Human papillomavirus capsids preferentially bind and infect tumor cells.


:We previously determined that human papillomavirus (HPV) virus-like particles (VLPs) and pseudovirions (PsV) did not, respectively, bind to or infect intact epithelium of the cervicovaginal tract. However, they strongly bound heparan sulfate proteoglycans (HSPG) on the basement membrane of disrupted epithelium and infected the keratinocytes that subsequently entered the disrupted site. We here report that HPV capsids (VLP and PsV) have the same restricted tropism for a wide variety of disrupted epithelial and mesothelial tissues, whereas intact tissues remain resistant to binding. However, the HPV capsids directly bind and infect most tumor-derived cell lines in vitro and have analogous tumor-specific properties in vivo, after local or intravenous injection, using orthotopic models for human ovarian and lung cancer, respectively. The pseudovirions also specifically infected implanted primary human ovarian tumors. Heparin and ι-carrageenan blocked binding and infection of all tumor lines tested, implying that tumor cell binding is HSPG-dependent. A survey using a panel of modified heparins indicates that N-sulfation and, to a lesser degree, O-6 sulfation of the surface HSPG on the tumors are important for HPV binding. Therefore, it appears that tumor cells consistently evolve HSPG modification patterns that mimic the pattern normally found on the basement membrane but not on the apical surfaces of normal epithelial or mesothelial cells. Consequently, appropriately modified HPV VLPs and/or PsV could be useful reagents to detect and potentially treat a remarkably broad spectrum of cancers.


Int J Cancer


Kines RC,Cerio RJ,Roberts JN,Thompson CD,de Los Pinos E,Lowy DR,Schiller JT




Has Abstract


2016-02-15 00:00:00












  • Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells.

    abstract::Tumor cells do not constitutively exhibit invasive activity, but rather, can be transiently induced to adhere and form lesions. We report here that the expression of seprase, a dominant EDTA-resistant gelatinase in malignant tumors, is dependent on tumor cell exposure to type I collagen gel (TICg). The induced seprase...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kennedy A,Dong H,Chen D,Chen WT

    更新日期:2009-01-01 00:00:00

  • Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11.

    abstract::Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cornall AM,Roberts JM,Garland SM,Hillman RJ,Grulich AE,Tabrizi SN

    更新日期:2013-11-01 00:00:00

  • Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer.

    abstract::Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Herbst A,Vdovin N,Gacesa S,Ofner A,Philipp A,Nagel D,Holdt LM,Op den Winkel M,Heinemann V,Stieber P,Graeven U,Reinacher-Schick A,Arnold D,Ricard I,Mansmann U,Hegewisch-Becker S,Kolligs FT

    更新日期:2017-05-01 00:00:00

  • No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency.

    abstract::Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vajdic CM,van Leeuwen MT,Turner JJ,McDonald AM,Webster AC,McDonald SP,Chapman JR,Kaldor JM,Grulich AE

    更新日期:2010-12-01 00:00:00

  • Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2.

    abstract::Folate is required for biological methylation and nucleotide synthesis, aberrations of which are thought to be the mechanisms that enhance colorectal carcinogenesis produced by folate inadequacy. These functions of folate also depend on the availability of other B-vitamins that participate in "one-carbon metabolism," ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Liu Z,Choi SW,Crott JW,Smith DE,Mason JB

    更新日期:2008-08-01 00:00:00

  • Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines.

    abstract::We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer and metastatic cancer respectively. We examined the expression of matrix-degrading enzymes and their inhibitors in these cell lines. Both cell lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kawamata H,Nakashiro K,Uchida D,Harada K,Yoshida H,Sato M

    更新日期:1997-01-06 00:00:00

  • Treatment of metastatic melanoma with autologous, hapten-modified melanoma vaccine: regression of pulmonary metastases.

    abstract::A human cancer vaccine composed of autologous tumor cells modified with the hapten dinitrofluorobenzene (DNP) induces cell-mediated immunity to the tumor cells and the development of inflammatory responses within metastatic sites. In this study we determined whether DNP vaccine could induce regression of established m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Berd D,Sato T,Cohn H,Maguire HC Jr,Mastrangelo MJ

    更新日期:2001-11-01 00:00:00

  • Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase.

    abstract::Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ellies LG,Fishman M,Hardison J,Kleeman J,Maglione JE,Manner CK,Cardiff RD,MacLeod CL

    更新日期:2003-08-10 00:00:00

  • Endogenous sex hormones and the risk of prostate cancer: a prospective study.

    abstract::Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in e...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Weiss JM,Huang WY,Rinaldi S,Fears TR,Chatterjee N,Hsing AW,Crawford ED,Andriole GL,Kaaks R,Hayes RB

    更新日期:2008-05-15 00:00:00

  • Regulation of cell turnover in the livers of tumour-bearing rats: occurrence of apoptosis.

    abstract::Growth of a highly-deviated ascites hepatoma (Yoshida AH-130) in rats caused initial hyperplastic enlargement of the liver, followed by progressive reduction to a size lower than that seen in controls. The time-course of this biphasic change in liver weight roughly corresponded to the exponential and stationary phases...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tessitore L,Valente G,Bonelli G,Costelli P,Baccino FM

    更新日期:1989-10-15 00:00:00

  • The prevalence of antibody to p42 of HTLV-I among ATLL patients in comparison with healthy carriers in Japan.

    abstract::A gene product (p42) of the long open reading frame, now termed tax, of the viral genome of human T-cell leukemia virus type I (HTLV-I) may be related to the transformation of T cells in adult T-cell leukemia-lymphoma (ATLL). To evaluate its association with the disease, we compared the prevalence of antibody to p42 i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yokota T,Cho MJ,Tachibana N,McLane MF,Takatsuki K,Lee TH,Mueller N,Essex M

    更新日期:1989-06-15 00:00:00

  • Differential lysis of melanoma clones by autologous recombinant interleukin 2-activated lymphocytes. Relationship with spontaneous resistance to doxorubicin (Dx).

    abstract::To investigate whether human melanoma cells intrinsically resistant to autologous LAKs do exist, and whether a relationship between the level of lysis of LAKs and spontaneous drug resistance can be identified at the clonal level, we studied 44 clones obtained from a metastatic melanoma lesion. The antigenic phenotype ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gambacorti-Passerini C,Rivoltini L,Supino R,Mariani M,Parmiani G

    更新日期:1988-10-15 00:00:00

  • A BALB/c 3T3-transformed cell line suitable for transfection assay of metastasis-inducing genes.

    abstract::A clonal cell line, 1-1ras1000, transformed by the activated c-Ha-ras oncogene, does not form metastases after i.v. injection into mice (experimental metastasis assay). Here, we show that this cell line is useful as a recipient to detect metastasis-inducing genes, using a transfection assay. Cells (1-1ras1000) were su...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tatsuka M,Ota T,Maeda M,Wada M,Yamagishi N,Taniguchi S,Seiki M,Odashima S

    更新日期:1997-03-28 00:00:00

  • Epidemiology and the causes of breast cancer.

    abstract::This article describes the characteristics of 3 dominant features of breast cancer epidemiology. These characteristics include the association of disease risk with childbearing, its relationship to ovarian activity and its international variation (particularly as the latter differs in the years before and after menopa...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: MacMahon B

    更新日期:2006-05-15 00:00:00

  • Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma.

    abstract::Using a recently developed autochthonous mouse model of squamous cell carcinoma (SCC), a combination therapy targeting polyamine metabolism was evaluated. The therapy combined 2-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and MQT 1426, a polyamine transport inhibitor. In 1 trial last...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen Y,Weeks RS,Burns MR,Boorman DW,Klein-Szanto A,O'Brien TG

    更新日期:2006-05-01 00:00:00

  • Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma.

    abstract::We have examined the effects of the synthetic matrix metalloproteinase inhibitor, batimastat (BB-94) and the angiotensin-converting enzyme inhibitor, captopril, on metalloproteinase activity of murine Lewis-lung-carcinoma cells (3LL) in vitro, and on local growth and lung metastasis of the same tumor implanted intramu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Prontera C,Mariani B,Rossi C,Poggi A,Rotilio D

    更新日期:1999-05-31 00:00:00

  • A phosphoarray platform is capable of personalizing kinase inhibitor therapy in head and neck cancers.

    abstract::Tyrosine kinase inhibitors are effective treatments for cancers. Knowing the specific kinase mutants that drive the underlying cancers predict therapeutic response to these inhibitors. Thus, the current protocol for personalized cancer therapy involves genotyping tumors in search of various driver mutations and subseq...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Klinghammer K,Keller J,George J,Hoffmann J,Chan EL,Hayman MJ

    更新日期:2018-01-01 00:00:00

  • Human ovarian tumors in primary culture: growth, characterization and initial evaluation of the response to cis platinum treatment in vitro.

    abstract::A novel cell culture system is reported for the growth of ovarian tumors. Two approaches were developed to isolate tumor cells, one for ovarian carcinomas and the other for benign cystomas or borderline cystadenomas, which yield virtually pure tumor-cell clusters. The plating efficiency exceeded 10% in approximately 8...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Balconi G,Broggini M,Erba E,D'Incalci M,Colombo N,Mangioni C,Bertolero F

    更新日期:1988-06-15 00:00:00

  • Racial/ethnic differences in colorectal cancer risk: the multiethnic cohort study.

    abstract::Incidence rates in the United States show clear racial/ethnic disparities for colorectal cancer. We examined the extent to which ethnic differences in risk factors could explain the age-adjusted variation in the risk of colorectal cancer, overall and by stage at diagnosis, among 165,711 African Americans, Japanese Ame...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ollberding NJ,Nomura AM,Wilkens LR,Henderson BE,Kolonel LN

    更新日期:2011-10-15 00:00:00

  • Genetic identification of multiple susceptibility genes involved in the development of endometrial carcinoma in a rat model.

    abstract::There are clear indications that inheritance plays an essential role in certain cases of human endometrial cancer, and there are at least 2 forms of early-onset heritable endometrial adenocarcinomas (EACs). Females of the BDII inbred rat strain are known to be genetically predisposed to endometrial carcinoma, and we h...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Roshani L,Wedekind D,Szpirer J,Taib Z,Szpirer C,Beckmann B,Rivière M,Hedrich HJ,Klinga-Levan K

    更新日期:2001-12-15 00:00:00

  • Germline variation in BRCA1/2 is highly ethnic-specific: Evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients.

    abstract::BRCA1 and BRCA2 play essential roles in maintaining the genome stability. Pathogenic germline mutations in these two genes disrupt their function, lead to genome instability and increase the risk of developing breast and ovarian cancers. BRCA mutations have been extensively screened in Caucasian populations, and the r...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bhaskaran SP,Chandratre K,Gupta H,Zhang L,Wang X,Cui J,Kim YC,Sinha S,Jiang L,Lu B,Wu X,Qin Z,Huang T,Wang SM

    更新日期:2019-08-15 00:00:00

  • Distribution and characterization of alpha hCG in the serum and tumor cytosol of patients with breast cancer.

    abstract::Serum and tumor tissue from breast cancer patients were evaluated for the presence of alpha subunit of hCG, by means of the specific radioimmunoassay. Elevated serum levels occurred in 0/50 (0%) of normal female controls, 1/17 (6%) of patients with benign breast disease, 3/53 (6%) of patients with primary breast cance...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shindelman JE,Ortmeyer AE,Wada HG,Stockdale F,Sussman HH

    更新日期:1980-05-15 00:00:00

  • Combined recombinant human interferon alpha 2 and cytotoxic agents studied in a clonogenic assay.

    abstract::A human tumor clonogenic assay has been used to test the antiproliferative effect of recombinant human leukocyte interferon alpha 2 alone and in combination with each of 8 cytotoxic agents. Cell lines derived from 6 human tumors and primary tumor cells from 13 patients have been used in these clonogenic assay studies....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Welander CE,Morgan TM,Homesley HD,Trotta PP,Spiegel RJ

    更新日期:1985-06-15 00:00:00

  • Improvement of hyperlipidemia by indomethacin in Min mice.

    abstract::Apc gene-deficient Min and Apc(1309) mice feature a hyperlipidemic state with a markedly low expression level of lipoprotein lipase (LPL) compared to their wild-type counterparts. We previously showed that induction of LPL mRNA by peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonists or an LPL sel...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Niho N,Mutoh M,Komiya M,Ohta T,Sugimura T,Wakabayashi K

    更新日期:2007-10-15 00:00:00

  • Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer-related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment and play an important role in the onset and progression of HCC through the secretion of g...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Ruan Q,Wang H,Burke LJ,Bridle KR,Li X,Zhao CX,Crawford DHG,Roberts MS,Liang X

    更新日期:2020-09-15 00:00:00

  • Cancer risk among patients with condylomata acuminata.

    abstract::Condylomata acuminata have been shown to increase the risk of anogenital cancers. However, previous studies have been of limited sample size and/or short follow-up duration, which prevent precise estimates of long-term excess risk, especially for specific cancer sites. We estimated the risk of specific cancers in a la...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nordenvall C,Chang ET,Adami HO,Ye W

    更新日期:2006-08-15 00:00:00

  • MAGE-1 and MAGE-3 or -6 expression in neuroblastoma-related pediatric solid tumors.

    abstract::MAGE-1 and MAGE-3 or -6 are genes encoding melanoma-rejection antigens recognized by cytotoxic T lymphocytes in an HLA-A1 restriction manner. MAGE-1 and MAGE-3 or -6 were expressed in 5/14 (36%) and 6/14 (43%) neuroblastoma (NB) cell lines, and in 20/41 (49%) and 24/41 (59%) clinical NB-related tumors, respectively. A...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ishida H,Matsumura T,Salgaller ML,Ohmizono Y,Kadono Y,Sawada T

    更新日期:1996-10-21 00:00:00

  • Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer.

    abstract::Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal different...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dokun OY,Florl AR,Seifert HH,Wolff I,Schulz WA

    更新日期:2008-12-15 00:00:00

  • Expression of the ras-related rap genes in human tumors.

    abstract::The expression of the recently described rap genes, closely related in the effector region to the ras proto-oncogenes, was examined by Northern blot analysis in 41 primary human tumors. The structural and in vitro biological properties of the rap gene products suggest their possible antagonistic action in the same eff...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Culine S,Olofsson B,Gosselin S,Honore N,Tavitian A

    更新日期:1989-12-15 00:00:00

  • Twenty-years experience with de novo metastatic breast cancer.

    abstract::Although new treatments have been widely studied to improve the survival of patients with metastatic breast cancer (BC), prognosis continues to be poor with an average survival time no longer than 3 years. We carried on a population-based study with the purpose of evaluating the outcome of metastatic breast cancer in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cortesi L,Toss A,Cirilli C,Marcheselli L,Braghiroli B,Sebastiani F,Federico M

    更新日期:2015-09-15 00:00:00