Resistance to etoposide-induced apoptosis in a Burkitt's lymphoma cell line.

abstract：:Although the net benefits of tamoxifen in adjuvant breast cancer therapy have been proven, the recurrence of the cancer in an aggressive and hormone independent form has been highly problematic. We previously demonstrated the important role mitochondrial DNA (mtDNA) plays in hormone-independence in prostate cancer. He...

journal_title：International journal of cancer

authors： Naito A,Carcel-Trullols J,Xie CH,Evans TT,Mizumachi T,Higuchi M

更新日期：2008-04-01 00:00:00

abstract：:Exfoliated nasopharyngeal (NP) cells from 62 normal Cantonese Chinese having IgA/VCA antibodies for more than a year and from 39 similar persons without IgA/VCA antibodies, were tested for the presence of EBV/DNA sequences by spot followed by blot hybridization tests, using the cloned internal repeat of B95-8 viral DN...

journal_title：International journal of cancer

authors： Desgranges C,Pi GH,Bornkamm GW,Legrand C,Zeng Y,de-Thé G

更新日期：1983-11-15 00:00:00

abstract：:The major obstacle for the treatment of gastric cancer is recurrence and metastasis; yet, its molecular mechanism is largely unknown. 2-methoxyestradiol (2-ME), a metabolite of the estradiol-17beta, has recently been demonstrated to have multifactorial effects against tumor proliferation and angiogenesis; how these ef...

journal_title：International journal of cancer

authors： Lin HL,Yang MH,Wu CW,Chen PM,Yang YP,Chu YR,Kao CL,Ku HH,Lo JF,Liou JP,Chi CW,Chiou SH

更新日期：2007-12-01 00:00:00

abstract：:Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...

journal_title：International journal of cancer

authors： Tomala J,Chmelova H,Strohalm J,Ulbrich K,Sirova M,Rihova B,Kovar M

更新日期：2011-10-15 00:00:00

abstract：:Colorectal cancer is the third most common form of malignancy, behind prostate and lung cancers. Despite recent advances in medicine, mortality from colorectal cancer remains high, highlighting the need for improved therapies. Numerous studies have demonstrated increased activation of EGFR and its family members (EGFR...

journal_title：International journal of cancer

authors： Nautiyal J,Banerjee S,Kanwar SS,Yu Y,Patel BB,Sarkar FH,Majumdar AP

更新日期：2011-02-15 00:00:00

abstract：:Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...

journal_title：International journal of cancer

authors： Daniel D,Kuchava V,Bondarenko I,Ivashchuk O,Reddy S,Jaal J,Kudaba I,Hart L,Matitashvili A,Pritchett Y,Morris SR,Sorrentino JA,Antal JM,Goldschmidt J

更新日期：2020-12-21 00:00:00

abstract：:An orang-utan (Pongo pygmaeus) suspension line, CP81, was shown to lack myeloid markers of lysozyme activity an d phagocytosis but to be positive for lymphocytic N-alkaline phosphatase activity, and to release a B-cell-tropic herpesvirus. This herpesvirus, termed Herpesvirus pongo, had 30--40% DNA homology with EBV an...

journal_title：International journal of cancer

authors： Rabin H,Neubauer RH,Hopkins RF 3rd,Nonoyama M

更新日期：1978-06-15 00:00:00

abstract：:Survivin protein is an attractive candidate for cancer immunotherapy since it is abundantly expressed in most common human cancers and mostly absent in normal adult tissues. Malignant mesothelioma (MM) is a deadly cancer associated with asbestos or erionite exposure for which no successful therapies are currently avai...

journal_title：International journal of cancer

authors： Bertino P,Panigada M,Soprana E,Bianchi V,Bertilaccio S,Sanvito F,Rose AH,Yang H,Gaudino G,Hoffmann PR,Siccardi A,Carbone M

更新日期：2013-08-01 00:00:00

abstract：:From C57BL mouse melanoma B-16 cells, variant clones were selected in vitro which were resistant to the lectins wheat-germ agglutinin and ricin. Cells were also selected which survived toxic concentrations of concanavalin A. Four different in vivo assays using intradermal, intravenous, intraperitoneal and intramuscula...

journal_title：International journal of cancer

authors： Tao TW,Burger MM

更新日期：1982-04-15 00:00:00

abstract：:Resistance to cisplatin is a major obstacle to successful treatment of head and neck squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this resistance, we compared the gene expression profiles between the cisplatin-sensitive SCC cell lines (Sa-3, H-1 and KB) and the cisplatin-resistant cell li...

journal_title：International journal of cancer

authors： Yamano Y,Uzawa K,Saito K,Nakashima D,Kasamatsu A,Koike H,Kouzu Y,Shinozuka K,Nakatani K,Negoro K,Fujita S,Tanzawa H

更新日期：2010-01-15 00:00:00

abstract：:Electroporation-based mono-gene therapy has received great interest in recent years but coadministration of different therapeutic genes for treatment of tumors has not been well explored. We hypothesize that electroporation is capable of delivering multiple genes that induce an additive or synergistic antitumor effect...

journal_title：International journal of cancer

authors： Liu J,Xia X,Torrero M,Barrett R,Shillitoe EJ,Li S

更新日期：2006-11-01 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...

journal_title：International journal of cancer

authors： Foong YT,Cheng HM,Sam CK,Dillner J,Hinderer W,Prasad U

更新日期：1990-06-15 00:00:00

abstract：:Gefitinib has shown meaningful antitumor activity with tolerable toxicity in chemotherapy-refractory NSCLC in previous studies. Moreover, EGFR expression failed to show a correlation with response. In an attempt to identify predictive markers of response, we have investigated the tumoral expression of key signaling mo...

journal_title：International journal of cancer

authors： Han SW,Hwang PG,Chung DH,Kim DW,Im SA,Kim YT,Kim TY,Heo DS,Bang YJ,Kim NK

更新日期：2005-01-01 00:00:00

abstract：:Imbalance in the Kb and Db region encoded molecules is observed in Lewis lung carcinoma clones. The uncloned metastatic population and the D122 high-metastatic clone show no expression of H-2Kb products, while the nonmetastatic A9 clone expresses Kb products. Twenty-nine new subclones of 3LL and A9 were analyzed for D...

journal_title：International journal of cancer

authors： Eisenbach L,Segal S,Feldman M

更新日期：1983-07-15 00:00:00

abstract：:In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93-01, 2001 and UK-IMPORT databases,...

journal_title：International journal of cancer

authors： van der Beek JN,Hol JA,Coulomb-l'Hermine A,Graf N,van Tinteren H,Pritchard-Jones K,Houwing ME,de Krijger RR,Vujanic GM,Dzhuma K,Schenk JP,Littooij AS,Ramírez-Villar GL,Murphy D,Ray S,Al-Saadi R,Gessler M,Godzinski J,R

更新日期：2021-01-18 00:00:00

abstract：:Chemotherapy is a well-established risk factor for acute myeloid leukemia (AML) but little is known about other prescription drugs and AML risk. We report data from a population-based Los Angeles County study in which 299 matched case-control pairs had complete data on prescription drug use and 88% of cases were subty...

journal_title：International journal of cancer

authors： Pogoda JM,Katz J,McKean-Cowdin R,Nichols PW,Ross RK,Preston-Martin S

更新日期：2005-04-20 00:00:00

abstract：:Colorectal cancer (CRC) represents the second most common cause of cancer mortality in the western world. The tumors frequently show metastatic spread which affects different organs such as lymph nodes, liver and lungs. Although the pattern of spread may vary, the initial step usually involves dissemination to regiona...

journal_title：International journal of cancer

authors： Sundlisaeter E,Dicko A,Sakariassen PØ,Sondenaa K,Enger PØ,Bjerkvig R

更新日期：2007-10-01 00:00:00

abstract：:The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR-E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was found between women with breast ...

journal_title：International journal of cancer

authors： Reed MJ,Beranek PA,Cheng RW,Ghilchik MW,James VH

更新日期：1985-04-15 00:00:00

abstract：:Various angiogenesis-related self-molecules have been considered to be therapeutic targets. However, the direct use of self-molecules as vaccines is not recommended because of the inherent ability of the host to develop immune tolerance. Antigen 43 (Ag43) is a surface protein found in E. coli and contains an α and a β...

journal_title：International journal of cancer

authors： Huang FY,Li L,Liu Q,Li YN,Bai RZ,Huang YH,Zhao HG,Guo JL,Zhou SL,Wang H,Lin YY,Tan GH

更新日期：2014-04-15 00:00:00

abstract：:Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxyl...

journal_title：International journal of cancer

authors： Guinter MA,McLain AC,Merchant AT,Sandler DP,Steck SE

更新日期：2018-08-01 00:00:00

abstract：:Epigenetic modification of gene expression plays an important role in the development of human cancers. The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and methylation specific PCR (MSP). Gene expression of 7 colon cancer cell lines was ev...

journal_title：International journal of cancer

authors： Yang E,Kang HJ,Koh KH,Rhee H,Kim NK,Kim H

更新日期：2007-08-01 00:00:00

abstract：:The effect of interferon on the long-term clinical outcome of patients with chronic hepatitis C remains unclear. This study included 594 patients with chronic hepatitis C who received interferon-alpha therapy (Interferon group) and 144 patients with chronic hepatitis C who did not receive interferon (Control group). T...

journal_title：International journal of cancer

authors： Tanaka H,Tsukuma H,Kasahara A,Hayashi N,Yoshihara H,Masuzawa M,Kanda T,Kashiwagi T,Inoue A,Kato M,Oshima A,Kinoshita Y,Kamada T

更新日期：2000-09-01 00:00:00

abstract：:Recombinant human interferon beta (rIFN-beta) inhibited in a time- and dose-dependent manner the proliferation of 18/18 human colon carcinoma cell lines in monolayer culture and 8/9 lines in a soft agar assay but had no effect on 4 human fibroblast cell lines. Maximal inhibition of cell proliferation by rIFN-beta requ...

journal_title：International journal of cancer

authors： Wong VL,Rieman DJ,Aronson L,Dalton BJ,Greig R,Anzano MA

更新日期：1989-03-15 00:00:00

abstract：:When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibi...

journal_title：International journal of cancer

authors： Lai PK,Alpers MP,MacKay-Scollay EM

更新日期：1977-07-15 00:00:00

abstract：:Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...

journal_title：International journal of cancer

authors： Maskarinec G,Nagata C,Shimizu H,Kashiki Y

更新日期：2002-11-01 00:00:00

abstract：:A panel of monoclonal antibodies (MAbs) has been obtained, directed against determinants of normal human colorectal epithelium. BALB/c mice were immunized and boosted with mucosal scrapings and cell membrane preparations from normal large intestine. In one case boosting was also performed with HT29 colon carcinoma cel...

journal_title：International journal of cancer

authors： Richman PI,Bodmer WF

更新日期：1987-03-15 00:00:00

abstract：:Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...

journal_title：International journal of cancer

authors： Llauradó M,Abal M,Castellví J,Cabrera S,Gil-Moreno A,Pérez-Benavente A,Colás E,Doll A,Dolcet X,Matias-Guiu X,Vazquez-Levin M,Reventós J,Ruiz A

更新日期：2012-04-01 00:00:00

abstract：:Understanding the role of signal transduction in regulating pathways responsible for cell growth, survival and apoptosis is critical for cancer therapy. We developed and characterized a HER2/neu and Fas overexpressing cell line (BNT.888 ACA2) from a salivary gland adenocarcinoma that arose in a HER2/neu transgenic mou...

journal_title：International journal of cancer

authors： Piechocki MP,Yoo GH,Dibbley SK,Amjad EH,Lonardo F

更新日期：2006-07-15 00:00:00

abstract：:Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...

journal_title：International journal of cancer

authors： Urhoj SK,Raaschou-Nielsen O,Hansen AV,Mortensen LH,Andersen PK,Nybo Andersen AM

更新日期：2017-06-01 00:00:00

abstract：:We have investigated the comparative initial DNA binding properties of 7 platinum-based anticancer drugs: 5 cis-oriented compounds, cisplatin, tetraplatin (Ormaplatin), JM118 [cis ammine dichloro (cyclohexylamine) platinum (II)], JM216 [bisacetato cis ammine dichloro (cyclohexylamine) platinum (IV)] and JM149 [cis amm...

journal_title：International journal of cancer

authors： Mellish KJ,Barnard CF,Murrer BA,Kelland LR

更新日期：1995-09-15 00:00:00