In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase.


:We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after which all mice were killed. CGP 48664A caused dose-related exponential decreases of L1210 cell numbers and spermidine and spermine contents. Putrescine contents increased exponentially. Polyamine changes in spleen and liver were less profound. L1210 growth inhibition was not accompanied by changes in cell cycle phase distribution. It is concluded that CGP 48664A is an effective inhibitor of S-adenosylmethionine decarboxylase but that CGP 48664A-induced changes in intracellular polyamine compositions are not necessarily the cause of growth inhibition.


Int J Cancer


Dorhout B,Te Velde RJ,Ferwerda H,Kingma AW,De Hoog E,Muskiet FA




Has Abstract


1995-04-10 00:00:00












  • Population dynamics of serologically identified coinfections with human papillomavirus types 11, 16, 18 and 31 in fertile-aged Finnish women.

    abstract::Licensed human papillomavirus (HPV) vaccines are expected to prevent high-risk (hr) HPV-infections (most notably types 16 and 18). Whether HPV vaccination will change the distribution of hrHPVs at the population level is open, since competition between HPV types is not well understood. Two stratified random subcohorts...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kaasila M,Koskela P,Kirnbauer R,Pukkala E,Surcel HM,Lehtinen M

    更新日期:2009-11-01 00:00:00

  • Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma.

    abstract::Germline mutation of the folliculin gene (BHD) at chromosome 17p11.2 is associated with the development of multiplex hamartomas of the hair follicles, chromophobe renal cell carcinomas (RCC) and renal oncocytomas (RO). We have analyzed the folliculin gene with sequencing for mutations and the chromosome 17p11.2 with m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nagy A,Zoubakov D,Stupar Z,Kovacs G

    更新日期:2004-04-10 00:00:00

  • Acrylamide exposure measured by food frequency questionnaire and hemoglobin adduct levels and prostate cancer risk in the Cancer of the Prostate in Sweden Study.

    abstract::Acrylamide, a probable human carcinogen, is formed during the cooking of many commonly consumed foods. Data are scant on whether dietary acrylamide represents an important cancer risk in humans. We studied the association between acrylamide and prostate cancer risk using 2 measures of acrylamide exposure: intake from ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wilson KM,Bälter K,Adami HO,Grönberg H,Vikström AC,Paulsson B,Törnqvist M,Mucci LA

    更新日期:2009-05-15 00:00:00

  • Quantitative association between body mass index and the risk of cancer: A global Meta-analysis of prospective cohort studies.

    abstract::Numerous studies have suggested that excess body weight is associated with increased cancer risk. To examine this putative association, we performed a systematic review and quantitative meta-analysis of cohort studies reporting body mass index (BMI) and the risk of 23 cancer types. PubMed, Embase, and Web of Science w...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Fang X,Wei J,He X,Lian J,Han D,An P,Zhou T,Liu S,Wang F,Min J

    更新日期:2018-10-01 00:00:00

  • Augmentation of natural killer activity by pyran copolymer in mice.

    abstract::Treatment of older mice with pyran copolymer, a known interferon-inducer, was found to result in a rapid boosting of cell-mediated cytolytic activity against YAC-1 tumor target cells. The effector cells were characterized as being non-adherent and were presumed to be natural killer (NK) cells. Augmentation occurred in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Santoni A,Puccetti P,Riccardi C,Herberman RB,Bonmassar E

    更新日期:1979-11-15 00:00:00

  • The 4th nation-wide study of adult T-cell leukemia/lymphoma (ATL) in Japan: estimates of risk of ATL and its geographical and clinical features. The T- and B-cell Malignancy Study Group.

    abstract::To estimate the annual incidence of adult T-cell leukemia/lymphoma (ATL) by district in Japan, a large-scale nationwide survey of ATL and of non-Hodgkin's lymphoma was performed in 1988. Questionnaires for the registration of ATL and of T-cell and non-T-cell lymphoma were distributed to the physicians in charge of thi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tajima K

    更新日期:1990-02-15 00:00:00

  • Physical inactivity, energy intake, obesity and the risk of rectal cancer in Canada.

    abstract::We conducted a population-based case-control study of 1,447 incident rectal cancer cases and 3,106 population controls aged 20-76 years to assess the effect of recreational physical activity, energy intake and obesity on rectal cancer risk in 7 of 10 Canadian provinces in 1994-97. After adjustment for the effect of va...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mao Y,Pan S,Wen SW,Johnson KC,Canadian Cancer Registries Epidemiology Research Group.

    更新日期:2003-07-20 00:00:00

  • The mechanism of exogenous B7.1-enhanced IL-12-mediated complete regression of tumors by a single electroporation delivery.

    abstract::Electroporation-based mono-gene therapy has received great interest in recent years but coadministration of different therapeutic genes for treatment of tumors has not been well explored. We hypothesize that electroporation is capable of delivering multiple genes that induce an additive or synergistic antitumor effect...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Liu J,Xia X,Torrero M,Barrett R,Shillitoe EJ,Li S

    更新日期:2006-11-01 00:00:00

  • Systemic and in situ natural killer and suppressor cell activities in mice bearing progressively growing murine sarcoma-virus-induced tumors.

    abstract::The activity of systemic and in situ natural killer (NK) cells was measured in 3- to 5-week-old CBA mice with progressively growing murine sarcoma virus (MSV)-induced tumors. Splenic NK activity was depressed in tumor-bearing mice. NK activity was quite low or not detectable in unfractionated cell suspensions from the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gerson J,Varesio L,Herberman RB

    更新日期:1981-02-15 00:00:00

  • Angiostatic immune reaction in colorectal carcinoma: Impact on survival and perspectives for antiangiogenic therapy.

    abstract::Angiogenesis and inflammation are the 2 major stroma reactions in colorectal carcinoma (CRC). Guanylate binding protein-1 (GBP-1) is a key mediator of angiostatic effects of inflammation. Therefore, we hypothesized that GBP-1 may be a biomarker of intrinsic angiostasis associated with an improved outcome in CRC patien...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Naschberger E,Croner RS,Merkel S,Dimmler A,Tripal P,Amann KU,Kremmer E,Brueckl WM,Papadopoulos T,Hohenadl C,Hohenberger W,Stürzl M

    更新日期:2008-11-01 00:00:00

  • Effects of a single dose of polychlorinated biphenyls to infant mice on N-nitrosodimethylamine-initiated lung and liver tumors.

    abstract::Polychlorinated biphenyls (PCBs) are widespread, chemically-stable environmental contaminants; some congeners are commonly found in human adipose tissue and breast milk. We investigated the effects of a single dose of one PCB mixture (Aroclor 1254) on tumors initiated by N-nitrosodimethylamine (NDMA), also a common en...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Anderson LM,Ward JM,Fox SD,Isaaq HJ,Riggs CW

    更新日期:1986-07-15 00:00:00

  • Lethal deformation of cancer cells in the microcirculation: a potential rate regulator of hematogenous metastasis.

    abstract::The hypothesis has been advanced that deformation-induced lethal mechanical trauma, resulting in surface-membrane rupture, is inflicted on circulating cancer cells trapped in the microcirculation, and that this rapid cell-killing mechanism is a potentially important rate regulator for hematogenous metastasis. We descr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weiss L,Nannmark U,Johansson BR,Bagge U

    更新日期:1992-01-02 00:00:00

  • The decline in the incidence of stomach cancer in Sweden 1960-1984: a birth cohort phenomenon.

    abstract::Trends in the incidence of stomach cancer among 52,604 patients notified to the National Swedish Cancer Registry in 1960 through 1984 were analysed. Age-standardized incidence rates declined throughout the period, from 47.1 to 24.6 per 10(5) in males and from 23.8 to 12.7 per 10(5) in females. Among males the decline ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hansson LE,Bergström R,Sparén P,Adami HO

    更新日期:1991-02-20 00:00:00

  • International trends in prostatic cancer.

    abstract::The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zaridze DG,Boyle P,Smans M

    更新日期:1984-02-15 00:00:00

  • Stromal cells from human benign prostate hyperplasia produce a growth-inhibitory factor for LNCaP prostate cancer cells, identified as interleukin-6.

    abstract::To understand specific interactions between stromal cells and epithelial cells in benign prostatic hyperplasia (BPH) and prostatic adenocarcinoma, we developed stromal-cell cultures from normal human prostate (PNX) and BPH (BH101), composed of fibroblasts and myofibroblasts. Their role in epithelial-cell growth was st...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Degeorges A,Tatoud R,Fauvel-Lafeve F,Podgorniak MP,Millot G,de Cremoux P,Calvo F

    更新日期:1996-10-09 00:00:00

  • Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.

    abstract::Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the tumors most resistant to chemotherapy. An important mechanism of tumor multidrug resistance is increased drug efflux medi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D

    更新日期:2005-06-20 00:00:00

  • Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice.

    abstract::The cystine/glutamate antiporter, system xc- , is essential for the efficient uptake of cystine into cells. Interest in the mechanisms of system xc- function soared with the recognition that system xc- presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenera...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sato M,Onuma K,Domon M,Hasegawa S,Suzuki A,Kusumi R,Hino R,Kakihara N,Kanda Y,Osaki M,Hamada J,Bannai S,Feederle R,Buday K,Angeli JPF,Proneth B,Conrad M,Okada F,Sato H

    更新日期:2020-12-01 00:00:00

  • Mothers' active and passive smoking during pregnancy and risk of brain tumours in children.

    abstract::As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Filippini G,Farinotti M,Lovicu G,Maisonneuve P,Boyle P

    更新日期:1994-06-15 00:00:00

  • Molecular variants of HPV-16 associated with cervical cancer in Indian population.

    abstract::Human papilloma virus is a causative factor in the etiology of cervical cancer with HPV16 being the most prevalent genotype associated with it. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV 16 besides being of phylogenetic importance, are associated with risk of viral persistence and progressio...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Pillai MR,Hariharan R,Babu JM,Lakshmi S,Chiplunkar SV,Patkar M,Tongaonkar H,Dinshaw K,Jayshree RS,Reddy BK,Siddiqui M,Roychoudury S,Saha B,Abraham P,Gnanamony M,Peedicayil A,Subhashini J,Ram TS,Dey B,Sharma C,Jain

    更新日期:2009-07-01 00:00:00

  • Tumor eradication by immunotherapy with biodegradable PLGA microspheres--an alternative to incomplete Freund's adjuvant.

    abstract::In experimental tumor immunotherapy, incomplete Freund's adjuvant (IFA) has been considered as the "gold standard" for T-cell vaccination in mice and humans in spite of its considerable adverse effects. Recently, we succeeded in eliciting strong CTL responses in mice after vaccination with biodegradable poly(D,L-lacti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mueller M,Schlosser E,Gander B,Groettrup M

    更新日期:2011-07-15 00:00:00

  • Extracellular matrix and HIF-1 signaling: the role of prolidase.

    abstract::Hypoxia-inducible factor-1 (HIF-1) plays an important role in stress-responsive gene expression. Although primarily sensitive to hypoxia, HIF-1 signaling can be regulated by a number of stress factors including metabolic stress, growth factors and molecules present in the extracellular matrix (ECM). Degradation of ECM...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Surazynski A,Donald SP,Cooper SK,Whiteside MA,Salnikow K,Liu Y,Phang JM

    更新日期:2008-03-15 00:00:00

  • Alpha-smooth-muscle actin and desmin expressions in human neuroblastoma cell lines.

    abstract::The neural crest gives rise to a variety of tissues, including peripheral neurons, Schwann cells, melanocytes and ectomesenchymal cells, which include the smooth-muscle cells of large arteries. Cell lines derived from neuroblastoma (a neural-crest tumor) exhibit at least 2 distinct morphological cell types, a neurobla...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sugimoto T,Ueyama H,Hosoi H,Inazawa J,Kato T,Kemshead JT,Reynolds CP,Gown AM,Mine H,Sawada T

    更新日期:1991-05-10 00:00:00

  • Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3.

    abstract::Extranodal, nasal NK/T-cell lymphomas are regularly Epstein-Barr virus (EBV)-positive, with a type II latency pattern, expressing thus EBNA-1 and LMP1. The contribution of EBV to the tumor development is not known. Similarly to normal natural killer (NK) cells, cell lines derived from malignancies with a NK phenotype ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Takahara M,Kis LL,Nagy N,Liu A,Harabuchi Y,Klein G,Klein E

    更新日期:2006-12-15 00:00:00

  • Parity and breast cancer risk: possible effect on age at diagnosis.

    abstract::We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pathak DR,Speizer FE,Willett WC,Rosner B,Lipnick RJ

    更新日期:1986-01-15 00:00:00

  • Brain-derived neurotrophic factor is a potential osteoclast stimulating factor in multiple myeloma.

    abstract::Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sun CY,Chu ZB,She XM,Zhang L,Chen L,Ai LS,Hu Y

    更新日期:2012-02-15 00:00:00

  • Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells.

    abstract::Ras expression induces increased expression and altered targeting of lysosomal proteases in multiple cell types, but the specific downstream cytoplasmic signaling pathways mediating these changes have not been identified. In this study, we compared the involvement of 3 major Ras effectors, Raf, phosphatidylinositol 3-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Collette J,Ulku AS,Der CJ,Jones A,Erickson AH

    更新日期:2004-11-01 00:00:00

  • Comprehensive genomic landscape and precision therapeutic approach in biliary tract cancers.

    abstract::Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Okamura R,Kurzrock R,Mallory RJ,Fanta PT,Burgoyne AM,Clary BM,Kato S,Sicklick JK

    更新日期:2021-02-01 00:00:00

  • Frequent allelic changes at chromosome 7q34 but lack of mutation of the BRAF in papillary renal cell tumors.

    abstract::We have analyzed the BRAF locus on chromosome 7q34 with microsatellites for allelic changes and exons 11 and 15 of the BRAF with sequencing for mutations in 50 kidney cancers including 20 papillary, 15 conventional and 15 chromophobe renal cell carcinomas (RCC). Allelic changes at the BRAF locus were seen in 16 of the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nagy A,Balint I,Kovacs G

    更新日期:2003-10-10 00:00:00

  • Non-MHC-restricted target-cell lysis by a CD4-CD8- TCR alpha beta T-cell line, as well as by TCR gamma delta T-cell lines, results from lymphokine-activated killing.

    abstract::A long-term CD4-CD8- TCR alpha beta human T-cell line, as well as similar CD4-CD8- TCR gamma delta T-cell lines for comparison, were generated from various tissues by negative selection using anti-CD4 and anti-CD8 monoclonal antibodies (MAbs) followed by positive selection with specific anti-TCR MAb and then repeated ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Maziarz RT,Groh V,Prendergast M,Fabbi M,Strominger JL,Burakoff SJ

    更新日期:1991-04-22 00:00:00

  • The proliferative response of low-density human cell cultures to tumor promoters and its relevance to carcinogenic mechanisms in vitro.

    abstract::The effects of the tumor promoter -12-O-tetradecanoyl phorbol-13-acetate, its analogues, and other tumor promoters, on the proliferation of human skin fibroblasts (SF) have been investigated. We have previously shown (Kopelovich and Bias, 1979), that TPA caused a biphasic (upward concave) dose effect in the cloning ef...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kopelovich L,Chou TC

    更新日期:1984-12-15 00:00:00