Abstract:
:Although the net benefits of tamoxifen in adjuvant breast cancer therapy have been proven, the recurrence of the cancer in an aggressive and hormone independent form has been highly problematic. We previously demonstrated the important role mitochondrial DNA (mtDNA) plays in hormone-independence in prostate cancer. Here, the role of mtDNA in breast cancer progression was investigated. We established hydroxytamoxifen (4-OHT) resistant HTRMCF by growing MCF-7, human breast adenocarcinoma cells, in the presence of 4-OHT. HTRMCF was cross-resistant to 4-OHT and ICI182,780 concurrent with the depletion of mtDNA. To further investigate the role of mtDNA depletion, MCF-7 was depleted of mtDNA by treatment with ethidium bromide. MCF Rho 0 was resistant to both 4-OHT and ICI182,780. Furthermore, cybrid (MCFcyb) prepared by fusion MCF Rho 0 with platelet to transfer mtDNA showed susceptibility to antiestrogen. Surprisingly, after withdrawal of 4-OHT for 8 weeks, HTRMCF and their clones became susceptible to both drugs concurrent with a recovery of mtDNA. Herein, our results substantiated the first evidence that the depletion of mtDNA induced by hormone therapy triggers a shift to acquired resistance to hormone therapy in breast cancer. In addition, we showed that mtDNA depletion can be reversed, rendering the cancer cells susceptible to antiestrogen. The fact that the hormone independent phenotype can be reversed should be a step toward more effective treatments for estrogen-responsive breast cancer.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Naito A,Carcel-Trullols J,Xie CH,Evans TT,Mizumachi T,Higuchi Mdoi
10.1002/ijc.23235subject
Has Abstractpub_date
2008-04-01 00:00:00pages
1506-11issue
7eissn
0020-7136issn
1097-0215journal_volume
122pub_type
杂志文章abstract::We have shown that modulation of intracellular calcium in EBV latently infected cells could induce the expression of viral antigens, and suggested that a protein kinase-C (PKC) may play a major role in the EBV genome activation. We now report further investigations on the role of PKC using 2 selective enzymatic inhibi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400624
更新日期:1987-12-15 00:00:00
abstract::Familial atypical multiple mole melanoma (FAMMM) is an autosomal dominant disease characterized by the familial occurrence of malignant melanoma of the skin and multiple atypical precursor lesions. Germline mutations in the p16 (CDKN2A) gene have been reported in at least a quarter of such families. An association has...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
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abstract::Colorectal (CRC) and gastric cancers (GC), the most common gastrointestinal malignancies, have been known to develop occasionally in a same patient. Previous studies have focused on the etiology of patients with multiple primary gastric and colorectal cancer (MPGCC); however, the carcinogenic process of MPGCC remains ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000601)86:5<678::aid-ijc
更新日期:2000-06-01 00:00:00
abstract::The incidence of breast cancer among women in Shanghai, a traditionally low-risk population, has increased substantially over the past 20 years. To evaluate the association of menstrual and reproductive factors with breast cancer risk and the influence of these factors on the temporal trend of breast cancer incidence,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000715)87:2<295::aid-ijc23>3.0
更新日期:2000-07-15 00:00:00
abstract::The role of gastrin in the control of growth of renal G401 cells isolated from a human nephroblastoma (Wilms' tumour) was investigated. G401 cell growth was enhanced in the presence of exogenous gastrin. Addition of anti-gastrin antibodies to serum-free medium significantly inhibited the growth of G401 cells. G401 cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570316
更新日期:1994-05-01 00:00:00
abstract::Hepatocellular carcinoma is the second leading cause of cancer deaths worldwide. It is characterized by unique features that can be utilized for selective and targeted therapy, which aids in preserving healthy tissues from deteriorating effects of traditional chemotherapeutics. In this minireview, a brief overview of ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
abstract::DNA repair is a complicated biological process, consisting of several distinct pathways, that plays a fundamental role in the maintenance of genomic integrity. The very important field of DNA repair and cancer risk has developed rapidly in the past decades. In this review of selected published data from our laboratory...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2009-03-01 00:00:00
abstract::The aim of this study was to examine the cellular distribution of osteopontin (OPN) protein [by immunohistochemical (IHC) analysis] and mRNA [by in situ hybridization (ISH)] in the primary tumors of lymph node negative (LNN) breast cancer patients and to determine whether the level of immunodetectable OPN may be assoc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19981023)79:5<502::aid-ijc
更新日期:1998-10-23 00:00:00
abstract::Recently, pegylated arginine deiminase (ADI; EC 3.5.3.6) has been used to treat the patients with hepatocellular carcinoma or melanoma, in which the level of argininosuccinate synthetase (ASS) activity is low or undetectable. The efficacy of its antitumor activity largely depends on the level of intracellular ASS, whi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22322
更新日期:2007-02-15 00:00:00
abstract::In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20614
更新日期:2005-02-20 00:00:00
abstract::Murine monoclonal antibody HRS-4 (Ab1), which defines the cell-bound and soluble CD30 antigen associated with Hodgkin's lymphoma, was used to generate monoclonal anti-idiotypic antibodies (Ab2) in syngeneic BALB/c mice. Murine monoclonal Ab2 14G9 and Ab2 9G10 directed against HRS-4 were shown to be anti-idiotypic Ab2 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500623
更新日期:1992-04-01 00:00:00
abstract::Our aim was to evaluate whether serum concentrations of squamous cell carcinoma antigen (SCC-Ag) are an independent prognostic factor in patients with vulvar cancer. We measured SCC-Ag in pretreatment serum samples of 55 patients with squamous cell vulvar cancer, 30 patients with vulvar intraepithelial neoplasia (VIN)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990621)84:3<299::aid-ijc
更新日期:1999-06-21 00:00:00
abstract::The association between breast cancer risk defined by the Tyrer-Cuzick score (TC) and disease prognosis is not well established. Here, we investigated the relationship between 5-year TC and disease aggressiveness and then characterized underlying molecular processes. In a case-only study (n = 2474), we studied the ass...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33270
更新日期:2021-02-15 00:00:00
abstract::Tissue recombinants (TRs) composed of mouse urogenital mesenchyme (mUGM) plus an immortalized nontumorigenic human prostatic epithelial cell line (BPH-1) were grown under the kidney capsule of male athymic nude mice under different hormonal conditions. The objectives were to determine temporal plasma concentrations of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21614
更新日期:2006-05-01 00:00:00
abstract::Organochlorine insecticides have been studied extensively in relation to breast cancer incidence, and results from two meta-analyses have been null for late-life residues, possibly due to measurement error. Whether these compounds influence survival remains to be fully explored. We examined associations between organo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29806
更新日期:2016-02-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) plays an important role in essential cellular processes such as proliferation, survival and migration. Aberrant activation of EGFR is frequently found in human cancers of various origins and has been implicated in cancer pathogenesis. The therapeutic antibody cetuximab (Erbitux)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28585
更新日期:2014-06-01 00:00:00
abstract::HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathoge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10240
更新日期:2002-04-10 00:00:00
abstract::Classical Hodgkin lymphoma (HL) is characterized by the presence of Hodgkin and Reed-Sternberg cells (H&RS) and a prominent lymphocytic infiltration. We previously reported Hodgkin-like adult T-cell leukemia/lymphoma (HL-like ATLL) (new WHO classification). Various CXC and CC chemokines are expressed on H&RS cells and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11301
更新日期:2003-09-20 00:00:00
abstract::ErbB-2 and EGF receptors are often co-expressed in human tumors and have been shown to synergize in the transformation of cells in experimental model systems. Transactivation of ErbB-2 can occur via ligand-induced heterodimerization with EGF receptor or other members of the ErbB family of receptor tyrosine kinases. We...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960208)65:4<538::AID-IJC
更新日期:1996-02-08 00:00:00
abstract::Chemokines and chemokine receptors mediate lymphocyte migration and tissue localization. To analyze CCL5 (RANTES) expression by EBV-infected cells, we examined the expression of CCL5 in BL cell lines. Among 4 BL cell lines, those infected with EBV selectively expressed the CCL5 gene and secreted CCL5. Four cell lines ...
journal_title:International journal of cancer
pub_type: 杂志文章,收录出版
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更新日期:2005-05-01 00:00:00
abstract::This phase I study tested the safety, feasibility, pharmacokinetics and pharmacodynamics of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion (HIPEC) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC) undergoing secondary cytoreductive surgery followed by p...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
abstract::Cholera toxin (which increases intracellular cAMP levels) significantly (p less than 0.05) increased the growth of MCF-7, T47-D and Hs578T human breast carcinoma cells in vitro. The effect of cholera toxin on growth of MCF-7 and T47-D cells was more pronounced in the presence of 17 beta-estradiol (p less than 0.05), i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360411
更新日期:1985-10-15 00:00:00
abstract::Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000601)86:5<610::aid-ijc
更新日期:2000-06-01 00:00:00
abstract::Both retinoids and anti-estrogens inhibit breast cancer cell proliferation with accumulation of cells in the G1 phase of the cell cycle, but the effect of retinoids is delayed compared to that of anti-estrogens. To determine whether this temporal difference is due to a simple delay in the action of retinoids on a comm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970127)70:3<291::aid-ijc
更新日期:1997-01-27 00:00:00
abstract::Nickel-2,3,7,8,12,13,17,18-octaacetic acid-5,10,15,20-tetra-[3-carboranyl-methoxyphenyl]-porphyrin octamethylester (NiTCP) was given in a Cremophor EL, a polyethoxylated castor oil, and propylene glycol emulsion to BALB/c mice bearing transplanted s.c. KHJJ mammary carcinomas. A total dose of 244 microg NiTCP/gram bod...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960927)68:1<114::AID-IJC
更新日期:1996-09-27 00:00:00
abstract::A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340504
更新日期:1984-11-15 00:00:00
abstract::Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...
journal_title:International journal of cancer
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更新日期:2011-09-15 00:00:00
abstract::The mta1 gene is a recently identified novel candidate metastasis-associated gene. The deduced amino acid sequence contains an src homology-3 domain binding motif, a zinc finger motif and possible phosphorylation sites, suggesting that this gene is involved in signal transduction or regulation of gene expression. The ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970822)74:4<459::aid-ijc
更新日期:1997-08-22 00:00:00
abstract::The relationship between chemosensitivity and p53 is currently considered from two mutually exclusive points of view: (1) wt p53 increases chemosensitivity due to apoptosis and (2) wt p53 decreases chemosensitivity due to growth arrest and DNA repair. We used p53-expressing adenovirus (Ad-p53) to directly evaluate eff...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980316)75:6<933::aid-ijc
更新日期:1998-03-16 00:00:00
abstract::Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20145
更新日期:2004-07-01 00:00:00