Immuno-selection in vivo of H-2D phenotypic variants from a metastatic clone of sarcoma cells results in cell lines of altered metastatic competence.


:To find out whether manipulation of H-2 expression on metastatic cells could alter their metastatic properties, we immunoselected in vivo H-2 antigen variants from a metastatic clone of the T10 sarcoma [originating in a (C57BL/6J X C3H.eB)FI mouse] and tested their metastatic capacity. The unselected metastatic cells (IE7) were previously found to express H-2Db and H-2Dk antigens, but they did not express the H-2K antigens of either parental haplotype. Transplantation of IE7 cells into C57BL/6J irradiated mice resulted in loss of H-2Dk expression and a reduction in H-2Db antigen density. Further transplantation of these cells into non-irradiated C57BL/6J mice led to a total loss of H-2 expression. The cells concomitantly lost their metastatic potency. Immunoselection of IE7 cells in C3H.eB irradiated and non-irradiated mice resulted in cells which were H-2Dk-positive but H-2Db-negative. Cells of these selected variants not only retained their metastatic potential, but in fact were far more metastatic than the unselected IE7 cells. Thus, changes in H-2 expression on tumor cells may alter their metastatic potential. In the case of T10 cells, H-2Dk expression seems to be directly involved in their metastatic capacity.


Int J Cancer


Katzav S,Segal S,Feldman M




Has Abstract


1984-03-15 00:00:00












  • Large scale in vivo micro-RNA loss of function screen identified miR-29a, miR-100 and miR-155 as modulators of radioresistance and tumor-stroma communication.

    abstract::Micro RNAs (miR) are master regulators of cellular transcriptome. We aimed to investigate the role of miR regulation on tumor radiosensitivity and development of local tumor recurrence by a novel large-scale in vivo loss of function screen. For stable miR silencing, human A431 tumor cells were transduced with lentivir...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fahim Golestaneh A,Lecker LSM,Schlegel J,Nowrouzi A,Schwager C,Meister S,Weichert W,Debus J,Abdollahi A

    更新日期:2019-06-01 00:00:00

  • Childhood cancers in Chennai, India, 1990-2001: incidence and survival.

    abstract::Childhood cancers (age at diagnosis: 0-14 years) comprise a variety of malignancies, with incidence varying worldwide by age, sex, ethnicity and geography, that provide insights into cancer etiology. A total of 1,334 childhood cancers registered in population-based cancer registry, Chennai, India, during 1990-2001 and...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Swaminathan R,Rama R,Shanta V

    更新日期:2008-06-01 00:00:00

  • Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer.

    abstract::Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer mortality worldwide. Emerging evidence indicates that tumour cells release substantial amounts of RNA into the bloodstream, in which RNA strongly resists RNases and is present at sufficient levels for quantitative analyses. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Xu W,Zhou G,Wang H,Liu Y,Chen B,Chen W,Lin C,Wu S,Gong A,Xu M

    更新日期:2020-05-15 00:00:00

  • Human melanoma-specific oncofetal antigen defined by a mouse monoclonal antibody.

    abstract::140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Liao SK,Clarke BJ,Khosravi M,Kwong PC,Brickenden A,Dent PB

    更新日期:1982-11-15 00:00:00

  • How many cervical cancers are prevented by treatment of screen-detected disease in young women?

    abstract::Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. Under various assumptions and using past data on CIN grade 3 (CIN3) registrations in England and Scotland, we estimate what...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sasieni P,Castanon A,Parkin DM

    更新日期:2009-01-15 00:00:00

  • Anti-CD30-IL-12 antibody-cytokine fusion protein that induces IFN-gamma secretion of T cells and NK cell-mediated lysis of Hodgkin's lymphoma-derived tumor cells.

    abstract::Interleukin-12 (IL-12) is a disulfide-linked p40-p35 heterodimeric cytokine and plays a key role in linking innate cellular immunity to an adaptive Th1 response against pathogens and tumor cells and in counteracting a Th2 immune response. The pathogenesis of Hodgkin's disease (HD) is partially attributed to a Th2 domi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Heuser C,Diehl V,Abken H,Hombach A

    更新日期:2003-09-10 00:00:00

  • Geographical epidemiology of prostate cancer in Great Britain.

    abstract::Prostate cancer incidence has increased during recent years, possibly linked to environmental exposures. Exposure to environmental carcinogens is unlikely to be evenly distributed geographically, which may give rise to variations in disease occurrence that is detectable in a spatial analysis. The aim of our study was ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jarup L,Best N,Toledano MB,Wakefield J,Elliott P

    更新日期:2002-02-10 00:00:00

  • Expression of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in benign, borderline, malignant primary and metastatic ovarian tumors.

    abstract::Elevated levels of expression of the urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 have shown to be related to poor prognosis in a variety of cancer types. In the present study, cytosolic levels of uPA and PAI-1 were determined with enzyme-linked immunosorbent assays in cytosols prepared from 244 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Burg ME,Henzen-Logmans SC,Berns EM,van Putten WL,Klijn JG,Foekens JA

    更新日期:1996-12-20 00:00:00

  • Correlation of total VEGF mRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small-cell lung cancer.

    abstract::We have quantified the expression of all 4 isoforms of vascular endothelial growth factor (VEGF) mRNA in non-small-cell lung cancer (NSCLC) using a new kinetic quantitative PCR method, real-time quantitative (RTQ) RT-PCR, and investigated the association between VEGF expression at the mRNA and protein levels and the c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yuan A,Yu CJ,Chen WJ,Lin FY,Kuo SH,Luh KT,Yang PC

    更新日期:2000-11-20 00:00:00

  • Effect of mistimed eating patterns on breast and prostate cancer risk (MCC-Spain Study).

    abstract::Modern life involves mistimed sleeping and eating patterns that in experimental studies are associated with adverse health effects. We assessed whether timing of meals is associated with breast and prostate cancer risk taking into account lifestyle and chronotype, a characteristic correlating with preference for morni...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kogevinas M,Espinosa A,Castelló A,Gómez-Acebo I,Guevara M,Martin V,Amiano P,Alguacil J,Peiro R,Moreno V,Costas L,Fernández-Tardón G,Jimenez JJ,Marcos-Gragera R,Perez-Gomez B,Llorca J,Moreno-Iribas C,Fernández-Villa T,

    更新日期:2018-11-15 00:00:00

  • Interleukin-2-stimulated natural killer activity against malignant and benign endometrium.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Timonen T,Lehtovirta P,Saksela E

    更新日期:1987-10-15 00:00:00

  • ETV5 transcription factor is overexpressed in ovarian cancer and regulates cell adhesion in ovarian cancer cells.

    abstract::Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Llauradó M,Abal M,Castellví J,Cabrera S,Gil-Moreno A,Pérez-Benavente A,Colás E,Doll A,Dolcet X,Matias-Guiu X,Vazquez-Levin M,Reventós J,Ruiz A

    更新日期:2012-04-01 00:00:00

  • Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects.

    abstract::Novel classes of drug that interfere with the signalling of the small G-protein Ras, the so-called Ras antagonists, are showing much promise as novel anti-cancer agents. In this study, we demonstrate that the novel Ras antagonist farnesylthiosalicylic acid (FTS) inhibits the growth of Colo 853 melanoma cells through a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Smalley KS,Eisen TG

    更新日期:2002-04-01 00:00:00

  • A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kohno H,Takahashi M,Yasui Y,Suzuki R,Miyamoto S,Kamanaka Y,Naka M,Maruyama T,Wakabayashi K,Tanaka T

    更新日期:2007-08-01 00:00:00

  • Human ovarian tumors in primary culture: growth, characterization and initial evaluation of the response to cis platinum treatment in vitro.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Balconi G,Broggini M,Erba E,D'Incalci M,Colombo N,Mangioni C,Bertolero F

    更新日期:1988-06-15 00:00:00

  • Telomerase components as a diagnostic tool in human oral lesions.

    abstract::Telomerase activity is considered to be a diagnostic marker of malignancy since most malignant cells express this activity and most somatic cells do not. However, the detection of telomerase activity is rather complicated and is affected by many factors. Recently, human telomerase components were cloned and found to c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sumida T,Hamakawa H,Sogawa K,Sugita A,Tanioka H,Ueda N

    更新日期:1999-01-05 00:00:00

  • Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development.

    abstract::Uveal melanoma is associated with a high tumor-related mortality due to the propensity to develop metastases. The mechanisms that are responsible for malignant dissemination are largely unknown and need to be explored to facilitate diagnosis and treatment of metastases. To identify molecules involved in dissemination,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Velden PA,Zuidervaart W,Hurks MH,Pavey S,Ksander BR,Krijgsman E,Frants RR,Tensen CP,Willemze R,Jager MJ,Gruis NA

    更新日期:2003-09-10 00:00:00

  • Fibronectin in human solid tumors.

    abstract::Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stenman S,Vaheri A

    更新日期:1981-01-01 00:00:00

  • Differences in lung cancer risk from smoking among Japanese, Chinese and Hawaiian women in Hawaii.

    abstract::The age-adjusted lung cancer incidence rates among Japanese, Chinese and Hawaiian women in Hawaii do not correlate to their respective cigarette smoking exposures. We conducted a case-control study to determine the lung cancer risk associated with smoking among these three ethnic groups of women by reviewing the medic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hinds MW,Stemmermann GN,Yang HY,Kolonel LN,Lee J,Wegner E

    更新日期:1981-03-15 00:00:00

  • Clustering of discrete cell properties essential for tumorigenicity and metastasis. I. Studies of Syrian hamster embryo fibroblasts spontaneously transformed in vitro.

    abstract::The expression of two discrete cell properties related to the host natural effector mechanisms, i.e., resistance to damage by H2O2, a cytotoxic product of activated macrophages, and the ability to secrete PGE, which inhibits NK-cell cytotoxicity, has been examined in parental Syrian hamster embryo cells spontaneously ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Deichman GI,Kluchareva TE,Matveeva VA,Kushlinsky NE,Bassalyk LS,Vendrov EL

    更新日期:1989-11-15 00:00:00

  • Tumor-reactive CD8+ T-cell clones in patients after NY-ESO-1 peptide vaccination.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Karbach J,Gnjatic S,Pauligk C,Bender A,Maeurer M,Schultze JL,Nadler K,Wahle C,Knuth A,Old LJ,Jäger E

    更新日期:2007-11-01 00:00:00

  • Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells.

    abstract::Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC). Current efforts to eradicate CRC predominantly focused on targeting the proliferation of rapidly growing cancer epithelial cells. This is largely ineffective with resistance arising in most tumors after exposure to chemotherapy. De...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Deng X,Ruan H,Zhang X,Xu X,Zhu Y,Peng H,Zhang X,Kong F,Guan M

    更新日期:2020-03-15 00:00:00

  • Diagnostic value of radiological breast imaging in a non-screening population.

    abstract::The aim of this study was to assess the diagnostic performance of breast imaging in the diagnosis of breast cancer in a non-screening population. In a consecutive set of patients referred for mammography in one year, the results of palpation and radiological breast imaging were scored on a 5-point grading scale and li...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Flobbe K,van der Linden ES,Kessels AG,van Engelshoven JM

    更新日期:2001-05-15 00:00:00

  • Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gratio V,Walker F,Lehy T,Laburthe M,Darmoul D

    更新日期:2009-04-01 00:00:00

  • Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives.

    abstract::Human mammary carcinoma cell lines (MCF-7) were analysed for their hormone sensitivity before and after transfection with a v-Ha-ras oncogene or with a neomycin-resistance gene followed by selection in vitro or in vivo. Our aim was to test how the expression of the ras oncogene would influence the estradiol sensitivit...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Van Roy F,Mareel M,Vleminckx K,Beyaert R,Fiers W,Devleeschouwer N,Muquardt C,Legros N,Bracke M,Leclercq G

    更新日期:1990-09-15 00:00:00

  • Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis.

    abstract::The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ghosh S,Ghosh A,Maiti GP,Alam N,Roy A,Roy B,Roychoudhury S,Panda CK

    更新日期:2008-12-01 00:00:00

  • Variation in promptness of presentation among 10,297 patients subsequently diagnosed with one of 18 cancers: evidence from a National Audit of Cancer Diagnosis in Primary Care.

    abstract::Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the 'patient interval'). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with genera...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Keeble S,Abel GA,Saunders CL,McPhail S,Walter FM,Neal RD,Rubin GP,Lyratzopoulos G

    更新日期:2014-09-01 00:00:00

  • Decreased frequency of HLA-DRB1 13 alleles in Frenchwomen with HPV-positive carcinoma of the cervix.

    abstract::Specific types of human papillomaviruses (HPV) are associated with most cases of pre-invasive and invasive neoplasia of the uterine cervix. HLA phenotype influences susceptibility and resistance to viral infections and may therefore influence the course of HPV-associated tumors. Some data suggest that specific HLA cla...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sastre-Garau X,Loste MN,Vincent-Salomon A,Favre M,Mouret E,de la Rochefordiere A,Durand JC,Tartour E,Lepage V,Charron D

    更新日期:1996-06-21 00:00:00

  • Gastrointestinal toxicity during induction treatment for childhood acute lymphoblastic leukemia: The impact of the gut microbiota.

    abstract::Intestinal mucositis is a common side effect of chemotherapy leading to diarrhea, abdominal pain and increased risk of infections. The intestinal microbiota has been recognized as a key regulator of mucosal immune responses. Therefore, we hypothesized that intestinal microbial changes would be associated with enterocy...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: De Pietri S,Ingham AC,Frandsen TL,Rathe M,Krych L,Castro-Mejía JL,Nielsen DS,Nersting J,Wehner PS,Schmiegelow K,Hasle H,Pamp SJ,Müller K

    更新日期:2020-10-01 00:00:00

  • Adenovirus-mediated tBid overexpression results in therapeutic effects on p53-resistant hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a very high mortality. Because the success of the conventional therapies is limited, gene therapy may represent an alternative for HCC management. Our earlier study has shown that Bid plays a role in the development of HCC. The aim of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Miao J,Chen GG,Chun SY,Yun JP,Chak EC,Ho RL,Lai PB

    更新日期:2006-10-15 00:00:00