Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases.

abstract：:Established cell lines derived from human malignant astrocytomas typically express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could form an autocrine loop. In this study, we screened for the essential components of a PDGF autocrine loop in fresh surgical isolates of human astrocytom...

journal_title：International journal of cancer

authors： Guha A,Dashner K,Black PM,Wagner JA,Stiles CD

更新日期：1995-01-17 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00

abstract：:Cervical cancer screening test performance has been hampered by either lack of sensitivity of Pap cytology or lack of specificity of Human Papillomavirus (HPV) testing. This uncertainty can lead to unnecessary referral and treatment, which is disturbing for patients and increases costs for health care providers. The i...

journal_title：International journal of cancer

authors： Bergeron C,Ronco G,Reuschenbach M,Wentzensen N,Arbyn M,Stoler M,von Knebel Doeberitz M

更新日期：2015-06-15 00:00:00

abstract：:The potential role of p16(INK4a) methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of p16(INK4a) by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it is strictly related to the carcinogenic process, ...

journal_title：International journal of cancer

authors： Di Vinci A,Perdelli L,Banelli B,Salvi S,Casciano I,Gelvi I,Allemanni G,Margallo E,Gatteschi B,Romani M

更新日期：2005-04-10 00:00:00

abstract：:As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...

journal_title：International journal of cancer

authors： Filippini G,Farinotti M,Lovicu G,Maisonneuve P,Boyle P

更新日期：1994-06-15 00:00:00

abstract：:Suramin is an experimental anti-neoplastic agent which has shown promising activity against prostatic carcinoma and lymphoma in clinical trials. To elucidate its mechanism of action, suramin was examined for an effect on the transport of folate compounds by tumor cells. Influx of the anti-folate methotrexate via the r...

journal_title：International journal of cancer

authors： Rideout DC,Bustamante A,Patel R,Henderson GB

更新日期：1995-06-09 00:00:00

abstract：:It is well known that tumors arising from tissues such as kidney, pancreas, liver and stomach are particularly refractory to treatment. Searching for new anticancer drugs using cells in culture has yielded some effective therapies, but these refractory tumors remain intractable. Studies that compare cells grown in sus...

journal_title：International journal of cancer

authors： Stein WD,Litman T,Fojo T,Bates SE

更新日期：2005-03-01 00:00:00

abstract：:A population-based study was conducted on 256 southern Chinese with cervical intraepithelial neoplasia grade III (CIN III) or invasive cervical cancer (ICC) and on 258 controls to examine the associations between HLA-B alleles, infection with high-risk human papillomaviruses (HPVs) and the development of cervical neop...

journal_title：International journal of cancer

authors： Chan PK,Cheung JL,Cheung TH,Lin CK,Tam AO,Chan DP,Zhou DX,Lo KW,Yim SF,Siu SS

更新日期：2006-03-15 00:00:00

abstract：:Uveal melanoma is associated with a high tumor-related mortality due to the propensity to develop metastases. The mechanisms that are responsible for malignant dissemination are largely unknown and need to be explored to facilitate diagnosis and treatment of metastases. To identify molecules involved in dissemination,...

journal_title：International journal of cancer

authors： van der Velden PA,Zuidervaart W,Hurks MH,Pavey S,Ksander BR,Krijgsman E,Frants RR,Tensen CP,Willemze R,Jager MJ,Gruis NA

更新日期：2003-09-10 00:00:00

abstract：:In our previous study on hepatocellular carcinoma (HCC) susceptibility genes in chronic hepatitis patients, we identified the MHC class I polypeptide-related sequence A (MICA). Natural killer cells eliminate various cancer cells, including HCC, by suppressing MICA shedding. Therefore, we investigated MICA sheddases an...

journal_title：International journal of cancer

authors： Arai J,Goto K,Tanoue Y,Ito S,Muroyama R,Matsubara Y,Nakagawa R,Kaise Y,Lim LA,Yoshida H,Kato N

更新日期：2018-11-15 00:00:00

abstract：:It is thought that TIL can be activated in vitro by rIL-2 and acquire specific anti-tumor activity. In this study, we investigated this possibility, using lymphocytes isolated from primary lung cancer tissues. In a first series of experiments, TILs and autologous PBLs from 16 patients were cultured in rIL-2 from 7 to ...

journal_title：International journal of cancer

authors： Yano T,Yasumoto K,Togami M,Ishida T,Kimura G,Sugimachi K,Nomoto K

更新日期：1989-04-15 00:00:00

abstract：:The role of plasma oxidant-antioxidant status in survival after breast cancer surgery was investigated in a cohort of patients (n = 363) hospitalized in Southern France between 1989 and 1992. The median follow-up was 8 years after surgery for histologically confirmed breast cancer. Plasma analyses were performed after...

journal_title：International journal of cancer

authors： Saintot M,Mathieu-Daude H,Astre C,Grenier J,Simony-Lafontaine J,Gerber M

更新日期：2002-02-10 00:00:00

abstract：:The absolute risk reduction by prophylaxis in chemotherapy-induced febrile neutropenia (FN) is largest in patients at highest underlying risk. Therefore, reliable predictive models are needed. Here, we develop and validate such a model for risk of FN during chemotherapy cycles 2-6. A prediction score for risk of FN du...

journal_title：International journal of cancer

authors： Aagaard T,Reekie J,Roen A,Daugaard G,Specht L,Sengeløv H,Mocroft A,Lundgren J,Helleberg M

更新日期：2020-01-15 00:00:00

abstract：:The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant disease were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosoma...

journal_title：International journal of cancer

authors： Fonatsch C,Kirchner HH,Schaadt M,Günzel M,Diehl V

更新日期：1981-10-15 00:00:00

abstract：:Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperatio...

journal_title：International journal of cancer

authors： Bertino P,Marconi A,Palumbo L,Bruni BM,Barbone D,Germano S,Dogan AU,Tassi GF,Porta C,Mutti L,Gaudino G

更新日期：2007-07-01 00:00:00

abstract：:Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antiobiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics, tumor selectivit...

journal_title：International journal of cancer

authors： Zou Y,Ling YH,Reddy S,Priebe W,Perez-Soler R

更新日期：1995-05-29 00:00:00

abstract：:G-protein-coupled receptor (GPCR)-stimulated androgen-independent activation of androgen receptor (AR) contributes to acquisition of a hormone-refractory phenotype by prostate cancer. We previously reported that regulator of G-protein signaling (RGS) 2, an inhibitor of GPCRs, inhibits androgen-independent AR activatio...

journal_title：International journal of cancer

authors： Wolff DW,Xie Y,Deng C,Gatalica Z,Yang M,Wang B,Wang J,Lin MF,Abel PW,Tu Y

更新日期：2012-04-01 00:00:00

abstract：:Oral tongue squamous cell carcinoma (OTSCC) is associated with poor prognosis. To improve prognostication, we analyzed four gene probes (TERC, CCND1, EGFR and TP53) and the centromere probe CEP4 as a marker of chromosomal instability, using fluorescence in situ hybridization (FISH) in single cells from the tumors of s...

journal_title：International journal of cancer

authors： Wangsa D,Chowdhury SA,Ryott M,Gertz EM,Elmberger G,Auer G,Åvall Lundqvist E,Küffer S,Ströbel P,Schäffer AA,Schwartz R,Munck-Wikland E,Ried T,Heselmeyer-Haddad K

更新日期：2016-01-01 00:00:00

abstract：:A new cell line (K-LL-3) with exceptional characteristics was derived from a bone-marrow aspirate from a patient with poorly differentiated lymphoblastic lymphoma. The cell line was established and the cells maintained on agar feeders for over 1 year. The morphology and cytochemical staining of the primary tumor and t...

journal_title：International journal of cancer

authors： Smith SD,Rosen D

更新日期：1979-04-15 00:00:00

abstract：:Although treatment of Hodgkin's lymphoma (HL) with a multi-drug approach has been very successful, its toxicity becomes evident after several years as secondary malignancies and cardiovascular disease. Therefore, the current goal in HL treatment is to find new therapies that specifically target the deregulated signali...

journal_title：International journal of cancer

authors： Mackenzie GG,Queisser N,Wolfson ML,Fraga CG,Adamo AM,Oteiza PI

更新日期：2008-07-01 00:00:00

abstract：:Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

journal_title：International journal of cancer

authors： Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

更新日期：1999-03-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor-suppressor and other genes related to cell differentiation, cell-cycle arrest or apoptosis of tumor cells. The...

journal_title：International journal of cancer

authors： Biran A,Brownstein M,Haklai R,Kloog Y

更新日期：2011-02-01 00:00:00

abstract：:The effect of all-trans-retinoic acid (RA) was examined on (1) transformation induced in C127 cells by transfection with plasmid pdBPV-1 (142-6), which contains DNA of bovine papillomavirus (BPV), (2) the capacity of transformed BPV DNA-containing clones to form colonies with transformed properties (e.g., piling up in...

journal_title：International journal of cancer

authors： Tsang SS,Li G,Stich HF

更新日期：1988-07-15 00:00:00

abstract：:The androgen receptor (AR) gene is a transcription factor responsible for mediating the physiological effects of androgens. Evidence suggests that androgens and the androgen receptor are involved in uterine cell proliferation. A polymorphic CAG repeat in exon 1 of the AR gene encodes a polyglutamine tract that is inve...

journal_title：International journal of cancer

authors： McGrath M,Lee IM,Hankinson SE,Kraft P,Hunter DJ,Buring J,De Vivo I

更新日期：2006-03-01 00:00:00

abstract：:Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli (APC), has a major role in colorectal cancer (CRC). Most components have not been assessed for mutation in sporadic CRC. We have analyzed AXIN2, CK1alpha, DKK1, GSK-3beta, SOX17, LRP6 and PPP2R1B, beta-catenin and ...

journal_title：International journal of cancer

authors： Suraweera N,Robinson J,Volikos E,Guenther T,Talbot I,Tomlinson I,Silver A

更新日期：2006-10-15 00:00:00

abstract：:Fibrin deposition in the microenvironment of tumor cells may be critical to tumor growth and metastasis formation. Procoagulant activities of tumor cells themselves, or of infiltrating macrophages, activated by the host's immune system to the tumor, may both contribute to coagulopathies associated with metastases. Lym...

journal_title：International journal of cancer

authors： Geczy CL,Ryan J,Walsh J,Goldstein D

更新日期：1986-05-15 00:00:00

abstract：:In addition to the known function in the glycolytic pathway, phosphoglycerate kinase 1 (PGK-1) promotes reduction of plasmin disulfide bonds leading to angiostatin formation and inhibition of tumor angiogenesis. In this study, the effects of PGK-1 on anti- tumor immunity against lung cancer were evaluated using the Te...

journal_title：International journal of cancer

authors： Tang SJ,Ho MY,Cho HC,Lin YC,Sun GH,Chi KH,Wang YS,Jhou RS,Yang W,Sun KH

更新日期：2008-12-15 00:00:00

abstract：:A continuous lymphoma cell line, BJAB, derived from the tumour of an exceptional African case of Burkitt's lymphoma, has previously been described. Unlike 97% of African BL cases studied, neither the original tumour cells nor the cell line contained detectable amounts of EBV (Epstein-Barr virus) DNA, nor did they expr...

journal_title：International journal of cancer

authors： Clements GB,Klein G,Povey S

更新日期：1975-07-15 00:00:00

abstract：:To better inform the next clinical trials of vascular disrupting agent combretastatin-A4-phosphate (CA4P) in patients with hepatic malignancies, this preclinical study aimed at evaluating CA4P therapeutic efficacy in rats with primary hepatocellular carcinomas (HCCs) of a full spectrum of differentiation and vasculari...

journal_title：International journal of cancer

authors： Liu Y,De Keyzer F,Wang Y,Wang F,Feng Y,Chen F,Yu J,Liu J,Song S,Swinnen J,Bormans G,Oyen R,Huang G,Ni Y

更新日期：2018-10-01 00:00:00

abstract：:A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) nega...

journal_title：International journal of cancer

authors： Rudolph A,Milne RL,Truong T,Knight JA,Seibold P,Flesch-Janys D,Behrens S,Eilber U,Bolla MK,Wang Q,Dennis J,Dunning AM,Shah M,Munday HR,Darabi H,Eriksson M,Brand JS,Olson J,Vachon CM,Hallberg E,Castelao JE,Carrac

更新日期：2015-03-15 00:00:00