Two distinct regions of deletion on chromosome 13q in primary nasopharyngeal carcinoma.

abstract：:A highly immunogenic variant of the murine L1210 leukemia cell (L1210/LN-1) for generation of tumor immunity has been obtained from culture of L1210 cells originally fused with human Lesch-Nyhan fibroblasts. In L1210/LN-1 cells, no human chromosomes were identified and chromosomes M1 and No. 1 carried by the parent L1...

journal_title：International journal of cancer

authors： Kawashima K,Nagura E,Watanabe E,Mizoguchi K,Saga S,Isobe K,Nakashima I,Yamada K,Oikawa T,Kojima K

更新日期：1983-10-15 00:00:00

abstract：:Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell culture. The results ...

journal_title：International journal of cancer

authors： Zhou H,Shen T,Luo Y,Liu L,Chen W,Xu B,Han X,Pang J,Rivera CA,Huang S

更新日期：2010-11-15 00:00:00

abstract：:Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in ...

journal_title：International journal of cancer

authors： Saxena QB,Mezey E,Adler WH

更新日期：1980-10-15 00:00:00

abstract：:Regulation of cell differentiation is most often impaired in malignant tumors and may represent a key mechanism for the progression of the disease. CCAAT-enhancer binding protein (C/EBP) is a family of transcription factors involved in the regulation of embryonic gut development in rodents, which has also been detecte...

journal_title：International journal of cancer

authors： Rask K,Thörn M,Pontén F,Kraaz W,Sundfeldt K,Hedin L,Enerbäck S

更新日期：2000-05-01 00:00:00

abstract：:To assess the effect of different hospital types or surgical volume on the survival of ovarian cancer patients, a nationwide and population-based analysis was carried out in Finland. The study included all 3,851 ovarian cancer patients operated from 1983-94. The patients were classified according to the hospital of th...

journal_title：International journal of cancer

authors： Kumpulainen S,Grénman S,Kyyrönen P,Pukkala E,Sankila R

更新日期：2002-12-10 00:00:00

abstract：:Human oocytes in different stages of maturation were obtained by follicular aspiration from women given Clomovid and Gonadex. Particles similar to type-C virus were observed in three out of 16 oocytes. The particles were irregularly distributed along the oocyte membrane. They were seen both in a state of budding and l...

journal_title：International journal of cancer

authors： Larsson E,Nilsson BO,Sundström P,Widéhn S

更新日期：1981-11-15 00:00:00

abstract：:Genome-wide association studies have identified more than 80 risk variants for prostate cancer, mainly in European or Asian populations. The generalizability of these variants in other racial/ethnic populations needs to be understood before the loci can be used widely in risk modeling. In our study, we examined 82 pre...

journal_title：International journal of cancer

authors： Han Y,Signorello LB,Strom SS,Kittles RA,Rybicki BA,Stanford JL,Goodman PJ,Berndt SI,Carpten J,Casey G,Chu L,Conti DV,Rand KA,Diver WR,Hennis AJ,John EM,Kibel AS,Klein EA,Kolb S,Le Marchand L,Leske MC,Murphy AB,

更新日期：2015-03-01 00:00:00

abstract：:Increasing use of heavy ions for cancer therapy and concerns from exposure to heavy charged particles in space necessitate the study of the basic biological mechanisms associated with exposure to heavy ions. As the most critical damage induced by ionizing radiation is DNA double strand break (DSB), this review focuses...

journal_title：International journal of cancer

authors： Okayasu R

更新日期：2012-03-01 00:00:00

abstract：:In the Japanese atomic bomb survivors, risk of lung cancer has been shown to increase with greater acute exposure to ionizing radiation. Although similar findings have been observed in populations exposed to low-dose, protracted radiation, such studies lack information on cigarette smoking history, a potential confoun...

journal_title：International journal of cancer

authors： Velazquez-Kronen R,Gilbert ES,Linet MS,Moysich KB,Freudenheim JL,Wactawski-Wende J,Simon SL,Cahoon EK,Alexander BH,Doody MM,Kitahara CM

更新日期：2020-12-01 00:00:00

abstract：:Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...

journal_title：International journal of cancer

authors： Cui Y,Whiteman MK,Flaws JA,Langenberg P,Tkaczuk KH,Bush TL

更新日期：2002-03-10 00:00:00

abstract：:Anthropometric measures have been related to risk of several cancers. For bladder cancer, however, evidence is sparse. Comparability of existing studies is hampered by use of different obesity-measures, inadequate control for smoking, and few female cases. This study examined associations between height, weight, waist...

journal_title：International journal of cancer

authors： Roswall N,Freisling H,Bueno-de-Mesquita HB,Ros M,Christensen J,Overvad K,Boutron-Ruault MC,Severi G,Fagherazzi G,Chang-Claude J,Kaaks R,Steffen A,Boeing H,Argüelles M,Agudo A,Sánchez MJ,Chirlaque MD,Barricarte Gurrea A

更新日期：2014-12-15 00:00:00

abstract：:In human breast cancer (HBC), as with many carcinoma systems, most matrix metalloproteinases (MMPs) are largely expressed by the stromal cells, whereas the tumour cells are relatively silent in MMP expression. To determine the tissue source of the most relevant MMPs, we xenografted HBC cell lines and HBC tissues into ...

journal_title：International journal of cancer

authors： Lafleur MA,Drew AF,de Sousa EL,Blick T,Bills M,Walker EC,Williams ED,Waltham M,Thompson EW

更新日期：2005-04-20 00:00:00

abstract：:This study investigates the clinical course of low grade squamous intraepithelial lesions (LSIL), HPV status and HPV16-specific immune response in a large prospective study of 125 women with LSIL followed cytologically, virologically and histologically. Women with low-grade abnormal smears were recruited and followed-...

journal_title：International journal of cancer

authors： Woo YL,van den Hende M,Sterling JC,Coleman N,Crawford RA,Kwappenberg KM,Stanley MA,van der Burg SH

更新日期：2010-01-01 00:00:00

abstract：:The cell-cycle regulator p16 inhibits the complex cdk4-cyclin D1 and controls G1-S transition. In human tumors, p16 inactivation is often accomplished by homozygous deletion (HD) of its encoding gene, CDKN2A. Methylation of the 5' CpG island promoter has been proposed as an alternative mechanism of inactivation. Expre...

journal_title：International journal of cancer

authors： Bortolotto S,Chiadò-Piat L,Cavalla P,Bosone I,Chiò A,Mauro A,Schiffer D

更新日期：2000-11-15 00:00:00

abstract：:The aim of our study was to estimate uptake of prostate-specific antigen (PSA) testing in an entire country, including time trends and geographical differences. Data from the Swedish Cancer Register on prostate cancer incidence between 1980 and 2007 and published data from the Gothenburg branch of the European randomi...

journal_title：International journal of cancer

authors： Jonsson H,Holmström B,Duffy SW,Stattin P

更新日期：2011-10-15 00:00:00

abstract：:Targeting of T lymphocytes against epidermal growth-factor-receptor (EGF-R)+ tumor cells was achieved by constructing a hybrid hybridoma which secretes an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb) of hybrid isotype (IgG1/IgG2a). Purification of biMAb molecules from parental anti-EGF-R and anti-CD3 MAb...

journal_title：International journal of cancer

authors： Ferrini S,Cambiaggi A,Sforzini S,Marciano S,Canevari S,Mezzanzanica D,Colnaghi MI,Grossi CE,Moretta L

更新日期：1993-12-02 00:00:00

abstract：:Angiogenesis is essential for tumor growth and metastasis. In the process of angiogenesis, the interaction between adhesive proteins of endothelial cells and extracellular matrix components plays an important role by mediating cell attachment, which is indispensable for their motility, and by transmitting the regulato...

journal_title：International journal of cancer

authors： Trochon V,Mabilat C,Bertrand P,Legrand Y,Smadja-Joffe F,Soria C,Delpech B,Lu H

更新日期：1996-05-29 00:00:00

abstract：:The age-adjusted incidence rates of cutaneous melanoma in Queensland in 1987 have been analysed for 16 anatomic sites, taking into account their surface areas. In men, the incidence of invasive melanoma on the ears, a chronically sun-exposed site, was extraordinarily high with annual rates of over 200 per 10(5) units ...

journal_title：International journal of cancer

authors： Green A,MacLennan R,Youl P,Martin N

更新日期：1993-01-21 00:00:00

abstract：:The association between subtypes of hepatitis C virus (HCV) and risk of hepatocellular carcinoma (HCC) remained inconclusive and evaluated in both case-control and cohort studies. In the case-control study, 397 HCC cases from medical centers were compared with 410 community-based non-HCC controls. All of them were ant...

journal_title：International journal of cancer

authors： Lee MH,Yang HI,Lu SN,Jen CL,You SL,Wang LY,L'Italien G,Chen CJ,Yuan Y,REVEAL-HCV Study Group.

更新日期：2014-09-01 00:00:00

abstract：:Our previous clinicopathologic study revealed an inverse association of liver metastasis of colorectal cancer and stromal expression of matrix metalloproteinase-9 (MMP-9) or urokinase receptor (uPAR). This suggests that host cells, particularly macrophages, expressing matrix-degrading enzymes/factors could be protecti...

journal_title：International journal of cancer

authors： Saito K,Takeha S,Shiba K,Matsuno S,Sorsa T,Nagura H,Ohtani H

更新日期：2000-04-01 00:00:00

abstract：:Thrombin is now recognized as an important factor in many cancers. Here, we examined the expression and role of the recently discovered thrombin receptor PAR4, in human colon cancer cells. PAR4 mRNA was found in 10 out of 14 (71%) human colon cancer cell lines tested but not in epithelial cells isolated from normal hu...

journal_title：International journal of cancer

authors： Gratio V,Walker F,Lehy T,Laburthe M,Darmoul D

更新日期：2009-04-01 00:00:00

abstract：:The aim of our study was to develop and validate a machine learning algorithm to predict response of individual HER2-amplified colorectal cancer liver metastases (lmCRC) undergoing dual HER2-targeted therapy. Twenty-four radiomics features were extracted after 3D manual segmentation of 141 lmCRC on pretreatment portal...

journal_title：International journal of cancer

authors： Giannini V,Rosati S,Defeudis A,Balestra G,Vassallo L,Cappello G,Mazzetti S,De Mattia C,Rizzetto F,Torresin A,Sartore-Bianchi A,Siena S,Vanzulli A,Leone F,Zagonel V,Marsoni S,Regge D

更新日期：2020-12-01 00:00:00

abstract：:We conducted a longitudinal cohort study to determine the association of Helicobacter pylori infection and the progression of chronic atrophic gastritis (CAG) with gastric cancer. A cohort of 4655 healthy asymptomatic subjects was followed for a mean period of 7.7 years. H. pylori infection was established by serum sp...

journal_title：International journal of cancer

authors： Ohata H,Kitauchi S,Yoshimura N,Mugitani K,Iwane M,Nakamura H,Yoshikawa A,Yanaoka K,Arii K,Tamai H,Shimizu Y,Takeshita T,Mohara O,Ichinose M

更新日期：2004-03-01 00:00:00

abstract：:Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of mesothelioma, ovarian cancer and other malignant tumors. The interaction between mesothelin and CA125 (also called MUC16) may facilitate the implantation and metastasis of tumors in the peritoneal cavity....

journal_title：International journal of cancer

authors： Ho M,Feng M,Fisher RJ,Rader C,Pastan I

更新日期：2011-05-01 00:00:00

abstract：:A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...

journal_title：International journal of cancer

authors： Goldenberg DM,Pavia RA

更新日期：1975-02-15 00:00:00

abstract：:Partial or total loss of chromosome 22 is often associated with tumors of the central nervous system and in particular with meningiomas. As in the case of other tumors, the ganglioside pattern is modified in transformed tissues. Cytogenetic analysis of 30 human meningiomas has been performed and the results compared t...

journal_title：International journal of cancer

authors： Berra B,Papi L,Bigozzi U,Serino D,Morichi R,Mennonna P,Rapelli S,Cogliati T,Montali E

更新日期：1991-02-01 00:00:00

abstract：:To find out whether manipulation of H-2 expression on metastatic cells could alter their metastatic properties, we immunoselected in vivo H-2 antigen variants from a metastatic clone of the T10 sarcoma [originating in a (C57BL/6J X C3H.eB)FI mouse] and tested their metastatic capacity. The unselected metastatic cells ...

journal_title：International journal of cancer

authors： Katzav S,Segal S,Feldman M

更新日期：1984-03-15 00:00:00

abstract：:Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) ...

journal_title：International journal of cancer

authors： Gao GF,Roth MJ,Wei WQ,Abnet CC,Chen F,Lu N,Zhao FH,Li XQ,Wang GQ,Taylor PR,Pan QJ,Chen W,Dawsey SM,Qiao YL

更新日期：2006-09-15 00:00:00

abstract：:Normal sera of Japanese quails caused lysis of tumor cells from a Rous sarcoma virus (RSV)-induced quail tumor (QT cells). Other tumor cell lines, including RSV-transformed quail embryo cells and methylcholanthrene-induced quail tumors, were not lysed. This naturally occurring cytolytic factor (NCLF) was sensitive to ...

journal_title：International journal of cancer

authors： Yoshikawa Y,Yamanouchi K,Hishiyama M,Kobune K

更新日期：1978-05-15 00:00:00

abstract：:Lung cancer is the leading cause of cancer mortality in the world. Although exposure to carcinogens is considered to be the main cause, genetic variation may contribute to lung cancer risk. Murine double minute 2, MDM2, is a key regulator of p53 activity and recently a polymorphism in the promoter region of the MDM2 g...

journal_title：International journal of cancer

authors： Lind H,Zienolddiny S,Ekstrøm PO,Skaug V,Haugen A

更新日期：2006-08-01 00:00:00