Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.


:Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras expressed in the airway epithelium (CcspCre/+ ; KrasLSL-G12D/+ ) were raised on diets compounded with myo-inositol. These animals form lung premalignant lesions in a stereotypical fashion over the ten weeks following weaning. Mice raised on myo-inositol containing diets showed potent reduction in the number, size, and stage of lesions as compared to those raised on control diets. myo-inositol has previously been reported to inhibit phosphoinositide 3-kinase (PI3K) signaling. However, in mice raised on myo-inositol, total PI3K signaling was largely unaffected. Proteomic and cytokine analyses revealed large reduction in IL-6 related pathways, including STAT3 phosphorylation. This effect was not due to direct inhibition of IL-6 production and autocrine signaling within the tumor cell, but rather through alteration in macrophage recruitment and in phenotype switching, with an increase in antitumoral M1 macrophages.


Int J Cancer


Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ




Has Abstract


2018-04-01 00:00:00












  • Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells.

    abstract::Hormone refractory prostate cancer poses a huge problem and standard of care chemotherapy has not been very successful. We used a novel strategy to combine properties of 2 well-studied class of compounds (selenium and COX-2 inhibitor) and examined the resulting effectiveness against prostate cancer. Bearing in mind th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Desai D,Sinha I,Null K,Wolter W,Suckow MA,King T,Amin S,Sinha R

    更新日期:2010-07-01 00:00:00

  • Quantitative evaluation of oxidative stress, chronic inflammatory indices and leptin in cancer patients: correlation with stage and performance status.

    abstract::In advanced cancer patients, the oxidative stress could take place either at the onset of disease or as a function of disease progression. To test this hypothesis, the following parameters were investigated: the erythrocyte activity of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), the serum ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mantovani G,Macciò A,Madeddu C,Mura L,Gramignano G,Lusso MR,Mulas C,Mudu MC,Murgia V,Camboni P,Massa E,Ferreli L,Contu P,Rinaldi A,Sanjust E,Atzei D,Elsener B

    更新日期:2002-03-01 00:00:00

  • Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development.

    abstract::Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fleuren ED,O'Toole S,Millar EK,McNeil C,Lopez-Knowles E,Boulghourjian A,Croucher DR,Schramek D,Brummer T,Penninger JM,Sutherland RL,Daly RJ

    更新日期:2010-09-01 00:00:00

  • Thyroid-associated genetic polymorphisms in relation to breast cancer risk in the Malmö Diet and Cancer Study.

    abstract::Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brandt J,Borgquist S,Almgren P,Försti A,Huss L,Melander O,Manjer J

    更新日期:2018-04-01 00:00:00

  • Reversal of multi-drug resistance in vitro by fatty acid-PEG-fatty acid diesters.

    abstract::Fatty acid ester surfactants, e.g., Cremophor EL and Solutol HS 15, that modulate multi-drug resistance (MDR) have been described; however, the drug potential of these preparations is unclear because of the molecular heterogeneity of these and other commercial surfactants. In previous experiments, an active but still ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Buckingham LE,Balasubramanian M,Safa AR,Shah H,Komarov P,Emanuele RM,Coon JS

    更新日期:1996-01-03 00:00:00

  • Cause-specific mortality after diagnosis of cancer among HIV-positive patients: A collaborative analysis of cohort studies.

    abstract::People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer dia...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Trickey A,May MT,Gill MJ,Grabar S,Vehreschild J,Wit FWNM,Bonnet F,Cavassini M,Abgrall S,Berenguer J,Wyen C,Reiss P,Grabmeier-Pfistershammer K,Guest JL,Shepherd L,Teira R,d'Arminio Monforte A,Del Amo J,Justice A,Cost

    更新日期:2020-06-01 00:00:00

  • Use of radiation therapy in posttransplant lymphoproliferative disorder (PTLD) after liver transplantation.

    abstract::Posttransplant lymphoproliferative disorder (PTLD) is a common and life-threatening complication of immunosuppression used to prevent rejection of solid organ and bone marrow transplants. There is no standardized treatment algorithm, but numerous management strategies are available. We describe a patient who developed...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Koffman BH,Kennedy AS,Heyman M,Colonna J,Howell C

    更新日期:2000-04-20 00:00:00

  • Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study.

    abstract::Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case-control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case-c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kühn T,Kaaks R,Becker S,Eomois PP,Clavel-Chapelon F,Kvaskoff M,Dossus L,Tjønneland A,Olsen A,Overvad K,Chang-Claude J,Lukanova A,Buijsse B,Boeing H,Trichopoulou A,Lagiou P,Bamia C,Masala G,Krogh V,Sacerdote C,Tumi

    更新日期:2013-10-01 00:00:00

  • Analysis of T-cell-receptor beta-chain-gene usage in peripheral-blood and tumor-infiltrating lymphocytes from human non-small-cell lung carcinomas.

    abstract::Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure of the TCRbeta chain...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Echchakir H,Asselin-Paturel C,Dorothee G,Vergnon I,Grunenwald D,Chouaib S,Mami-Chouaib F

    更新日期:1999-04-12 00:00:00

  • Asthma and risk of lethal prostate cancer in the Health Professionals Follow-Up Study.

    abstract::Inflammation, and more generally, the immune response are thought to influence the development of prostate cancer. To determine the components of the immune response that are potentially contributory, we prospectively evaluated the association of immune-mediated conditions, asthma and hayfever, with lethal prostate ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Platz EA,Drake CG,Wilson KM,Sutcliffe S,Kenfield SA,Mucci LA,Stampfer MJ,Willett WC,Camargo CA Jr,Giovannucci E

    更新日期:2015-08-15 00:00:00

  • Idiotypic protein-pulsed dendritic cell vaccination in multiple myeloma.

    abstract::Idiotypic protein (Id) produced by myeloma cells is clone-specific and may be a suitable tumor-specific antigen for immune targeting. Advances in dendritic cell (DC) technology suggest the opportunity for using this potent antigen presentation system to deliver myeloma Id to the autologous host to elicit anti-tumor im...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Lim SH,Bailey-Wood R

    更新日期:1999-10-08 00:00:00

  • Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas.

    abstract::The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer. MicroRNAs are involved in crucial biological processes like carcinogenesis by regulating gen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bjaanaes MM,Halvorsen AR,Solberg S,Jørgensen L,Dragani TA,Galvan A,Colombo F,Anderlini M,Pastorino U,Kure E,Børresen-Dale AL,Brustugun OT,Helland A

    更新日期:2014-10-15 00:00:00

  • Suppressor cell activity in melanoma patients. II. Concanavalin A-induced suppressor cells in relation to tumor growth and suppressor T-cell subsets.

    abstract::The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Werkmeister J,Phillips G,McCarthy W,Hersey P

    更新日期:1981-07-15 00:00:00

  • Potentiation of the anti-tumor effect of actinomycin D by tumor necrosis factor alpha in mice: correlation between in vitro and in vivo results.

    abstract::The anti-tumor effects of actinomycin D (Act D) and recombinant human tumor necrosis factor (TNF)-alpha have been studied on 4 established murine tumor cell lines: MmB16 melanoma, Lewis lung (LL/2) carcinoma, L1 sarcoma and L1210 leukemia. During short-term incubation (24 hr) Act D produced dose-dependent cytostatic/c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lasek W,Giermasz A,Kuc K,Wańkowicz A,Feleszko W,Gołab J,Zagozdzon R,Stokłosa T,Jakóbisiak M

    更新日期:1996-05-03 00:00:00

  • Changes in tumor-specific antigen expression during passage in vitro and in vivo of newly derived methylcholanthrene-induced sarcomas of BALB/C mice.

    abstract::The characteristics of tumor antigens of the transplantation type, TATA, were studied in a series of methylcholanthrene-induced sarcomas in pedigreed BALB/cAN mice. Each of the six sarcomas exhibited unique TATA when assayed for tumor rejection in syngeneic hosts. In three instances, however, in sarcomas CI-I, CII-5 a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Law LW

    更新日期:1980-02-15 00:00:00

  • Nutrients and gastric cancer risk. A population-based case-control study in Sweden.

    abstract::A population-based case-control study of gastric cancer was conducted in areas with contrasting incidence rates in Sweden. Face-to-face interviews were carried out with 338 (74.1%) of all eligible cases and 679 (77.3%) of the selected controls. Consumption of selected nutrients during adolescence and 20 years prior to...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hansson LE,Nyrén O,Bergström R,Wolk A,Lindgren A,Baron J,Adami HO

    更新日期:1994-06-01 00:00:00

  • Temporal trends in the incidence and survival of cancers of the upper aerodigestive tract in Ontario and the United States.

    abstract::The Ontario Cancer Registry (OCR) and the Surveillance, Epidemiology and End Results (SEER) databases were used to describe temporal trends in the incidence and survival of squamous cancers of the upper aerodigestive tract (UADT) in Ontario and the US between 1984 and 2001. Between the 1984-86 and 1999-01 periods, the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gupta S,Kong W,Peng Y,Miao Q,Mackillop WJ

    更新日期:2009-11-01 00:00:00

  • Incidence of childhood cancer in Cuba (1986-1990).

    abstract::Cancer is an infrequent disease in childhood. However, it is responsible for 13.06% of child deaths between 1 and 14 years in Cuba. The aim of our work was to describe the incidence of childhood cancer in the period 1986 to 1990 using data reported to the National Cancer Registry (NCR) of Cuba. All cancer cases betwee...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Martín AA,Alert JA,Renó JS,Lonchong M,Grueiro S

    更新日期:1997-08-07 00:00:00

  • Qualitative and quantitative differences between Burkitt lymphoma and lymphoblastoid cell lines in the expression of membrane ecto-nucleotidases and in the response to agonists of the A2-type adenosine receptor.

    abstract::The activity of ecto-nucleotidases has been determined on intact cells from Burkitt lymphoma (BL) and lymphoblastoid cell lines established in vitro (LCLs). BL cells never express ecto-5'-nucleotidase (5'-N) and exhibit only low levels of ecto-ATPase activity, whereas LCL-cells usually express both enzymes to varying ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gutensohn W,Jahn H

    更新日期:1988-03-15 00:00:00

  • Complement-dependent cytotoxic antibodies in the course of cervical carcinoma.

    abstract::Complement-dependent cytotoxic antibodies to three cervical carcinoma cell lines (Me-180, SW-732 and HeLa) and to Herpes simplex virus type 2 (HSV-2)-infected cells were determined in a long-term study of women with cervical carcinoma. Cytolysis of surface antigens differed significantly between the cervical carcinoma...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Christenson B

    更新日期:1977-11-15 00:00:00

  • Human papillomavirus capsids preferentially bind and infect tumor cells.

    abstract::We previously determined that human papillomavirus (HPV) virus-like particles (VLPs) and pseudovirions (PsV) did not, respectively, bind to or infect intact epithelium of the cervicovaginal tract. However, they strongly bound heparan sulfate proteoglycans (HSPG) on the basement membrane of disrupted epithelium and inf...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kines RC,Cerio RJ,Roberts JN,Thompson CD,de Los Pinos E,Lowy DR,Schiller JT

    更新日期:2016-02-15 00:00:00

  • Quantitative analysis of survivin mRNA expression in urine and tumor tissue of bladder cancer patients and its potential relevance for disease detection and prognosis.

    abstract::Suppression of apoptosis may favor the onset and progression of cancer. Survivin is an inhibitor of apoptosis that has been suggested as a novel diagnostic/prognostic marker of bladder cancer. In this study, survivin mRNA expression was measured by a sensitive real-time PCR assay in tumor tissue and urine from bladder...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weikert S,Christoph F,Schrader M,Krause H,Miller K,Müller M

    更新日期:2005-08-10 00:00:00

  • Childhood cancer incidence in Queensland, 1979-88.

    abstract::Data on the incidence of childhood cancer in Queensland during the 10-year period 1979-88 are presented. During this period, 786 cases were registered. The average annual crude and age-standardized (to the world population) incidence rates for both sexes were 12.63 and 13.30 per 100,000 respectively. The incidence of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McWhirter WR,Petroeschevsky AL

    更新日期:1990-06-15 00:00:00

  • Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α.

    abstract::Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, treatment with the v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kim YJ,Lee HJ,Kim TM,Eisinger-Mathason TS,Zhang AY,Schmidt B,Karl DL,Nakazawa MS,Park PJ,Simon MC,Yoon SS

    更新日期:2013-01-01 00:00:00

  • The 8.1 ancestral MHC haplotype is strongly associated with colorectal cancer risk.

    abstract::Many recent data indicate that some alleles encoded in the central major histocompatibility complex (MHC) region (Class III) of short arm of chromosome 6 may modify the risk of cancer development. Therefore we determined 4 single nucleotide polymorphisms (SNPs) of this region (TNF-alpha -308 G > A, RAGE -429 T > C, HS...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tóth EK,Kocsis J,Madaras B,Bíró A,Pocsai Z,Fust G,Blaskó B,Karádi I,Adány R,Laki J

    更新日期:2007-10-15 00:00:00

  • Relationships among tumor responsiveness, cell sensitivity, doxorubicin cellular pharmacokinetics and drug-induced DNA alterations in two human small-cell lung cancer xenografts.

    abstract::In an attempt to understand the underlying cellular/biochemical factors of sensitivity/resistance in human small-cell lung cancer (SCLC), 2 SCLC tumor lines were compared with respect to tumor responsiveness to drug treatment, cell sensitivity, cellular doxorubicin accumulation, and DNA topoisomerase-II-mediated DNA c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pratesi G,Capranico G,Binaschi M,De Isabella P,Pilotti S,Supino R,Zunino F

    更新日期:1990-10-15 00:00:00

  • Fine-mapping of a region of chromosome 5p15.33 (TERT-CLPTM1L) suggests a novel locus in TERT and a CLPTM1L haplotype are associated with glioma susceptibility in a Chinese population.

    abstract::Two genome-wide association studies (GWAS) have identified 5p15.33 (TERT-CLPTM1L) as one of the susceptible regions for glioma in European background. A replication research of our group highlighted the association signals in the TERT gene of this region in a Chinese Han population. To comprehensively explore the regi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhao Y,Chen G,Zhao Y,Song X,Chen H,Mao Y,Lu D

    更新日期:2012-10-01 00:00:00

  • IGFBP-3 prolongs the p53 response and enhances apoptosis following UV irradiation.

    abstract::Neoplastic transformation is characterised by an imbalance in favour of cell growth over programmed cell death (apoptosis). The tumour-suppressor gene p53, responsible for maintaining cell-cycle control, is mutated in the majority of human cancers. Loss of function of the target genes of p53 are therefore important in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hollowood AD,Lai T,Perks CM,Newcomb PV,Alderson D,Holly JM

    更新日期:2000-11-01 00:00:00

  • Melanoma progression-associated glycoprotein MUC18/MCAM mediates homotypic cell adhesion through interaction with a heterophilic ligand.

    abstract::MUC18/MCAM is a cell-surface glycoprotein that is strongly expressed on advanced human melanomas. Transfection of 3 MCAM-negative melanoma cell lines with MCAM cDNA led to cell-surface expression and to a MCAM-dependent homotypic adhesion. This adhesion was independent of divalent cations and was inhibited at 4 degree...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Johnson JP,Bar-Eli M,Jansen B,Markhof E

    更新日期:1997-11-27 00:00:00

  • Canine testicular tumors: epidemiologic features of 410 dogs.

    abstract::Histologically confirmed testicular tumors were diagnosed in 410 dogs from 12 North American veterinary university hospitals and clinics. Three tumor-cell types, Sertoli cell tumor, interstitial cell tumor and seminoma, were about equally represented. Several breeds were identified with high risk for different testicu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hayes HM Jr,Pendergrass TW

    更新日期:1976-10-15 00:00:00