A prospective study of erythrocyte polyunsaturated fatty acids and risk of colorectal serrated polyps and conventional adenomas.

abstract：:Hereditary non-polyposis colorectal cancer (HNPCC) is known to be associated with several extracolonic cancers, e.g., cancers of the endometrium, stomach, urinary tract, small bowel and ovary. An association between HNPCC and brain tumours has also been reported, although previous risk analysis did not reveal an exces...

journal_title：International journal of cancer

authors： Vasen HF,Sanders EA,Taal BG,Nagengast FM,Griffioen G,Menko FH,Kleibeuker JH,Houwing-Duistermaat JJ,Meera Khan P

更新日期：1996-02-08 00:00:00

abstract：:To test whether alloimmunization with H-2 or/and non-H-2 different normal tissues may increase the immunity to syngeneic tumors, groups of BALB/c (H-2d) mice were immunized with a series of allogeneic lymphoid cells and then challenged i.p. with syngeneic lymphoma cells. The outgrowth of otherwise lethal doses of the ...

journal_title：International journal of cancer

authors： Parmiani G,Sensi ML,Carbone G,Colombo M,Pierotti M,Ballinari D,Hilgers J,Hilkens J

更新日期：1982-03-15 00:00:00

abstract：:Patients with idiopathic pulmonary fibrosis (IPF) have higher risk of developing lung cancer, for example, squamous cell carcinoma (SCC), and show poor prognosis, while the molecular basis has not been fully investigated. Here we conducted DNA methylome analysis of lung SCC using 20 SCC samples with/without IPF, and n...

journal_title：International journal of cancer

authors： Hata A,Nakajima T,Matsusaka K,Fukuyo M,Morimoto J,Yamamoto T,Sakairi Y,Rahmutulla B,Ota S,Wada H,Suzuki H,Matsubara H,Yoshino I,Kaneda A

更新日期：2020-01-15 00:00:00

abstract：:Burkitt's lymphoma cells that vary in their phenotypic characteristics show significantly different degrees of susceptibility to radiation-induced apoptosis. Propensity to undergo apoptosis is reflected in the degradation of substrates such as DNA-dependent protein kinase but the status of bcl-2, c-myc and p53 has bee...

journal_title：International journal of cancer

authors： Zhao EG,Song Q,Cross S,Misko I,Lees-Miller SP,Lavin MF

更新日期：1998-08-31 00:00:00

abstract：:Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glio...

journal_title：International journal of cancer

authors： Tsen AR,Long PM,Driscoll HE,Davies MT,Teasdale BA,Penar PL,Pendlebury WW,Spees JL,Lawler SE,Viapiano MS,Jaworski DM

更新日期：2014-03-15 00:00:00

abstract：:HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key carcinogenic events in several types of tumors, and both are well- validat...

journal_title：International journal of cancer

authors： Soler M,Mancini F,Meca-Cortés O,Sánchez-Cid L,Rubio N,López-Fernández S,Lozano JJ,Blanco J,Fernández PL,Thomson TM

更新日期：2009-12-01 00:00:00

abstract：:Apoptosis protease-activating factor 1 (APAF-1), a transcriptional target of p53, is a cytosolic adaptor protein that links the mitochondrial apoptosis pathway to the caspase cascade. Here, we aimed to study the impact of APAF-1 expression levels on cell death induced by anticancer drugs or ionizing irradiation (IR) a...

journal_title：International journal of cancer

authors： Sturm I,Bosanquet AG,Radetzki S,Hummel M,Dörken B,Daniel PT

更新日期：2006-05-01 00:00:00

abstract：:The hepatitis B virus (HBV) is a major causative agent of chronic liver disease and subsequent liver cirrhosis worldwide. The reduced sensitivity of virus-infected liver cells to apoptosis may play a role in the failure to remove virus-infected cells and eventually promote viral chronicity. The purpose of our study wa...

journal_title：International journal of cancer

authors： Barreiros AP,Sprinzl M,Rosset S,Höhler T,Otto G,Theobald M,Galle PR,Strand D,Strand S

更新日期：2009-01-01 00:00:00

abstract：:T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...

journal_title：International journal of cancer

authors： Kudoh S,Stanley J,Edinger MG,Tubbs RR,Klein E,Bukowski RM,Finke JH

更新日期：1994-08-01 00:00:00

abstract：:Infection by oncogenic human papillomavirus (HPV) is a necessary but not sufficient cause of cervical carcinoma. Several host genetic and viral factors have been reported to increase the risk of carcinoma development given an HPV infection. In our study, we have analysed the contribution of HPV 16 E6 sequence subtype ...

journal_title：International journal of cancer

authors： Beskow AH,Engelmark MT,Magnusson JJ,Gyllensten UB

更新日期：2005-11-20 00:00:00

abstract：:Very recently, BRAF mutations were found in about 2/3 of malignant melanomas and at lower frequencies in other human cancers. The BRAF gene codes for a protein in the mitogen-activated protein kinase (MAPK) pathway. All mutations identified to date are within the kinase domain, with a single missense mutation (V599E) ...

journal_title：International journal of cancer

authors： Meyer P,Klaes R,Schmitt C,Boettger MB,Garbe C

更新日期：2003-08-10 00:00:00

abstract：:Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...

journal_title：International journal of cancer

authors： Simão TA,Ribeiro FS,Amorim LM,Albano RM,Andrada-Serpa MJ,Cardoso LE,Mendonça GA,de Moura-Gallo CV

更新日期：2002-09-01 00:00:00

abstract：:Messenger RNA differential display was used to study liver-gene expression in paired tumor and non-tumor tissues from hepatocellular carcinoma (HCC) patients. mRNA differential display and Northern-blot analyses showed that a 0.8-kb cDNA fragment was diminished or absent from the tumorous tissues of 7 HCC patients. Th...

journal_title：International journal of cancer

authors： Chen YM,Shiu JY,Tzeng SJ,Shih LS,Chen YJ,Lui WY,Chen PH

更新日期：1998-03-02 00:00:00

abstract：:Although thyroid cancer is suspected to have a nutritional etiology, prospective studies examining the relationship between diet and thyroid cancer are lacking. During 1996-1997, NIH-AARP Diet and Health Study participants, ages 51-72 years, completed a 37-item food frequency questionnaire about diet at ages 12-13 yea...

journal_title：International journal of cancer

authors： Braganza MZ,Potischman N,Park Y,Thompson FE,Hollenbeck AR,Kitahara CM

更新日期：2015-11-15 00:00:00

abstract：:In both the rat kidney and lung, inhalation of cigarette smoke diluted with air (1/15) for a limited period of time (15 min) specifically induces aryl hydrocarbon hydroxylase (AHH)2 in less than 4 h. Up to four successive inhalations administered at 2-h intervals activities. The maximal effect corresponds to about 10 ...

journal_title：International journal of cancer

authors： Van Cantfort J,Gielen J

更新日期：1977-04-15 00:00:00

abstract：:The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...

journal_title：International journal of cancer

authors： Bartel F,Meye A,Würl P,Kappler M,Bache M,Lautenschläger C,Grünbaum U,Schmidt H,Taubert H

更新日期：2001-05-20 00:00:00

abstract：:To identify genes associated with radioresistant oral squamous cell carcinoma (OSCC), we compared gene expression signatures between OSCC cell lines exhibiting radioresistance and cells with radiosensitivity after X-ray irradiation in a dose-dependent manner using Affymetrix GeneChip analysis with Human Genome-U133 pl...

journal_title：International journal of cancer

authors： Ishigami T,Uzawa K,Higo M,Nomura H,Saito K,Kato Y,Nakashima D,Shiiba M,Bukawa H,Yokoe H,Kawata T,Ito H,Tanzawa H

更新日期：2007-05-15 00:00:00

abstract：:We use the population-based Family-Cancer Database from Sweden to study familial breast cancer. The size of the population and the nation-wide registration of cancer offer unique possibilities for epidemiological studies of familial cancer, including complete and unbiased identification of cases in the probands and in...

journal_title：International journal of cancer

authors： Hemminki K,Vaittinen P

更新日期：1998-07-29 00:00:00

abstract：:This study was aimed at comparing screen-detected and symptomatic breast carcinomas with regard to the prevalence of positive immunostaining for c-erb-B-2 oncoprotein. Paraffin sections of 81 breast carcinomas detected through the National Screening Programme were examined for the over-expression of c-erbB-2 oncoprote...

journal_title：International journal of cancer

authors： Soomro S,Taylor P,Shepard HM,Feldmann M,Sinnett HD,Shousha S

更新日期：1993-08-19 00:00:00

abstract：:The INK4A gene, localized to human chromosome 9p21, encodes p16INK4A, a tumor suppressor that functions at least in part through the inhibition of CDK4, a cyclin-dependent kinase encoded by a gene at 12q13. To examine INK4A gene alterations in uncultured samples of osteosarcoma and the relationship between INK4A and C...

journal_title：International journal of cancer

authors： Wei G,Lonardo F,Ueda T,Kim T,Huvos AG,Healey JH,Ladanyi M

更新日期：1999-01-18 00:00:00

abstract：:The 1100delC mutation of the cell cycle checkpoint kinase 2 (CHEK2) gene confers an increased risk for breast cancer, but the clinical impact of other CHEK2 gene variants remains unclear. We determined the frequency of two functionally relevant CHEK2 gene mutations, I157T and IVS2+1G > A, in two large series of breast...

journal_title：International journal of cancer

authors： Bogdanova N,Enssen-Dubrowinskaja N,Feshchenko S,Lazjuk GI,Rogov YI,Dammann O,Bremer M,Karstens JH,Sohn C,Dörk T

更新日期：2005-08-20 00:00:00

abstract：:We show that siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast, colon and other human cancer cell lines. Src and PTP alpha RNAi induced apoptosis in estrogen receptor (ER)-negative breast cancer and colon cancer cells, but not in immortalized noncan...

journal_title：International journal of cancer

authors： Zheng X,Resnick RJ,Shalloway D

更新日期：2008-05-01 00:00:00

abstract：:Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimi...

journal_title：International journal of cancer

authors： Herbst A,Vdovin N,Gacesa S,Ofner A,Philipp A,Nagel D,Holdt LM,Op den Winkel M,Heinemann V,Stieber P,Graeven U,Reinacher-Schick A,Arnold D,Ricard I,Mansmann U,Hegewisch-Becker S,Kolligs FT

更新日期：2017-05-01 00:00:00

abstract：:Serum vitamin D3-binding protein (Gc protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of breast cancer patients was lost or reduced because Gc protein was deglycosylated by serum alpha-N-acetylgalactosaminidase (Nagalase) secreted from cance...

journal_title：International journal of cancer

authors： Yamamoto N,Suyama H,Yamamoto N,Ushijima N

更新日期：2008-01-15 00:00:00

abstract：:Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...

journal_title：International journal of cancer

authors： Haas M

更新日期：1978-01-15 00:00:00

abstract：:The purpose of this study was to assess the relationship between progression-free survival (PFS) in patients treated with DFMO + PCV (procarbazine, CCNU, vincristine) chemotherapy for malignant gliomas with tumor cell ornithine decarboxylase (ODC) activity. Formalin-fixed slides were obtained for study patients with a...

journal_title：International journal of cancer

authors： Levin VA,Jochec JL,Shantz LM,Aldape KD

更新日期：2007-11-15 00:00:00

abstract：:The predictive effect of circulating tumor DNA (ctDNA) in colorectal cancer (CRC) treatment is still highly discussed. The primary objective of our study was to investigate a possible prognostic/predictive value of ctDNA under regorafenib treatment. This prospective multicenter translational biomarker phase II pilot s...

journal_title：International journal of cancer

authors： Unseld M,Belic J,Pierer K,Zhou Q,Moser T,Bauer R,Piringer G,Gerger A,Siebenhüner A,Speicher M,Heitzer E,Prager GW

更新日期：2021-03-15 00:00:00

abstract：:Biopsies were obtained from 12 patients suspected of having nasopharyngeal carcinoma (NPC). A portion of the tissue was submitted for histopathology and another for Western blotting using a murine monoclonal antibody (MAb), MA6. Touch smears of the tissues were also prepared immediately prior to extraction and Western...

journal_title：International journal of cancer

authors： Yip TC,Chan KH,Choy D,Chan CW,Ng MH

更新日期：1987-04-15 00:00:00

abstract：:The Hong Kong Chinese population has an unusually high incidence of colorectal cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 yea...

journal_title：International journal of cancer

authors： Ho JW,Yuen ST,Chung LP,Kwan KY,Chan TL,Leung SY,Chan AS,Tse Cw,Lam PW,Luk IS

更新日期：2000-07-20 00:00:00

abstract：:Smoking and second-hand smoke (SHS) exposure have been recently linked to a higher risk of breast cancer in women. The aim of this work is to estimate the number of deaths and disability-adjusted life years (DALYs) from breast cancer attributable to these two risk factors in the European Union (EU-28) in 2017. The com...

journal_title：International journal of cancer

authors： Carreras G,Lachi A,Boffi R,Clancy L,Gallus S,Fernández E,López MJ,Soriano JB,López Nicolás Á,Semple S,Behrakis P,Gorini G,TackSHS Project Investigators.

更新日期：2020-11-01 00:00:00