Abstract:
:Non-specific cross-reacting antigens (NCA-95 = CD66b and NCA-50/90 = CD66c) are members of the CEA (carcinoembryonic antigen = CD66e) family. Analysis of mRNA levels of CD66c in colon tumors suggests that this antigen is strongly up-regulated compared to its normal counterpart and could, therefore, be of clinical interest. CD66c is also expressed in normal lung and spleen tissues and, above all, on granulocytes. The appearance of CD66b in serum, the only strictly granulocyte-specific antigen, could point to the involvement of granulocytes in disease. Specific sandwich ELISAs have been established to determine CEA, CD66b and CD66c levels in serum. Controls have been carried out by testing sera from patients with benign tumors or inflammatory diseases and from healthy individuals. In sera of most patients suffering from solid tumors, sensitivities for CD66c are comparable to or lower than those for CEA. CD66c showed a much higher sensitivity in early colon tumor stages. Sensitivities over 40% have been determined for CD66b in sera of patients with uterine and kidney carcinomas. CML patients revealed sensitivities of 84% for CD66c and 47% for CD66b. Investigations of sera from patients with inflammatory colon diseases which are negative for CEA showed high sensitivity for CD66c but not for the granulocyte-specific CD66b. Patients with mastopathy revealed sensitivities of over 40% for both CD66c and CD66b. CD66b, CD66c and CEA are independently regulated proteins in a high percentage of patients. The simultaneous determination of CEA and CD66b/c can increase the sensitivities for malignant tumors but high sensitivities of CD66b/c for benign diseases limit their usefulness as tumor markers. CD66b may be interesting as a marker for kidney and corpus carcinomas, for which good markers are not yet available.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Grunert F,Daniel S,Nagel G,von Kleist S,Jantscheff Pdoi
10.1002/ijc.2910630308subject
Has Abstractpub_date
1995-11-03 00:00:00pages
349-55issue
3eissn
0020-7136issn
1097-0215journal_volume
63pub_type
杂志文章abstract::Topically applied vasoconstrictor is a new strategy to prevent oral mucositis and alopecia, two complications of chemotherapy and stem-cell transplant. We sought to determine whether mice treated with topical vasoconstrictor minutes before chemotherapy to suppress L1210 leukemia would develop a vasoconstrictor-induced...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30037
更新日期:2016-06-15 00:00:00
abstract::We report the incidence of cervical intraepithelial neoplasia (CIN) among HIV-infected women who did not have any colposcopic or histopathological evidence of CIN at baseline. Of the 1,023 women without any CIN at baseline, 855 (83.6%) have been followed up to a maximum of 6.4 years contributing 2,875 person years of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31826
更新日期:2019-03-01 00:00:00
abstract::Both epigallocatechin gallate (EGCG) and curcumin have shown efficacy in various in vivo and in vitro models of cancer. This study was designed to determine the efficacy of these naturally derived polyphenolic compounds in vitro and in vivo, when given in combination. Studies in MDA-MB-231 cells demonstrated that EGCG...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23328
更新日期:2008-05-01 00:00:00
abstract::Signal transduction pathways controlling tumor cell locomotion are not yet well understood. We have studied the role of protein kinase C (PKC)-dependent protein phosphorylation associated with changes in cell shape and locomotor activity of Walker carcinosarcoma cells in culture. We show that the inhibitory effect of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960208)65:4<473::AID-IJC
更新日期:1996-02-08 00:00:00
abstract::Six distinct cell surface antigens of human trophoblast and choriocarcinoma were defined with MAbs. The distribution of the antigens was determined by MHA assays on 150 tumor cell lines and normal cell cultures and by immunofluorescence tests with a wide range of normal adult and fetal tissues and a tumor panel. Antig...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350409
更新日期:1985-04-15 00:00:00
abstract::OCT-4 (also known as POU5F1) is a key regulator of self-renewal in embryonic stem cells. Regarding the new cancer stem cell concept, the expression of such genes is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior, such as tumor recurrence or resistance to therapies. Although OCT...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22508
更新日期:2007-04-01 00:00:00
abstract::Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publicatio...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.30443
更新日期:2017-02-01 00:00:00
abstract::Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430538
更新日期:1989-05-15 00:00:00
abstract::The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n-3 and n-6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three US prospective cohorts ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33190
更新日期:2021-01-01 00:00:00
abstract::Regulatory T cells (Treg) mediate amelioration of disease and immune homeostasis by inhibiting immune activation and maintaining peripheral immune tolerance. The suppressive mechanisms and clinical significance of Treg have not been completely elucidated in patients with acute myeloid leukemia (AML). Here, we demonstr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25791
更新日期:2011-09-15 00:00:00
abstract::Oxidative stress plays a role in the regulation of cancer cell metastasis which involves cell invasion and adhesion that could be supported by ADAM proteins through the activities of their metalloprotease and disintegrin domains. We hypothesized that oxidative stress could act through the induction of ADAM9 protein in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25746
更新日期:2011-08-15 00:00:00
abstract::Malignant mesothelioma (MM) is a highly aggressive form of cancer with limited treatment options. Although the role of NK cells has been studied in many solid tumors, the pattern of NK-cell subsets and their recognition of mesothelioma cells remain to be explored. We used RNA expression data of MM biopsies derived fro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32363
更新日期:2019-10-15 00:00:00
abstract::Histone deacetylase inhibitors, such as phenylbutyrate, are currently undergoing clinical trials as potential anticancer agents. Phenylbutyrate can induce cell differentiation and apoptosis in a number of cancer cell types and can act in synergy with ionizing radiation and chemotherapy to induce apoptosis. We used the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10609
更新日期:2002-10-10 00:00:00
abstract::It is currently under debate whether the low serum cholesterol levels that are frequently observed in cancer patients represent a risk factor for/or, rather, are a consequence of the tumour. We postulate that malignant tumours are directly involved in an increased catabolism of cholesterol-rich low-density lipoprotein...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610405
更新日期:1995-05-16 00:00:00
abstract::In a proportion of patients presenting mismatch repair (MMR)-deficient tumors, no germline MMR mutations are identified, the so-called Lynch-like syndrome (LLS). Recently, MMR-deficient tumors have been associated with germline mutations in POLE and MUTYH or double somatic MMR events. Our aim was to elucidate the mole...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30820
更新日期:2017-10-01 00:00:00
abstract::Human papillomavirus (HPV) vaccines protect against infections with the most oncogenic HPV types, cervical intraepithelial neoplasia (CIN) and cervical cancer. We investigated whether development of cervical intraepithelial neoplasia (CIN) lesions in HPV-vaccinated women is associated with vaccine-targeted HPV types o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32848
更新日期:2020-05-01 00:00:00
abstract::Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25655
更新日期:2011-07-01 00:00:00
abstract::The effect of EGF on the soft agar colony-forming ability of fresh human tumor cells was assessed in 40 specimens obtained from various types of carcinoma including those of the breast, endometrium ovary, and other sites. Cells from four established human tumor cell lines (three breast and one endometrial) were also i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300611
更新日期:1982-12-15 00:00:00
abstract::The results from the population-based cancer registry for the city of Ho Chi Minh in 1995-1996 represent the first information on the incidence of cancer in southern Viet Nam. A total of 4,080 cancer cases in males and 4,338 in females were registered, corresponding to age-standardized incidence rates (ASRs) of 130.9 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980518)76:4<472::aid-ijc
更新日期:1998-05-18 00:00:00
abstract::The cytogenetic response to G2-phase X-irradiation was examined in phytohemagglutinin-stimulated peripheral-blood lymphocytes from 69 individuals, a few of whom were cancer patients. The cancer patients had not received radiation or chemotherapy. The responses of cells arrested by Colcemid 30 to 90 min after X-irradia...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540412
更新日期:1993-06-19 00:00:00
abstract::Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (E...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000415)86:2<229::aid-ijc
更新日期:2000-04-15 00:00:00
abstract::We recently reported that standardized quantitative immunohistochemical (IHC) assays allowed prediction of an adverse outcome among 572 node negative (N-) patients with breast carcinoma (BrCa). To further validate our prior findings, we repeated the IHC stains including a second series of BrCa diagnosed at Yale Univer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27371
更新日期:2012-08-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) describes a process occurring during development and oncogenesis by which epithelial cells obtain fibroblast-like properties and show reduced cell adhesion and increased motility. In this report, we demonstrated typical EMT in human mammary epithelial MCF10A small interfering (s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21559
更新日期:2006-04-01 00:00:00
abstract::Radiation therapy (RT) continues to be a cornerstone in the treatment for many cancers. Unfortunately, not all individuals respond effectively to RT resulting clinically in two groups consisting of nonresponders (progressive disease) and responders (tumor control/cure). The mechanisms that govern the outcome of radiot...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28558
更新日期:2014-05-15 00:00:00
abstract::Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies, due mainly to the prevalence of undetected metastatic disease. The process of cell invasion during intraperitoneal anchoring of metastatic lesions requires concerted regulation of many processes, including modulation of adhes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24347
更新日期:2009-08-15 00:00:00
abstract::The role of retinoic acid receptor (RAR) expression in sensitivity to N-(4-hydroxyphenyl)retinamide (4HPR or fenretinide) as well as on the tumorigenicity of human ovarian carcinoma cells was examined. Two human ovarian cancer cell lines, A2780 and IGROV-1, with a 10-fold difference in sensitivity to 4HPR were chosen ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990531)81:5<829::aid-ijc
更新日期:1999-05-31 00:00:00
abstract::The murine B16 melanoma (H-2b) was transfected with a retroviral vector containing the mouse IFN-alpha 1 gene. IFN-alpha 1-transfected cells produced IFN-alpha in vitro and exhibited an altered phenotype characterized by a decreased rate of multiplication, enhanced expression of H-2 antigens, an antiviral state to VSV...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910600216
更新日期:1995-01-17 00:00:00
abstract::Multiple myeloma (MM) is the second most common hematologic malignancy characterized by the clonal expansion of plasma cells. Despite continuing advances, novel biomarkers are needed for diagnosis and prognosis of MM. In our study, we characterized the diagnostic and prognostic potential of circulating microRNAs (miRN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29199
更新日期:2015-04-15 00:00:00
abstract::A subgroup of head and neck squamous cell carcinomas (HNSCCs) contains high-risk human papillomavirus-type 16 (HPV16). The viral E6 and E7 oncoproteins inactivate the p53 and pRb proteins, respectively. We examined the causative effect of HPV16 E6 and E7 expression on the immortalization of normal oral keratinocytes (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25474
更新日期:2011-04-01 00:00:00
abstract::Melanoma-associated germline mutations affecting the tumor suppressor and cyclin-dependent kinase (CDK) inhibitor, CDKN2A/p16INK4a, have been identified in over 100 melanoma-prone families worldwide. To predict the melanoma risk for carriers of specific mutations, mutant p16INK4a can be tested in biochemical and cellu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21265
更新日期:2005-11-20 00:00:00