Elevated stromelysin-1 and reduced collagenase-IV expression in invasive rat embryo fibroblasts expressing E1A deletion mutants + T24-H-ras.

abstract：:The relation between human papillomavirus type 16 (HPV 16) viral load in cervical scrapes and development of high-grade cervical intraepithelial neoplasia (CIN II or III) was studied in a nested case-control study of women with normal cytology (group A) and in a cohort of women with abnormal cytology (group B). HPV 16...

journal_title：International journal of cancer

authors： van Duin M,Snijders PJ,Schrijnemakers HF,Voorhorst FJ,Rozendaal L,Nobbenhuis MA,van den Brule AJ,Verheijen RH,Helmerhorst TJ,Meijer CJ

更新日期：2002-04-01 00:00:00

abstract：:When effector cells from most individuals are tested directly against a number of target cells for cell-mediated cytotoxicity, most of the reactivity is non-selective. This apparent non-selectiveness is a result of specific activity against multiple antigens on target cells by each effector suspension. The specific re...

journal_title：International journal of cancer

authors： Akira D,Takasugi M

更新日期：1977-06-15 00:00:00

abstract：:We describe 2-step and 3-step strategies for intraperitoneal tumor radio-localization by means of monoclonal antibodies (MAbs). Nude mice bearing intraperitoneal human colon carcinoma tumors were injected i.p. with biotinylated MAb AUAI, followed 24 hr later by radioiodinated streptavidin (2-step). The uptake of radio...

journal_title：International journal of cancer

authors： Paganelli G,Pervez S,Siccardi AG,Rowlinson G,Deleide G,Chiolerio F,Malcovati M,Scassellati GA,Epenetos AA

更新日期：1990-06-15 00:00:00

abstract：:Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we tested the hypothesis that a C to T variant (Thr241Met) of DNA...

journal_title：International journal of cancer

authors： Shen H,Sturgis EM,Dahlstrom KR,Zheng Y,Spitz MR,Wei Q

更新日期：2002-06-20 00:00:00

abstract：:We have addressed the role of bacterial co-infection in viral oncogenesis using as model Epstein-Barr virus (EBV), a human herpesvirus that causes lymphoid malignancies and epithelial cancers. Infection of EBV carrying epithelial cells with the common oral pathogenic Gram-negative bacterium Aggregatibacter actinomycet...

journal_title：International journal of cancer

authors： Frisan T,Nagy N,Chioureas D,Terol M,Grasso F,Masucci MG

更新日期：2019-01-01 00:00:00

abstract：:Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated as the cellular ori...

journal_title：International journal of cancer

authors： Meder L,König K,Ozretić L,Schultheis AM,Ueckeroth F,Ade CP,Albus K,Boehm D,Rommerscheidt-Fuss U,Florin A,Buhl T,Hartmann W,Wolf J,Merkelbach-Bruse S,Eilers M,Perner S,Heukamp LC,Buettner R

更新日期：2016-02-15 00:00:00

abstract：:In order to examine whether or not the expression of the apoptosis-related receptor Fas (CD-95/APO-1) and its ligand (FasL) has relevance for patient survival, immunohistochemistry was used to analyze the proteins of both factors in 164 non-small cell lung carcinomas. Patients with Fas-positive tumors exhibited signif...

journal_title：International journal of cancer

authors： Koomägi R,Volm M

更新日期：1999-06-21 00:00:00

abstract：:The synthetic retinoid fenretinide [N-(4-hydroxyphenyl)retinamide, 4-HPR] has demonstrated growth inhibition and induction of apoptosis of various malignant cells, including lung cancer cell lines. 4-HPR is now being investigated in several clinical trials. In our study, we show that 4-HPR inhibits growth on a broad p...

journal_title：International journal of cancer

authors： Ohlmann CH,Jung C,Jaques G

更新日期：2002-08-10 00:00:00

abstract：:We performed microsatellite analysis and tested telomerase activity in paired tissue and urine of bladder cancer patients from frozen archived samples. DNA obtained from microdissected tumor and urine sediment was analyzed and compared to peripheral lymphocytes for microsatellite alterations (loss of heterozygosity [L...

journal_title：International journal of cancer

authors： Linn JF,Lango M,Halachmi S,Schoenberg MP,Sidransky D

更新日期：1997-12-19 00:00:00

abstract：:Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV/AIDS. It is interesting therefore that recent studies foun...

journal_title：International journal of cancer

authors： D'Souza G,Burk RD,Zhong Y,Minkoff H,Massad LS,Xue X,Watts DH,Anastos K,Palefsky JM,Levine AM,Colie C,Castle PE,Strickler HD

更新日期：2012-09-15 00:00:00

abstract：:140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...

journal_title：International journal of cancer

authors： Liao SK,Clarke BJ,Khosravi M,Kwong PC,Brickenden A,Dent PB

更新日期：1982-11-15 00:00:00

abstract：:We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after w...

journal_title：International journal of cancer

authors： Dorhout B,Te Velde RJ,Ferwerda H,Kingma AW,De Hoog E,Muskiet FA

更新日期：1995-04-10 00:00:00

abstract：:The MDR1 gene product P-glycoprotein (Pgp) plays a key role in multidrug resistance of cancer cells. Pgp is an ATP-driven efflux pump that extrudes a variety of dissimilar hydrophobic cytotoxic compounds. P-glycoprotein overexpression results in multidrug resistance (MDR) of tumor cell lines in vitro as well as in can...

journal_title：International journal of cancer

authors： Niv R,Assaraf YG,Segal D,Pirak E,Reiter Y

更新日期：2001-12-15 00:00:00

abstract：:Sunlight is essential for the production of vitamin D in the body. Evidence exists to suggest that vitamin D metabolites may have a role in tumor growth suppression. In this large study, involving over a million cancer patients from the United Kingdom, we have analyzed the role of season of diagnosis and sunlight expo...

journal_title：International journal of cancer

authors： Lim HS,Roychoudhuri R,Peto J,Schwartz G,Baade P,Møller H

更新日期：2006-10-01 00:00:00

abstract：:Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...

journal_title：International journal of cancer

authors： Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

更新日期：2021-01-15 00:00:00

abstract：:We have previously shown that AEV infection of leukosis-free chickens provokes an erythroleukemia in the infected birds, and that the target cell for virus transformation is most likely an early pro-erythroblast comparable to the BFU-E. The virus infection correlates with a block in differentiation which was studied a...

journal_title：International journal of cancer

authors： Therwath A,Scherrer K

更新日期：1982-05-15 00:00:00

abstract：:Apoptin is a chicken anemia virus-derived, p53-independent, bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in tumor cells. To explore the use of the Apoptin gene in cancer gene therapy, we constructed a recombinant fowlpox virus expressing the Apoptin protein (vFV-Apoptin) and co...

journal_title：International journal of cancer

authors： Li X,Jin N,Mi Z,Lian H,Sun L,Li X,Zheng H

更新日期：2006-12-15 00:00:00

abstract：:The activity of systemic and in situ natural killer (NK) cells was measured in 3- to 5-week-old CBA mice with progressively growing murine sarcoma virus (MSV)-induced tumors. Splenic NK activity was depressed in tumor-bearing mice. NK activity was quite low or not detectable in unfractionated cell suspensions from the...

journal_title：International journal of cancer

authors： Gerson J,Varesio L,Herberman RB

更新日期：1981-02-15 00:00:00

abstract：:The metastatic dissemination of cancer cells to remote areas of the body is the most problematic aspect in cancer patients. Among cancers, melanomas are notoriously difficult to treat due to their significantly high metastatic potential even during early stages. Hence, the establishment of advanced therapeutic approac...

journal_title：International journal of cancer

authors： Kinoshita R,Sato H,Yamauchi A,Takahashi Y,Inoue Y,Sumardika IW,Chen Y,Tomonobu N,Araki K,Shien K,Tomida S,Torigoe H,Namba K,Kurihara E,Ogoshi Y,Murata H,Yamamoto KI,Futami J,Putranto EW,Ruma IMW,Yamamoto H,Soh J

更新日期：2019-07-15 00:00:00

abstract：:Molecular markers predictive of prostate cancer prognosis are urgently needed. Overexpression of the antiapoptotic protein, Bcl-2, has repeatedly been shown to be associated with adverse outcome in this malignancy. We hypothesized that a regulatory BCL2 -938C>A promoter polymorphism, which significantly affects promot...

journal_title：International journal of cancer

authors： Bachmann HS,Heukamp LC,Schmitz KJ,Hilburn CF,Kahl P,Buettner R,Nückel H,Eisenhardt A,Rübben H,Schmid KW,Siffert W,Eggert A,Schramm A,Schulte JH

更新日期：2011-11-15 00:00:00

abstract：:Apigenin is a plant flavonoid that is thought to play a role in the prevention of carcinogenesis. However, its mechanism of action has not yet been elucidated. Because of the importance of angiogenesis in tumor growth, we investigated the effect of apigenin on endothelial and smooth-muscle cells in an in vitro model. ...

journal_title：International journal of cancer

authors： Trochon V,Blot E,Cymbalista F,Engelmann C,Tang RP,Thomaïdis A,Vasse M,Soria J,Lu H,Soria C

更新日期：2000-03-01 00:00:00

abstract：:Increases in the incidence of childhood acute lymphoblastic leukemia (ALL) have been reported in some countries, while other reports from similar geographical regions have indicated stable rates. The reasons for the discrepancies have been debated in the literature, with the focus on whether the observed increases are...

journal_title：International journal of cancer

authors： Milne E,Laurvick CL,de Klerk N,Robertson L,Thompson JR,Bower C

更新日期：2008-03-01 00:00:00

abstract：:In the past, it has been impossible to carry out immunohistological staining as part of a rapid histopathological diagnosis during surgery because the available methods were too time-consuming. The present report introduces a rapid indirect immunoperoxidase method that requires only 10-12 min. Thus, the immunological ...

journal_title：International journal of cancer

authors： Gerdes J

更新日期：1985-02-15 00:00:00

abstract：:By rosetting with SRBC coupled to rabbit-anti-human IgM, the surface IgM-negative cells of human fetal bone marrow were enriched, and subsequently infected and transformed by Epstein-Barr virus (EBV). Single clones of the transformed cells were obtained. Ninety percent of the resulting cell clones were surface-immunog...

journal_title：International journal of cancer

authors： Ernberg I,Falk K,Hansson M

更新日期：1987-02-15 00:00:00

abstract：:Prostate stem cell antigen (PSCA) and prostate-specific antigen (PSA) are overexpressed in most prostate cancers. PSCA- and PSA-derived, HLA-A2 binding peptides are specific targets for T-cell responses in vitro. A phase I/II trial was performed to demonstrate feasibility, safety and induction of antigen-specific immu...

journal_title：International journal of cancer

authors： Thomas-Kaskel AK,Zeiser R,Jochim R,Robbel C,Schultze-Seemann W,Waller CF,Veelken H

更新日期：2006-11-15 00:00:00

abstract：:The influence of 4 murine monoclonal antibodies (MAbs) directed against surface determinants of a metastasizing rat adenocarcinoma (BSp73ASML) on metastatic spread was evaluated and compared to their in vivo binding as well as to the induction of a humoral anti-MAb response, especially with respect to the development ...

journal_title：International journal of cancer

authors： Reber S,Matzku S,Günthert U,Ponta H,Herrlich P,Zöller M

更新日期：1990-11-15 00:00:00

abstract：:The role of transcript variants of cyclin D1 in cancer biology is unclear. Most tumors with high levels of cyclin D1 express 2 transcripts due to alternative splicing: one full-length transcript of 4.4 kb and one short transcript of approximately 1.7 kb. The short transcript lacks part of the 3'UTR region regulating m...

journal_title：International journal of cancer

authors： Sander B,Flygare J,Porwit-Macdonald A,Smith CI,Emanuelsson E,Kimby E,Liden J,Christensson B

更新日期：2005-11-10 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is constitutively activated in many cancers, including oral squamous cell carcinoma (OSCC), and is involved in the invasive characteristics of OSCC, such as growth, antiapoptotic activity and protease production. However, the cellular mechanism underlying NF-κB's promotion of bone invasion by...

journal_title：International journal of cancer

authors： Furuta H,Osawa K,Shin M,Ishikawa A,Matsuo K,Khan M,Aoki K,Ohya K,Okamoto M,Tominaga K,Takahashi T,Nakanishi O,Jimi E

更新日期：2012-09-01 00:00:00

abstract：:mTOR inhibition led to activation of upstream receptor tyrosine kinases (RTKs) and AKT, which may attenuate the efficacy of mTOR kinase inhibitors. We sought to discover efficient drug combination with mTOR inhibitors by elucidating the survival feedback loops induced by mTOR inhibition in breast cancer. The feedback ...

journal_title：International journal of cancer

authors： Chen SM,Guo CL,Shi JJ,Xu YC,Chen Y,Shen YY,Su Y,Ding J,Meng LH

更新日期：2014-11-15 00:00:00

abstract：:We investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific inhibitor of alphav series integrins, and acts as an antiangiogenic. U251 human glioma cells express alphavbeta3 and alphavbeta5 integrins. We used in vitro ass...

journal_title：International journal of cancer

authors： Mikkelsen T,Brodie C,Finniss S,Berens ME,Rennert JL,Nelson K,Lemke N,Brown SL,Hahn D,Neuteboom B,Goodman SL

更新日期：2009-06-01 00:00:00