometrium, stomach, urinary tract, small bowel and ovary. An association between HNPCC and brain tumours has also been reported, although previous risk analysis did not reveal an exces...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vasen HF,Sanders EA,Taal BG,Nagengast FM,Griffioen G,Menko FH,Kleibeuker JH,Houwing-Duistermaat JJ,Meera Khan P

    更新日期:1996-02-08 00:00:00

  • TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics.

    abstract::Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Simão TA,Ribeiro FS,Amorim LM,Albano RM,Andrada-Serpa MJ,Cardoso LE,Mendonça GA,de Moura-Gallo CV

    更新日期:2002-09-01 00:00:00

  • Quality diet indexes and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study.

    abstract::There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Luu HN,Neelakantan N,Geng TT,Wang R,Goh GB,Clemente JC,Jin A,van Dam RM,Jia W,Behari J,Koh WP,Yuan JM

    更新日期:2020-10-31 00:00:00