Abstract:
:The effect of serum from mice bearing methylcholanthrene-induced fibrosarcomas on the lympho-proliferative responses of their spleen and lymph-node cells to 3 M KCl-solubilized tumor antigens has been investigated. Low concentrations of serum (less than or equal to 2.5%) collected throughout the course of tumor growth were inhibitory. Normal sera collected from age-matched control mice were often slightly inhibitory, but to a significantly lesser extent at identical serum concentrations. The inhibitory effect of tumor-bearing serum was not limited to homologous tumors, but was also observed when cross-reacting syngeneic tumor antigens or serum from animals bearing other syngeneic tumors were added to the assay mixture. At the low concentrations used, tumor-bearing sera inhibited only tumor-antigen-induced proliferation, and not proliferation induced by T cell mitogens. The inhibitory effects of tumor-bearing sera on lympho-proliferative responses to soluble tumor antigens appear to be similar to the inhibition seen as "serum blocking" in other assays of tumor immunity.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Calderwood MB,Forbes JT,Smith RTdoi
10.1002/ijc.2910200312subject
Has Abstractpub_date
1977-09-15 00:00:00pages
400-7issue
3eissn
0020-7136issn
1097-0215journal_volume
20pub_type
杂志文章abstract::Resveratrol, which may occur in wine, was suggested to act as a chemopreventive agent against the carcinogenic effects of ethanol. The assumption was based on data from experimental animals, which have shown that resveratrol above certain thresholds may reduce the incidence of tumours in several of the alcohol-related...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28336
更新日期:2014-01-01 00:00:00
abstract::Loss of imprinting (LOI) of insulin-like growth factor 2 (IGF2) is a common event in many cancers and typically activates the maternally silenced allele. The resulting biallelic IGF2 expression correlates strongly with the hypomethylation of a differentially methylated region (DMR) near its promoter. It has also been ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25086
更新日期:2010-08-01 00:00:00
abstract::The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270616
更新日期:1981-06-15 00:00:00
abstract::Although tumor-specific T lymphocytes recognize tumor-associated antigens (TAA) present on their cell surface via major histocompatibility complex (MHC) molecules, T cells require other activating signals. These are provided by costimulatory molecules, including B7-1 (CD80), B7-2 (CD86) and intercellular adhesive mole...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990827)82:5<714::aid-ijc
更新日期:1999-08-27 00:00:00
abstract::The expression of oestrogen (ER), progesterone (PR) and androgen (AR) receptors in female breast cancer was investigated by immunohistochemistry on snap-frozen tissue specimens of a series of 100 breast cancers. For detection of the AR we used a recently developed mouse monoclonal antibody specific for the N-terminal ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520415
更新日期:1992-10-21 00:00:00
abstract::Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that sever...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32138
更新日期:2019-08-15 00:00:00
abstract::An antiserum to SF antigen was shown to be selectively cytotoxic to two human fibroblast lines, while two tumor cell lines (one melanoma and one Hela cell line) were resistant. The selective cytotoxicity was also demonstrable in mixtures of fibroblasts and tumor cells. The cytotoxic effect was abrogated by admixture o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180317
更新日期:1976-09-15 00:00:00
abstract::We previously demonstrated that leptin, an adipose-derived hormone, induces cell proliferation in a model of preneoplastic (IMCE (Apc(Min/+)), but not normal (YAMC (Apc(+/+)), colon epithelial cells by inducing autocrine IL-6 production and trans-IL-6 signaling. Low serum adiponectin is associated with colon, prostate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23436
更新日期:2008-06-01 00:00:00
abstract::In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32565
更新日期:2020-05-01 00:00:00
abstract::The causative role of human papillomaviruses (HPV) and HPV16 variants has been extensively studied in uterine cervix dysplastic lesions and invasive carcinoma; few such studies, however, have been performed in penile tumors. We have investigated HPV genotype and HPV16 variant distribution on 41 penile cancer biopsies ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23062
更新日期:2008-01-01 00:00:00
abstract::Adherent cells with the ability to inhibit NK activity were found in the spleens of young 8-week-old SJL/J mice. Such suppressor cells were also found in the spleens of other low-NK-reactive strains, but not in the spleen of age-matched high-NK-reactive strains. These suppressor cells had the characteristics of macrop...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280621
更新日期:1981-12-01 00:00:00
abstract::We have used differential-display PCR (DD-PCR) to compare renal-cell carcinoma (RCC) and normal kidney gene expression with the aim of identifying genes specifically associated with RCC. Using a modified DD-PCR approach, which was non-radioactive, quicker and simpler than the conventional method, 24 cDNA samples were ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001201)88:5<726::aid-ijc7>3.0.
更新日期:2000-12-01 00:00:00
abstract::The human tumor line LOX was established as an s.c. xenograft in nude mice from a lymph-node metastasis of a patient with malignant melanoma. I.v. injection into adult nude mice of single-cell suspensions prepared from xenografts resulted in progressively growing lung tumor colonies that killed the animals. No differe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410322
更新日期:1988-03-15 00:00:00
abstract::In recent years, Akt signaling has gained recognition for its functional role in more aggressive, therapy-resistant malignancies. As it is frequently constitutively active in cancer cells, several drugs are being investigated for their ability to inhibit Akt signaling. The purpose of this study is to determine effect ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24419
更新日期:2009-08-15 00:00:00
abstract::Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25859
更新日期:2011-10-15 00:00:00
abstract::The influence of prolonged treatment with antilymphocyte globulin on tumour incidence in BN/a and BN/b mice was studied. One ALG sample appeared to be highly leukaemogenic in two independent experiments. All treated mice developed, after a short latency period, non-thymic lymphomas with involvement of abdominal lymph ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180615
更新日期:1976-12-15 00:00:00
abstract::The relationship between occupation and exposure to several occupational agents and Hodgkin's disease (HD) was investigated in a case-control study of 152 cases and 613 controls with acute diseases admitted to all hospitals in Pordenone province, north-east Italy. Among cases, there was a significant excess of individ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910480608
更新日期:1991-07-30 00:00:00
abstract::High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000801)87:3<360::aid-ijc8>3.0.
更新日期:2000-08-01 00:00:00
abstract::DNA synthesis in heterokaryons of mouse peritoneal macrophages and various proliferating cultured cells was analyzed. Macrophages did not inhibit replication in the nuclei of non-immortalized and spontaneously immortalized cells (rat fibroblasts and macrophages, mouse pre-macrophages, NIH3T3 cells). On the contrary, t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440611
更新日期:1989-12-15 00:00:00
abstract::Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japan...
journal_title:International journal of cancer
pub_type: 历史文章,杂志文章
doi:10.1002/ijc.10673
更新日期:2002-11-01 00:00:00
abstract::Oncolytic adenoviruses are being developed as novel anticancer therapeutics and currently undergoing clinical trials. We previously demonstrated that telomerase-specific replication-competent adenovirus (Telomelysin: OBP-301), in which the human telomerase reverse transcriptase (hTERT) promoter regulates viral replica...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21846
更新日期:2006-07-15 00:00:00
abstract::Rapid tumor growth and metastasis are 2 major problems associated with treatment of malignant melanoma. Therefore, drugs that can intervene these processes are of clinical importance. Pentoxifylline (PTX), a methyl xanthine derivative, has been shown to inhibit B16F10 melanoma tumor growth and metastasis. We hypothesi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22843
更新日期:2007-10-01 00:00:00
abstract::Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU homeobox genes in human breast cancer cell lines and human breast ti...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990331)81:1<104::aid-ijc
更新日期:1999-03-31 00:00:00
abstract::We reported that tumor endothelial cells (TECs) differ from normal endothelial cells (NECs) in many aspects, such as gene expression profiles. Although CXCR7 is reportedly highly expressed in blood vessels of several tumors, its function in TECs is still unknown. To investigate this role, we isolated TECs from mouse t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29655
更新日期:2015-12-15 00:00:00
abstract::We examined the expression of tumor-suppressor protein p53 in a variety of laryngeal carcinomas from 43 patients (25 primary, 13 metastatic and 5 recurrent cases), 13 normal laryngeal tissues and 7 benign laryngeal nodule biopsy specimens, using the polyclonal antibody CM-1. Previously we have reported a high incidenc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530615
更新日期:1993-04-01 00:00:00
abstract::Since it is difficult to predict the probability of persistent teratoma or of a viable tumor in patients with normalized tumor markers and a normal CT scan following chemotherapy for advanced stage testis cancer, recommendations regarding adjunctive surgery have ranged from observation to surgical exploration for all ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0215(19991210)83:6<852::aid-ijc
更新日期:1999-12-10 00:00:00
abstract::The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990129)80:3<396::aid-ijc
更新日期:1999-01-29 00:00:00
abstract::The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910370619
更新日期:1986-06-15 00:00:00
abstract::We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510516
更新日期:1992-07-09 00:00:00
abstract::Recurrent deletions of chromosome fragments observed in neoplasms are thought to participate in tumor development through the inactivation of tumor-suppressor genes. In gliomas, the most frequent deletions involve chromosome arms 9p, 10q, 17p, 19q and 22q. We have analysed deletions of chromosome 22 in gliomas by stud...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600409
更新日期:1995-02-08 00:00:00