In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase.

abstract：:HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathoge...

journal_title：International journal of cancer

authors： Caldes T,Godino J,de la Hoya M,Garcia Carbonero I,Perez Segura P,Eng C,Benito M,Diaz-Rubio E

更新日期：2002-04-10 00:00:00

abstract：:To investigate whether human melanoma cells intrinsically resistant to autologous LAKs do exist, and whether a relationship between the level of lysis of LAKs and spontaneous drug resistance can be identified at the clonal level, we studied 44 clones obtained from a metastatic melanoma lesion. The antigenic phenotype ...

journal_title：International journal of cancer

authors： Gambacorti-Passerini C,Rivoltini L,Supino R,Mariani M,Parmiani G

更新日期：1988-10-15 00:00:00

abstract：:Mutant KRAS provides a driving force for enhancement of cancer stem cells (CSCs) characteristics contributing transformation of colorectal cancer (CRC) cells harboring adenomatous polyposis coli (APC) mutations. Here, we identified the factors mediating the promotion of CSCs properties induced by KRAS mutation through...

journal_title：International journal of cancer

authors： Hwang JH,Yoon J,Cho YH,Cha PH,Park JC,Choi KY

更新日期：2020-05-15 00:00:00

abstract：:To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...

journal_title：International journal of cancer

authors： Daino K,Ugolin N,Altmeyer-Morel S,Guilly MN,Chevillard S

更新日期：2009-08-01 00:00:00

abstract：:BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range o...

journal_title：International journal of cancer

authors： Blair PB,Lane ML

更新日期：1978-04-15 00:00:00

abstract：:Rabbits were immunized with extracts of primary or grafted intestinal adeno-carcinomas induced by carcinogenic drugs in inbred rats. After absorption with normal tissue extracts, the antisera were able to recognize three tumor-associated antigens. Two of them were glycoproteins, present in cancer cells but also, in tr...

journal_title：International journal of cancer

authors： Martin F,Martin MS,Bordes M,Knobel S

更新日期：1975-01-15 00:00:00

abstract：:Childhood brain tumors (CBT) are the leading cause of cancer death in children, yet their etiology remains largely unknown. Tobacco smoke contains 61 known carcinogens and increases the risk of several adult cancers. This study investigated associations between parental smoking and risk of CBT in a population-based ca...

journal_title：International journal of cancer

authors： Milne E,Greenop KR,Scott RJ,Ashton LJ,Cohn RJ,de Klerk NH,Armstrong BK

更新日期：2013-07-01 00:00:00

abstract：:Using data from a large health plan, we performed a cohort study of thyroid cancer among 204,964 persons (aged 10--89 at baseline in 1964--1973, 54% female) followed for a median of 20 years. There were 196 incident thyroid cancers (73 in men, 123 in women). Risk was independently and positively related to female gend...

journal_title：International journal of cancer

authors： Iribarren C,Haselkorn T,Tekawa IS,Friedman GD

更新日期：2001-09-01 00:00:00

abstract：:A previously published case-control study of agricultural risk factors involved male cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases (ICD). This study has been expanded with the inclusion of cases registered under ICD code 200, and additional controls. The expa...

journal_title：International journal of cancer

authors： Pearce NE,Sheppard RA,Smith AH,Teague CA

更新日期：1987-02-15 00:00:00

abstract：:In Japan, cervical cancer incidence has increased since the late 1990s especially among young women, despite a decreasing trend in most developed countries. Here, we examined age, period and birth cohort trends in cervical cancer incidence rates from 1985 to 2012. Incidence rates were ascertained using three populatio...

journal_title：International journal of cancer

authors： Utada M,Chernyavskiy P,Lee WJ,Franceschi S,Sauvaget C,de Gonzalez AB,Withrow DR

更新日期：2019-05-01 00:00:00

abstract：:Recently reported genome-wide association studies have identified more than 20 common low-penetrance colorectal cancer (CRC) susceptibility loci. Recent studies have reported that copy number variations (CNVs) are considered important human genomic variants related to cancer, while the contribution of CNVs remains unc...

journal_title：International journal of cancer

authors： Park C,Kim JI,Hong SN,Jung HM,Kim TJ,Lee S,Kim SJ,Kim HC,Kim DH,Cho B,Park JH,Sung J,Lee DS,Kang M,Son HJ,Kim YH

更新日期：2017-01-01 00:00:00

abstract：:Recent reports suggest that autoantibodies directed to aberrantly glycosylated mucins, in particular MUC1 and MUC4, are found in patients with colorectal cancer. There is, however, limited information on the autoantibody levels before clinical diagnosis, and their utility in cancer screening in the general population....

journal_title：International journal of cancer

authors： Pedersen JW,Gentry-Maharaj A,Nøstdal A,Fourkala EO,Dawnay A,Burnell M,Zaikin A,Burchell J,Papadimitriou JT,Clausen H,Jacobs I,Menon U,Wandall HH

更新日期：2014-05-01 00:00:00

abstract：:In a hospital-based case-control study of esophageal cancer undertaken in Athens (1989-1991), 43 patients with incident esophageal squamous-cell carcinoma and 56 patients with incident esophageal adenocarcinoma were compared to 200 injury patients. Personal interviews were conducted in the hospital setting, and dietar...

journal_title：International journal of cancer

authors： Tzonou A,Lipworth L,Garidou A,Signorello LB,Lagiou P,Hsieh C,Trichopoulos D

更新日期：1996-11-04 00:00:00

abstract：:APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...

journal_title：International journal of cancer

authors： De Giovanni C,Landuzzi L,Nicoletti G,Astolfi A,Croci S,Micaroni M,Nanni P,Lollini PL

更新日期：2004-03-20 00:00:00

abstract：:A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occurring HPV infectio...

journal_title：International journal of cancer

authors： Giannoudis A,Graham DA,Southern SA,Herrington CS

更新日期：1999-09-24 00:00:00

abstract：:A panel of 7 diagnostic cytopathologists, i.e., physicians trained to diagnose the malignant potential of human cells in Papanicolaou-stained smears, was asked to evaluate two sets of microscope slides of stained coverslip preparations of 28 cell culture lines, 15 of which were neoplastic. Slide Set I consisted of 13 ...

journal_title：International journal of cancer

authors： Boone CW,Sanford KK,Frost JK,Mantel N,Gill GW,Jones GM

更新日期：1986-09-15 00:00:00

abstract：:Angiogenesis inhibitors have been used to treat some cancers, but the therapeutic potential of these agents for gastric cancer has remained unclear. To investigate their therapeutic potential, we examined the effect of ZD6474, an agent that selectively targets vascular endothelial growth factor receptor-2 (VEGFR-2; KD...

journal_title：International journal of cancer

authors： Arao T,Yanagihara K,Takigahira M,Takeda M,Koizumi F,Shiratori Y,Nishio K

更新日期：2006-01-15 00:00:00

abstract：:Tumor infiltrating T cells are a predictor of patient outcome in patients with colorectal cancer (CRC). However, many T cell populations have been associated with both poor and positive patient prognoses, indicating a need to further understand the role of different T cell subsets in CRC. In this study, the T cell inf...

journal_title：International journal of cancer

authors： Taylor ES,McCall JL,Shen S,Girardin A,Munro FM,Black MA,Ward-Hartstonge KA,Kemp RA

更新日期：2018-10-15 00:00:00

abstract：:Prostate stem cell antigen (PSCA) and prostate-specific antigen (PSA) are overexpressed in most prostate cancers. PSCA- and PSA-derived, HLA-A2 binding peptides are specific targets for T-cell responses in vitro. A phase I/II trial was performed to demonstrate feasibility, safety and induction of antigen-specific immu...

journal_title：International journal of cancer

authors： Thomas-Kaskel AK,Zeiser R,Jochim R,Robbel C,Schultze-Seemann W,Waller CF,Veelken H

更新日期：2006-11-15 00:00:00

abstract：:Hormonal therapies targeting androgen receptor (AR) are effective in prostate cancer (PCa), but often the cancers progress to fatal castrate-resistant disease. Improved understanding of the cellular events during androgen deprivation would help to identify survival and stress pathways whose inhibition could synergize ...

journal_title：International journal of cancer

authors： Saeed K,Östling P,Björkman M,Mirtti T,Alanen K,Vesterinen T,Sankila A,Lundin J,Lundin M,Rannikko A,Nordling S,Mpindi JP,Kohonen P,Iljin K,Kallioniemi O,Rantala JK

更新日期：2015-06-01 00:00:00

abstract：:The characteristics of tumor antigens of the transplantation type, TATA, were studied in a series of methylcholanthrene-induced sarcomas in pedigreed BALB/cAN mice. Each of the six sarcomas exhibited unique TATA when assayed for tumor rejection in syngeneic hosts. In three instances, however, in sarcomas CI-I, CII-5 a...

journal_title：International journal of cancer

authors： Law LW

更新日期：1980-02-15 00:00:00

abstract：:Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...

journal_title：International journal of cancer

authors： Rashidkhani B,Akesson A,Lindblad P,Wolk A

更新日期：2005-12-10 00:00:00

abstract：:Epstein-Barr virus genome-positive Burkitt's lymphoma is endemic in Africa and Papua New Guinea and in both countries the tumour is restricted to regions with holoendemic malaria. The present work has compared groups of healthy indigenous individuals living in malarious and non-malarious regions of Papua New Guinea fo...

journal_title：International journal of cancer

authors： Moss DJ,Burrows SR,Castelino DJ,Kane RG,Pope JH,Rickinson AB,Alpers MP,Heywood PF

更新日期：1983-06-15 00:00:00

abstract：:A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast-cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER+ tumors is analyzed. ER,...

journal_title：International journal of cancer

authors： Levin E,Actis AM,Caruso S,Gass H,Romero R,Qualeta N,Levin RW

更新日期：1997-11-14 00:00:00

abstract：:The human MUC1 gene expresses at least 2 type 1 membrane proteins: MUC1/REP, a polymorphic high m.w. MUC1 glycoprotein often highly expressed in breast cancer tissues and containing a variable number of tandem 20 amino acid repeat units, and the MUC1/Y protein, which lacks this repeat array and, therefore, is not poly...

journal_title：International journal of cancer

authors： Baruch A,Hartmann M,Zrihan-Licht S,Greenstein S,Burstein M,Keydar I,Weiss M,Smorodinsky N,Wreschner DH

更新日期：1997-05-29 00:00:00

abstract：:3-Nitrobenzanthrone (3-NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3-NBA is likely to occur primarily via the respiratory tract. In our study female Sprague Dawley rats were...

journal_title：International journal of cancer

authors： Bieler CA,Cornelius MG,Klein R,Arlt VM,Wiessler M,Phillips DH,Schmeiser HH

更新日期：2005-10-10 00:00:00

abstract：:Malignant glioma is one of the most aggressive cancers. For the development of effective therapeutic strategies against such malignant diseases, elucidation of molecular targets is necessary. We found that inactivated Sendai virus particle (HVJ-E) induced extensive cell death in the human glioblastoma cell line U251MG...

journal_title：International journal of cancer

authors： Tanaka M,Shimbo T,Kikuchi Y,Matsuda M,Kaneda Y

更新日期：2010-04-15 00:00:00

abstract：:Human blood monocytes are very potent to take up antigens. Like macrophages in tissue, they efficiently degrade exogenous protein and are less efficient than dendritic cells (DCs) at cross-presenting antigens to CD8+ T cells. Although it is generally accepted that DCs take up tissue antigens and then migrate to lymph ...

journal_title：International journal of cancer

authors： Faure F,Jouve M,Lebhar-Peguillet I,Sadaka C,Sepulveda F,Lantz O,Berre S,Gaudin R,Sánchez-Ramón S,Amigorena S

更新日期：2018-01-01 00:00:00

abstract：:Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...

journal_title：International journal of cancer

authors： Urhoj SK,Raaschou-Nielsen O,Hansen AV,Mortensen LH,Andersen PK,Nybo Andersen AM

更新日期：2017-06-01 00:00:00

abstract：:The studies reported here explore the relationship between tumor-specific transplantation antigens (TSTA) and (1) the expression of serologically defined specificities, and (2) the immunogenicity of H-2K- or H-2D-determined alloantigens on methylcholanthrene (MCA)-induced murine fibrosarcomas. Expression of H-2K and H...

journal_title：International journal of cancer

authors： Chauvenet PH,Smith RT

更新日期：1978-07-15 00:00:00