Progenitor and pre-B lymphocytes transformed by Epstein-Barr virus.


:By rosetting with SRBC coupled to rabbit-anti-human IgM, the surface IgM-negative cells of human fetal bone marrow were enriched, and subsequently infected and transformed by Epstein-Barr virus (EBV). Single clones of the transformed cells were obtained. Ninety percent of the resulting cell clones were surface-immunoglobulin-negative, and of 8 clones which were further studied, 5 lacked intracellular, cytoplasmic Ig as measured by immunofluorescence. Control cell clones derived from the same material without pre-selection expressed surface Ig and also secreted Ig. Utilization of a panel of B-cell-specific monoclonal antibodies (MAbs) showed no difference between the cell clones expressing surface Ig and those that did not. The progenitor B-cell lines did not show a phenotype resembling that of cell lines derived from B-cell malignancies, such as high agarose clonability. In spite of their immature Ig-phenotype, these clones showed rearrangement of at least one heavy chain Ig-allele. Efforts to induce differentiation in these clones were unsuccessful. These clones may represent progenitor B cells, or B cells with faulty heavy-chain rearrangement. EBV can apparently be used as a tool to derive cell lines representing different levels of B-cell differentiation, and can also transform immature B cells, which may be useful in the analysis of B-cell differentiation.


Int J Cancer


Ernberg I,Falk K,Hansson M




Has Abstract


1987-02-15 00:00:00












  • Androgen receptor-interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions.

    abstract::Hormonal therapies targeting androgen receptor (AR) are effective in prostate cancer (PCa), but often the cancers progress to fatal castrate-resistant disease. Improved understanding of the cellular events during androgen deprivation would help to identify survival and stress pathways whose inhibition could synergize ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Saeed K,Östling P,Björkman M,Mirtti T,Alanen K,Vesterinen T,Sankila A,Lundin J,Lundin M,Rannikko A,Nordling S,Mpindi JP,Kohonen P,Iljin K,Kallioniemi O,Rantala JK

    更新日期:2015-06-01 00:00:00

  • A randomized trial comparing conventional cytology to liquid-based cytology and computer assistance.

    abstract::Liquid-based cytology (LBC) has replaced conventional cytology (CC) for cervical cancer screening in some countries. However, it remains unclear whether LBC is superior to CC. A randomized controlled trial was conducted between August 2007 and March 2009 in Germany to compare LBC, alone and in combination with compute...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Klug SJ,Neis KJ,Harlfinger W,Malter A,König J,Spieth S,Brinkmann-Smetanay F,Kommoss F,Weyer V,Ikenberg H

    更新日期:2013-06-15 00:00:00

  • Dose-dense adjuvant chemotherapy in HER2-positive early breast cancer patients before and after the introduction of trastuzumab: Exploratory analysis of the GIM2 trial.

    abstract::Dose-dense adjuvant chemotherapy is standard of care in high-risk early breast cancer patients. However, its role in HER2-positive patients is still uncertain. In this exploratory analysis of the GIM2 trial, we investigated the efficacy of dose-dense chemotherapy in HER2-positive breast cancer patients with or without...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lambertini M,Poggio F,Bruzzone M,Conte B,Bighin C,de Azambuja E,Giuliano M,De Laurentiis M,Cognetti F,Fabi A,Bisagni G,Durando A,Turletti A,Urracci Y,Garrone O,Puglisi F,Montemurro F,Ceppi M,Del Mastro L,GIM2 invest

    更新日期:2020-07-01 00:00:00

  • Steady state levels of transforming growth factor-beta1 and -beta2 mRNA and protein expression are elevated in colonic tumors in vivo irrespective of dietary lipids intervention.

    abstract::Colonic tumors of human origin produce abundant transforming growth factor (TGF)-beta suggesting that TGF-beta is critical to their growth. Dietary lipids regulate a number of growth factors including TGF-beta. Whether elevated TGF-beta levels are consistently expressed in colonic tumors irrespective of the environmen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Raju J,McCarthy B,Bird RP

    更新日期:2002-08-20 00:00:00

  • Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus.

    abstract::Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal growth factor receptor-2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer and to determine the effect of IGF-1R and HE...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kalinina T,Bockhorn M,Kaifi JT,Thieltges S,Güngör C,Effenberger KE,Strelow A,Reichelt U,Sauter G,Pantel K,Izbicki JR,Yekebas EF

    更新日期:2010-10-15 00:00:00

  • Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma.

    abstract::Human kallikrein 11 (hK11/trypsin-like serine protease/TLSP, encoded by the KLK11 gene) is a member of the kallikrein family of secreted serine proteases. Recently, we developed a highly sensitive and specific immunoassay for hK11 and found that this protease is expressed in the prostate, stomach and trachea as well a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Borgoño CA,Fracchioli S,Yousef GM,Rigault de la Longrais IA,Luo LY,Soosaipillai A,Puopolo M,Grass L,Scorilas A,Diamandis EP,Katsaros D

    更新日期:2003-09-10 00:00:00

  • Serological response to HPV16 in CIN-III and cervical cancer patients. Case-control studies in Spain and Colombia.

    abstract::This study evaluates the association of antibodies against HPV-16-derived peptides with cervical cancer and estimates the sensitivity and specificity of the serological assays in relation to HPV DNA detection in cervical cells by PCR. Study subjects were derived from 4 case-control studies carried out in Spain and Col...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: De Sanjosé S,Hamsíková E,Muñoz N,Bosch FX,Hofmannová V,Gili M,Izarzugaza I,Viladiu P,Tormo MJ,Moreo P,Muñoz MT,Ascunce N,Tafur L,Shah KV,Vonka V

    更新日期:1996-03-28 00:00:00

  • Enhancement by TPA of phenotypes associated with transformation in carcinogen-treated human cells: evidence for a selective mechanism.

    abstract::The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) was found to increase the incidence of phenotypic alterations induced by the direct-acting carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in human endometrial stromal cells. Following carcinogen treatment, changes in saturation density, gamma-glutam...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Siegfried JM,Kaufman DG

    更新日期:1983-10-15 00:00:00

  • Binding of some metastatic tumor cell lines to fibrous elastin and elastin peptides.

    abstract::Recent suggestions that tumor-cell targeting of elastin-rich tissues (e.g., lung) correlates with the presence of surface elastin receptors have been investigated. Receptors for insoluble (fibrous) elastin and for soluble elastin peptides have been implemented in these correlations. A rapid assay for binding of insolu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Svitkina TM,Parsons DF

    更新日期:1993-03-12 00:00:00

  • Study of Epstein-Barr virus-determined nuclear antigen (EBNA) by chromatography on fixed cell nuclei.

    abstract::Low ionic strength (50 to 100 mM NaCl) and pH 6.0 were found to be optimal conditions for in vitro conversion of Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA)-negative nuclei to EBNA-positive nuclei by addition of the complement-fixing (CF) antigen extracted from Raji cells. In vitro conversion of nuclei ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hirsch I,Suchánková A,Závadová H,Vonka V

    更新日期:1978-11-15 00:00:00

  • PBX3 is a putative biomarker of aggressive prostate cancer.

    abstract::There is a great need to identify new and better prognostic and predictive biomarkers to stratify prostate cancer patients for optimal treatment. The aims of this study were to characterize the expression profile of pre-B cell leukemia homeobox (PBX) transcription factors in prostate cancer with an emphasis on investi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ramberg H,Grytli HH,Nygård S,Wang W,Ögren O,Zhao S,Løvf M,Katz B,Skotheim RI,Bjartell A,Eri LM,Berge V,Svindland A,Taskén KA

    更新日期:2016-10-15 00:00:00

  • Tumoricidal activity of high-dose tumor necrosis factor-alpha is mediated by macrophage-derived nitric oxide burst and permanent blood flow shutdown.

    abstract::This study investigates the role of tumor nitric oxide (NO) and vascular regulation in tumor ulceration following high-dose tumor necrosis factor-alpha (TNF) treatment. Using TNF-responsive (MethA) and nonresponsive (LL2) mouse tumors, tumor NO concentration was measured with an electrochemical sensor and tumor blood ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Menon C,Bauer TW,Kelley ST,Raz DJ,Bleier JI,Patel K,Steele K,Prabakaran I,Shifrin A,Buerk DG,Sehgal CM,Fraker DL

    更新日期:2008-07-15 00:00:00

  • Preserved foods and nasopharyngeal carcinoma: a case-control study among Singapore Chinese.

    abstract::The association between the consumption of preserved foods in infancy, childhood and adulthood and the risk of nasopharyngeal carcinoma was investigated in a case-control study among Singapore Chinese: 200 cases (73% male) were compared with 406 hospital controls (71% male). Significantly increased risks were observed...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee HP,Gourley L,Duffy SW,Esteve J,Lee J,Day NE

    更新日期:1994-12-01 00:00:00

  • Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines.

    abstract::Receptors for the third component of complement (C3) were demonstrated on the surface of established human lymphoid cell lines by a membrane fluorescence test with FITC- or TRITC-conjugated antibodies against human C3. Two-color fluorescence staining of EBV receptors and C3 receptors showed complete overlapping of gre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yefenof E,Klein G,Jondal M,Oldstone MB

    更新日期:1976-06-15 00:00:00

  • Cell kinetics of CD34-positive hematopoietic cells following chemotherapy plus colony-stimulating factors in advanced breast cancer.

    abstract::Bone-marrow (BM) hematopoietic precursors are recruited into proliferative activity when colony-stimulating factors (CSF) are sequenced with chemotherapy (CT). Previous studies suggested that further CT can be safely administered only when the increased proliferative activity of these cells has subsided, because most ...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Danova M,Rosti V,Mazzini G,De Renzis MR,Locatelli F,Cazzola M,Riccardi A,Ascari E

    更新日期:1995-11-27 00:00:00

  • In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma.

    abstract::A glutamine analogue, L-glutamic acid gamma-monohydroxamate (GAH) demonstrated complete cytotoxicity against L1210 cells in culture and marked anti-tumoral activity in vivo against L1210 leukemia and B16 melanoma. In vitro, GAH caused concentration-dependent inhibition of L1210 cell growth, with complete cell death be...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vila J,Thomasset N,Navarro C,Doré JF

    更新日期:1990-04-15 00:00:00

  • Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity.

    abstract::A variable fraction of anaplastic large-cell lymphomas (ALCLs) exhibits a t(2;5)(p23;q35) translocation that results in expression of the chimeric hyperphosphorylated protein NPM-ALK (p80). Tumor cells expressing NPM-ALK exhibit markedly enhanced proliferative activity, but comparative cellular kinetic studies on ALK(...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leoncini L,Lazzi S,Scano D,Mura A,Onida A,Massarelli G,Tosi P,Barbini P,Cevenini G,Massai MR,Pileri S,Falini B,Giordano A,Kraft R,Laissue JA,Cottier H

    更新日期:2000-06-15 00:00:00

  • Expression of multiple angiogenic cytokines in cultured normal human prostate epithelial cells: predominance of vascular endothelial growth factor.

    abstract::The cytokines that regulate angiogenesis in normal and malignant prostate tissue are not well studied. Using an RT-PCR-based screen, we observed that cultured, low-passage normal human prostate epithelial cells (PrECs) express a variety of cytokines which have been shown to have angiogenic and/or endothelial cell-acti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Campbell CL,Savarese DM,Quesenberry PJ,Savarese TM

    更新日期:1999-03-15 00:00:00

  • Pyrimethamine sensitizes pituitary adenomas cells to temozolomide through cathepsin B-dependent and caspase-dependent apoptotic pathways.

    abstract::Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dai C,Zhang B,Liu X,Guo K,Ma S,Cai F,Yang Y,Yao Y,Feng M,Bao X,Deng K,Jiao Y,Wei Z,Junji W,Xing B,Lian W,Wang R

    更新日期:2013-10-15 00:00:00

  • Clinicopathological and prognostic significance of circulating tumor cells in patients with gastric cancer: a meta-analysis.

    abstract::The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane d...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Huang X,Gao P,Sun J,Chen X,Song Y,Zhao J,Xu H,Wang Z

    更新日期:2015-01-01 00:00:00

  • Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner.

    abstract::Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Copeland BT,Bowman MJ,Boucheix C,Ashman LK

    更新日期:2013-10-15 00:00:00

  • Erratum: Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999).

    abstract::Chen, B., Liu, X., Savell, V.H., Dilday, B.R., Johnson, M.W., Jenkins, J.J., and Parham, D.M., Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999). Due to a printer's error, the bottom of Figure 3 was cut off after the proofs had been approved by the author. The correct fi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

    更新日期:1999-12-10 00:00:00

  • Several murine metastasizing tumors possess a cysteine proteinase with cancer procoagulant characteristics.

    abstract::Cancer Procoagulant (CP), a cysteine proteinase which triggers blood coagulation by directly activating Factor X (FX) in the absence of Factor VII (F VII), has recently been isolated from rabbit V2 carcinoma and biochemically characterized. We have studied the procoagulant activity of tissue extracts from 4 murine exp...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Falanga A,Bolognese Dalessandro AP,Casali B,Roncaglioni MC,Donati MB

    更新日期:1987-06-15 00:00:00

  • DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate.

    abstract::Ferric nitrilotriacetate (Fe-NTA) causes renal proximal tubular necrosis, a consequence of iron ion-mediated free-radical-associated damage, that finally leads to a high incidence of renal adenocarcinoma in male rats and mice. We have investigated the levels of typical hydroxyl radical-induced DNA base modifications i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Toyokuni S,Mori T,Dizdaroglu M

    更新日期:1994-04-01 00:00:00

  • Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: the EPIC study.

    abstract::Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zamora-Ros R,Rinaldi S,Biessy C,Tjønneland A,Halkjaer J,Fournier A,Boutron-Ruault MC,Mesrine S,Tikk K,Fortner RT,Boeing H,Förster J,Trichopoulou A,Trichopoulos D,Papatesta EM,Masala G,Tagliabue G,Panico S,Tumino R,P

    更新日期:2015-03-01 00:00:00

  • Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel.

    abstract::HER2 represents an important signaling pathway in breast and other cancers. Herceptin has demonstrated clinical activity, but resistance is common. Thus, new therapeutic approaches to the HER2 pathway are needed. Grb2 is an adaptor protein involved in Ras-dependent signaling induced by HER2 receptors. A specific Grb2-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gril B,Vidal M,Assayag F,Poupon MF,Liu WQ,Garbay C

    更新日期:2007-07-15 00:00:00

  • The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer.

    abstract::Tumour cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumour microenvironment, and outcome in patients with colorectal cancer. A c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Roseweir AK,Clark J,McSorley ST,vanWyk HC,Quinn JA,Horgan PG,McMillan DC,Park JH,Edwards J

    更新日期:2019-05-01 00:00:00

  • The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired.

    abstract::Melanoma-associated germline mutations affecting the tumor suppressor and cyclin-dependent kinase (CDK) inhibitor, CDKN2A/p16INK4a, have been identified in over 100 melanoma-prone families worldwide. To predict the melanoma risk for carriers of specific mutations, mutant p16INK4a can be tested in biochemical and cellu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Becker TM,Ayub AL,Kefford RF,Mann GJ,Rizos H

    更新日期:2005-11-20 00:00:00

  • Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.

    abstract::In human breast cancer (HBC), as with many carcinoma systems, most matrix metalloproteinases (MMPs) are largely expressed by the stromal cells, whereas the tumour cells are relatively silent in MMP expression. To determine the tissue source of the most relevant MMPs, we xenografted HBC cell lines and HBC tissues into ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lafleur MA,Drew AF,de Sousa EL,Blick T,Bills M,Walker EC,Williams ED,Waltham M,Thompson EW

    更新日期:2005-04-20 00:00:00

  • Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.

    abstract::Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectio...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kho PF,Amant F,Annibali D,Ashton K,Attia J,Auer PL,Beckmann MW,Black A,Brinton L,Buchanan DD,Chanock SJ,Chen C,Chen MM,Cheng THT,Cook LS,Crous-Bous M,Czene K,De Vivo I,Dennis J,Dörk T,Dowdy SC,Dunning AM,Dürst

    更新日期:2021-01-15 00:00:00