Abstract:
:The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-cell contact interactions. The expression of HLA DR on Raji cells has a modulatory effect on the SV-IV-induced cytotoxic activity. The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Peluso G,Marchese M,Furgi A,Ranieri M,Russo Spena S,Ravagnan G,Fuggetta MP,Porta R,Metafora V,Metafora Sdoi
10.1002/(sici)1097-0215(19970717)72:2<321::aid-ijcsubject
Has Abstractpub_date
1997-07-17 00:00:00pages
321-8issue
2eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19970717)72:2<321::AID-IJCjournal_volume
72pub_type
杂志文章abstract::In an ongoing case-control study in Athens on the etiology of hepatocellular carcinoma (HCC), an analysis was made in order to assess whether HCV genotype 1b is associated with hepatocellular carcinoma (HCC). The HCV genotype was determined in 17 HCC patients, 87 patients with chronic hepatitis C (CHC) without cirrhos...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960927)68:1<51::AID-IJC1
更新日期:1996-09-27 00:00:00
abstract::Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31152
更新日期:2018-04-01 00:00:00
abstract::There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32091
更新日期:2019-07-01 00:00:00
abstract::Prostate-specific antigen (PSA) has been characterized as a specific prostate marker, although recent studies have suggested the existence of PSA of nonprostatic sources. We have assessed the presence of PSA by an ultrasensitive assay in 276 serum and nonserum samples from women. Our data show the presence of PSA in 9...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19961115)68:4<424::AID-IJC
更新日期:1996-11-15 00:00:00
abstract::Fischer rat thyroid epithelial cella (FRT) growing continuously in culture were infected with the Kirsten murine sarcoma virus KiMSV(KiMuLV) and found to produce this virus constitutively. Although the morphology of the FRT cells did not change appreciably, the cells became malignant after infection with KiMSV(KiMuLV)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280519
更新日期:1981-11-15 00:00:00
abstract::Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the treatment of metastatic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26120
更新日期:2011-10-01 00:00:00
abstract::A 42-kDa recombinant protein, PX141, consisting of the trans-activator protein encoded by human T-cell leukemia virus (HTLV-1) (tax1 antigen) and the amino-terminal fusion peptide of 12 amino acid residues of the alpha-peptide encoded by the plasmid pUC19 was produced. In order to investigate the immunogenicity of the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480423
更新日期:1991-06-19 00:00:00
abstract::We have established 3 new EBV-negative cell lines, designated Sc-1, Ri-1 and Ci-1, from patients with B-cell lymphoma/leukemia. We characterized them by cytogenetics and by study of surface membrane antigens with a panel of monoclonal antibodies (MAbs), surface and cytoplasmic immunoglobulin (Ig) expression and Ig hea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390116
更新日期:1987-01-15 00:00:00
abstract::The Hong Kong Chinese population has an unusually high incidence of colorectal cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 yea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000720)89:4<356::aid-ijc7>3.0.
更新日期:2000-07-20 00:00:00
abstract::The expression of two discrete cell properties related to the host natural effector mechanisms, i.e., resistance to damage by H2O2, a cytotoxic product of activated macrophages, and the ability to secrete PGE, which inhibits NK-cell cytotoxicity, has been examined in parental Syrian hamster embryo cells spontaneously ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440526
更新日期:1989-11-15 00:00:00
abstract::Our group has conducted two previous studies on the association between vitamin D binding protein (DBP) and renal cell carcinoma (RCC), the most common form of kidney cancer, finding strong inverse associations. We undertook the current analysis to replicate our findings in a different study population that included w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32758
更新日期:2020-08-01 00:00:00
abstract::Breast cancer screening is known to reduce breast cancer mortality. A high breast density may affect this reduction. We assessed the effect of screening on breast cancer mortality in women with dense and fatty breasts separately. Analyses were performed within the Nijmegen (Dutch) screening programme (1975-2008), whic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30430
更新日期:2017-01-01 00:00:00
abstract::Human malignant mesothelioma (HMM) is resistant to many anticancer drugs, including doxorubicin. Mevastatin and simvastatin, 2 inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase, potentiated the intracellular accumulation and the cytotoxicity of doxorubicin in HMM cells constitutively expressing P-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21832
更新日期:2006-07-01 00:00:00
abstract::HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathoge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10240
更新日期:2002-04-10 00:00:00
abstract::The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n-3 and n-6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three US prospective cohorts ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33190
更新日期:2021-01-01 00:00:00
abstract::Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31974
更新日期:2019-05-01 00:00:00
abstract::The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer. MicroRNAs are involved in crucial biological processes like carcinogenesis by regulating gen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28828
更新日期:2014-10-15 00:00:00
abstract::The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of pri-miR-34b/c (423 bp from the transcription start site), located...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25342
更新日期:2011-01-15 00:00:00
abstract::Lysine-specific demethylase 1 (LSD1), a histone lysine demethylase with the main specificity for H3K4me2, has been shown to be overexpressed in rhabdomyosarcoma (RMS) tumor samples. However, its role in RMS biology is not yet well understood. Here, we identified a new role of LSD1 in regulating adhesion of RMS cells. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32806
更新日期:2020-06-15 00:00:00
abstract::Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33206
更新日期:2021-01-15 00:00:00
abstract::With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarco...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990209)80:4<581::aid-ijc
更新日期:1999-02-09 00:00:00
abstract::We previously reported that DX-8951f, a novel water-soluble camptothecin analog, significantly inhibits the growth of various human and murine tumors in vitro and in vivo. The antitumor effects and topoisomerase I inhibitory activity of DX-8951f are stronger than those of other current camptothecin analogs. In this st...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970807)72:4<680::aid-ijc
更新日期:1997-08-07 00:00:00
abstract::PAX3 encodes a transcription factor, which with Zic1 is necessary for induction of the neural crest during early embryonic development. There are 7 human PAX3 isoforms (a-h). PAX3e is the full length isoform comprising 10 exons. PAX3c comprises 8 exons plus 5 codons of intron 8, while PAX3g has a truncated transactiva...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22316
更新日期:2007-03-15 00:00:00
abstract::Understanding the reasons for nonparticipation in cancer screening may give clues about how to improve compliance. However, limited cooperation has hampered research on nonparticipant profiles. We took advantage of Sweden's comprehensive demographic and health care registers to investigate characteristics of all parti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23208
更新日期:2008-04-01 00:00:00
abstract::We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510516
更新日期:1992-07-09 00:00:00
abstract::We have previously demonstrated that the delta isoform of protein kinase C (PKCdelta) is importantly involved in cell growth inhibition and tumor suppression in colon cancer cells. To investigate further the activity and mechanism of action of PKCdelta, we have retrovirally transduced a PKCdelta cDNA in HCT116 human c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20535
更新日期:2005-01-01 00:00:00
abstract::An antiserum to SF antigen was shown to be selectively cytotoxic to two human fibroblast lines, while two tumor cell lines (one melanoma and one Hela cell line) were resistant. The selective cytotoxicity was also demonstrable in mixtures of fibroblasts and tumor cells. The cytotoxic effect was abrogated by admixture o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180317
更新日期:1976-09-15 00:00:00
abstract::Although the existence of a humoral response against tumor-associated antigens is well appreciated, a systematic analysis of its possible induction by the tumor remains missing. We compared the specific IgG response of Stage IV melanoma patients during vaccination. Patients had been treated within 2 clinical trials wi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11537
更新日期:2004-01-10 00:00:00
abstract::Routine pathological examination cannot distinctively predict the clinical course of meningiomas because even histologically benign tumors may recur after gross total resection. Numerous efforts have been made for the evaluation of different immunohistochemical assays in meningioma prognosis. We investigated the progn...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11013
更新日期:2003-05-10 00:00:00
abstract::The relationship between the biomarker of vitamin D status, 25(OH)D, and the risk for colorectal neoplasia is suggestive but equivocal. Questions remain regarding whether there are differential associations between 25(OH)D and colorectal adenoma by gender, colorectal subsite or features of baseline and recurrent adeno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28316
更新日期:2013-12-15 00:00:00