Abstract:
:Interleukin-12 (IL-12) has potent antitumor activities via natural killer cells and cytotoxic T lymphocytes. However, the molecular mechanisms whereby IL-12 induces tumoricidal activities are poorly understood. Here, we report the genome-wide analysis of gene expression in a primary murine mammary carcinoma model that resembles human breast cancer, following the therapeutic application of recombinant IL-12, which restricted tumor growth and metastasis. IL-12 was able to curtail neovascularization in the tumor as well as enhance the number of tumor-infiltrating lymphocytes. Comprehensive examination of global gene expression revealed IL-12-induced molecular changes associated with tumor regression and reduced lung metastasis, thus providing a high-resolution snapshot of a host response against a developing malignancy and a rich source of potential targets for therapeutic intervention of breast cancer.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Shi X,Liu J,Xiang Z,Mitsuhashi M,Wu RS,Ma Xdoi
10.1002/ijc.20145keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
570-8issue
4eissn
0020-7136issn
1097-0215journal_volume
110pub_type
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journal_title:International journal of cancer
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