Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.

abstract：:Improved biomarkers for prostate cancer (PC) risk stratification are urgently needed. Here, we aimed to develop a novel multimarker model for prediction of biochemical recurrence (BCR) after curatively intended radical prostatectomy (RP), based on minimally invasive sampling of blood and urine. We initially measured t...

journal_title：International journal of cancer

authors： Fredsøe J,Rasmussen AKI,Mouritzen P,Borre M,Ørntoft T,Sørensen KD

更新日期：2019-11-01 00:00:00

abstract：:Established cell lines derived from human malignant astrocytomas typically express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could form an autocrine loop. In this study, we screened for the essential components of a PDGF autocrine loop in fresh surgical isolates of human astrocytom...

journal_title：International journal of cancer

authors： Guha A,Dashner K,Black PM,Wagner JA,Stiles CD

更新日期：1995-01-17 00:00:00

abstract：:Markers of exposure to polycyclic aromatic hydrocarbons (urinary 1-hydroxypyrene-glucuronide) and aromatic amines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 nonsmokers. DNA adducts were determined by P32-postlabeling in the exfoliated bladder cells...

journal_title：International journal of cancer

authors： Vineis P,Talaska G,Malaveille C,Bartsch H,Martone T,Sithisarankul P,Strickland P

更新日期：1996-01-26 00:00:00

abstract：:In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are li...

journal_title：International journal of cancer

authors： Reduzzi C,Vismara M,Silvestri M,Celio L,Niger M,Peverelli G,De Braud F,Daidone MG,Cappelletti V

更新日期：2020-06-15 00:00:00

abstract：:Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mice, which had not received any ...

journal_title：International journal of cancer

authors： Oesch F,Bentley P,Glatt HR

更新日期：1976-10-15 00:00:00

abstract：:The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-...

journal_title：International journal of cancer

authors： Peluso G,Marchese M,Furgi A,Ranieri M,Russo Spena S,Ravagnan G,Fuggetta MP,Porta R,Metafora V,Metafora S

更新日期：1997-07-17 00:00:00

abstract：:Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...

journal_title：International journal of cancer

authors： Zariwala M,Schmid S,Pfaltz M,Ohgaki H,Kleihues P,Schäfer R

更新日期：1994-03-15 00:00:00

abstract：:The influence of viremia on hepatic injury in patients infected with hepatitis C virus was examined by analysis of the relationship between alanine aminotransferase activity and the amount of hepatitis C virus RNA in sequential serum samples from I untreated patient with acute hepatitis C and 3 untreated patients with...

journal_title：International journal of cancer

authors： Gunji T,Kato N,Mori S,Ootsuyama Y,Hijikata M,Imawari M,Shimotohno K

更新日期：1992-11-11 00:00:00

abstract：:In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down-regulation of Bcl-X(L) expression and apoptosis, whereas recurrence...

journal_title：International journal of cancer

authors： Brotin E,Meryet-Figuière M,Simonin K,Duval RE,Villedieu M,Leroy-Dudal J,Saison-Behmoaras E,Gauduchon P,Denoyelle C,Poulain L

更新日期：2010-02-15 00:00:00

abstract：:In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93-01, 2001 and UK-IMPORT databases,...

journal_title：International journal of cancer

authors： van der Beek JN,Hol JA,Coulomb-l'Hermine A,Graf N,van Tinteren H,Pritchard-Jones K,Houwing ME,de Krijger RR,Vujanic GM,Dzhuma K,Schenk JP,Littooij AS,Ramírez-Villar GL,Murphy D,Ray S,Al-Saadi R,Gessler M,Godzinski J,R

更新日期：2021-01-18 00:00:00

abstract：:Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...

journal_title：International journal of cancer

authors： Mancuso P,Martin-Padura I,Calleri A,Marighetti P,Quarna J,Rabascio C,Braidotti P,Bertolini F

更新日期：2011-09-15 00:00:00

abstract：:The presented results show the effect of targeting of collagen receptor, alpha1beta1 integrin expressed on the endothelial cells on the development of experimental melanoma and pathological angiogenesis. Obtustatin, a snake venom KTS-disintegrin, was applied as a specific inhibitor of this integrin. This low molecular...

journal_title：International journal of cancer

authors： Brown MC,Staniszewska I,Del Valle L,Tuszynski GP,Marcinkiewicz C

更新日期：2008-11-01 00:00:00

abstract：:A cytogenetic study, including prophase-prometaphase chromosome analysis, of a patient with EBV-genome-negative acute lymphocytic leukemia of B-cell type with Burkitt-type cells is presented. All bone-marrow mitoses examined had a 14q+ marker chromosome which was identified as a reciprocal 8;14 translocation of exactl...

journal_title：International journal of cancer

authors： Mitelman F,Andersson-Anvret M,Brandt L,Catovsky D,Klein G,Manolov G,Manolova Y,Mark-Vendel E,Nilsson PG

更新日期：1979-07-15 00:00:00

abstract：:The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the "molecular switch" model, postulates that CIN3 can evolve directly from ...

journal_title：International journal of cancer

authors： Nedjai B,Reuter C,Ahmad A,Banwait R,Warman R,Carton J,Boer S,Cuzick J,Lorincz AT

更新日期：2018-10-01 00:00:00

abstract：:The numbers of new cancer cases in 16 common sites occurring in 1980 have been estimated for 24 areas of the world for which the United Nations produces population estimates. For the world as a whole, the total number of new cases was 6.35 million, almost exactly evenly divided between the developed and developing cou...

journal_title：International journal of cancer

authors： Parkin DM,Läärä E,Muir CS

更新日期：1988-02-15 00:00:00

abstract：:Cell lines established from T-cell leukemias have recently been reported to exhibit a chromosome translocation t(8;14) involving proto-oncogene c-myc and the gene of the T-cell receptor alpha-chain(TcR-alpha). In this work, we have studied a case of T-cell leukemia presenting a t(8;14)(q24;q11) translocation that was ...

journal_title：International journal of cancer

authors： Mathieu-Mahul D,Sigaux F,Zhu C,Bernheim A,Mauchauffe M,Daniel MT,Berger R,Larsen CJ

更新日期：1986-12-15 00:00:00

abstract：:We have separated subpopulations of macrophages from an immunogenic fibrosarcoma by the technique of unit gravity velocity sedimentation. The activation state of these subpopulations was determined by measurement of the Fc receptor avidity of adherent cells, and by their 5' nucleotidase and acid phosphatase activity. ...

journal_title：International journal of cancer

authors： Moore K,McBride WH

更新日期：1980-11-15 00:00:00

abstract：:Human papillomavirus (HPV) has been identified as a causative agent of cervical cancer and oropharyngeal cancer (OPC). Intriguingly, estrogen and HPV were shown to play synergistic roles in cervical carcinogenesis. We recently demonstrated that the apolipoprotein B mRNA-editing catalytic polypeptide 3 (APOBEC3, A3) fa...

journal_title：International journal of cancer

authors： Kano M,Kondo S,Wakisaka N,Wakae K,Aga M,Moriyama-Kita M,Ishikawa K,Ueno T,Nakanishi Y,Hatano M,Endo K,Sugimoto H,Kitamura K,Muramatsu M,Yoshizaki T

更新日期：2019-09-15 00:00:00

abstract：:Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...

journal_title：International journal of cancer

authors： Busson P,Zhang Q,Guillon JM,Gregory CD,Young LS,Clausse B,Lipinski M,Rickinson AB,Tursz T

更新日期：1992-04-01 00:00:00

abstract：:To investigate the relationship between p16 methylation and Helicobacter pylori infection in precancerous gastric lesions, a population-based study was conducted in Linqu County, a high-risk area of gastric cancer in China. Methylation status of p16 was evaluated by methylation-specific polymerase chain reaction in 92...

journal_title：International journal of cancer

authors： Dong CX,Deng DJ,Pan KF,Zhang L,Zhang Y,Zhou J,You WC

更新日期：2009-01-15 00:00:00

abstract：:A cyclin-dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p...

journal_title：International journal of cancer

authors： Shima K,Nosho K,Baba Y,Cantor M,Meyerhardt JA,Giovannucci EL,Fuchs CS,Ogino S

更新日期：2011-03-01 00:00:00

abstract：:Human T-lymphotropic virus type I (HTLV-I) carriers often have abnormal lymphocytes (Ably) that resemble malignant cells of adult T-cell leukemia (ATL). To identify predictors of the level of Ably in a longitudinal study of asymptomatic HTLV-I carriers, we analyzed data from 215 subjects (67 men and 148 women) with mu...

journal_title：International journal of cancer

authors： Hisada M,Okayama A,Tachibana N,Stuver SO,Spiegelman DL,Tsubouchi H,Mueller NE

更新日期：1998-07-17 00:00:00

abstract：:Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal uroth...

journal_title：International journal of cancer

authors： Cindolo L,Benvenuto G,Salvatore P,Pero R,Salvatore G,Mirone V,Prezioso D,Altieri V,Bruni CB,Chiariotti L

更新日期：1999-02-19 00:00:00

abstract：:The purpose of our study was to develop specific, sensitive, objective assays for early detection of disseminated tumour cells in patients with colorectal cancer (CRC). Carcinoembryonic antigen (CEA) and cytokeratin 20 (CK20) were chosen as markers because they are selectively expressed in epithelial cells with mainta...

journal_title：International journal of cancer

authors： Oberg AN,Lindmark GE,Israelsson AC,Hammarström SG,Hammarström ML

更新日期：2004-08-10 00:00:00

abstract：:Identification of loss of heterozygosity on specific genetic loci is crucial for understanding the pathogenesis of prostate cancer at the molecular level. This is especially important because the deleted regions may contain putative tumor suppressor genes. Chromosome 3p loss appears to be frequently associated with va...

journal_title：International journal of cancer

authors： Dahiya R,McCarville J,Hu W,Lee C,Chui RM,Kaur G,Deng G

更新日期：1997-03-28 00:00:00

abstract：:Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...

journal_title：International journal of cancer

authors： Franceschi S,Levi F,Randimbison L,La Vecchia C

更新日期：1996-07-03 00:00:00

abstract：:Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated in nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with renal tumorigenesis. In this study...

journal_title：International journal of cancer

authors： Béraud C,Dormoy V,Danilin S,Lindner V,Béthry A,Hochane M,Coquard C,Barthelmebs M,Jacqmin D,Lang H,Massfelder T

更新日期：2015-10-01 00:00:00

abstract：:Desmoids represent the most important cause of death, after colorectal cancer, in patients affected with familial adenomatous polyposis (FAP), an inherited disease due to mutations in the APC gene. The aims of our study were to estimate the risk of developing desmoids in FAP patients and to evaluate the association be...

journal_title：International journal of cancer

authors： Bertario L,Russo A,Sala P,Eboli M,Giarola M,D'amico F,Gismondi V,Varesco L,Pierotti MA,Radice P,Hereditary Colorectal Tumours Registry.

更新日期：2001-03-20 00:00:00

abstract：:The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...

journal_title：International journal of cancer

authors： Werkmeister J,Phillips G,McCarthy W,Hersey P

更新日期：1981-07-15 00:00:00

abstract：:Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo biolumines...

journal_title：International journal of cancer

authors： Perez C,Jukica A,Listopad JJ,Anders K,Kühl AA,Loddenkemper C,Blankenstein T,Charo J

更新日期：2015-07-15 00:00:00