Lymphokine-induced monocyte procoagulant activity is depressed in patients with advanced malignancies.

abstract：:WAVE3, an actin cytoskeleton remodeling protein, is highly expressed in advanced stages of breast cancer and influences tumor cell invasion. Loss of miR-31 has been associated with cancer progression and metastasis. Here, we show that the activity of WAVE3 to promote cancer cell invasion is regulated by miR-31. An inv...

journal_title：International journal of cancer

authors： Sossey-Alaoui K,Downs-Kelly E,Das M,Izem L,Tubbs R,Plow EF

更新日期：2011-09-15 00:00:00

abstract：:ERK and RSK2 drive proliferation and invasion of many cancers. Phosphoprotein enriched in astrocytes 15 (PEA15) binds ERK and RSK2 and high PEA15 levels can impair ERK- and RSK2-dependent transcription. PEA15 expression also inversely correlates with cell motility and invasiveness. We therefore tested PEA15 effects on...

journal_title：International journal of cancer

authors： Gawecka JE,Geerts D,Koster J,Caliva MJ,Sulzmaier FJ,Opoku-Ansah J,Wada RK,Bachmann AS,Ramos JW

更新日期：2012-10-01 00:00:00

abstract：:The majority of small-cell lung cancers (SCLCs) express p16 but not pRb. Given our previous study showing loss of pRb in Merkel cell carcinoma (MCC)/neuroendocrine carcinoma of the skin and the clinicopathological similarities between SCLC and MCC, we wished to determine if this was also the case in MCC. Twenty-nine M...

journal_title：International journal of cancer

authors： Cook AL,Pollock PM,Welch J,Walsh MD,Bowman RV,Baumann KC,Hayward NK,Leonard JH

更新日期：2001-08-01 00:00:00

abstract：:Spleen cells from BALB/c mice bearing syngeneic, methylcholanthrene-induced sarcomas were cultured in vitro. In agreement with previous observations, two tumor-specific activities could be demonstrated in the culture supernatants: the supernatants suppressed (blocked) specific lymph-node cell-mediated cytotoxicity dir...

journal_title：International journal of cancer

authors： Nelson K,Pollack SB,Hellström KE

更新日期：1975-10-15 00:00:00

abstract：:We conducted a population-based case-control study of 1,447 incident rectal cancer cases and 3,106 population controls aged 20-76 years to assess the effect of recreational physical activity, energy intake and obesity on rectal cancer risk in 7 of 10 Canadian provinces in 1994-97. After adjustment for the effect of va...

journal_title：International journal of cancer

authors： Mao Y,Pan S,Wen SW,Johnson KC,Canadian Cancer Registries Epidemiology Research Group.

更新日期：2003-07-20 00:00:00

abstract：:Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...

journal_title：International journal of cancer

authors： Namekawa T,Ikeda K,Horie-Inoue K,Suzuki T,Okamoto K,Ichikawa T,Yano A,Kawakami S,Inoue S

更新日期：2020-02-15 00:00:00

abstract：:We have previously shown that anti-Ly-6C monoclonal antibody (MAb) 2B6-F2 identifies a subset of (CBA +/- C57BL/6)F1 splenic NK-1.1+ natural T (NT) cells which kill the NK-sensitive YAC-1 target in vitro. Furthermore, these Ly-6C+ cells are responsible for 40-50% of in vitro YAC-1 killing in all mouse strains tested. ...

journal_title：International journal of cancer

authors： Martiniello R,Burton RC,Smart YC

更新日期：1996-05-16 00:00:00

abstract：:Promoter hypermethylation of various tumor-related genes is extremely frequent in gastric carcinoma (GC) associated with Epstein-Barr virus (EBV). To investigate the significance of the promoter methylation in this type of GC, we examined the methylation densities of the promoter regions of p14ARF and p16INK4A in EBV-...

journal_title：International journal of cancer

authors： Sakuma K,Chong JM,Sudo M,Ushiku T,Inoue Y,Shibahara J,Uozaki H,Nagai H,Fukayama M

更新日期：2004-11-01 00:00:00

abstract：:The glycoprotein 90K was originally described as a tumor-secreted antigen and subsequently found to have immunostimulatory activity as well as other possible functions. This protein interacts with an endogenous lectin, galectin-3, and may play a role in tumor metastasis through this interaction. Because 90K is heavily...

journal_title：International journal of cancer

authors： Tinari N,Kuwabara I,Huflejt ME,Shen PF,Iacobelli S,Liu FT

更新日期：2001-01-15 00:00:00

abstract：:Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understoo...

journal_title：International journal of cancer

authors： Scott ME,Ma Y,Kuzmich L,Moscicki AB

更新日期：2009-03-15 00:00:00

abstract：:Human papilloma virus (HPV) infection is considered as an important aetiological factor for anal squamous cell carcinoma (ASCC) but is not sufficient for tumour progression. This carcinoma is poorly understood at the molecular level. Using the largest cohort of cases to date we investigated the molecular mechanisms un...

journal_title：International journal of cancer

authors： Patel H,Polanco-Echeverry G,Segditsas S,Volikos E,McCart A,Lai C,Guenther T,Zaitoun A,Sieber O,Ilyas M,Northover J,Silver A

更新日期：2007-12-15 00:00:00

abstract：:HER2 is an erbB/HER type 1 tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer, significantly prolonging survival when combined with cytotoxic chemot...

journal_title：International journal of cancer

authors： Cox G,Vyberg M,Melgaard B,Askaa J,Oster A,O'Byrne KJ

更新日期：2001-05-15 00:00:00

abstract：:Long-term survival rates for advanced ovarian cancer patients have not changed appreciably over the past four decades; therefore, development of new, effective treatment modalities remains a high priority. Tumor Treating Fields (TTFields), a clinically active anticancer modality utilize low-intensity, intermediate fre...

journal_title：International journal of cancer

authors： Voloshin T,Munster M,Blatt R,Shteingauz A,Roberts PC,Schmelz EM,Giladi M,Schneiderman RS,Zeevi E,Porat Y,Bomzon Z,Urman N,Itzhaki A,Cahal S,Kirson ED,Weinberg U,Palti Y

更新日期：2016-12-15 00:00:00

abstract：:Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 s...

journal_title：International journal of cancer

authors： Minicozzi P,Van Eycken L,Molinie F,Innos K,Guevara M,Marcos-Gragera R,Castro C,Rapiti E,Katalinic A,Torrella A,Žagar T,Bielska-Lasota M,Giorgi Rossi P,Larrañaga N,Bastos J,Sánchez MJ,Sant M,European HR Working Group on

更新日期：2019-05-01 00:00:00

abstract：:A human cancer vaccine composed of autologous tumor cells modified with the hapten dinitrofluorobenzene (DNP) induces cell-mediated immunity to the tumor cells and the development of inflammatory responses within metastatic sites. In this study we determined whether DNP vaccine could induce regression of established m...

journal_title：International journal of cancer

authors： Berd D,Sato T,Cohn H,Maguire HC Jr,Mastrangelo MJ

更新日期：2001-11-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the 5-year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the p...

journal_title：International journal of cancer

authors： Ling Z,Cheng B,Tao X

更新日期：2020-10-22 00:00:00

abstract：:The mode of transmission of human herpesvirus 8 (HHV8) was investigated in two seroepidemiological studies of Swedish women who completed a questionnaire about sexual behavior. Seropositivity for HHV8 antibodies, measured using an indirect immunofluorescence assay, was linked to a high number (>10) of sexual partners ...

journal_title：International journal of cancer

authors： Tedeschi R,Caggiari L,Silins I,Kallings I,Andersson-Ellström A,De Paoli P,Dillner J

更新日期：2000-07-15 00:00:00

abstract：:A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into drug by human beta-glucuronidase (GUS) released from tumor cells in ...

journal_title：International journal of cancer

authors： Houba PH,Boven E,van der Meulen-Muileman IH,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

更新日期：2001-02-15 00:00:00

abstract：:O6-alkylguanine-DNA alkyltransferase (MGMT) represents the first line of defense against the toxic, mutagenic and carcinogenic effects of O6-alkylguanine adducts in DNA. These adducts mediate the biological activity from a series of alkylating agents, such as the tobacco-specific nitrosamines, believed to contribute t...

journal_title：International journal of cancer

authors： Povey AC,O'Donnell P,Barber P,Watson M,Margison GP,Santibáñez Koref MF

更新日期：2006-07-15 00:00:00

abstract：:We performed an integrated array comparative genomic hybridization (aCGH) and expression microarray analysis of 8 normal gastric tissues and 38 primary tumors, including 25 intestinal and 13 diffuse gastric adenocarcinomas to identify genes whose expression is deregulated in association with copy number alteration. Ou...

journal_title：International journal of cancer

authors： Myllykangas S,Junnila S,Kokkola A,Autio R,Scheinin I,Kiviluoto T,Karjalainen-Lindsberg ML,Hollmén J,Knuutila S,Puolakkainen P,Monni O

更新日期：2008-08-15 00:00:00

abstract：:To monitor recent trends in oral and pharyngeal cancer mortality in 38 European countries, we analyzed data provided by the World Health Organization over the period 1975-2004. Joinpoint analysis was used to identify significant changes in trends. In the European Union (EU), male mortality rates rose by 2.1% per year ...

journal_title：International journal of cancer

authors： Garavello W,Bertuccio P,Levi F,Lucchini F,Bosetti C,Malvezzi M,Negri E,La Vecchia C

更新日期：2010-07-01 00:00:00

abstract：:For breast cancer, many prognostic markers that initially appeared promising have failed to maintain their clinical predictive value. Few reports have analyzed the consistency over time of biological and clinical information provided by biomarkers. Tumour cell proliferation has acquired relevance as an indicator of pr...

journal_title：International journal of cancer

authors： Silvestrini R,Daidone MG,Luisi A,Mastore M,Leutner M,Salvadori B

更新日期：1997-02-20 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...

journal_title：International journal of cancer

authors： Tsang YS,Lo KW,Leung SF,Choi PH,Fong Y,Lee JC,Huang DP

更新日期：1999-10-29 00:00:00

abstract：:Wilms tumor is the most frequent renal neoplasm in children, but our understanding of its genetic basis is still limited. We performed cDNA microarray experiments using 63 primary Wilms tumors with the aim of detecting new candidate genes associated with malignancy grade and tumor progression. All tumors had received ...

journal_title：International journal of cancer

authors： Zirn B,Hartmann O,Samans B,Krause M,Wittmann S,Mertens F,Graf N,Eilers M,Gessler M

更新日期：2006-04-15 00:00:00

abstract：:Metastatic tumor formation via vessel route begins with cancer cell extravasation from vessel lumen, migration into the connective tissue surrounding vessels, and invasion into target organ parenchyma. Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) have been recognized to play an i...

journal_title：International journal of cancer

authors： Aokage K,Ishii G,Ohtaki Y,Yamaguchi Y,Hishida T,Yoshida J,Nishimura M,Nagai K,Ochiai A

更新日期：2011-04-01 00:00:00

abstract：:Pancreatic cancer is almost always fatal, in part because of its delayed diagnosis, poor prognosis, rapid progression and chemoresistance. Oncogenic proteins are stabilized by the Hsp90, making it a potential therapeutic target. We investigated the oxidative stress-mediated dysfunction of Hsp90 and the hindrance of it...

journal_title：International journal of cancer

authors： Sarkar S,Dutta D,Samanta SK,Bhattacharya K,Pal BC,Li J,Datta K,Mandal C,Mandal C

更新日期：2013-02-01 00:00:00

abstract：:From C57BL mouse melanoma B-16 cells, variant clones were selected in vitro which were resistant to the lectins wheat-germ agglutinin and ricin. Cells were also selected which survived toxic concentrations of concanavalin A. Four different in vivo assays using intradermal, intravenous, intraperitoneal and intramuscula...

journal_title：International journal of cancer

authors： Tao TW,Burger MM

更新日期：1982-04-15 00:00:00

abstract：:Non-specific cross-reacting antigens (NCA-95 = CD66b and NCA-50/90 = CD66c) are members of the CEA (carcinoembryonic antigen = CD66e) family. Analysis of mRNA levels of CD66c in colon tumors suggests that this antigen is strongly up-regulated compared to its normal counterpart and could, therefore, be of clinical inte...

journal_title：International journal of cancer

authors： Grunert F,Daniel S,Nagel G,von Kleist S,Jantscheff P

更新日期：1995-11-03 00:00:00

abstract：:In this study, the anticancer effect of prednisolone was investigated using rats with normal endogen adrenaline levels (intact), reduced adrenaline levels (metyrosine-induced) and adrenaline deficiency (adrenalectomized) via gastric adenocarcinoma model. Gastric adenocarcinoma was induced with N-methyl-N'-nitro-N-nitr...

journal_title：International journal of cancer

authors： Suleyman H,Cadirci E,Albayrak A,Halici Z,Gundogdu C,Hacimuftuoglu A

更新日期：2010-04-01 00:00:00

abstract：:The DNA configuration of the immunoglobulin (Ig) heavy and light chain genes and the expression of B-cell-related markers were evaluated in 13 cases of non-T, non-B, non-common ("null") acute lymphoblastic leukaemia (ALL). A rearrangement of the Ig heavy-chain gene was found in all cases studied; in 5 of these a struc...

journal_title：International journal of cancer

authors： Foa R,Migone N,Basso G,Cattoretti G,Pizzolo G,Lauria F,Casorati G,Giubellino MC,Capuzzo F,Cantù-Rajnoldi A

更新日期：1986-09-15 00:00:00