Progenitor and pre-B lymphocytes transformed by Epstein-Barr virus.


:By rosetting with SRBC coupled to rabbit-anti-human IgM, the surface IgM-negative cells of human fetal bone marrow were enriched, and subsequently infected and transformed by Epstein-Barr virus (EBV). Single clones of the transformed cells were obtained. Ninety percent of the resulting cell clones were surface-immunoglobulin-negative, and of 8 clones which were further studied, 5 lacked intracellular, cytoplasmic Ig as measured by immunofluorescence. Control cell clones derived from the same material without pre-selection expressed surface Ig and also secreted Ig. Utilization of a panel of B-cell-specific monoclonal antibodies (MAbs) showed no difference between the cell clones expressing surface Ig and those that did not. The progenitor B-cell lines did not show a phenotype resembling that of cell lines derived from B-cell malignancies, such as high agarose clonability. In spite of their immature Ig-phenotype, these clones showed rearrangement of at least one heavy chain Ig-allele. Efforts to induce differentiation in these clones were unsuccessful. These clones may represent progenitor B cells, or B cells with faulty heavy-chain rearrangement. EBV can apparently be used as a tool to derive cell lines representing different levels of B-cell differentiation, and can also transform immature B cells, which may be useful in the analysis of B-cell differentiation.


Int J Cancer


Ernberg I,Falk K,Hansson M




Has Abstract


1987-02-15 00:00:00












  • PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.

    abstract::ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gawecka JE,Geerts D,Koster J,Caliva MJ,Sulzmaier FJ,Opoku-Ansah J,Wada RK,Bachmann AS,Ramos JW

    更新日期:2012-10-01 00:00:00

  • Plasma DNA microsatellite panel as sensitive and tumor-specific marker in lung cancer patients.

    abstract::The majority of lung cancer patients have tumor-derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect alterations in plasma and tumor DNA in 34 patients who underwent bronchoscopy for lung cancer, including 11 small cel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Beau-Faller M,Gaub MP,Schneider A,Ducrocq X,Massard G,Gasser B,Chenard MP,Kessler R,Anker P,Stroun M,Weitzenblum E,Pauli G,Wihlm JM,Quoix E,Oudet P

    更新日期:2003-06-20 00:00:00

  • ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancer.

    abstract::Although early detection and systemic therapies have improved the diagnosis and clinical cure rate of breast cancer, breast cancer remains the most frequently occurring malignant cancer in women due to a lack of sufficiently effective treatments. Thus, to develop potential targeted therapies and thus benefit more pati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Liu ZH,Chen ML,Zhang Q,Zhang Y,An X,Luo YL,Liu XM,Liu SX,Liu Q,Yang T,Liu YM,Liu BL,Zhou AJ,Li MZ,Liu YJ,Liu ZX,Zhong Q

    更新日期:2020-07-15 00:00:00

  • HIPEC ROC I: a phase I study of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion followed by postoperative intravenous platinum-based chemotherapy in patients with platinum-sensitive recurrent epithelial ovarian cancer.

    abstract::This phase I study tested the safety, feasibility, pharmacokinetics and pharmacodynamics of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion (HIPEC) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC) undergoing secondary cytoreductive surgery followed by p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zivanovic O,Abramian A,Kullmann M,Fuhrmann C,Coch C,Hoeller T,Ruehs H,Keyver-Paik MD,Rudlowski C,Weber S,Kiefer N,Poelcher ML,Thiesler T,Rostamzadeh B,Mallmann M,Schaefer N,Permantier M,Latten S,Kalff J,Thomale J,

    更新日期:2015-02-01 00:00:00

  • Low frequency of BRAF and CDKN2A mutations in endometrial cancer.

    abstract::Several pathways have been implicated in the pathogenesis of endometrial carcinoma. Based on recent reports, BRAF mutations provide an alternative route for activation of the RAS signalling pathway. The CDKN2A (p16) tumour suppressor gene is also altered in several tumour types. We therefore wanted to assess the patte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Salvesen HB,Kumar R,Stefansson I,Angelini S,MacDonald N,Smeds J,Jacobs IJ,Hemminki K,Das S,Akslen LA

    更新日期:2005-07-20 00:00:00

  • Cell-mediated immune reactivity of Sinclair melanoma-bearing swine to 3 M KCl extracts of swine and human melanoma.

    abstract::Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hook RR Jr,Hamby CV,Millikan LE,Berkelhammer J,Stills HF Jr,Oxenhandler RW

    更新日期:1983-05-15 00:00:00

  • Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma.

    abstract::Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family of polypeptide growth factors, which includes EGF, transforming growth factor alpha(TGF-alpha), amphiregulin (AR) and betacellulin (BTC). To assess the potential role of HB-EGF in human gastric carcinomas, the expre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Naef M,Yokoyama M,Friess H,Büchler MW,Korc M

    更新日期:1996-05-03 00:00:00

  • Sequence variation and physical state of human papillomavirus type 16 cervical cancer isolates from Australia and New Caledonia.

    abstract::Sequence diversity over 2600 nucleotides of the upstream regulatory region (URR) and the E6 and E2/E4 genes of 34 human papillomavirus (HPV)16 cervical cancer isolates from Australia and New Caledonia was investigated. One 81 base duplication, 41 single base substitutions and 1 single base insertion were identified in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Watts KJ,Thompson CH,Cossart YE,Rose BR

    更新日期:2002-02-20 00:00:00

  • LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.

    abstract::Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that sever...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cadenas C,Vosbeck S,Edlund K,Grgas K,Madjar K,Hellwig B,Adawy A,Glotzbach A,Stewart JD,Lesjak MS,Franckenstein D,Claus M,Hayen H,Schriewer A,Gianmoena K,Thaler S,Schmidt M,Micke P,Pontén F,Mardinoglu A,Zhang C,K

    更新日期:2019-08-15 00:00:00

  • A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

    abstract::Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we tested the hypothesis that a C to T variant (Thr241Met) of DNA...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shen H,Sturgis EM,Dahlstrom KR,Zheng Y,Spitz MR,Wei Q

    更新日期:2002-06-20 00:00:00

  • Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways.

    abstract::A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains high-risk human papillomavirus-type 16 (HPV16). The viral E6 and E7 oncoproteins inactivate the p53 and pRb proteins, respectively. We examined the causative effect of HPV16 E6 and E7 expression on the immortalization of normal oral keratinocytes (...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Smeets SJ,van der Plas M,Schaaij-Visser TB,van Veen EA,van Meerloo J,Braakhuis BJ,Steenbergen RD,Brakenhoff RH

    更新日期:2011-04-01 00:00:00

  • Rab11-FIP2 promotes the metastasis of gastric cancer cells.

    abstract::Rab11-FIP2 can interact with MYO5B and plays an important role in regulating plasma membrane recycling. Our previous study has shown that MYO5B is epigenetically silenced and associated with c-Met signaling in human gastric cancer. However, little is known of the function of Rab11-FIP2 in gastric cancer. In this study...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dong W,Qin G,Shen R

    更新日期:2016-04-01 00:00:00

  • Distinct clinical features associated with microsatellite instability in colorectal cancers of young patients.

    abstract::The Hong Kong Chinese population has an unusually high incidence of colorectal cancer in the young, suggestive of hereditary susceptibility. To search for a genetic basis for this predisposition, we studied the incidence of microsatellite instability (MSI) in paraffin-embedded colectomy specimens of 124 young (<50 yea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ho JW,Yuen ST,Chung LP,Kwan KY,Chan TL,Leung SY,Chan AS,Tse Cw,Lam PW,Luk IS

    更新日期:2000-07-20 00:00:00

  • Randomized phase II trial of TEGAFIRI (tegafur/uracil, oral leucovorin, irinotecan) compared with FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) in patients with unresectable/recurrent colorectal cancer.

    abstract::Irinotecan-based chemotherapy with bevacizumab is one of the first-line standard therapies for metastatic colorectal cancer (mCRC). TEGAFIRI (UFT/LV + irinotecan) is an irinotecan-based chemotherapy regimen. Currently, few clinical data regarding TEGAFIRI are available. This study evaluated the efficacy and safety of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Shigeta K,Hasegawa H,Okabayashi K,Tsuruta M,Ishii Y,Endo T,Ochiai H,Kondo T,Kitagawa Y

    更新日期:2016-08-15 00:00:00

  • Quality diet indexes and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study.

    abstract::There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Luu HN,Neelakantan N,Geng TT,Wang R,Goh GB,Clemente JC,Jin A,van Dam RM,Jia W,Behari J,Koh WP,Yuan JM

    更新日期:2020-10-31 00:00:00

  • Electrical power lines and childhood leukemia: a study from Greece.

    abstract::Residential proximity to electrical power lines of different voltage in relation to childhood leukemia was investigated through a case-control study undertaken in Greece during 1993-1994. The study comprised 117 incident cases of childhood leukemia and 202 age-, gender- and place-of-residence-matched controls. Four me...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Petridou E,Trichopoulos D,Kravaritis A,Pourtsidis A,Dessypris N,Skalkidis Y,Kogevinas M,Kalmanti M,Koliouskas D,Kosmidis H,Panagiotou JP,Piperopoulou F,Tzortzatou F,Kalapothaki V

    更新日期:1997-11-04 00:00:00

  • DCC gene alteration in human endometrial carcinomas.

    abstract::The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gima T,Kato H,Honda T,Imamura T,Sasazuki T,Wake N

    更新日期:1994-05-15 00:00:00

  • Inhibition of experimental pulmonary metastasis by controlling biodistribution of catalase in mice.

    abstract::In a previous study, we showed that targeted delivery of bovine liver catalase to hepatocytes by direct galactosylation augmented the inhibitory effect of the enzyme on experimental hepatic metastasis of colon carcinoma cells (unpublished data). Here, we examined the ability of catalase to inhibit tumor metastasis to ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nishikawa M,Tamada A,Kumai H,Yamashita F,Hashida M

    更新日期:2002-05-20 00:00:00

  • Cyclic AMP inhibits TGFbeta1-induced cell-scattering and invasiveness in murine-transformed keratinocytes.

    abstract::Mouse-transformed keratinocytes cultured in the presence of transforming growth factor beta1 (TGF-beta1) acquire an array of morphologic and functional properties that give rise to a migratory phenotype that expresses mesenchymal molecular markers. This cellular conversion involves activation of the Ras-ERK pathway, e...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Santibáñez JF,Olivares D,Guerrero J,Martínez J

    更新日期:2003-12-10 00:00:00

  • Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis.

    abstract::The prognostic role of inflammation index like neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer (CRC) remains controversial. We conduct a meta-analysis to determine the predictable value of NLR in the clinical outcome of CRC patients. The analysis was carried out based on the data from 16 studies (19 cohorts)...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Li MX,Liu XM,Zhang XF,Zhang JF,Wang WL,Zhu Y,Dong J,Cheng JW,Liu ZW,Ma L,Lv Y

    更新日期:2014-05-15 00:00:00

  • Estrogen and progesterone receptor mRNA levels in primary breast cancer: association with patient survival and other clinical and tumor features.

    abstract::The relative expression of estrogen receptor (ER) and progesterone receptor (PR) mRNA transcripts was measured in 71 primary breast-cancer biopsies. ER and PR binding activity were estimated in parallel by the dextran-coated-charcoal method. There was a close correlation between the amount of ER mRNA and estradiol bin...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nagai MA,Marques LA,Yamamoto L,Fujiyama CT,Brentani MM

    更新日期:1994-11-01 00:00:00

  • Resistance of human breast-cancer cells to the pure steroidal anti-estrogen ICI 182,780 is not associated with a general loss of estrogen-receptor expression or lack of estrogen responsiveness.

    abstract::To elucidate the mechanisms responsible for the development of anti-estrogen resistance, we have cloned and established 3 stable ICI-182,780-resistant sub-lines, MCF-7/182R-1, MCF-7/182R-6 and MCF-7/182R-7 from the estrogen-receptor(ER)-positive and estrogen-responsive human breast-cancer MCF-7 cell line by long-term ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Larsen SS,Madsen MW,Jensen BL,Lykkesfeldt AE

    更新日期:1997-09-17 00:00:00

  • Seasonal variations do not affect the superiority of fecal immunochemical tests over guaiac tests for colorectal cancer screening.

    abstract::The aim of this study was to compare the seasonal variation in performance of a faecal immunochemical test for haemoglobin (FIT) and a guaiac test (gFOBT) for colorectal cancer screening. From June 2009 to May 2011, 18,290 screening participants (50-74 years old) performed OC-SENSOR quantitative FIT (1 sample) and Hem...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chausserie S,Levillain R,Puvinel J,Ferrand O,Ruiz A,Raginel T,Lantieri O,Launoy G,Guittet L

    更新日期:2015-04-15 00:00:00

  • Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity.

    abstract::9-cis-Retinoic acid (9cRA) and 1alpha,25-dihydroxyvitamin D3 (1,25D) show promise as potential chemopreventive agents. We examined 9cRA and 1,25D, alone and in combination, for their potential to inhibit carcinogen (NNK)-induced lung carcinogenesis in A/J mice. A/J mice (n=14/group) were treated with 9cRA (7.5, 15, or...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mernitz H,Smith DE,Wood RJ,Russell RM,Wang XD

    更新日期:2007-04-01 00:00:00

  • Breast cancer extent and survival among diabetic women in a Finnish nationwide cohort study.

    abstract::Breast cancer (BC) and diabetes mellitus (DM) are major health problems. We examined the association between DM and BC stage at diagnosis and subsequent survival in a Finnish cohort of female BC patients. All BC cases (N = 73,170) diagnosed in 1995-2013 with dates and causes of death were identified from the Finnish C...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Murto MO,Artama M,Pukkala E,Visvanathan K,Murtola TJ

    更新日期:2018-06-01 00:00:00

  • The effect of azathioprine on host cell infiltration and growth of a murine fibrosarcoma.

    abstract::Azathioprine (AZ) was injected into C57 Black mice before or after IM implantation of the syngeneic fibrosarcoma FS6, and observations were made on tumour growth and on the cellular composition of the fibrosarcomas. When multiple injections were given to the tumour-bearing host the tumours regressed. The percentage of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Evans R

    更新日期:1977-07-15 00:00:00

  • Biodistribution of 111In-labelled SCN-bz-DTPA-BC-2 MAb following loco-regional injection into glioblastomas.

    abstract::We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

    更新日期:1997-05-29 00:00:00

  • Non-MHC-restricted target-cell lysis by a CD4-CD8- TCR alpha beta T-cell line, as well as by TCR gamma delta T-cell lines, results from lymphokine-activated killing.

    abstract::A long-term CD4-CD8- TCR alpha beta human T-cell line, as well as similar CD4-CD8- TCR gamma delta T-cell lines for comparison, were generated from various tissues by negative selection using anti-CD4 and anti-CD8 monoclonal antibodies (MAbs) followed by positive selection with specific anti-TCR MAb and then repeated ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Maziarz RT,Groh V,Prendergast M,Fabbi M,Strominger JL,Burakoff SJ

    更新日期:1991-04-22 00:00:00

  • Expression of transforming growth factor alpha messenger RNA in the normal and neoplastic gastro-intestinal tract.

    abstract::The presence of TGF alpha mRNA has been reported previously to occur in primary colon cancers. We report the expression of the normal 4.5 kb TGF alpha transcript in the mucosa of the normal human gastro-intestinal tract from oesophagus through to colon. The highest levels of human TGF alpha mRNA occurred in the duoden...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Malden LT,Novak U,Burgess AW

    更新日期:1989-03-15 00:00:00

  • International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons.

    abstract::Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mirabello L,Troisi RJ,Savage SA

    更新日期:2009-07-01 00:00:00